Dengue Fever Cases Research Articles

Demographic Profile of Patients with Dengue Fever Presented in a Tertiary Care Hospital of Bangladesh

Background: Dengue is an important tropical infection caused by an arbovirus having four serotypes (DENV-1, DENV-2, DENV-3, DENV-4) transmitted through the bite of infected female Aedes mosquito. Dengue is a challenging disease with multisystemic, varied, atypical, and sometimes life-threatening presentations. It presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS) and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Each year, thousands of dengue infections are reported and there are several outbreaks of dengue in several countries including Bangladesh and this imply the global importance of this infection. The objectives of this study was to determine the sociodemographic variables of patient suffering from DF during an epidemic outbreak. Methods: This hospital review analyzed the hospital records of DF cases of BIRDEM General Hospital, Dhaka from June 2019 to December 2019. Patients with suspected dengue fever attending at the outdoor/emergency or admitted indoor were taken as study subjects. Data were collected from hospital records. Study protocol was approved by the Institutional Review Board. All the relevant data regarding history and examination findings of the patients, the laboratory reports were collected. Statistical package for social science (SPSS) version 22, was used for data entry and statistical analysis. Results: Total 292 dengue patients were enrolled in this study. Mean age of all patient was 35.63±15.22 years (11-85 year) with male predominance (54.8%). Maximum patients were from urban residence (83.9%), non-smoker (73.6%), had active lifestyle (63.4%) and normal body mass index (68.5%). Overall, 65.1% patients had no comorbidity and 89.4% had no concurrent acute illness. Conclusion: Although the results of this study cannot be generalized to other cities of Bangladesh, our findings will allow public health agencies in Bangladesh to concentrate their efforts to battle against dengue. J Bangladesh Coll Phys Surg 2023; 41: 63-68

Pemanfaatan Tanaman Lokal Serai (Cymbopogon Nardus) sebagai Spray Anti Nyamuk oleh Kader Pkk Kelurahan Pucang Sawit

One of the diseases that is still a health problem in Central Java Province is Dengue Hemorrhagic Fever (DHF). Surakarta is the city with the highest death rate (CFR) due to dengue fever in Central Java Province at 14.6%. Lack of knowledge and awareness of dengue fever is one of the causes of the high number of dengue fever cases. This service activity was carried out as an effort to prevent dengue fever by increasing community knowledge through Family Welfare Development (PKK) cadres regarding dengue fever and the use of herbal plants in the environment to prevent dengue fever. Community service was carried out in Pucang Sawit Village, Jebres, Surakarta which was attended by representatives from each Neighborhood Association (RT). Starting with counseling about dengue fever and the use of natural ingredients for dengue fever, especially the lemongrass plant, then continued with the practice of making repellent spray products from the lemongrass plant. Evaluation of the service implementation process is carried out by carrying out pre-tests and post-tests by service participants to determine the level of participants' knowledge of dengue fever and the use of Serai as a repellant, before and after service activities. The average pre-test and post-test scores obtained were 80.31 and 89.69 respectively. This value shows an increase in community knowledge before and after the extension activities were carried out.

Sosialisasi Pencegahan dan Pengendalian Demam Berdarah Dengue (DBD) di RT 001, Kelurahan Karingau, Kecamatan Balikpapan Barat

The spread of Dengue Hemorrhagic Fever (DHF) is very fast, especially in countries with tropical climates such us Indonesia. This is because high rainfall makes it easier for the Aedes aegypti mosquito to breed and continue its life cycle. DHF is an acute febrile disease caused by a virus infection. According to the World Health Organization, Indonesia is the country with the highest cases of dengue fever in Southeast Asia. Based on data in June 2022, there were 45.000 cases of dengue fever and the number increased in July 2022 to 52.000 cases of dengue fever. The aim of carrying out this PkM activity is to increase the knowledge of the Kariangau Village community in efforts to prevent and control dengue fever. The method used is socialization of ways to prevent and control dengue fever. This activity was carried out on August 12, 2023 at Posyandu RT 001 Kariangau Village and involved the local community.

