AbstractPurposeTo evaluate, through in vitro studies, the bond strength of vitreous and hybrid ceramics with self‐etching surface treatment compared to conventional treatment.MethodsThis systematic review followed the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) and was registered on the open science framework (OSF) platform for in vitro studies. A population, intervention, control, and outcome (PICO) question was formulated: “Does the surface conditioning of glass and hybrid ceramics with self‐etching silane present a bond strength similar to that of conventional bonding?”. A literature search was carried out in the PubMed, Embase, Web of Science, Cochrane Library, and ProQuest databases until September 2023. The Joanna Briggs Institute (JBI) critical appraisal guidelines for quasi‐experimental studies were used for risk assessment of bias. The meta‐analysis was based on the inverse variance (IV) method (p < 0.05).ResultsA total of 29 in vitro studies published between 2017 and 2022 were included in this systematic review, totaling 1889 ceramic samples. The meta‐analysis indicated a significant decrease in the bond strength of HF 4%–5% with silane compared to self‐etching (p < 0.05; MD: 0.34; 95% CI: 0.13–0.35; I2 = 3%, p = 0.42), while it indicated that there was no significant difference between self‐etching compared to 9%–10% HF with silane (p = 0.92; MD: 0.02; 95% CI: −0.32 to 0.36; I2 = 14%, p = 0.32).ConclusionSelf‐etching primer presents bond strength that is superior to or similar to conventional surface treatment on glass and hybrid ceramics.