Cause Of Myopia Research Articles

Cultural roots of the myopia boom in Confucian Asia and their implications.

Current evidence implicates educational pressures and reduced outdoor time as major causes of myopia. This paper examines the ongoing battle against the myopia epidemic in East Asia, including its cultural offshoots such as Singapore, where over 80% of young adults are myopic. East Asian societies share deeply rooted Confucian values that attach great importance to education and familial obligations, with heavy parental investment in education and the perception that academic excellence reflects filial piety. Coupled with a strong emphasis on standardised test results, East Asian children face intense educational pressures from a young age. Existing education-based myopia prevention strategies focus either on top-down school reforms to promote more outdoor time for studentsduring school hours oron bottom-up awareness initiatives encouraging lifestyle changes. However, the entrenched Confucian worldview suggests that more extensive top-down reforms aimed at reducing competition in education, combined with widespread bottom-up awareness initiatives targeting the public-particularly parents, given their active involvement in children's education outside of school-may be required to truly turn the tide on myopia.

Myopia, Sodium Chloride, and Vitreous Fluid Imbalance: A Nutritional Epidemiology Perspective.

Theories of myopia etiology based on near work and lack of outdoor exposure have had inconsistent support and have not prevented the rising prevalence of global myopia. New scientific theories in the cause and prevention of myopia are needed. Myopia prevalence is low in native people consuming traditional diets lacking in sodium chloride, and nutritional epidemiological evidence supports the association of rising myopia prevalence with dietary sodium intake. East Asian populations have among the highest rates of myopia associated with high dietary sodium. Similar associations of sodium and rising myopia prevalence were observed in the United States in the late 20th century. The present perspective synthesizes nutritional epidemiology evidence with pathophysiological concepts and proposes that axial myopia occurs from increased fluid retention in the vitreous of the eye, induced by dietary sodium chloride intake. Salt disturbs ionic permeability of retinal membranes, increases the osmotic gradient flow of fluid into the vitreous, and stretches ocular tissue during axial elongation. Based on the present nutritional epidemiology evidence, experimental research should investigate the effect of sodium chloride as the cause of myopia, and clinical research should test a very low-salt diet in myopia correction and prevention.

Study of risk factors in myopic individuals among medical students in Chennai, Tamil Nadu

Background: The incidence of myopia is increasing at an alarming rate. Investigating the causes of myopia gives us a better understanding of it. This gives us better odds of preventing the occurrence and retarding the condition's progression. The study used a method called stratified sampling to select 100 individuals who were near-sighted. They belonged to the age of 17-30 years old and pursued medicine in the district of Kanchipuram. The role of risk factors was assessed through a questionnaire. Result: The percentage of subjects with low, medium, and high myopia was 77, 18, and 5, respectively. The role of heredity, diet, academic performance, time spent doing near work, and outdoor work was indeed found to play significant roles in the development and progression of myopia. Conclusion: The incidence of myopia is constantly increasing, especially in Asian countries. To prevent myopia and its complications, we need to take significant steps to reduce the risk factors that can be changed.

Intraperitoneal Injection of MCC950 Inhibits the Progression of Myopia in Form-Deprivation Myopic Mice.