The Impact of Environmental and Behavioral Factors on the Incidence of Dengue Hemorrhagic Fever in Indonesia: Meta-analysis

Cases of dengue fever in Indonesia will increase to 143,000 by the end of 2022. The aim of the research is to examine the impact of environmental and behavioral factors on the incidence of dengue hemorrhagic fever in Indonesia. This research uses the Meta-Analysis Method with PICOS technology. Some sources of information used include Google Scholar, Research Gate, and Plos ONE, with the help of keywords such as "Environmental factors" and "Behavior." 193 articles were obtained, 151 articles came from Google Scholar, 37 articles from Research Gate, and 5 articles from Plos ONE. The articles obtained were filtered using inclusion criteria such as articles that had a 2x2 table, and discussed dengue fever and behavior with the number of selected articles being 21. At the screening stage, researchers used a cross-sectional research design. JASP application version 0.16.3.0 was used to process meta-analysis data. The key findings show that the habit of hanging clothes has a 2.386 higher risk as a cause of dengue hemorrhagic fever, with the pooled OR value as follows e0.87 = 2.386 (CI 95% 0.17-1.57). The presence of larvae has a risk of 2.075 for dengue fever with the following pooled value e0.73 = 2.075 (CI 95% 0.12-1.33). Meanwhile, the 3 M movement has a risk of 0.406 for the incidence of dengue fever with the following pooled value e-0.90 = 0.406 (CI 95% -1.66-0.15). the conclusion is There is an influence of the habit of hanging clothes, the presence of larvae and the 3M movement on the incidence of dengue hemorrhagic fever.

Distribution Pattern and Density Figure on The Incident Of DHF

Dengue hemorrhagic fever (DHF) is a disease that causes death, known for > 200 years, and has become a health problem in the world, especially in developing countries, including Indonesia. Deli Serdang Regency had the highest number of cases in North Sumatra Province in 2019 with 1,326 cases, in 2020 there were 974 cases, IR: 50.4. In 2021, the Regency/City ranked 14th out of 514 Regency/City in Indonesia for the highest number of dengue fever cases in 2021 with 803 cases, IR/morbidity rate: 34.63/100,000 population, CFR/death rate: 0.12%. It is possible to identify the location of the patient down to the address of the individual's location, so as to obtain information regarding the distribution pattern of cases in each region using the Geographic Information System (GIS). The aim of this research was to obtain a vector entomological survey (CI, BI, HI, ABJ), and the distribution pattern of Dengue Hemorrhagic Fever (DHF). Research used a case control design, determining the location of houses referring to FUNASA and WHO regulations (taking into account the number of buildings and House Index (HI) with household members as subjects of 100 case houses and 100 control houses consisting of 22 sub-districts in Deli Serdang Regency. Based on the distribution results using Stascan, there are 4 clusters and the case points for dengue fever sufferers are located at a distance of 500 - 1500 m from the Community Health Center. Data on dengue fever sufferers in each community health center buffer in Deli Serdang Regency contained 81 cases.

HUBUNGAN PERILAKU SISWA SEKOLAH DASAR DENGAN KEJADIAN DEMAM BERDARAH DENGUE (DBD) DI KECAMATAN DOLOK BATU NANGGAR KABUPATEN SIMALUNGUN TAHUN 2023

