This study investigated the dispersion and evaporation characteristics of droplets and droplet nuclei emitted during human respiratory activities. A specially designed wind tunnel was filled with purified air, wherein selected subjects performed various respiratory activities with their heads positioned inside. An optical particle sizer was used to collect particles with sizes of 0.3–10 μm at 63 points in front of the mouth. The dilution factors were analyzed to investigate the impact of combining the exhaled airflow with ambient air on droplet evaporation. At a distance of 0.01 m from the mouth opening, the volume concentration of the particles was the highest during breathing, followed by coughing and speaking. The volumetric concentration of particles decreased with an increase in the distance from the inlet for all activities. The spatial volume concentration distribution of particles showed that coughing tended to disperse the particles in the forward direction, whereas speaking tended to disperse them laterally. Utilizing these findings in CFD analysis can provide in-depth insights into dispersion and evaporation dynamics. This can contribute significantly to the development of preventive measures through the implementation of proactive HVAC systems to effectively remove infectious particles and control the spread of infectious diseases. Future studies should explore a wider range of particle sizes and advanced sampling techniques for a clear understanding of respiratory particle dynamics and infection control strategies.