Myopia, one of the most prevalent ocular diseases worldwide, is projected to affect nearly half of the global population by 2050. The main cause of myopia in most patients is axial myopia, which primarily occurs due to the elongation of the eyeball, driven by changes in the extracellular matrix (ECM) of scleral cells. Previous studies have shown that NLRP3, an important inflammatory mediator, plays a critical role in regulating the expression of MMP-2 in the sclera. This, in turn, leads to a decrease in the expression of Collagen-1, a major component of the scleral ECM, triggering the remodeling of the scleral ECM. This study aimed to investigate the effect of MCC950, an inhibitor of NLRP3, on the progression of myopia using a mouse form-deprivation myopia (FDM) model. The FDM mouse model was constructed by subjecting three-week-old C57BL/6J mice to form-deprivation. The mice were divided into experimental (n = 10/group; FDM2M, FDM4M, FDM2W, and FDM4W) and control groups (n = 5/group). The experimental groups were further categorized based on the duration of form deprivation (2 and 4 weeks, labeled as 2 and 4, respectively) and the type of injection received (MCC950 or saline, labeled as M and W, respectively). MCC950 was injected at a concentration of 50 mg/mL, with a dose of 10 mg per kilogram of body weight. Meanwhile, the saline group received the same volume of saline. Refraction and axial length measurements were performed for each eye. The expression levels of NLRP3, caspase-1, IL-1β, IL-18, MMP-2, and Collagen-1 in the sclera were assessed using immunohistochemistry and Western blotting. The intraperitoneal injection of MCC950 did not significantly affect refraction or axial length in normal mice (p > 0.05). However, in FDM mice, MCC950 attenuated the elongation of the axial length and resulted in a smaller shift towards myopia compared to the saline group (FDM4M vs. FDM4W, p = 0.03 and p < 0.05, respectively). MCC950 decreased MMP-2 expression (p < 0.05) but increased Collagen-1 expression (p < 0.05) in the experimental eyes when compared to the saline group. Within the MCC950 group, the expression of MMP-2 was increased in the experimental eyes at 4 weeks (p < 0.05), while that of Collagen-1 was decreased (p < 0.05), which is consistent with changes in refractive error. Immunohistochemical analysis yielded similar results (p < 0.05). MCC950 also reduced the expression levels of NLRP3 (p = 0.03), caspase-1 (p < 0.05), IL-1β (p < 0.05), and IL-18 (p < 0.05) in the experimental eyes compared to the saline group. Within the MCC950 group, the expression levels of NLRP3 and caspase-1 were comparable between the experimental and control eyes (p > 0.05), whereas IL-18 expression was higher in experimental eyes (p < 0.05). IL-1β expression was higher in the experimental eyes only at week 4 (p < 0.05). The intraperitoneal injection of MCC950 can inhibit the progression of myopia in FDM mice, possibly by regulating collagen remodeling in the sclera through the NLRP3-MMP-2 signaling pathway. Therefore, MCC950 holds promise as a potential therapeutic agent for controlling the progression of myopia.

Perubahan Pengetahuan dan Sikap Terhadap Pencegahan Miopia Melalui Permainan Roda Putar

SD Al-Azhar 32 Padang is one of the schools with a high level of competition and is a full-day system school with students all day at school. Students' low knowledge and attitude toward myopia prevention are the causes of myopia in school-age children. Myopia prevention efforts need to be made to reduce the incidence of myopia in schoolchildren. This activity can be supported by a rotating wheel educational game tool. This study aims to determine changes in the knowledge and attitudes of schoolchildren toward myopia prevention efforts at Al-Azhar 32 elementary school in Padang. This research uses mixed-methods research (quantitative-qualitative), qualitatively using exploratory case studies and quantitatively using a quasi-experiment with a one-group pretest and posttest design. The population in this study were fifth-grade elementary school students, with a sample size of 64 people. Sampling technique with a purposive sample Informants in the study were eye health workers, health promotion workers, elementary school teachers, and graphic design experts. Data analysis consisted of univariate analysis and bivariate analysis with a paired t-test. The design of the rotating wheel educational game tool is attractive, and the colors vary. The average knowledge obtained before and after the intervention was 7.13 and 11.45, while the average attitude before and after the intervention was 37.23 and 44.06. The results showed that there was an average change in knowledge (p-value = 0.0001) and attitude (p-value = 0.0001). The conclusion of this study is that there are changes in the knowledge and attitudes of elementary school children toward myopia prevention efforts at Al-Azhar 32 elementary school in Padang. It is hoped that the school will follow up by incorporating education on myopia prevention efforts with a rotating wheel educational game into UKS activities at school.

