Centripetal Movement Research Articles

О парадоксальном способе самосознания: рок-культура как маркер идентичности

One of the tools that participate in the transformation of the identity system at the stage of transition from modern culture to postmodern culture is rock culture. It offers a person a number of identification opportunities that have different properties compared to the possibilities of defining oneself in a manner characteristic of modern culture. There is a partial rejection of identity markers characteristic to the modern era. The identity formed by rock culture, in accordance with current theoretical concepts, can be attributed to multiple, small narrative identities. As its fundamental characteristic feature, the presence of an indefinite core of identity is considered, which is understood as a set of phenomena perceived and interpreted by the subject as a basis for establishing one’s own identity with other subjects. This uncertainty lies in the weak definitions of rock, in the desire of subjects to refuse to positively identify themselves with rock, in denying the existence of this phenomenon as such. At the same time, rock does not turn into its own opposite, does not assume the functions of the excluded Other, remaining an object of centrifugal or centripetal motion. In addition, the weakening of the core of identity is due to the fact that the concept of rock turns into the focus of axiological aspirations of the subject. Rock culture is appropriated by the subject, turning into an absolute epicenter of identification. Subjectivity, thus, is taken out of the framework of one’s own personality and is endowed with the characteristics of an object, while receiving the name of rock. The real object for building identity disappears, being replaced by a subject, or at least a separate segment of it.

Let us play something else: Thoughts on ‘games are different’ and game scholarship in the Trump era

This piece takes its cue from a pair of incidents – a not unfamiliar theme in game studies – relating to game scholarship and its engagement with right-wing politics. In the first case, well-known game scholar Bonnie ‘Bo’ Ruberg called on editors and reviewers to stop insisting that scholars include a reference to a certain online campaign of harassment, doxing and threats of physical violence. In the second case, I had a reviewer insist that I had to include a reference to the ‘Fortnite to alt-right pipeline’ because clearly games were causing alt-right lunacy. To be sure, these both constitute genre criticism – among others – at its most reductive and cynical, deciding what the institutional and audience expectations entail based on an assumption of the industrial ones. Then, biographical criticism and assertions about authorial intent or the necessary ‘touchstones’ began to appear. There seems to be a consistent and persistent insistence that somehow even the best and most accomplished scholars should forget decades of scholarship because ‘games are different’ and this tendency has been conditioned and shaped by reading games through the ‘lens’ of the Trump presidency. This is important because it confirms that essays about games still tend to fit into one of the two boxes Ruberg ticks: game scholars who are not necessarily adept at the specific content area or specialists in a given field who are not really game scholars. It is telling and symptomatic of the centripetal and centrifugal movements in game studies; that is, from within and without. Admittedly, games are different, but not so different that we should forget or ignore decades of scholarship or worse, do not bother to find out if it exists at all. Not only are many of these positions ahistorical – ignoring the fact that, as some much maligned games quite cleverly point out repeatedly within, the same things have been said about the corrupting power of soap operas, romance novels, comic books, wrestling, rap and hip hop, backwards masking in heavy metal and plain old rock ‘n’ roll – the positions are also tacitly or unwittingly ageist, classist and/or occasionally racist, homophobic and transphobic even as the author purports to be concerned with inequitable representations. Moreover, there are peculiarly US American concerns that are transposed onto ostensibly universal ones. These reveal that even the most ‘woke’ of the American left can be a cultural imperialist and that American exceptionalism is inescapable if not ineluctable.