Dengue hemorrhagic fever is an infectious disease that can cause extraordinary events (KLB). Dengue Hemorrhagic Fever spreads in Southeast Asia. Western Pacific & Caribbean. Indonesia is an endemic region that has spread to all corners of the country. According to the North Sumatra Provincial Health Ministry, the number of dengue hemorrhagic fever (DHF) sufferers in the region between January and September 2022 was 5,270 cases. According to the Simalungun District Health Office, in December 2022 there were 999 cases of dengue fever and 13 deaths in Simalungun. The results of the initial study of student behavior are still not enough to eradicate mosquito nests (PSN). This type of research is a quantitative study with an analytic observation study design using cross-sectional methods. This research was conducted in the elementary school area 091690 Serbelawan. The population in this study were elementary school students in Dolok Batu Nanggar Elementary School. In this study the analysis used the chi-square or chi-square formula (x2). . The results showed that there was a relationship between the behavior of throwing garbage and the incidence of DHF at the level of p = 0.045, namely <α = 0.05. There is a relationship between the behavior of draining the bathtub and the incidence of DHF at the level of p = 0.020, namely <α = 0.05. There is no relationship between the use of anti-mosquito lotion and the incidence of DHF at the level of p=0.684, namely <α = 0.05. It is suggested to the head of the Puskesmas to develop health education about the dangers of dengue fever mosquitoes.

Dengue-induced Guillain–Barre syndrome: a case series

BackgroundDengue virus is an RNA virus that is associated with a myriad of neurological manifestations. Less than 5% of patients develop neuromuscular complications. Guillain–Barre syndrome (GBS) is an uncommon neurological sequelae of dengue fever. Studies have shown acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN) to be the most common variants associated with dengue fever in Asian countries. Very few cases have been reported from Pakistan to date.Case presentationWe present four adult patients with dengue-associated GBS. The time interval between onset of symptoms of dengue fever and development of lower limb weakness in all patients was between 6 and 20 days. Dengue was diagnosed based on either serology or dengue NS1 antigen testing. Acute inflammatory demyelinating polyneuropathy (AIDP) (n = 1), AMAN (n = 1), and AMSAN (n = 2) variants were identified. One patient had a coexisting myopathy which has not been previously reported. All patients showed good recovery after treatment with plasmapheresis or intravenous immunoglobulins.ConclusionsOur case series is valuable in contributing to the limited pool of reported cases of dengue fever complicated by GBS. Early detection of new onset symmetrical limb weakness during or after a dengue infection is imperative for early treatment and to limit disability.

Spatio-temporal Clustering Analysis of Dengue Hemorrhagic Fever Cases in West Java 2016 – 2021

In 2020, WHO included dengue as a global health threat among 10 other diseases. This is also a problem in Indonesia, especially the province of West Java. Based on data from the Ministry of Health for 2022, West Java is the largest contributor to cases of Dengue Hemorrhagic Fever (DHF) in Indonesia. The spread of dengue fever is through mosquitoes, but climate also greatly influences the spread of this disease. The spread of West Java is quite wide, consisting of 27 city districts and a relatively high population density. This greatly influences the increase in the number of dengue fever cases. In this research, we will group years with the same dengue fever cases and identify groups of districts/cities in West Java with the same pattern of dengue fever cases for 2016 to 2021. The results obtained are that 2016 is the group with the highest number of cases. Meanwhile, from 27 city districts in West Java, three groups were obtained. Group 1 is the group with the highest number of cases consisting of Sukabumi City, Bandung City, Cimahi City, Depok City, Tasikmalaya City.

Thực trạng mắc bệnh sốt xuất huyết Dengue và một số yếu tố thời tiết tương quan với số ca mắc bệnh sốt xuất huyết tại thành phố Pleiku, tỉnh Gia Lai giai đoạn 2012 – 2021

The study was conducted to understand the current status of dengue hemorrhagic fever cases and some related weather factors in Pleiku city, Gia Lai province in the period of 2012 - 2021. A cross-sectional study was conducted by using secondary data on all reports on the number of dengue fever cases and vector indicators and of the hydro-meteorological station of the Central Highlands region, monthly average indicators of weather in Pleiku city, Gia Lai province from August 2021 to September 2022. From 2012 to 2021, Pleiku city had 10,031 cases of dengue hemorrhagic fever with an overall incidence rate of 347.48/100,000 people, a higher rate of dengue fever than some other provinces. The incidence of Dengue Hemorrhagic Fever is not uniform from year to year, it is cyclical in 3 years and according to the rainy season. Minimum temperature, humidity, and rainfall by month/season correlate positively with incidence From the results, it is recommended to increase monitoring, control, and detection of outbreaks in places with high population density from the time preparing for the rainy season - May every year. It is necessary to raise people's awareness about disease prevention, improve their status and equip them with knowledge to prevent mosquito bites, especially those over 15 years old who need to be equipped with protective clothing to avoid mosquito bites when working. Keywords: Dengue hemorrhagic fever, weather factors, Gia Lai province

