Central Monitoring Research Articles

Social and labor situation in the Russian Federation in the new economic and political conditions

The article is based on the materials of the analytical bulletin of the Center for Monitoring and Analysis of Social and Labor Conflicts of the Saint Petersburg Humanitarian University of Trade Unions. The social and labor situation in the Russian Federation and the conflict potential in the labor sphere continue to be formed under the influence of unstable global and domestic economic conditions. The article presents statistical data on social and labor conflicts.

Development of the legal framework for land monitoring and protection in the digital environment

Relevance of the research topic. The need to complete the land reform, the main goal of which is the restructuring of land relations, as well as the introduction of changes in the structure of land and the form of management, determines the need for systematic and full-scale monitoring observations and research. Formulation of the problem. Central authorities cannot always see the "holistic picture" of land relations, both at the level of districts, regions, and at the national level, and cannot always find optimal solutions for improving land relations. Therefore, there was a need to implement a land relations monitoring system that is constantly updated and stores information to provide data analysis and forecasting, as well as the development of science-based recommendations for effective management. Analysis of recent research and publications. Questions related to the legal regulation of land monitoring and protection found their place in the scientific works of various scientists, such as M. Yerofeiev, N. Malysheva, S. Sharapov, as well as many others. The problem of land protection was studied by such respected scientists in this field as: Yu. Shemshuchenko, V. Andreitsev, N. Tytova, M. Shulha, P. Kulynych, V. Nosik, G. Hutsuliak, D. Dobriak, N. Mazii, A. Sokhnych, A. Tretiak and others. Selection of unexplored parts of the general problem. The current state of studying the problem requires improvement and a clear definition of the legal basis for monitoring and protecting land in the digital environment. The adaptation of the existing legal framework for land monitoring and protection to the legislative norms of the European Union determines its functional development in the conditions of constant restructuring of land relations in Ukraine. Setting the task, the goal of the research. The purpose of the research is to analyze the existing system of land monitoring and protection, to identify problems and to study the prospects for the development of legal aspects of their functioning in the digital environment. The task of research is to collect and analyze information about the state of natural resources for use in the process of exploitation, management and determination of the limits of use of these resources. The research involves obtaining the necessary data and using them to implement management functions in relation to the natural resources being exploited. The survey methodology. The methods of collecting, analyzing, summarizing information, as well as methods of research observation, which reflect the current state and prospects for the development of land monitoring and protection, are applied. Such methods are built primarily on the basis of collected data related to the monitoring and implementation of land protection in Ukraine today. With the help of the analysis of the specified legislation and the collected library sources of information, it is possible to carry out a full analysis of the work on a real basis and answer all the questions. Presentation of the main material (results of work). It was established that one of the main tasks of land monitoring and protection is the creation of a base of objective information that will be used in assessing the state of land resources. It was found that the information obtained with the help of the state land cadastre serves as a legal basis for making the necessary decisions by state bodies in the field of research, monitoring and land protection. It is also proposed to adopt a special law to ensure the legal status of monitoring and protection of land relations, the final stage of which should be the creation of an electronic data array. Field of application of results. The results of the study can be applied in the field of agricultural economics and state administration in terms of monitoring and protection of land resources. Conclusions according to the article. The monitoring and protection of land nowadays requires a complete improvement of its methodology. It is necessary to create an effective national monitoring system that will be responsible for the quality of lands and soils. This is due to the fact that the acquired data make it possible to constantly adjust both the quantitative norms and regulations that are subject to control, as well as the improvement of organizational and legal support for monitoring and land protection through the creation of a special body that will monitor and protect land in its work, i.e the Center for Monitoring and Land Protection of Ukraine.

