Case Of Granular Cell Tumor Research Articles

S2400 Granular Cell Tumor: A Rare Disease of Esophagus

Introduction: Granular cell tumors (GCTs) are rare, often benign tumors of neurogenic origin. GCTs are usually found incidentally but can present with dysphagia in symptomatic patients. They are diagnosed via biopsy and histology following an esophagogastroduodenoscopy( EGD). We present a case of a 46-year-old female who presented with dysphagia, GERD, and weight loss diagnosed with esophageal granular cell tumor following an EGD. Case Description/Methods: A 46 years old female with a past medical history of H. pylori gastritis presents with complaints of dysphagia for 3 months and GERD associated with weight loss. EGD reviewed a single 4 mm nodule found in the lower third of the esophagus with the appearance of a lipoma (Figure). Biopsy of esophagus nodule resulted in esophageal squamous epithelium with focal granular cell tumor; Immunohistochemistry tumor cells are positive for S100, CD56, CD68, negative for calretinin and AE1/3 supporting rare esophageal granular cell tumor. EUS demonstrated a 4.7 mm x 2.6 mm intramural (subepithelial) lesion appeared to originate from within the superficial mucosa (Layer 1), Patient underwent repeat EGD with en-bloc cap and band-assisted endoscopic mucosal resection (EMR) followed by 3 hemoclips placed for hemostasis. The patient was discharged home on a proton pump inhibitor. The patient reports clinical improvement on follow-up after 4 weeks. Discussion: GCTs are thought to originate from Schwann cells; the prevalence of GCTs is challenging to determine as there have been roughly 300 documented cases of GCTs discussed in the literature. Conversely, patients with larger diameter lesions typically present with indolent dysphagia and other less common symptoms such as gastro-esophageal reflux disease, dyspepsia, chest pain, cough, or nausea. GCTs on EGD appear sessile, yellow-white in color, and firm, with a negative pillow sign. After performing EGD, an endoscopic ultrasound (EUS) is diagnostically utilized to ascertain tumor invasion and provide a biopsy through fine needle aspiration (FNA). Histopathological diagnosis, including immunohistological staining, is essential for confirmation of GCT. Immunohistological staining is positive for S-100, PAS (Periodic Acid Schiff), neuron-specific enolase, nestin, and vimentin. Patients whose neoplasms are less than 1 cm in diameter are treated conservatively with endoscopic follow-up, with tumors greater than 1 cm in diameter, or having clinical symptoms that need endoscopic or surgical resection.Figure 1.: A: EUS showing 4.7 mm x 2.6 mm hypoechoic intramural (subepithelial) lesion was found in the lower third of the esophagus. It appeared to originate from within the superficial mucosa (Layer 1). A tissue diagnosis was obtained prior to this exam. B: EGD significant for sessile, yellow white in color, and firm mass followed by EMR. C: Histopathology with H&E showing clusters of polygonal cells with granular eosinophilic cytoplasm (top) and S100 stain (below).

Granular Cell Tumor of the Deep Lobe of the Parotid Gland Presenting With Respiratory Obstruction: Clinicopathologic Report of a Rare Presentation

Background Granular cell tumor (GCT) is a very rare, slow-growing, benign neoplasm with a controversial etiology, recently believed to be derived from Schwann cells. Hardly grows large and is also infrequently seen in children. Seventy percent of this tumor is seen in the head and neck with 1/3 in other parts of the body. Seldom occurs in the parotid gland and more so, the deep lobe of the parotid, where it may initially be asymptomatic but when large, it may result in respiratory obstruction. Case report : An 8-year-old female presented with a large right lateral upper neck-facial swelling of 3 months duration with a change in voice, difficulty swallowing, and respiratory distress. We reported an uncommon case of GCT of the deep lobe of parotid in a child with respiratory distress due to tumor obstruction of the airway. Tumor excision with preservation of the facial nerve was successfully performed. The histopathological report confirms the diagnosis of GCT. The child recovered to full general health with no signs of recurrence. Conclusion Granular cell tumor is a rare neoplasm, treatment is local surgical excision. Recurrence is uncommon, even if the lesion is not entirely removed. Microscopically this tumor may mimic a malignancy because of pseudoepitheliomatous hyperplasia of the overlying epithelium. The pathologist should be aware of this possibility to avoid a mistaken diagnosis of cancer.