Relationship between Knowledge and the Role of Community Leaders on the Incidence of DHF

Lampung Province recorded 3,484 cases of Dengue Fever (DHF) or 435 cases in a month. Or there are 14 cases a day. South Lampung recorded 185 people who experienced DHF from January to August 2022. The purpose of this study was to determine the relationship between knowledge and the role of community leaders on the incidence of DHF in the working area of the Hajimena Health Center, South Lampung Regency in 2023. This type of research is quantitative with a cross sectional approach with a population of 96 respondents and the number of samples is the same as the population because it uses total sampling tectics because the population is less than 100 the entire population is sampled using univariate and bivariate analysis tests. To determine the frequency distribution of the dependent variable (DHF incidence) and to determine the relationship between the independent variables (knowledge and the role of community leaders). The results of univariate research are that there are 26 people who experience DHF, there are 55 respondents who have good knowledge and there are 42 respondents who have poor knowledge, and the role of community leaders is 65 respondents who play a good role and there are 32 respondents who do not play a good role. Bivariate results There is a significant relationship between the knowledge of community leaders on the incidence of DHF (pvalue = 0.011) and There is a significant relationship between the role of community leaders on the incidence of DHF (pvalue = 0.000) in the working area of the Hajimena Health Center in 2023. To improve the knowledge and role of community leaders in paying attention to the condition of the community environment and eradicating mosquito nests, support from health agencies such as health centers and health offices is needed.

Comparison of clinical and laboratory parameters of primary vs secondary dengue fever in travellers.

Dengue fever (DF), caused by the dengue virus (DENV), is the most common arboviral disease in travellers worldwide. It is hypothesized that compared with primary DF, secondary DF may result in antibody-dependent enhancement of the immune response, resulting in more severe disease. We aimed to compare clinical and laboratory parameters in travellers with primary and secondary DF to determine whether secondary DF is associated with markers of severe disease. We conducted a retrospective cohort study, which included all patients diagnosed with DF at the Central Virology Laboratory of the Israeli Ministry of Health during 2008-19. Clinical, laboratory and virological data were extracted from laboratory and patient records. A diagnosis of DENV infection was based on a positive nonstructural protein 1 (NS1) test, polymerase chain reaction or serology testing for immunoglobulin M (IgM) and immunoglobulin G (IgG). Primary and secondary infections were classified based on travel history, NS1 result and IgM/IgG ratio. Severe DF was defined according to WHO classification. We identified 245 DF cases: 210 (86%) primary and 35 (14%) secondary. Whilst fever duration was significantly longer in secondary compared with primary infections (6.4 vs 5.3days, P = 0.027), mean Aspartate aminotransferase levels were significantly higher in primary compared with secondary cases (146 vs 65U/L, P < 0.001), and no other clinical or laboratory parameter differed significantly between the groups. Of note, only four patients had severe DF, all had primary infections and none died. In a cohort of returning travellers with DF, secondary infection, compared with primary infection, was not associated with a consistent trend towards greater severity of the clinical and laboratory markers examined in this study.

NEGLIGENCE OF ASIANS ON DENGUE FEVER

Dengue is a virus carried by mosquitoes, and it has recently expanded quickly in most Asia countries. The virus is spread mostly by female Aedes Aegypti mosquitoes among the Asian people. Due to high negligence among Asians, the virus was transmitted among everyone till late. Dengue fever is the most widespread arthropod-borne virus impacting humans today, corresponding to public health issues. Because of human negligence, the virus has spread widely to the present day. As a result, dengue fever cases keep increasing. Several reasons contribute to the spread of dengue fever among Asians, primarily their fear of the virus's repercussions. Additionally, increasing migration of people and environmental changes have accelerated the rate of viral propagation. This article discusses the causes, types of dengue fever, modes of transmission, risk factors, clinical symptoms, complications, diagnosis, incubation period, previous years' dengue fever statistics in a few Asian countries, treatments/vaccines, and preventions and controls associated with dengue virus that everyone should know to prevent and stop the virus transmission not only in Asia but all over the world are.