Integration of DInSAR-PS-Stacking and SBAS-PS-InSAR Methods to Monitor Mining-Related Surface Subsidence

Over-exploitation of coal mines leads to surface subsidence, surface cracks, collapses, landslides, and other geological disasters. Taking a mining area in Nalintaohai Town, Ejin Horo Banner, Ordos City, Inner Mongolia Autonomous Region, as an example, Sentinel-1A data from January 2018 to October 2019 were used as the data source in this study. Based on the high interference coherence of the permanent scatterer (PS) over a long period of time, the problem of the manual selection of ground control points (GCPs) affecting the monitoring results during refinement and re-flattening is solved. A DInSAR-PS-Stacking method combining the PS three-threshold method (the coherence coefficient threshold, amplitude dispersion index threshold, and deformation velocity interval) is proposed as a means to select ground control points for refinement and re-flattening, as well as a means to obtain time-series deformation by weighted stacking processing. A SBAS-PS-InSAR method combining the PS three-threshold method to select PS points as GCPs for refinement and re-flattening is also proposed. The surface deformation results monitored by the DInSAR-PS-Stacking and SBAS-PS-InSAR methods are analyzed and verified. The results show that the subsidence location, range, distribution, and space–time subsidence law of surface deformation results obtained by DInSAR-PS-Stacking, SBAS-PS-InSAR, and GPS methods are basically the same. The deformation results obtained by these two InSAR methods have a good correlation with the GPS monitoring results, and the MAE and RMSE are within the acceptable range. The error showed that the edge of the subsidence basin was small and that the center was large. Both methods were found to be able to effectively monitor the coal mine, but there were also shortcomings. DInSAR-PS-Stacking has a strong ability to monitor the settlement center. SBAS-PS-InSAR performed well in monitoring slow and small deformations, but its monitoring of the settlement center was insufficient. Considering the advantages of these two InSAR methods, we proposed fusing the time-series deformation results obtained using these two InSAR methods to allow for more reliable deformation results and to carry out settlement analysis. The results showed that the automatic two-threshold (deformation threshold and average coherence threshold) fusion was effective for monitoring and analysis, and the deformation monitoring results are in good agreement with the actual situation. The deformation information obtained by the comparison, and fusion of multiple methods can allow for better monitoring and analysis of the mining area surface deformation, and can also provide a scientific reference for mining subsidence control and early disaster warning.

Monitoring of adverse drug reactions in individuals with type 2 diabetes mellitus receiving oral hypoglycemic agents

Background: This study intends to ascertain the prevalence and overall burden of various adverse drug reactions (ADRs) driven by oral antidiabetics for treating type II diabetes mellitus (T2DM) in India. Methods: Patients with T2DM taking oral antidiabetic medications participated in prospective observational research. Data collection used the pretested format by the Indian pharmacovigilance program to record the history of drugs suspected to be responsible for ADRs. The causality evaluation is according to the guidelines of the Uppsala Monitoring Center and the World Health Organization. Results: This study included 424 patients with established diabetes. Female patients showed a non-significant higher percentage of ADRs (p = 0.059). Naranjo’s assessment recorded 51 suspected ADRs with significant (p = 0.042) categorical differences in casualty. According to ADR severity, there was a significant (p = 0.048) difference between moderate 8.25% (n = 35) and mild 3.80% (n = 16); however, none of the ADRs showed severity. Metformin caused abdominal discomfort, itching, and rashes, accounting for 4.95% (n = 21) of all reported adverse reactions. Gliclazide and glimepiride induced hypoglycemia, itch, and rashes, 1.65% (n = 7), abdominal pain, 1.18% (n = 5), flatulence caused by acarbose, abdominal discomfort caused by pioglitazone, and pedal edema caused by pioglitazone 1.18% (n = 5). Conclusion: ADRs due to oral antidiabetic agents are a frequent problem. Therefore, active pharmacovigilance is essential for risk identification, management, and establishing a robust antidiabetic drug ADR database.

A New Dimension in Ensuring Safety of Laser and Light-Based Devices in Dermatological Practice- Materiovigilance Programme

Introduction of LASERS and their applications have given new multiple dimensions for less invasive, more precise and effective treatment of skin lesions with some adverse events following treatment in clinical practice of Dermatology. They are source of electromagnetic irradiation with application for cutting, destruction, coagulation or restoration of skin tissues. The main objective of this study is to bring in more of awareness about technical and practical hinderances expected during application of Lasers for ensuring effective management while treating skin lesions. As Indians have more dermal melanin content are prone for skin injuries and complications subjected to light-based devices treatment, which may lead to permanent sequelae. Prioritizing safety of patients before, during and after treatment following adverse events, to follow certain standard guidelines and timely reporting of adverse events while using medical devices to Materiovigilance Programme of India cell for improving more effective treatment for better patient treatment outcome with quality health care treatment approach. Clinicians who are treating with lasers must have complete knowledge on usage of devices and their adverse events, to follow standard protocols for quick action and timely treatment of patients and timely reporting to Bio medical Engineering department for correction of devices. Regular conduction of sensitization and awareness programmes to all healthcare professionals to notify and report to Medical Device Monitoring Centres for effective implementation of Materio-vigilance Programme of India.