Study on the flow characteristics of heterogeneous particles in three types of biomass fast pyrolysis down-tube reactors

A novel staircase down-tube reactor has been developed to solve the problem of the short residence time of ceramic balls in a vertical down-tube reactor and flow separation of biochar powder and ceramic balls in a V-shaped down-tube reactor. Numerical simulation was performed using a coupled approach that combined the Discrete Element Method (DEM) and Computational Fluid Dynamics (CFD) to simulate the mixing flow of heterogeneous particles (biochar powder and ceramic balls) in three types of down-tube reactors: staircase, vertical, and V-shaped structure. The results show that at an equivalent vertical height. The average residence time for ceramic ball in a staircase down-tube reactor is longer than that of the other two types (tstaircase structure = 1.6 s > tV-shaped structure = 1.0 s > tvertical structure = 0.6 s). The average residence time of biochar powder in three types of down-tube reactors can be classified as follows: tV-shaped structure = tstaircase structure = 1.2 s > tvertical structure = 1.1 s. The flow separation and centripetal motion of heterogeneous particles were observed in V-shaped down-tube reactor. A distinct periodic motion is exhibited in staircase down-tube reactor, it has great significance for exploring the flow and heat transfer regularity of heterogeneous particles. Eccentric distance (E.d) was proposed as a measure of the spatial utilization efficiency of the device. While the degree of coherence (D.c) was used to assess the degree of flow separation among heterogeneous particles.

A cross-sectional study of macular displacement after macular hole surgery with ILM peeling in patients with idiopathic macular hole.

To examine the retinal displacement and change in mean superficial foveal avascular zone (FAZ) after successful closure of macular hole (MH) with vitrectomy with internal limiting membrane peeling (ILM) and gas tamponade. A total of 45 patients with idiopathic MH who underwent 23G pars plana vitrectomy with ILM peeling and tamponade with 20% SF6/14% C3F8 were included. Follow-up visits were performed at 2, 4, and 8 weeks. OCT and OCT-A scans were performed along with detailed ocular examination. Distance between optic disc and an easily identifiable vascular bifurcation nasal and temporal to fovea, FAZ, was noted. Chi-square test (categorical data) and Mann-Whitney U test and t tests for other parameters were performed for statistical analysis. The mean displacement (µm) of an easily identifiable vascular bifurcation in the nasal quadrant was 96.58 ± 36.55 at 8 weeks and in the temporal quadrant was 273.07 ± 85.51 at 8 weeks. The change was statistically significant in the temporal quadrant (P = <0.001). The mean BCVA changed from a minimum of 0.08 at the preoperative timepoint to a maximum of 0.23 at 8 weeks (P = <0.001). The mean FAZ area (mm²) decreased from a maximum of 0.37 at the preoperative timepoint to a minimum of 0.19 at 8 weeks (p = <0.001). The retina in the temporal quadrant is displaced significantly more than nasal quadrant after successful closure of macular hole. The mean superficial FAZ also decreases suggesting a centripetal movement of the foveal tissue postoperatively.

Acceleration characteristics of composite flame in the initial stage of gas/coal dust explosion and analysis of disaster intensification

To clarify the strengthening mechanism of gas/coal dust coupling explosion disasters, a 20 L spherical explosion test system, high-speed schlieren, and PIV analysis were used to study the acceleration characteristics and pressure change of composite flames in the initial stage of gas/coal dust explosion, and the flow field characteristics were also analyzed. The results showed that methane concentration had the most important influence on the formation and development of composite flame. When the methane concentration was 7.5% and 9%, the composite flame propagation showed obvious acceleration characteristics and developed spherically, the flame boundary was clear and smooth, with the whole flame being continuous and bright white. Meanwhile, the Markstein length of composite flame is positive, and increased with the increase of methane concentration and dust particle size but decreased with the increase of coal dust mass concentration, the Markstein length for 9% gas concentration was 7 times larger than 6% gas concentration, indicating the increase of gas concentration can obviously inhibit the instability of composite flame, which prolonged the residence time of coal dust particles in the composite flame, resulting in the enhancement of the pyrolysis of coal dust and improvement of explosion intensity. The PIV test results of 9% gas/coal dust explosion showed that due to the high initial explosion intensity, the negative pressure in the center of the composite flame made most of the coal dust particles undergo centripetal movement, and a large number of coal dust particles gathered around the front of the flame. At the same time, a large number of large vortices in opposite directions were formed around the front of the flame, which promoted rapid contact between the coal dust surface and oxygen and intensified the combustion reaction. The research results can provide guidance for the prevention and control of gas/coal dust composite explosion disasters.

