The hybrid nanomaterials of platinum/cerium oxide/multi-walled carbon nanotubes ( Pt/CeO2 /MWCNTs) are synthesized successfully via impregnation and polyol processes. MWCNTs serve as an excellent supporter where CeO2 nanoparticles are decorated with well-distributed Pt nanoparticles. Images show the average particle size of crystalline Pt and CeO2 on MWCNTs are 3–7 and 20–30 nm, respectively. In electrochemical reaction, the redox peak of Pt/CeO2 -700°C/MWCNTs reveals lower potential and higher current density in methanol electro-oxidation than those of other Pt -based ones. The study indicates that the cerium oxide in Pt/CeO2 -700°C/MWCNTs catalyst will enhance significantly the oxygen ions transportation between the interface of Pt and MWCNTs to eliminate the CO poison effect on Pt catalyst.