Effects of general anesthesia on ocular Refraction: An observational study

Refractive error is an ocular condition whereby light rays do not focus onto the macula for visual processing when they enter the eye. The most prevalent type, myopia, often known as short sightedness, is brought on when light rays entering the eye are focused anterior to the macula, blurring distance vision. Though rare, there are few situations that can call for the introduction of performing objective ocular refraction under GA. Refractive testing under general anesthesia (GA) is more safely suited for patients with conditions like subjective difficulty with charts, poor testing cooperation, nonorganic visual impairment refractions, physically or developmentally disabled patients, and those with co-existing ophthalmic pathology. A 2-week prospective observational study was conducted in our hospital to look at the anesthetic methods used for ocular surgery at two sizable ophthalmic units. The anesthetist filled out a questionnaire for each case. The types of anesthetics used, the choice of ventilation or spontaneous respiration, the anesthetic agents used, the use and type of muscle relaxants, the presence of any significant ocular deviation, and any corrective actions taken, such as deepening anesthesia or giving a muscle relaxant, were among the information gathered.90 procedures in all were surveyed within the 2-week period. 52.2% (47) of them anesthesia was provided by consultant anesthetist, 25.6% (23) provided by Anesthesia Post Graduate Trainee(PGT) and 22.2% (20) provided by specialist registrar anesthesia. 74% (23) of the patients with NDMR out of the total 59% (31) ventilated patients had NDMR. 42% (22) of the patients had surgery done while they were spontaneously breathing, and 14% (3) of them had muscle relaxants to help with intubation. Total intravenous anesthesia was administered to one patient. In the poll, 29% (15) of the patients chose atracurium as their preferred NDMR, whereas 21% (11) chose vecuronium. In total, 50% of the patients in the survey had no planned NDMR. In 8% (4) of patients, there was a significant ocular deviation. One of these four patients had total intravenous anesthesia (TIVA), while the other three were ventilated. None of them had taken NDMRs, or non-depolarizing muscle relaxants. In one case, the anaesthesia was deepened, and in two other cases, NDMR was administered as a remedy for the deviation. The prevalence of this condition was 18% in patients not receiving NDMR.The objective refraction values showed that myopia manifested as a result of general anesthesia. Under the same circumstances, corneal refractive values flatten, indicating that the primary cause of myopia was ciliary muscle contraction. We hypothesize that this alteration resulted from ciliary muscle contraction and parasympathetic dominance during general anesthesia.

The Prevalence of Myopia and its Associated Factors Among School-Aged Children in Pamijahan Village, Bogor District

Globaly, the prevalence of refractive errors, especially myopia in children, has increased significantly. The cause of myopia is multifactorial. Near-work activities and family history are some suggested factors associated with myopia. However, there has not been enough data on these factors and their association with myopia in Indonesia. This study aims to determine the prevalence and factors associated with myopia in primary and middle schoolaged children in Pamijahan Village, Bogor District, West Java, Indonesia. Data were taken in a cross-sectional design based on the visual acuity, anterior and posterior eye examination. A 14-item questionnaire regarding myopia-associated factors including family history, playing outdoors, and near-work activities, was distributed to the subjects. The data were taken from June to September 2018. Analysis was conducted using SPSS version 20. The prevalence of myopia in Pamijahan Village is 4,9% out of 474 subjects. Family history, including parental (p=0.001, OR 4.49) and sibling history (p=0.001, OR 5.58), was shown to be associated with the increasing risk of myopia in children while near-work activities and playing outdoors were not associated with myopia in children of Pamijahan Village.