Representation of Motion Direction in Visual Area MT Accounts for High Sensitivity to Centripetal Motion, Aligning with Efficient Coding of Retinal Motion Statistics.

The overrepresentation of centrifugal motion in the middle temporal visual area (area MT) has long been thought to provide an efficient coding strategy for optic flow processing. However, this overrepresentation compromises the detection of approaching objects, which is essential for survival. In the present study, we revisited this long-held notion by reanalyzing motion selectivity in area MT of three macaque monkeys (two males, one female) using random-dot stimuli instead of spot stimuli. We found no differences in the number of neurons tuned to centrifugal versus centripetal motion; however, centrifugally tuned neurons showed stronger tuning than centripetally tuned neurons. This was attributed to the heightened suppression of responses in centrifugal neurons to centripetal motion compared with that of centripetal neurons to centrifugal motion. Our modeling implies that this intensified suppression accounts for superior detection performance for weak centripetal motion stimuli. Moreover, through Fisher information analysis, we establish that the population sensitivity to motion direction in peripheral vision corresponds well with retinal motion statistics during forward locomotion. While these results challenge established concepts, considering the interplay of logarithmic Gaussian receptive fields and spot stimuli can shed light on the previously documented overrepresentation of centrifugal motion. Significantly, our findings reconcile a previously found discrepancy between MT activity and human behavior, highlighting the proficiency of peripheral MT neurons in encoding motion direction efficiently.SIGNIFICANCE STATEMENT The efficient coding hypothesis states that sensory neurons are tuned to specific, frequently experienced stimuli. Whereas previous work has found that neurons in the middle temporal (MT) area favor centrifugal motion, which results from forward locomotion, we show here that there is no such bias. Moreover, we found that the response of centrifugal neurons for centripetal motion was more suppressed than that of centripetal neurons for centrifugal motion. Combined with modeling, this provides a solution to a previously known discrepancy between reported centrifugal bias in MT and better detection of centripetal motion by human observers. Additionally, we show that population sensitivity in peripheral MT neurons conforms to an efficient code of retinal motion statistics during forward locomotion.

Patterns of small involuntary fixation saccades (SIFSs) in different neurodegenerative diseases: the role of noise

During the attempt to steadily fixate at a single spot, sequences of small involuntary fixation saccades (SIFSs, known also as microsaccades οr intrusions) occur which form spatio-temporal patterns such as square wave jerks (SWJs), a pattern characterised by alternating centrifugal and centripetal movements of similar magnitude. In many neurodegenerative disorders, SIFSs exhibit elevated amplitudes and frequencies. Elevated SIFS amplitudes have been shown to favour the occurrence of SWJs (“SWJ coupling”). We analysed SIFSs in different subject groups comprising both healthy controls (CTR) and patients with amyotrophic lateral sclerosis (ALS) and progressive supranuclear palsy (PSP), i.e. two neurodegenerative diseases with completely different neuropathological basis and different clinical phenotypes. We show that, across these groups, the relations between SIFS amplitude and the relative frequency of SWJ-like patterns and other SIFS characteristics follow a common law. As an explanation, we propose that physiological and technical noise comprises a small, amplitude-independent component that has little effect on large SIFSs, but causes considerable deviations from the intended amplitude and direction of small ones. Therefore, in contrast to large SIFSs, successive small SIFSs have a lower chance to meet the SWJ similarity criteria. In principle, every measurement of SIFSs is affected by an amplitude-independent noise background. Therefore, the dependence of SWJ coupling on SIFS amplitude will probably be encountered in almost any group of subjects. In addition, we find a positive correlation between SIFS amplitude and frequency in ALS, but none in PSP, suggesting that the elevated amplitudes might arise at different sites in the two disorders.

Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction

One of the most common cell shape changes driving morphogenesis in diverse animals is the constriction of the apical cell surface. Apical constriction depends on contraction of an actomyosin network in the apical cell cortex, but such actomyosin networks have been shown to undergo continual, conveyor belt-like contractions before the shrinking of an apical surface begins. This finding suggests that apical constriction is not necessarily triggered by the contraction of actomyosin networks, but rather can be triggered by unidentified, temporally-regulated mechanical links between actomyosin and junctions. Here, we used C. elegans gastrulation as a model to seek genes that contribute to such dynamic linkage. We found that α-catenin and β-catenin initially failed to move centripetally with contracting cortical actomyosin networks, suggesting that linkage is regulated between intact cadherin-catenin complexes and actomyosin. We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin, as contributing to C. elegans gastrulation. We found that ZYX-1/zyxin is among a family of LIM domain proteins that have transcripts that become enriched in multiple cells just before they undergo apical constriction. We developed a semi-automated image analysis tool and used it to find that ZYX-1/zyxin contributes to cell-cell junctions' centripetal movement in concert with contracting actomyosin networks. These results identify several new genes that contribute to C. elegans gastrulation, and they identify zyxin as a key protein important for actomyosin networks to effectively pull cell-cell junctions inward during apical constriction. The transcriptional upregulation of ZYX-1/zyxin in specific cells in C. elegans points to one way that developmental patterning spatiotemporally regulates cell biological mechanisms in vivo. Because zyxin and related proteins contribute to membrane-cytoskeleton linkage in other systems, we anticipate that its roles in regulating apical constriction in this manner may be conserved.

“May God Bless Us, So That All the Ends of the Earth Will Fear Him!” (Ps 67:8): The Spatial Perspective in the Eschatological Vision of God’s Universal Rule in the Cluster of Psalms 65–68

Psalms 65–68 form a tight collection or “cluster” of psalms close to the conclusion of Book II of the Psalter. The implied redactors’ purpose with this cluster was to offer thanksgiving and praise to God for manifesting his eschatological rule over the entire world. This article investigates the function of spatial descriptions in defining God’s rule over the cosmos in these four psalms. After establishing harmony in the world, God is present as King in his temple in Zion. To dwell in his vicinity is the pinnacle of his people’s blessing and privilege. Further away from Jerusalem, all nations, even to the ends of the earth, worship and praise God and bring him gifts. There is a centripetal movement of joy, worship, praise, and tribute toward God from all who accept his benevolent rule over the world, but also a centrifugal movement away from him by those who oppose his rule and refuse to accept it.

Arnold Bennett’s Naturalistic and Democratic Interiors in The Old Wives’ Tale (1908)

We know the terms in which Virginia Woolf dismissed Edwardian writers for relying exclusively on materialism. However, another take on Arnold Bennett’s specific approach to objects and interior spaces is made possible by a reappraisal of his naturalistic method. This type of Edwardian fiction reveals a political agenda buoyed up by an empirical narrative praxis. Drawing on Bennett’s The Old Wives’ Tale (1908), we show that Edwardian literary interiors turn into literary tools from which considering oneself, the others and the world out there, differently. Interiors in this novel should be read in spatial, physical, and narrative terms, since Bennett invents new modes of dwelling in order to endow his characters with new ways of narrating themselves. The Baines sisters literally and literarily are the place they inhabit, to the point of being unaware of any distinction between inside and outside. The main narrative strategy of the book is inflected by a centripetal movement that makes us move down and within various forms of interior places and narratives, in which interiority leads to unexpected intimate moments. Seeing, understanding and taming interior places so as to assert oneself narratively and intimately: such is the gist of Bennett’s democratic literary proposition. This is how his naturalism based on an empirical art of the narrative and a surprising use of interior monologue gestures towards a democratic opening of literature in which doorframes, windows and thresholds help us reconsider the aesthetic and political meanings of interiority.