Granular cell tumor of the trachea mimicking an infiltrating thyroid cancer. A case report.

Introduction and importanceGranular cell tumor (GCT) is a rare neurogenic neoplasm originating from Schwann cells that predominantly affects women and can involve skin and mucousae. In the respiratory system it most frequently involves bronchi and larynx, while it is rare in the trachea.Case presentationA 26-year old female smoker was hospitalized for a suspected hypoechoic nodule in the right thyroid lobe closely adherent to the trachea. At preoperative computed tomography tracheal lumen was totally clear. The patient underwent a total thyroidectomy with lymph node dissection and tracheal shaving. The postoperative course was complicated by an extensive subcutaneous bilatreral emphysema associated with respiratory distress appeared on the fifth day.Bronchoscopy revealed a right anterolateral subcentimeter lesion near the second tracheal ring. Histologically, the diagnosis was consistent with a tracheal GCT developing into the thyroid parenchyma. The patient was discharged on the twentieth postoperative day. At the follow-up bronchoscopy the lesion was completely healed and at the last 12 month follow-up the patient is doing well.Clinical discussionTracheal tumors are uncommon neoplasms accounting for about 2% of the total respiratory tree tumors. In literature we found <50 papers concerning tracheal GCT and in almost all of the cases patients complained about respiratory symptoms.ConclusionWe report here a rare case of benign GCT of the trachea with extraluminal development, in a young patient who did not complain about preoperative respiratory symptoms, presented on ultrasound as a thyroid nodule with suspected cytology.

Investigation of the Molecular Profile of Granular Cell Tumours and Schwannomas of the Oral Cavity.

Granular cell tumours (GCTs) are rare submucosal lesions, thought to develop from Schwann cells, characterised by large polygonal cells with abundant lysosomes. The objectives of this study are to investigate whether GCTs have an antigen-presenting cell (APC) phenotype or a neural crest phenotype using immunohistochemistry and to compare expression profiles with Schwannomas. Immunoreactivity to CD68, HLA-DR, CD163, CD40 and CD11c (APC phenotype) and markers of neural crest cell (NCC) origin S100, SOX10, NSE and GAP43 in 23 cases of GCTs and 10 cases of Schwannomas were evaluated. RT-qPCR was used to identify a possible NCC developmental phenotype in 6 cases of GCTs. GAP43 was identified as a new NCC marker for GCTs, and some evidence was found for an APC phenotype from CD68 and HLA-DR immunoreactivity. RT-qPCR failed to identify an NCC developmental phenotype of GCTs, likely due to technical issues.

Novel case of a granular cell tumour mimicking breast malignancy and a metachronous axillary skin lesion

Abstract A 51-year-old woman presented with an asymptomatic screen-detected lesion of the right breast. The core biopsy showed a granular cell tumour (GCT). Twelve months later the woman presented with an incidental finding of a skin lesion in the left axillary fold during her annual breast surveillance review. Histopathology confirmed a second metachronous GCT. GCTs are an uncommon benign tumour of Schwann cell origin that can infrequently be multifocal. Due to the non-specific clinical presentation and radiological features, the gold standard of diagnosis relies on histologic assessment. We describe a novel case of metachronous GCT within the breast tissue mimicking a breast malignancy as a mammography screen-detected lesion, followed by a second GCT mimicking a scar lesion on the contralateral axillary fold.

Immunohistochemical study of autophagy associated molecules and cell adhesion molecules in canine intracranial granular cell tumors