The Prevalence of Myopia and its Associated Factors Among School-Aged Children in Pamijahan Village, Bogor District

Globaly, the prevalence of refractive errors, especially myopia in children, has increased significantly. The cause of myopia is multifactorial. Near-work activities and family history are some suggested factors associated with myopia. However, there has not been enough data on these factors and their association with myopia in Indonesia. This study aims to determine the prevalence and factors associated with myopia in primary and middle schoolaged children in Pamijahan Village, Bogor District, West Java, Indonesia. Data were taken in a cross-sectional design based on the visual acuity, anterior and posterior eye examination. A 14-item questionnaire regarding myopia-associated factors including family history, playing outdoors, and near-work activities, was distributed to the subjects. The data were taken from June to September 2018. Analysis was conducted using SPSS version 20. The prevalence of myopia in Pamijahan Village is 4,9% out of 474 subjects. Family history, including parental (p=0.001, OR 4.49) and sibling history (p=0.001, OR 5.58), was shown to be associated with the increasing risk of myopia in children while near-work activities and playing outdoors were not associated with myopia in children of Pamijahan Village.

Variation of choroidal thickness during the waking period over three consecutive days in different degrees of myopia and emmetropia using optical coherence tomography.

To investigate the diurnal variation in subfoveal choroidal thickness (SFCT) during the waking period over three consecutive days in different degrees of myopia and emmetropia. A total of 60 adult volunteers were grouped into low, moderate, high myopia, and emmetropia subgroups. SFCT, axial length (AL), anterior chamber depth (ACD), and intraocular pressure (IOP) were measured every 2 h from 8 AM to 8 PM for three successive days. The mean values of daily change amplitude were 3.18 mmHg (IOP), 0.05 mm (AL), 0.17 mm (ACD), and 13.51 μm (SFCT). The values of AL and ACD increased simultaneously with spherical equivalent refraction (SER), but SFCT was the opposite. IOP had a diurnal variation, and there was no difference among the four groups. AL of the high myopia group, ACD of the emmetropia group, and SFCT of each myopia group had diurnal variation over three consecutive days. AL had a high mean value at noon every day, and SFCT had a low mean value at noon every day. The choroid thickness of subjects with different degrees of myopia had a significant diurnal variation. The change of diurnal variation between emmetropic and myopic subjects may be one of the causes of myopia.

Peripheral defocus as it relates to myopia progression: A mini-review

Myopia is the most common refractive error in the world and has reached a pandemic level. The potential complications of progressive myopia have inspired researchers to attempt to understand the sources of myopia and axial elongation and to develop modalities to arrest progression. Considerable attention has been given over the past few years to the myopia risk factor known as hyperopic peripheral blur, which is the focus of this review. It will discuss the primary theories believed to be the cause of myopia and the parameters considered to contribute to and influence the effect of peripheral blur, such as the surface retinal area of blur or the depth of blur. The multitude of optical devices designed to provide peripheral myopic defocus will be mentioned, including bifocal and progressive addition ophthalmic lenses, peripheral defocus single-vision ophthalmic lenses, orthokeratology lenses, and bifocal or multifocal center distance soft lenses, as well as their effectivity as discussed in the literature to date.

Differences and causes of myopia among students in different stages in the same region in Xi'an

Differences and causes of myopia among students in different stages in the same region in Xi'an

The prevalence and causes of pediatric uncorrected refractive error: Pooled data from population studies for Global Burden of Disease (GBD) sub-regions.