Solar Powered Wireless Sensor Network for Water Quality Monitoring and Classification

Water is essential for human being, also for animals and plants. In Indonesia, there are a lot of residential living in the riverbank which have poor water conditions. People frequenty use water from the river for daily activities. To determine the quality of water, samples are usually taken and tested in the laboratory. This method is less efficient in time and also cost. In order to determine and monitor the quality of water, this paper discuss the Wireless Sensor Network (WSN) to monitor the quality of water from a distance with the self powered sensor node. One of the issue in developing the WSN is the energy. Since this is implemented in outdoor, therefore it is possible to use solar panel to produce the energy. In this study three indicators; pH, TDS, and turbidity; were used to determine water quality based on the Indonesian Minister of Health Regulation. The results examine the WSN performance, and also the analysys of the solar energy supply for each sensor node. The WSN successfully works in detect and clasify tha water quality category and display it in the monitoring center or user. The sensors are calibrated and works with tolerable error of sensor reading of 5,1%. The WSN node is embedded with solar panel to supply the energy for node component. Therefore it able to extend the lifetime of the networks devices with renewable energy to implement the Green WSN.

Application of GNS3 to Study the Security of Data Exchange between Power Electronic Devices and Control Center

This paper proposes the use of the GNS3 IP network modeling platform to study/verify whether the exchanged information between power electronic devices and a control center (Monitoring and Control Centre) is secure. For the purpose of this work, a power distribution unit (PDU) and a UPS (Uninterruptable Power Supply) that are used by internet service providers are studied. Capsa Free network analyzer and Wireshark network protocol analyzer were used as supporting tools. A working model of an IP network in GNS3 has been created through which this research has been carried out. In addition to checking whether the exchanged information is secure, a characterization of the generated traffic has been made, showing results for the generated traffic and which ports generate the most traffic. These carried-outstudies show that the exchanged information is not secure. As a way to secure the exchanged information, the use of VPN (Virtual Private Network) technology is proposed; thanks to a VPN, the exchange of information is secure. The obtained results confirm this and validate the applicability of GNS3 to test/study whether data exchange between power electronic devices and a control center is secure.

Long-Range Self-Powered IoT Devices for Agriculture Aquaponics

The aim of this project is to establish a controlled environment in the aquaculture industry by minimizing human errors and reducing the need for manpower. Additionally, the project seeks to enable remote monitoring of aquatic environments from any location in the world. By utilising mobile phone applications, the physical presence of humans can be significantly reduced. The device is capable of collecting and transmitting data from a variety of sensors, including those that measure temperature, humidity, and pH levels. This real-time monitoring and analysis of the aquaponics systems allows farmers and growers to make informed decisions about water usage, fish health, and other productivity-related factors. Ultimately, this system can improve productivity and efficiency in the aquaculture industry. Aquaculture is a growing industry worldwide, and the need for sustainable and efficient practices is increasing. The use of technology and automation has become more common in recent years as a means of improving productivity and reducing human error. The proposed system for aquaculture monitoring aims to address these issues by utilizing sensors and microcontrollers to create a controlled environment for aquatic organisms. The system employs various sensors to measure critical parameters such as water temperature, pH, and turbidity, and sends this data to a central monitoring system. Farmers and growers can then access this data remotely and make informed decisions about the health and productivity of their aquatic systems. This can lead to better control over water quality and temperature, improved feeding practices, and ultimately higher yields.

Investigating potential drivers of increased central line...associated bloodstream infections during the coronavirus disease 2019 (COVID-19) Omicron surge

Central line...associated bloodstream infection rates increased during the Omicron surge at our rural academic medical center. To identify potential drivers of this increase, we investigated period- and patient-specific factors associated with the increase in central line...associated bloodstream infection. Increased central line utilization, decreased central line bundle compliance monitoring, increased proportion of traveling nurses, increased short-term venous catheter use in the internal jugular vein, increased multilumen catheter use, decreased port...associated infection, and increased patient acuity were significantly associated with the surge. Our results helped us target our local infection prevention efforts.