Threshold dynamics of an almost periodic vector-borne disease model.

Many infectious diseases cannot be transmitted from human to human directly, and the transmission needs to be done via a vector. It is well known that vectors' life cycles are highly dependent on their living environment. In order to investigate dynamics of vector-borne diseases under environment influence, we propose a vector-borne disease model with almost periodic coefficients. We derive the basic reproductive number [Formula: see text] for this model and establish a threshold type result on its global dynamics in terms of [Formula: see text]. As an illustrative example, we consider an almost periodic model of malaria transmission. Our numerical simulation results show that the basic reproductive number may be underestimated if almost periodic coefficients are replaced by their average values . Finally, we use our model to study the dengue fever transmission in Guangdong, China. The parameters are chosen to fit the reported data available for Guangdong. Numerical simulations indicate that the annual dengue fever case in Guangdong will increase steadily in the near future unless more effective control measures are implemented. Sensitivity analysis implies that the parameters with strong impact on the outcome are recovery rate, mosquito recruitment rate, mosquito mortality rate, baseline transmission rates between mosquito and human. This suggests that the effective control strategies may include intensive treatment, mosquito control, decreasing human contact number with mosquitoes (e.g., using bed nets and preventing mosquito bites), and environmental modification.

Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016-2019.

Acute undifferentiated febrile illness is a common challenge for clinicians, especially in tropical and subtropical countries. Incorrect or delayed diagnosis of febrile patients may result in medical complications or preventable deaths. Common causes of acute undifferentiated febrile illness in Colombia include leptospirosis, rickettsioses, dengue fever, malaria, chikungunya, and Zika virus infection. In this study, we described the acute undifferentiated febrile illness in postmortem patients reported as suspected cases of leptospirosis through the national leptospirosis surveillance in Colombia, 2016-2019. We retrospectively analyze human fresh and formalin-fixed tissue samples from fatal suspected leptospirosis cases reported by the Public Health Laboratories in Colombia. Leptospirosis confirmation was made by immunohistochemistry, real-time polymerase chain reaction (PCR) in the tissue samples. In some cases, the serum sample was used for confirmation by Microagglutination test (MAT). Simultaneously, tissue samples were tested by PCR for the most common viral (dengue, Zika, and chikungunya), bacterial (Brucella spp., and Rickettsia spp.), and parasitic (malaria). Fresh tissue samples from 92 fatal suspected leptospirosis cases were reported to the National Reference Laboratory from 22/32 departments in Colombia. We confirmed leptospirosis in 27% (25/92) of cases. Other pathogens identified by real-time PCR were Brucella spp. (10.9%), Rickettsia spp. (14.1%), and dengue (2.2%). Dengue (6.9%), hepatitis (3.5%), and Yellow Fever cases (2.2%) were detected by the pathology. All patients were negative for chikungunya and Plasmodium spp. Most cases were classified as undifferentiated febrile illnesses (45.7%; 42/92). This study underscores the importance of early and accurate recognition of leptospirosis to prevent mortalities. Moreover, it draws attention to the existence of other febrile syndromes in Colombia, including rickettsiosis and brucellosis, that currently lack sufficient human surveillance and regular reporting. Expanding laboratory surveillance to include viruses such as Hantavirus, Mayaro virus, Oropouche virus, and West Nile virus is crucial.

