Relevance. In modern vegetable growing in the southern and central regions of Russia, new scientific developments are widely used, including the use of new varieties and hybrids, a drip irrigation system, fertigation with soluble fertilizers with microelements. All these agricultural practices make it possible to increase the yield of vegetable crops by several times, as well as to significantly increase the efficiency of applied fertilizers. The purpose of our work was to establish the effectiveness of the use of calculated doses of mineral fertilizers for tomato with the main application and top dressing under drip irrigation.Methodology. Research in 2019-2021 on ordinary heavy loamy chernozem of the experimental field of the Birutchecutskaya Vegetable Experimental Station – branch of FSBSI Federal Scientific Vegetable Center (Rostov Region, Novocherkassk) with a new variety of tomato Krasny banker.Results. It was revealed that without fertilization, the yield of tomatoes was at the level of 32-35 t/ha; the use of the recommended dose of N120P120K120 in the main application increased the yield to 64- 72 t/ha; the use of the estimated dose of mineral fertilizers (for a yield of 100 t/ha) increased the yield of tomatoes to 95 t/ha. The use of three-fold root feeding of plants with drip irrigation increased the yield by 21%, and with foliar feeding – by 2-8%. As a root top dressing for drip irrigation, a solution of microcrystalline water-soluble fertilizer "Master" with a different ratio of nutrients was used, and for foliar top dressing, an organomineral nanofertilizer with growth-stimulating activity "Arksoil KKR" was used. In general, a set of agrochemical practices made it possible to increase the tomato yield under drip irrigation from 33.7 to 102.8 t/ha, more than 3 times, without reducing the dry matter content in fruits and without nitrate contamination of products.