Salmonella Typhimurium induces genome-wide expression and phosphorylation changes that modulate immune response, intracellular survival and vesicle transport in infected neutrophils

Salmonella Typhimurium is a food-borne pathogen that causes salmonellosis. When in contact with the host, neutrophils are rapidly recruited to act as first line of defense. To better understand the pathogenesis of this infection, we used an in vitro model of neutrophil infection to perform dual RNA-sequencing (both host and pathogen). In addition, and given that many pathogens interfere with kinase‐mediated phosphorylation in host signaling, we performed a phosphoproteomic analysis. The immune response was overall diminished in infected neutrophils, mainly JAK/STAT and toll-like receptor signaling pathways. We found decreased expression of proinflammatory cytokine receptor genes and predicted downregulation of the mitogen-activated protein (MAPK) signaling pathway. Also, Salmonella infection inhibited interferons I and II signaling pathways by upregulation of SOCS3 and subsequent downregulation of STAT1 and STAT2. Additionally, phosphorylation of PSMC2 and PSMC4, proteasome regulatory proteins, was decreased in infected neutrophils. Cell viability and survival was increased by p53 signaling, cell cycle arrest and NFkB-proteasome pathways activation. Combined analysis of RNA-seq and phosphoproteomics also revealed inhibited vesicle transport mechanisms mediated by dynein/dynactin and exocyst complexes, involved in ER-to-Golgi transport and centripetal movement of lysosomes and endosomes. Among the overexpressed virulence genes from Salmonella we found potential effectors responsible of these dysregulations, such as spiC, sopD2, sifA or pipB2, all of them involved in intracellular replication. Our results suggest that Salmonella induces (through overexpression of virulence factors) transcriptional and phosphorylation changes that increases neutrophil survival and shuts down immune response to minimize host response, and impairing intracellular vesicle transport likely to keep nutrients for replication and Salmonella-containing vacuole formation and maintenance.

Kinetics of phagosome maturation is coupled to their intracellular motility.

Immune cells degrade internalized pathogens in phagosomes through sequential biochemical changes. The degradation must be fast enough for effective infection control. The presumption is that each phagosome degrades cargos autonomously with a distinct but stochastic kinetic rate. However, here we show that the degradation kinetics of individual phagosomes is not stochastic but coupled to their intracellular motility. By engineering RotSensors that are optically anisotropic, magnetic responsive, and fluorogenic in response to degradation activities in phagosomes, we monitored cargo degradation kinetics in single phagosomes simultaneously with their translational and rotational dynamics. We show that phagosomes that move faster centripetally are more likely to encounter and fuse with lysosomes, thereby acidifying faster and degrading cargos more efficiently. The degradation rates increase nearly linearly with the translational and rotational velocities of phagosomes. Our results indicate that the centripetal motion of phagosomes functions as a clock for controlling the progression of cargo degradation.

Tazkiyah sebagai Epistemologi Irfani: Perspektif Wahiduddin Khan tentang Spiritualitas Perdamaian

Religious views which tends to be exoteric and only looking at the formal legal aspect, often gives an over-sensitive views, emotional, and unconsciously giving violence actions. Wahiduddin Khan is a figure who aware of this problem, so he develope the concept of tazkiyah as the basis for the spirituality of peace. Tazkiyah according to Khan focused on intellectual development that touches the heart, so it built the integration between rationality and spirituality which is construct the forms a complete human being. This research was conducted with a descriptive qualitative approach through literature review. This research founded four stages of four stages of tazkiyah: abstraction, internalization, transcendence, and humanization. Tazkiyah is a combination of rational awareness, feelings in the heart (spiritual events) and practical actions that connecting two currents of centripetal and centrifugal motion. The inward movement is closer to mystical awareness and the outward movement is a form of participation in building traditions and social institutions. This combination will produce spirituality that manifests in the awareness and attitude of peace.

Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation.