BackgroundThere are limited systematic reviews on the prevalence of uncorrected refractive errors in children. We aimed to summarize the prevalence and causes of pediatric uncorrected refractive error (URE) from studies in the Global Burden of Disease (GBD) sub-regions.MethodsThe pooled analysis used the individual participant data (ages less than 20 years old) from population-based studies around the world by regions. URE was defined as presenting VA < 6/18 and improving to ≥ 6/18 or ≥1 line on using a pinhole in either eye, with main causes of myopia, hyperopia or astigmatism. Each study provided data on any URE, myopia, hyperopia or astigmatism by age, gender, and ethnicity. Prevalence rates were directly age and gender standardized to the 2020 world population with all age groups. Estimates were calculated by study and sub-regions after pooling. Summary estimates included studies in which URE was assessed from a pinhole-corrected refraction in the better eye.ResultsThe combined pooled data contained 302,513,219 patients including 8 963 URE cases individuals from 57 studies. Prevalence varied by age and GBD sub-regions and differed by gender. The age- and region-standardized prevalence of URE was 3.41 per 1000 (CI, 1.53~7.62) in Western Pacific region (12 studies), 2.26 per 1000 (CI, 0.85~6.01) in South-East Asia region (14 studies), 5.85 per 1000 (CI, 3.75~9.13) in Americans (11 studies) and 4.40 per 1000 (CI, 3.0~6.45) in Eastern Mediterranean region (13 studies). On the basis of these data, myopia was the first-leading cause in female children with 12~17 age group, with the prevalence rate 18.2 per 1000 (CI, 11.52~23.61). Astigmatism was detected in 27.2 per 1000 male children with 6~11 age group (CI: 19.12–30.68).ConclusionsPrevalence of URE available data within these sub-regions are widely disparate. Myopia and astigmatism in young age children continue as the leading cause of URE worldwide. Providing appropriate refractive correction to those individuals whose vision can be improved is an important public health endeavor with implications for safety and quality of life.

Effects of General Anesthesia on Ocular Refraction

ABSTRACT Purpose General anesthesia alters the autonomic nervous system. This study aimed to investigate the effects of general anesthesia on objective ocular refraction. Methods A total of 57 patients (112 eyes) under 15 years of age who underwent strabismus surgery under general anesthesia were included in this study. Objective refraction values, corneal refraction values, and pupil diameter were measured using a HandyRef-K, a hand-held refractive keratometer, in the operating room before and during general anesthesia before strabismus surgery. Results The spherical power of the myopic eye increased from −0.75 D to −2.29 D (diopter); the cylindrical power increased from −0.90 D to −1.39 D (p < .01 for all). The corneal refractive power decreased by an average of 0.25 D (p < .01). The spherical refractive power was negatively correlated with the age and the amount of change between cycloplegia before general anesthesia and during general anesthesia (r = −0.32, p < .05). Conclusions General anesthesia resulted in manifestation of myopia as noted by the objective refraction values. Corneal refractive values flatten under the same conditions, suggesting that the contraction of the ciliary muscles was the main cause of myopia. We speculate that this change was due to parasympathetic dominance and contraction of the ciliary muscles during general anesthesia.

A complement to the theory of biological evolution: individual evolution and genetic mechanism hypothesis

Abstract In this article, by studying some clinical cases of myopia patients and performing the related analyses, we proposed a conjecture for the causes of myopia and its underlying genetic pathway. Based on that, we designed an experiment to prove the hypothesis of individual evolution. Individual evolution refers to the process of individual trait changes caused by certain external environmental factors, which can be inherited to the next generation. The generation (n) of cloned mice will be classified into X (n1, n1…nx) groups, and the daily exercise amount of each group will be defined as Tx (exercise time). Firstly, we will compare the changes in weight and muscle volume among all groups. Subsequently, the first generation of cloned mice will be used to obtain the second generation of cloned mice, and then grouped in the same way. Then, we will evaluate the effects of exercise on gene expression. For the nth generation, the expression levels of individual genes will be determined, and the individual evolution related indexes will be measured. Environmental factors can affect the changes in an individual state, and such alteration can be fed back to the genetic pathways and passed from one generation to the next.