Granular cell tumors (GCTs) are characterized by abundant eosinophilic cytoplasmic granules. Based on the hypothesis that canine intracranial GCT is a subtype of meningioma and its cytoplasmic granules are formed through autophagy processes, histopathological and immunohistochemical examination were performed on biopsy samples from 7 cases of canine intracranial GCTs and 15 cases of conventional meningiomas. Histopathologically, 7/7 cases of GCTs involved the meninges; foci of meningothelial-like cells were observed in 3/7 cases; brain invasion was observed in 2/7 cases. Immunohistochemically, neoplastic cells of GCTs were positive for E-cadherin and negative for S100, cytokeratin, CD204, and β-catenin in 7/7 cases. Neoplastic cells of 15/15 cases of meningiomas were positive for E-cadherin, and negative for S100 and CD204. Immunoreactivity of meningiomas for cytokeratin and β-catenin was observed in 6/15 cases and 8/15 cases, respectively. Cytoplasmic granules of GCTs were positive for ubiquitin (5/7), p62 (5/7), and LC3 (7/7). Compared to GCTs, the ratios of ubiquitin (6/15) and p62 (3/15) positive cases were lower in meningiomas, and 15/15 cases were negative for LC3. These findings indicate that the biological natures of GCTs including anatomical location, histopathological features and immunoreactivity for E-cadherin are almost in conformity with those of meningiomas. The immunoreactivity for autophagy associated molecules may suggest the possible involvement of autophagy in cytoplasmic granule formation of canine intracranial GCTs.

An Extremely Rare Case of Granular Cell Tumour of Right Nasal Vestibule

Granular Cell Tumour (GCT) of nasal and paranasal area is an extremely rare entity, while the most common site is the tongue in oral cavity. GCT was first time described by Abrikossoff in 1926, which occurs in 3rd to 5th decades of life and most frequently involving the head and neck region. Abrikossoff in 1926, first time described GCT, to be derived from smooth muscle and gave the term myoblastomas, also known as Abrikossoff’s tumours. Schwann cell origin of GCT was demonstrated on immunohistochemistry through positive S100 protein identification. Herein, the authors report a case of GCT arising from right nasal vestibule in a 28- year-old female who presented with swelling since three months. On gross examination, the specimen revealed firm red and white pieces of tissue measuring 0.8x0.8x0.5cm. Diagnosis was made by histopathological examination which was confirmed by PAS special stain and S100 immunohistochemistry. Author also abridge the clinical information, microscopic features, treatment and patient status after follow-up. This case is believed to be the 7th reported case of GCT as primary lesion at this location.

Retinal granular cell tumor: a case report

BackgroundTo report a rare case of granular cell tumor invading the retina.Case presentationA 56-year-old female complained of blurred vision for 2 weeks in her left eye. An irregular-shaped retinal mass in the inferonasal and extending to the optic disc accompanied by dense exudation and extensive serous retinal detachment was observed. Several intravitreal bevacizumab injections were ineffective for stabilizing retinal exudation and intraocular pressure (IOP). Vitrectomy was performed to re-attach the retina and obtain a tumor biopsy specimen. Histopathological analysis revealed that the intraocular mass was a granular cell tumor. Immunohistochemical studies demonstrated that the tumor was positive for S100 and CD68, focal positive for neurofilaments, but negative for ERG and HMB-45. Local recurrence and distant metastasis were not found, but visual acuity had worsened to no light perception at the last visit due to uncontrolled intraocular pressure and retinal exudation after the surgery.ConclusionsGranular cell tumor is a rare benign neoplasm, but it can lead to devastating visual loss if it invades the retina adjacent to the optic nerve head.

A solitary granular cell tumor of stomach: A rare entity

Granular cell tumor (GCT) is uncommon, originates from Schwann cell and is usually benign. It is most commonly seen in skin and subcutaneous tissue of chest and upper extremity, tongue, breast, female genital tract and respiratory tract. Involvement of Gastrointestinal Tract (GIT) is seen only in 8% of cases and still rarer in stomach; more frequent in esophagus followed by colon. Most of GCTs are reported to be synchronously associated with the similar tumor at esophagus or other gastrointestinal location [1]. Here we report a rare case of solitary GCT of stomach.

A case of esophageal granular cell tumor diagnosed by mucosal incision-assisted biopsy

For an esophageal submucosal mass suspicious of granular cell tumor (GCT) based on gross appearance and endoscopic ultrasound findings, a sufficient number of biopsy specimens is required for a definite diagnosis using immunohistochemical examination. When the specimen obtained by forceps biopsy is insufficient, endoscopic ultrasound-fine needle aspiration (EUS-FNA) is believed to be an useful alternative. However, it may be difficult to obtain an adequate amount of tumor material using EUS-FNA. Mucosal incision-assisted biopsy (MIAB) is a simple method that can collect larger amounts of specimens. This procedure is helpful for physicians who encounter the problem of obtaining an adequate amount of biopsy material from esophageal tumors suspicious for GCT. We present a case of esophageal GCT that was successfully diagnosed through MIAB.