Natural Killer (NK) cells provide key resistance against viral infections and tumors. A diverse set of activating and inhibitory NK cell receptors (NKRs) interact with cognate ligands presented by target host cells, where integration of dueling signals initiated by the ligand-NKR interactions determines NK cell activation or tolerance. Imaging experiments over decades have shown micron and sub-micron scale spatial clustering of activating and inhibitory NKRs. The mechanistic roles of these clusters in affecting downstream signaling and activation are often unclear. To this end, we developed a predictive in silico framework by combining spatially resolved mechanistic agent based modeling, published TIRF imaging data, and parameter estimation to determine mechanisms by which formation and spatial movements of activating NKG2D microclusters affect early time NKG2D signaling kinetics in a human cell line NKL. We show co-clustering of NKG2D and the guanosine nucleotide exchange factor Vav1 in NKG2D microclusters plays a dominant role over ligand (ULBP3) rebinding in increasing production of phospho-Vav1(pVav1), an activation marker of early NKG2D signaling. The in silico model successfully predicts several scenarios of inhibition of NKG2D signaling and time course of NKG2D spatial clustering over a short (~3 min) interval. Modeling shows the presence of a spatial positive feedback relating formation and centripetal movements of NKG2D microclusters, and pVav1 production offers flexibility towards suppression of activating signals by inhibitory KIR ligands organized in inhomogeneous spatial patterns (e.g., a ring). Our in silico framework marks a major improvement in developing spatiotemporal signaling models with quantitatively estimated model parameters using imaging data.

Intraocular accommodative movements in monkeys; relationship to presbyopia

Our goal was to quantify the age-related changes in the dynamic accommodative movements of the vitreous and aqueous humor in iridic, aniridic, phakic and aphakic primate eyes.Six bilaterally iridic and four bilaterally iridectomized rhesus monkeys, ranging in age from 6 to 25 years, received a stimulating electrode in the midbrain Edinger-Westphal nucleus to induce accommodation, measured by a Hartinger coincidence refractometer. One of the four iridectomized monkeys underwent unilateral extracapsular and another monkey underwent intracapsular lens extraction. Eyes were imaged utilizing specialized techniques and contrast agents to resolve intraocular structures.During accommodation the anterior hyaloid membrane and the posterior lens capsule bowed backward. Central vitreous fluid and structures/strands moved posteriorly toward the optic nerve region as peripheral vitreous, attached to the vitreous zonule, was pulled forward by ciliary muscle contraction. Triamcinolone particles injected intravitreally were also observed in the anterior chamber and moved from the anterior chamber toward the cleft of the anterior hyaloid membrane and then further posteriorly into the vitreous-filled cleft between the vitreous zonule and the ciliary body pars plana. These accommodative movements occurred in all eyes, and declined with age.There are statistically significant accommodative movements of various intravitreal structures. The posterior/anterior fluid flow between the anterior chamber and the vitreous compartments during accommodation/disaccommodation represents fluid displacement to allow/facilitate lens thickening. The posterior accommodative movement of central vitreous fluid may result from centripetal compression of the anterior tips of the cistern-like structure attached to the vitreous zonule, and posterior displacement of the central trunk of the cistern during ciliary muscle contraction and centripetal muscle movement. The findings may have implications for presbyopia.

Hypercorrection as a Symptom of Language Change: Majorcan Catalan Standard Pronunciation

The mutual influence between dialects and standard language in terms of upward or downward convergence, the creation of a diaglossic repertoire, and a typology of relations dialects/standard is of utmost importance for the analysis of language evolution. Majorcan Catalan is an eastern Catalan dialect, traditionally considered as archaic. Data from television programs show a tendency to adapt pronunciation to a standard mainly based on central Catalan dialects, even disregarding concessions granted by the prescriptive grammar. This article is focused on the causes of this centripetal movement and on the function either accelerating or decelerating of (para)prescriptive works in the process. Data from an annotated oral corpus (Corpus Oral de la Llengua Catalana) are used. The results are consistent with a centripetal movement in the construction of the standard Catalan as used in formal registers in the Balearic Islands. A proposal is made for the interpretation of the relevant data as evidence of an evolution from a gliding access to standard to a shifting access.

