Minimum Quantity Lubrication nanofluid (MQL-nanofluid) is a viable sustainable alternative to conventional flood cooling and provides very good cooling and lubrication in the machining of difficult to cut materials such as titanium and Inconel. The cutting action provides very difficult conditions for the coolant to access the cutting zone and the level of difficulty increases with higher cutting speeds. Furthermore, high compressive stresses, strain hardening and high chemical activity results in the formation of a ‘seizure zone’ at the tool-chip interface. In this work, the impact of MQL-nanofluid at the seizure zone and the corresponding effects on tool wear, surface finish, and power consumption during machining of Ti-6Al-4V was investigated. Aluminum Oxide (Al2O3) nanoparticles were selected to use as nano-additives at different weight fraction concentrations (0, 2, and 4 wt.%). It was observed that under pure MQL strategy there was significant material adhesion on the rake face of the tool while the adhesion was reduced in the presence of MQL-nanofluid at the tool-chip interface, thus indicating a reduction in the tool chip contact length (TCCL) and reduced seizure effect. Furthermore, the flank wear varied from 0.162 to 0.561 mm and the average surface roughness (Ra) varied from 0.512 to 2.81 µm. The results indicate that the nanoparticle concentration and the reduction in the seizure zone positively influence the tool life and quality of surface finish.