S2114 IgG4-Related Disease: An Uncommon Location

Introduction: Granular cell tumors (GCTs) of the esophagus are rare and benign neoplasms of neural cell origin. The lesions are often incidentally identified during upper endoscopic evaluation for other indications. We report a case of esophageal GCT in a young patient who presented with heartburn. Case Description/Methods: A 29-year-old white woman with a history of bulimia nervosa, gastroesophageal reflux disease, and chronic diarrhea following a recent COVID-19 infection presented to the clinic with heartburn and regurgitation that had been ongoing for years. She recently switched her omeprazole to famotidine to prepare for conception, which made her symptoms worse. Her physical examination and laboratory investigations were unremarkable. Esophagogastroduodenoscopy showed a single 6 mm yellowish, firm, submucosal nodule in the distal esophagus (Fig. 1A) and chronic gastritis. The nodule was biopsied with cold forceps and proved to be a granular cell tumor (Fig. 1B). The granular cell tumor cells were negative for pan-cytokeratin and positive for S100 (Fig 1C). They were negative for CD45 and Synaptophysin by immunohistochemistry staining. Biopsy of the distal esophagus also confirmed a short segment of Barrett's esophagus without dysplasia. Gastric body and antrum biopsy showed mild chronic gastritis negative for Helicobacter pylori. She was scheduled for an endoscopic ultrasound followed by possible endoscopic mucosal resection. Discussion: Even though esophageal GCTs are benign incidental findings, they have malignant potential (1-4%). Mortality is related to the size, growth, and invasiveness of the tumor. Indications for endoscopic or surgical resection are large size ≥ 1 cm, rapid growth, high suspicion of malignancy, transmural infiltration, and persistent symptoms. Endoscopic resection techniques include endoscopic mucosal resection and submucosal tunnel endoscopic resection. The later is more preferred in lesions < 3 cm. One study reported no recurrence of esophageal GCTs after resection in 14 cases at a median of 4-year follow-up.

Granular cell tumour of cecum mimicking a neuroendocrine tumor

Granular cell tumor (GCT) is a benign soft tissue neoplasm generally believed to be of nerve sheath origin. It is most frequently seen in skin, subcutaneous tissue and oral cavity. GCTs are uncommon in gastrointestinal tract (GIT), in which the majority are located in the esophagus. In this article, we report a case of GCT involving cecum in a 22 years lady. She had a sessile polyp in the cecum which was thought to be NET. Typical histomorphology and expression of S-100 on immunohistochemistry confirmed the diagnosis.We have reviewed, the GCTs of cecum reported previously with emphasis on the differential diagnosis. To best of our knowledge, this is only the 3 case of GCT of cecum reported in the Indian literature. Colonic GCTs are extremely uncommon. This is just the third case of GCT of colon in Indian literature. GCTs pose a diagnostic challenge due to lack of symptoms or nonspecific symptoms. Awareness of this entity helps in preventing misdiagnosis as happened in this case and avoiding further unnecessary treatment.

Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck.

Brain-derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis, and plasticity. They have also been studied in the behavior of central nervous system tumors. Here, we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. This cross-sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC), and 4 malignant peripheral nerve sheath tumor (MPNST) were submitted to immunohistochemistry with BDNF, TrkB, and p75NTR antibodies. A semi-quantitative analysis was performed. The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC, and MPNST (P<.0001); and TN showed less percentage of positive cell compared to SC (P=.0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (P=.009), NF (P=.0138) and SC (P=.0069). Also, a decrease in TN compared to GCT (P=.007) was observed. Our results showed the immunoreactivity of BDNF, TrkB, and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest down-regulation during the acquisition of malignant phenotype.

Granular cell tumor of nasal cavity: An uncommon occurrence with review of literature

Granular cell tumors (GCTs) are uncommon benign lesions which usually occur in head and neck region, with tongue being the most common site. Lesions involving nasal and paranasal areas are extremely rare. We report a case of GCT arising from left nasal cavity in a 15 year old female who presented with unilateral epistaxis since 4-5 months.

