A case of esophageal granular cell tumor diagnosed by mucosal incision-assisted biopsy

Yasuhiro Inokuchi,Shin Maeda,Kei Hayashi,Nozomu Machida,Mitsuhiro Furuta,Mamoru Watanabe,Yoshihiro Kaneta

doi:10.1007/s12328-021-01535-y

Abstract

For an esophageal submucosal mass suspicious of granular cell tumor (GCT) based on gross appearance and endoscopic ultrasound findings, a sufficient number of biopsy specimens is required for a definite diagnosis using immunohistochemical examination. When the specimen obtained by forceps biopsy is insufficient, endoscopic ultrasound-fine needle aspiration (EUS-FNA) is believed to be an useful alternative. However, it may be difficult to obtain an adequate amount of tumor material using EUS-FNA. Mucosal incision-assisted biopsy (MIAB) is a simple method that can collect larger amounts of specimens. This procedure is helpful for physicians who encounter the problem of obtaining an adequate amount of biopsy material from esophageal tumors suspicious for GCT. We present a case of esophageal GCT that was successfully diagnosed through MIAB.

Highlights

A granular cell tumor is a tumor which can develop in various organs, such as skin, oral cavity, lung, bronchi, bladder, uterus and gastrointestinal tract
In certain conditions when the usual biopsy by forceps fails to confirm a definite diagnosis of esophageal granular cell tumors (GCT), it is believed that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a useful alternative
We introduced a mucosal incision-assisted biopsy (MIAB) for GCT; this is a simple biopsy method to obtain a sufficient number of tumor specimens for a histopathological diagnosis of GCT

Summary

Introduction

A granular cell tumor is a tumor which can develop in various organs, such as skin, oral cavity, lung, bronchi, bladder, uterus and gastrointestinal tract. Keywords Mucosal incision-assisted biopsy (MIAB) · Granular cell tumor (GCT) · Endoscopic ultrasound-fine needle aspiration (EUS-FNA) · Endoscopic submucosal dissection (ESD) · Positron emission tomography-computed tomography (PET-CT) Ultrasonographyguided fine needle aspiration is useful in the diagnosis of granular cell tumors (GCT) in breast [1, 2].

Results

Conclusion