Population Genetic Study on the European Flounder (Platichthys flesus) from the Southern Baltic Sea Using SNPs and Microsatellite Markers.

The European flounder (Platichthys flesus), which is closely related to the recently discovered Baltic flounder (Platichthys solemdali), is currently the third most commercially fished species in the Baltic Sea. According to the available data from the Polish Fisheries Monitoring Center and fishermen's observations, the body condition indices of the species in the Baltic Sea have declined in recent years. The aim of the present study was to obtain information on the current patterns of genetic variability and the population structure of the European flounder and to verify whether the Baltic flounder is present in the southern Baltic Sea. Moreover, we aimed to verify whether the observed decline in the body condition indices of the species in the Baltic Sea might be associated with adaptive alterations in its gene pool due to increased fishing pressure. For this purpose, 190 fish were collected from four locations along the central coastline of Poland, i.e., Mechelinki, Władysławowo, the Vistula Lagoon in 2018, and the Słupsk Bank in 2020. The fish were morphologically analyzed and then genetically screened by the application of nineteen microsatellite DNA and two diagnostic SNP markers. The examined European flounder specimens displayed a high level of genetic diversity (PIC = 0.832-0.903, I = 2.579-2.768). A lack of significant genetic differentiation (Fst = 0.004, p > 0.05) was observed in all the examined fish, indicating that the European flounder in the sampled area constitutes a single genetic cluster. A significant deficiency in heterozygotes (Fis = 0.093, p < 0.05) and overall deviations from Hardy-Weinberg expectations (H-WE) were only detected in fish sampled from the Słupsk Bank. The estimated effective population size (Ne) among the sampled fish groups varied from 712 (Słupsk Bank) to 10,115 (Władysławowo and Mechelinki). However, the recorded values of the Garza-Williamson indicator (M = 0.574-0.600) and the lack of significant (p > 0.05) differences in Heq > He under the SMM model did not support the species' population size changes in the past. The applied SNP markers did not detect the presence of the Baltic flounder among the fish sampled from the studied area. The analysis of an association between biological traits and patterns of genetic diversity did not detect any signs of directional selection or density-dependent adaptive changes in the gene pool of the examined fish that might be caused by increased fishing pressure.

Central Versus Peripheral Arterial Pressure Monitoring in Patients Undergoing Cardiac Surgery: A Prospective Observational Study

The aortic-to-radial arterial pressure gradient is described during and after cardiopulmonary bypass (CPB), and can lead to underestimating arterial blood pressure. The authors hypothesized that central arterial pressure monitoring would be associated with lower norepinephrine requirements than radial arterial pressure monitoring during cardiac surgery. An observational prospective cohort with propensity score analysis. At a tertiary academic hospital's operating room and intensive care unit (ICU). A total of 286 consecutive adult patients undergoing cardiac surgery with CPB (central group: 109; radial group: 177) were enrolled and analyzed. To explore the hemodynamic effect of the measurement site, the authors divided the cohort into 2 groups according to a femoral/axillary (central group) or radial (radial group) site of arterial pressure monitoring. The primary outcome was the intraoperative amount of norepinephrine administered. Secondary outcomes included norepinephrine-free hours and ICU-free hours at postoperative day 2 (POD2). A logistic model with propensity score analysis was built to predict central arterial pressure monitoring use. The authors compared demographic, hemodynamic, and outcomes data before and after adjustment. Central group patients had a higher European System for Cardiac Operative Risk Evaluation. (EuroSCORE) compared to the radial group-7.9 ± 14.0 versus 3.8 ± 7.0, p < 0.001. After adjustment, both groups had similar patient EuroSCORE and arterial blood pressure levels. Intraoperative norepinephrine dose regimens were 0.10 ± 0.10 µg/kg/min in the central group and 0.11 ± 0.11 µg/kg/min in the radial group (p=0.519). Norepinephrine-free hours at POD2 were 38 ± 17 hours versus 33 ± 19 hours in central and radial groups, respectively (p=0.034). The ICU-free hours at POD2 were greater in the central group: 18 ± 13 hours versus 13 ± 13 hours, p=0.008. Adverse events were less frequent in the central group than in the radial group-67% versus 50%, p=0.007. No differences in the norepinephrine dose regimen were found according to the arterial measurement site during cardiac surgery. However, norepinephrine use and length of stay in the ICU were shorter, and adverse events were decreased when central arterial pressure monitoring was used.