S3393 Granular Cell Tumor of the Colon - Surprise Beneath the Mucosa!

INTRODUCTION: Granular Cell Tumors (GCT) are a rare soft tissue neoplasm that arise from Schwann cells. Even though these tumors are generally benign, 1-2% of the cases have been reported to be malignant. Although usually found in the oral cavity or subcutaneous tissue, 8% of cases manifest in the gastrointestinal (GI) tract. In those patients, the esophagus is the most frequently affected organ, followed by the duodenum, anus, stomach. The least common sites are the colon and rectum. To date ∼ 150 cases of Colonic GCT have been reported in the English literature. Most GCT tend to be asymptomatic and less than 2cm in size, hence they are usually discovered incidentally during routine colonoscopy or abdominal imaging. Herein we report a unique case of GCT of the ascending colon measuring 11mm in size in a patient presenting with constipation that was treated successfully with endoscopic resection. CASE DESCRIPTION/METHODS: A 55-year old male with a history of external hemorrhoids presented to the GI clinic with constipation for two weeks. His previous colonoscopy eight months prior revealed a one cm polyp in the ascending colon, but it was not removed due to poor preparation. Repeat Colonoscopy revealed an 11 mm semi pedunculated polyp in the ascending colon. The polyp was removed with hot snare polypectomy followed by the placement of hemostatic clips. (Figure#1). Histopathologic examination of the resected polyp showed an intramucosal and submucosal tumor composed of polygonal cells with abundant amphophilic granular cytoplasm and centrally or eccentrically located small round or irregularly shaped nuclei (Figure#2). Margins of the resected polyp were free of tumor. Immunohistochemical analysis showed tumor cells were positive for S100 (Figure#3), CD68, and inhibin and negative for CD117 and neurofilament. On the basis of the above findings, the tumor was diagnosed as GCT. He followed up with a gastroenterologist as an outpatient one month later and had reported no symptoms. DISCUSSION: Colonic GCT are usually discovered at the time of colonoscopy as small, sessile, yellowish-white nodules or polyps covered by normal-appearing mucosa. Definitive diagnosis can be made by histopathology and immunohistochemical analysis. Endoscopic removal is the safest and most effective treatment. Though typically benign, gastroenterologists should be aware of malignant features such as a size greater than 4cm or rapid growth. It is important to consider GCT when one encounters a subepithelial lesion during colonoscopy.Figure 1.: A-11mm semi-pedunculated polyp in the ascending colon B-Prophylactic application of resolution clip at the polyp removal site.Figure 2.: The morphology of granular cell tumor in intramucosal and focally submucosal location in a colon polyp (H&E: 10x). Infiltrative growth pattern with nested or trabecular cellular clusters or sheets are appreciated. The cells are with abundant amphophilic granular cytoplasm and centrally or eccentrically located small round or irregularly shaped nuclei. No necrosis or mitosis is appreciated.Figure 3.: S100 positive staining highlighted the infiltrating trabecular growth pattern of this granular cell tumor (H&E: 10x).

S1910 A Case Series of Esophageal Granular Cell Tumor in Eosinophilic Esophagitis

