A tremendous amount of technology (e.g., online learning platforms, virtual reality, artificial intelligence, and robots) has been utilized to create rich interactive activities to upgrade preservice teachers’ knowledge and skills. However, there is a challenge to transform teacher preparation programs into a fully realized technological pedagogical content knowledge (TPACK) application environment. Teachers’ technology leadership (TTL) should be considered to empower preservice teachers to apply TPACK. Since there was no empirical evidence concerning the impact of technology leadership on student outcomes, this study investigated the relationship between TTL and postgraduate preservice teachers’ application of TPACK by collecting quantitative data in Chinese normal university. Factor analyses were first conducted; and results indicated that the questionnaire combined the ISTE-E standards and TPACK framework was a reliable and valid survey instrument. The descriptive statistics results showed that TTL (professional growth and leadership, digital citizenship, technology collaboration, and technology-empowered learning) was highly perceived, and postgraduate preservice teachers’ TPACK components were at medium levels. Structural equation modeling test results revealed that TTL positively and significantly influenced all dimensions of postgraduate preservice teachers’ TPACK. Finally, limitations of the study and suggestions for future research are provided along with theoretical and practical implications.