TO THE SELFHOUSE: THE CENTRIPETAL MOVEMENT OF SYMBOLS IN VIRGINIA WOOLF'S TO THE LIGHTHOUSE

Modernism is a literary movement which appeared around 1914. New technologies and the horrible effect of World War I, made many authors question the future of this modern machine (human being) who declined any kind of tradition for the sake of the new sentiment. Modernist fiction used two significant tools: one is the stream of consciousness to reveal the inner self of the characters, and the other one is employing the symbol to reflect hidden reality through the life of the characters. Virginia Woolf is considered as one of the most prominent modernist authors who employ the various modern techniques in her fictions such as To the Lighthouse. The aim of this article is followed in two different steps: first, the discussion of the roles of different symbols and signs through the whole work to reflect how these symbols function in the novel as a web of signs; and second, the exploration of the centripetal movement of various symbols and colors to show an unattainable concept of reality in modern life.

Front Cover: Computational Insights into the Allosteric Effect and Dynamic Structural Features of the SARS‐COV‐2 Spike Protein (Chem. Eur. J. 6/2022)

Although the prefusion conformation of the spike protein of SARS-COV-2 can be stabilized alone, a spontaneously and energy-friendly centripetal movement of the receptor binding domain occurs when spike protein binds to ACE2. During the binding process, several residues, especially Phe329 and Phe515, play a significant role in the allosteric effect. As a result, two potential cleavage sites S1/S2 and S2′ are exposed on the surface. More information can be found in the Research Article by A. Zhang, J. Fu et al. (DOI: 10.1002/chem.202104215).

Computational Insights into the Allosteric Effect and Dynamic Structural Features of the SARS‐COV‐2 Spike Protein

COVID‐19 caused by SARS‐COV‐2 is continuing to surge globally. The spike (S) protein is the key protein of SARS‐COV‐2 that recognizes and binds to the host target ACE2. In this study, molecular dynamics simulation was used to elucidate the allosteric effect of the S protein. Binding of ACE2 caused a centripetal movement of the receptor‐binding domain of the S protein. The dihedral changes in Phe329 and Phe515 played a key role in this process. Two potential cleavage sites S1/S2 and S2′ were exposed on the surface after the binding of ACE2. The binding affinity of SARS‐COV‐2 S protein and ACE2 was higher than that of SARS‐COV. This was mainly due to the mutation of Asp480 in SARS‐COV to Ser494 in SARS‐COV‐2, which greatly weakened the electrostatic repulsion. The result provides a theoretical basis for the SARS‐COV‐2 infection and aids the development of biosensors and detection reagents.

КЛАССИЧЕСКИЕ И НЕКЛАССИЧЕСКИЕ СТРУКТУРЫ ДРАМЫ

The article attempts to apply a structural approach to the existence and development of the dramatic genre. The au-thor proceeds from the position of two types of structures – classical (order structure) and non-classical (chaos struc-ture). The constant transformation of one structure into another throughout history demonstrates a certain stable mechanism of change, when the centripetal movements of the classical structure give way to centrifugal ones, which causes the classical structure to collapse. In the future, it opens, expands and transforms. Then this mechanism goes in reverse order. Thus, artistic culture, in particular, dramatic (as well as social, historical) processes of compression and expansion, closeness and openness take place over two large cycles. This is a constant «drawing» of the movement of cycles from the classical structure (order) to the non-classical (chaos) and becomes the key to unraveling the existence of the dramatic genre for large periods, perhaps for the period of the entire civilization, showing the «curve» of the course and transformations of the dramatic genre, which does not fit into the linear paradigm. At the same time, this «curve» also testifies to the transformations of social and historical structures. In connection with all this, it is possible to put forward some hypotheses that can be confirmed in related sciences – quantum physics, philosophy, etc. In gen-eral, this indicates the existence of some kind of supra-historical law or meta-law that operates in the universe. In order to understand the movement of genres, in this case, the dramatic, it is not enough to use only a historical descriptive approach. A kind of permanent, universal law of transformations of the existence and movement of the genre gives a structural approach