Influence of Atmospheric Air Pollution on Frequency of Congenital Anomalies (on an example of a region)

INTRODUCTION: Atmospheric air pollution is the underlying factor of a great number of human diseases in both industrialized and developing countries. Studies show that exposure to atmospheric pollutions in pregnancy can be associated with an increased risk of congenital anomalies (CAs).&#x0D; AIM: To analyze the impact of atmospheric air pollutants in Ryazan city on the incidence of CAs in newborns.&#x0D; MATERIALS AND METHODS: The data of monitoring of CAs by Ryazan Regional Perinatal Center; information on atmospheric air pollution of the Federal Service for Hydrometeorology and Environmental Monitoring, of Ryazan Center for Hydrometeorology and Environmental Monitoring, of Rospotrebnadzor of the Ryazan region are presented. The statistical analysis was conducted using free R computing environment (ver. 4.1.2).&#x0D; RESULTS: In 2019, the prevalence of CAs in Ryazan was 24.09 per 1,000 newborns; in the period 20102021, the absolute number of recorded CAs grew by 244.57%. The most common congenital anomalies were Q21.0 Ventricular septal defects (28.5%, 95% CI: 20.836.2%) and Q62.0 Congenital hydronephrosis (7.3%, 95% CI: 2.911.7%). Correlation was recorded with such air pollutant as sulfur dioxide (SO2) in the second month of pregnancy (AOR 1.39; 95%; CI 1.051.83, p 0.05) and the third month of pregnancy (AOR 1.59; 95% CI 1.172.16, p 0.05). No statistically significant relationship was established between CAs and carbon monoxide (CO), nitrogen dioxide (NO2) and ozone (O3, p 0.05).&#x0D; CONCLUSION: The study confirms the association between atmospheric air pollution and frequency of CAs. In particular, SO2 has a negative effect in the second and third months of pregnancy. In this context, it is important that the authority bodies of the region and governmental regulatory agencies direct their efforts to reduction of the pollution of the environment which should help reduce the frequency of CAs in children.

Status and Trend of the Main Allergenic Pollen Grains and Alternaria Spores in the City of Rome (2003–2019)

Today a large part of the European population is exposed to levels of air pollution exceeding the standards recommended by the World Health Organization. Moreover, air pollution and the seasonal emission of allergenic pollen are progressively affecting human health and can cause severe allergic reactions, particularly when air pollution combines with pollen allergen peaks. Unlike atmospheric pollutants of anthropogenic origin, pollen sources have a pulsating trend that leads to high values in the flowering period and values close to, or equal to, zero in the rest of the year. This aspect makes essential the definition of data coverage standards for the main allergenic taxa. For air quality assessment detailed classification criteria for monitoring stations are defined by international standards, not the same from the European Standards for the Sampling and analysis of airborne pollen grains and fungal spores. This paper describes the status and the air concentration trends of the main allergenic pollen and the Alternaria spore measured in Rome from 2003 to 2019 by the Aerobiological Monitoring Center of Tor Vergata (Rome) and calculated by the Seasonal Kendall test with the open-source OpenAir R package. The analysis was carried out on the daily concentrations of the most widespread allergenic taxa in Italy: Asteraceae, Betulaceae, Corylaceae, Cupressaceae/Taxaceae, Poaceae, Oleaceae, Urticaceae and the Alternaria spores.

On the results of the development of labor relations in the Russian Federation in the new economic and political realities

The article is based on the materials of the analytical bulletin of the Center for Monitoring and Analysis of Social and Labor Conflicts, St. Petersburg Humanitarian University of Trade Unions. In the coming 2023, the social and labor situation in the Russian Federation and the conflict potential in the labor sphere continue to be formed under the influence of unstable global and domestic economic conditions. The article presents statistical data on social and labor conflicts. Based on the analysis of political and socio-economic changes taking place in the country and in the world, the author makes a forecast of further changes in social and labor relations.