The efficacy of selected acupuncture points UB 2, TW 23, GB 37, GB 1, EX 3, on myopia – case report

Myopia is a community health problem worldwide. The cause of myopia is both equally environmental and genetic risk factors. It occurs in more than 50% of the people in many developed countries and is approximate to be very high; the risk associated with axial elongation from myopia is the 6th foremost leading cause of blindness. People with undiagnosed short-sightedness including eyestrain and headache from stress clearly glimpse things in space. Short-sightedness also can be the outcome of the vision outermost of the cornea that is too curved for the level of the eyeball or a lens that is too solid. Acupuncture is one of the oldest and most typically used balancing and opportunity scientific treatments around the globe. Acupuncture is the training of inserting and manipulating needles into the superficial skin, subcutaneous tissue, and mucks of the body at specific acupuncture points.This study aims to find the effect of acupuncture points on vision and the power of the lens in people with myopia.

Можливості корекції психоемоційного стану дітей із міопією засобами плавання

Children's low vision is one of the world's pressing health problems. The problem of myopia is due to its prevalence among different groups of the population, the high incidence of young people. Myopia is one of the main causes of myopia and disability in patients of this nosological group, which occupies a leading place among human visual pathologies. The article considers the possibilities of correcting the psycho-emotional state of children with myopia by swimming, the study of the impact of these tools on the psycho-emotional state of students with myopia (development of methods for correcting psycho-emotional state, which promotes proper use of exercise in classes with children with myopia). The main theoretical problem of corrective swimming of children with myopia was to substantiate the specifics of the content, means and methods of corrective action, which, in contrast to general didactic principles of teaching, based on understanding the structure of the primary defect and the peculiarity of development of visual impairment in order to increase the psycho-emotional state of visually impaired children of primary school age. The need for corrective work in the process of swimming was confirmed throughout the study. The process of teaching swimming to children with myopia, which depended on a number of conditions (creating comfort for visual functions, correct construction of training taking into account the characteristics of children with myopia, individual-differentiated approach, providing a positive emotional attitude to classes, taking into account the child's health) development of physical, psychomotor and intellectual abilities of children and adjusted a number of psychohygienic and psychophysical processes, as well as provided a high level of physical and mental health of children with myopia.

Advances in biomedical study of the myopia-related signaling pathways and mechanisms.

Myopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focused on the genetic pathogenesis of myopia in recent years. Scleral remodeling and excessive axial elongating induced retina thinning and even retinal detachment are myopia's most important pathological manifestations. The related signaling pathways are indispensable in myopia occurrence and development, such as dopamine, nitric oxide, TGF-β, HIF-1α, etc. We review the current major and recent progress of biomedicine on myopia-related signaling pathways and mechanisms.

Myopia

Refractive disorder is the most common cause of visual impairment in the world, and one of them is myopia. Myopia is a condition of the eye failing to focus light from an object causes it to focus in front of the retina. The elongation of the axis of the eyeball and the high refractive power of the cornea and lens might be the cause of myopia. Myopic patients often complain of blurred vision when looking at a far objects. There are several risk factors of myopia, including genetics, gender, age and environment.This article is literature review. The purpose of this paper is to provide an overview related to refractive disorders, especially myopia. The management of myopia patients can be divided into 2, including optical therapy and pharmacological therapy. Optical therapy includes the smallest negative spherical glasses that provide maximum visual acuity, contact lenses, and orthokeratology. Management of myopic patients aims to reduce progression and complications by providing optical therapy in the form of spherical glasses, contact lenses, and orthokeratology

Influencing Factors and Prevention of Myopia in College Students

Myopia has become a key public health problem in many countries due to its rapid growth.The number of college students in our country is increasing, the proportion of college students myopia is increasing. It is of great significance to analyze the influencing factors of myopia and scientifically formulate preventive strategies to effectively control the proportion of myopia. This paper analyzes the causes of myopia from the aspects of heredity, environment and behavior habit, and puts forward some preventive measures for myopia.

To the pathogenesis and treatment of myopia and its consequences L. Мiillеr (Wien. kl. Woch., 1926, №.12)

L. Miiller (Wien. Kl. Woch., 1926, No. 12) reports on his new method of surgical treatment of myopia, which is the result of his research into the causes of myopia.