INTRODUCTION: Granular cell tumors (GCTs) are rare, soft tissue neoplasms arising from Schwann cells and can be found anywhere in the body. Gastrointestinal GCTs represent 6–10% of all cases with the majority arising in the esophagus. On endoscopy, GCTs appear as white-grey or a yellow subepithelial lesion. Most GCTs are benign, but approximately 0.5–2% of cases progress to malignancy and carry a poor prognosis. Eosinophilic esophagitis (EoE) is a chronic, immune-mediated condition characterized by eosinophil-predominant inflammation of the esophagus. We present three cases of esophageal GCTs diagnosed endoscopically in the setting of EoE. CASE DESCRIPTION/METHODS: Case 1: A 25 year-old female with asthma and environmental allergies presented with chronic dysphagia and intermittent solid food impaction never requiring endoscopy. She underwent EGD which showed mild inflammation. There was also a 5 mm small nodular area with adherent exudate (Figure 1). Biopsies of the proximal and distal esophagus revealed squamous mucosa containing innumerable intraepithelial eosinophils, consistent with EoE. Additionally, the nodule was found to be a GCT. Case 2 :A 38 year-old male with a history of biopsy-proven EoE presented for a follow up EGD after receiving PPI therapy for twelve weeks. EGD revealed a normal esophagus (Figure 2); however, random biopsies revealed incidental GCT in the mid-esophagus. Case 3: A 33 year-old male with a history of childhood environmental allergies presented with chronic dysphagia and intermittent solid food impaction. On EGD, the esophagus appeared normal. However, random biopsies from the mid esophagus showed eosinophilia consistent with EoE as well as a GCT. Therefore, repeat EGD was performed with white light along with endoscopic ultrasound to further evaluate for GCT and revealed a 2 mm submucosal lesion (Figure 3). DISCUSSION: The relationship between GCT and EoE remains unclear. Previously, case reports noted the simultaneous finding of GCT in patients with EoE on EGD. Here, we present three different endoscopic findings of esophageal GCT. Most notably, in two cases GCT was not diagnosed visually, but rather histologically. These cases add to the growing body of literature associating EoE and GCT, though a pathophysiologic relationship has not yet been drawn. Whether the presence of GCT in these cases is completely incidental or immune-mediated is unknown. Thus, as the prevalence of EoE continues to increase, clinicians should be aware of the association between GCT and EoE.Figure 1.: EGD of the esophagus revealing a 5 mm granulosa cell tumor (GCT).Figure 2.: Normal endoscopic appearance of the esophagus without endoscopic appearance of a GCT.Figure 3.: Submucosal GCT seen on white light endoscopy.

Tumor de células granulares: relato de caso

O tumor de células granulares (TCG) é uma neoplasia benigna de origem neural incomum que acomete tecidos moles. Possui predileção pelo sexo feminino entre as 4ª e 6ª décadas de vida e apresenta-se clinicamente como um nódulo submucoso indolor em dorso de língua. O tratamento de escolha é a remoção total da lesão, apresentando um bom prognóstico, com casos raros de recidiva. O objetivo deste trabalho foi relatar um caso de tumor de células granulares em uma paciente do sexo feminino, localizada em dorso de língua, com cerca de 3 anos de evolução. A lesão foi removida completamente e a paciente segue sem sinais de recidiva. Com isso, o tumor de células granulares deve ser considerado como diagnóstico diferencial de lesões nodulares na língua, especialmente em mulheres.

Tumor de células granulares en esófago Presentación de caso y revisión de literatura

El tumor de células granulares o de Abrikossoff es un tumor infrecuente. Usualmente es benigno, pero existen casos documentados de malignidad. Puede encontrarse en cualquier localización anatómica, y se sabe que posee derivación neural. Un 4-6% se localiza en el tracto gastrointestinal y un tercio de ellos, en esófago. Es un tumor usualmente asintomático, por lo que la mayoría se diagnostica en endoscopías realizadas por otras causas. La edad de diagnóstico es alrededor de los 30-60 años. Macroscópicamente, se observa como una masa sésil, firme, blanco-amarillenta y está localizada principalmente en submucosa. A la histología e inmunohistoquímica se documenta granulaciones y positividad para S-100 y PAS diastasa resistente. En este trabajo se presenta un caso de tumor de células granulares de esófago con características típicas descritas en la literatura, diagnosticado en el Hospital Escalante Pradilla. A nuestro conocimiento, es el primer tumor de Abrikossoff de esófago reportado en Costa Rica.

A Case of Pediatric Laryngeal Granular Cell Tumor

Granular cell tumor is rare tumor origination from Schwann cell. It occurs extremely rarely in pediatric age. Treatment is complete resection, but this may not always be possible because of the risk of airway stenosis or vocal cord paralysis. Six year-old male patient visited otolaryngology clinic due to dyspnea and stridor. Posterior glottis mass was indentified and was partially resected to confirm histology and resolve airway obstruction. One year after operation, the patient was living well without re-growing of tumor. We report a case of granular cell tumor in pediatric larynx with a review of literature. Key words: Granular cell tumor ㆍ larynx ㆍ pediatric 핵심용어: 과립 세포 ì¢ ì–‘ ㆍ 후두 ㆍ 소아

A case of granular cell tumor of the stomach resected by endoscopic submucosal dissection

A case of granular cell tumor of the stomach resected by endoscopic submucosal dissection