New seismic monitoring center in South America to assess the liquefaction risk posed by subduction earthquakes

The east of Cali is composed of loose sand deposits with high water table levels. This condition and the high seismic hazard of the city make cyclic liquefaction one of the main hazards in the city, which may affect more than 600,000 citizens and important infrastructures such as the city’s main drinking water treatment plants. Therefore, it was decided to design and implement a seismic monitoring center to study the behavior of liquefiable soils under local seismogenic conditions, in which subduction earthquakes predominate. First, more than 130 earthquakes from two seismic monitoring centers with liquefiable layers in the USA were studied to determine the requirements for the adequate design of the monitoring center. Then, a robust geotechnical and seismic characterization of the study area including SPT, CPTu, and seismic and ambient noise tests were carried out. From this information, the specifications and location of the instruments and, in general, the characteristics of the monitoring center were defined. The monitoring center has been planned to be established in two stages, and the first one has already been built and commissioned. The implementation of the first stage allowed to adequately record 35 earthquakes from different seismogenic sources, most of them from subduction earthquakes, and to verify that the potentially liquefiable layer remains saturated throughout the year. Subsequent ground motion sensors will allow to deeply study and understand large shear strains and excess pore pressures generation in the soil deposit, as well as their relationships with different intensity measures. The experience shared herein can benefit the design, construction, and operation of other seismic monitoring centers across the world.

Sources of bias in observational studies of covid-19 vaccine effectiveness.

Sources of bias in observational studies of covid-19 vaccine effectiveness.

The impact of mortality underreporting on the association of ambient temperature and PM10 with mortality risk in time series study

Properly analyzing and reporting data remains a challenging task in epidemiologic research, as underreporting of data is often overlooked. The evaluation on the effect of underreporting remains understudied. In this study, we examined the effect of different scenarios of mortality underreporting on the relationship between PM10, temperature, and mortality. Mortality data, PM10, and temperature data in seven cities were obtained from Provincial Center for Disease Control and Prevention (CDC), China Meteorological Data Sharing Service System, and China National Environmental Monitoring Center, respectively. A time-series design with a distributed lag nonlinear model (DLNM) was used to examine the effects of five mortality underreporting scenarios: 1) Random underreporting of mortality; 2) Underreporting is monotonically increasing (MI) or monotonically decreasing (MD); 3) Underreporting due to holiday and weekends; 4) Underreporting occurs before the 20th day of each month, and these underreporting will be added after the 20th day of the month; and 5) Underreporting due to holiday, weekends, MI, and MD. We observed that underreporting at random (UAR) scenario had little effect on the association between PM10, temperature, and daily mortality. However, other four underreporting not at random (UNAR) scenarios mentioned above had varying degrees of influence on the association between PM10, temperature, and daily mortality. Additionally, in addition to imputation under UAR, the variation of minimum mortality temperature (MMT) and attributable fraction (AF) of mortality attributed to temperature in the same imputation scenarios is inconsistent in different cities. Finally, we observed that the pooled excess risk (ER) below MMT was negatively associated with mortality and the pooled ER above MMT was positively associated with mortality. This study showed that UNAR impacted the association between PM10, temperature, and mortality, and potential underreporting should be dealt with before analyzing data to avoid drawing invalid conclusions.

Feasibility and Accuracy of Noninvasive Continuous Arterial Pressure Monitoring during Transcatheter Atrial Fibrillation Ablation

Transcatheter atrial fibrillation (AF) ablation is still carried out with continuous invasive radial arterial blood pressure (IBP) monitoring in many centers. Continuous noninvasive blood pressure (CNBP) measurement using the volume-clamp method is a noninvasive alternative method used in ICU. No data on CNBP reliability are available in the electrophysiology lab during AF ablation, where rhythm variations are common. The objective of the present study was to compare continuous noninvasive arterial pressure measured with the ClearSight device (Edwards Lifesciences, Irvine, CA, USA) with invasive radial artery pressure used as the reference method during AF ablation. We prospectively enrolled 55 consecutive patients (age 62 ± 11 years, 80% male) undergoing transcatheter AF ablation (62% paroxysmal, 38% persistent) at our center. Standard of care IBP monitoring via a radial cannula and a contralateral noninvasive finger volume-clamp CNBP measurement device were positioned simultaneously in all patients for the entire procedure. Bland-Altman analysis was used to analyze the agreement between the two techniques. A total of 1219 paired measurements for systolic, diastolic, and mean arterial pressure were obtained in 55 subjects, with a mean (SD) of 22 (9) measurements per patient. The mean bias (SD) was -12.97 (13.89) mmHg for systolic pressure (level of agreement -14.24-40.20; correlation coefficient 0.84), -1.85 (8.52) mmHg for diastolic pressure (level of agreement -18.54-14.84; correlation coefficient 0.77) and 2.31 (8.75) mmHg for mean pressure (level of agreement -14.84-19.46; correlation coefficient 0.85). In patients undergoing AF ablation, CNBP monitoring with the ClearSight device showed acceptable agreement with IBP monitoring. Larger studies are needed to confirm the potential clinical implications of continuous noninvasive BP monitoring during AF ablation.

Electric vehicle entire-trip navigation and charging reservation method based on a high-speed communication network

Having a large number of electric vehicles (EVs) on the road will lead to vehicle congestion, long waiting times at charging stations (CSs), and even the inability to find an available charging position. Main technical challenges in mobile EVs charging may include charging information exchanges between EVs and CSs, EV traveling route and CS selection, and EV charging planning. To solve the above problems, this study provides an optimization solution for entire-trip charging and navigation of EVs, which balances charging resources, protects the travel time of EV drivers, and prioritizes renewable energy. The communication scheme of an EV charging network is designed, including real-time communication between the CSs, EV drivers, road condition monitoring center, power grid company, and the charging control center distributed in every parking lot. CSs in each road segment sort vehicles arriving at stations, allocate charging time slots, provide charging start times, and adjust those times for EVs with reservations that have not yet arrived. EV drivers can plan vehicle charging on their smart devices. The optimization of electric navigation can reduce the travel time or cost for drivers, ensure safe electricity usage, calculate vehicle routes, select CSs, and provide charging time intervals. The effectiveness of the method is verified on a regional road network in China, and the results show that it can balance the charging resource distribution of a CS, guarantee EV state of charge level, greatly reduce travel cost or travel time, provide precise waiting time, and prioritize renewable energy.

Antimicrobial Activity of Gepotidacin Tested against Escherichia coli and Staphylococcus saprophyticus Isolates Causing Urinary Tract Infections in Medical Centers Worldwide (2019 to 2020).

The in vitro activities of gepotidacin and comparator agents against 3,560 Escherichia coli and 344 Staphylococcus saprophyticus collected from female (81.1%) and male (18.9%) patients with urinary tract infections (UTIs) in a global prospective surveillance program in 2019 to 2020 were determined. Isolates collected from 92 medical centers in 25 countries, including the United States, Europe, Latin America, and Japan, were tested for susceptibility by reference methods in a central monitoring laboratory. Gepotidacin inhibited 98.0% (3,488/3,560 isolates) of E. coli and 100% (344/344 isolates) of S. saprophyticus at gepotidacin concentrations of ≤4 μg/mL and ≤0.25 μg/mL, respectively. This activity was largely unaffected with isolates that demonstrated resistance phenotypes to other oral standard-of-care antibiotics, including amoxicillin-clavulanic acid, cephalosporins, fluoroquinolones, fosfomycin, nitrofurantoin, and trimethoprim-sulfamethoxazole. Gepotidacin also inhibited 94.3% (581/616 isolates) of E. coli isolates with an extended-spectrum β-lactamase-producing phenotype, 97.2% (1,085/1,129 isolates) of E. coli isolates resistant to ciprofloxacin, 96.1% (874/899) of E. coli isolates resistant to trimethoprim-sulfamethoxazole, and 96.3% (235/244 isolates) of multidrug-resistant E. coli isolates at gepotidacin concentrations of ≤4 μg/mL. In summary, gepotidacin demonstrated potent activity against a large collection of contemporary UTI E. coli and S. saprophyticus strains collected from patients worldwide. These data support the further clinical development of gepotidacin as a potential treatment option for patients with uncomplicated UTIs.