Experience in conducting an epidemiological analysis of dengue incidence in the Socialist Republic of Vietnam using geographic information systems

Aim: To identify regional epidemiological features of dengue fever and substantiate approaches to conducting epidemiological surveillance for this infection taking into account the regional features of its distribution and risk factors affecting its formation.Materials and methods: Retrospective epidemiological analysis of dengue incidence in the provinces of the Socialist Republic of Vietnam from 2017 to 2022. To conduct the epidemiological analysis of dengue incidence, a free version of the GIS Axioms (ГИС Аксиомы) program and the Google Earth application were used.Results: It was noted that cases of dengue fever were registered in all 63 provinces of the country, however, the dynamics of incidence levels had wide spatial and temporal ranges. Excepting Hanoi (189.6 0/0000), dengue incidence in the northern provinces are lower than those in the southern provinces. The highest average long-term incidence of dengue fever was observed in Da Nang (659.8 0/0000), Binh Duong (623.3 0/0000), Quang Binh (565.5 0/0000), Ba Ria-Vung Tau (554.6 0/0000) and Khanh Hoa (544.8 0/0000). The results of a comparative analysis of dengue incidence and the main factors influencing it in the adjacent, the incidences of dengue fever of which are significantly different from each other, are shown. The application of geoinformation systems for epidemiological analysis has been demonstrated. It has been established that the distribution of the population of Vietnam differs greatly between the administrative regions of the country, and the use of population density for epidemiological analysis and forecasting of the epidemiological situation of infectious diseases, including dengue fever, can lead to incorrect results.Conclusion: The epidemiological situation of dengue fever in Vietnam is characterized by high incidence rates, their wide ranges of spatial and temporal variability, and geographical heterogeneity. The use of GIS technologies is one of the promising approaches for epidemiological analysis and monitoring of dengue fever, as well as other infectious diseases.

Correlation between hematocrit and inferior vena cava collapsibility in adult patients with dengue fever: A prospective, observational study at a tertiary care setup in Eastern India

Background: Dengue fever (DF) is a vector-borne arboviral infection prevalent in tropical and sub-tropical countries. Early recognition of severity of the disease with appropriate fluid management is a challenge to the clinicians. Increase in capillary permeability is the pathophysiological hallmark of the disease which parallels with increase in hematocrit. This study aimed to evaluate the inferior vena cava (IVC) collapsibility and its relation to hematocrit. Methods: A prospective, observational study was conducted in the inpatient department of tropical medicine over a period of 1 year in a tertiary care set up in Eastern India. Clinical data and hematocrit of adult dengue cases were documented and their IVC collapsibility determined by bedside ultrasonography (USG) was recorded. Association was assessed between IVC collapsibility and hematocrit. Results were statistically analyzed. Results: Seventy dengue cases were included - 59 cases of DF with warning signs and 11 cases of dengue hemorrhagic fever (DHF). 85.7% of study population presented at febrile phase of their illness. Bedside USG was correlated with hematocrit on day 2 of admission. IVC was collapsible in 79.7% cases of DF and 90.9% cases of DHF. Of the 47 DF cases with collapsible IVC, 95.7% had high hematocrit, while all DHF cases with collapsible IVC had high hematocrit. A significant association between IVC collapsibility and hematocrit was noted (P = 0.000). Conclusion: The assessment of intravascular volume status by bedside USG-IVC collapsibility is a helpful noninvasive and better tool than hematocrit for determining fluid resuscitation in DF.

The Role Of Cadres In Providing Prevention Of Dengue Hemorrhagic Fever (DHF) In Bandung City

The number of dengue fever incidents in 2020 was 111, a decrease compared to the year previously it was 45 Bandung City Health Profile in 2020, 176 per 100,000 population. Proportion type sex dengue fever cases in 2020 show that cases of dengue fever in men are more Lots compared to women. Type of research This that is a descriptive-analytic qualitative (exploratory study) using a cross-sectional design, Research was carried out in Bandung City, West Java Province. The sampling technique used is non-probability of use Purposive Sampling method where method uses criteria that have been chosen by the researcher in choose sample. The Chi-square test was obtained Where There is a significant relationship between knowledge cadre p-value of 0.070, giving counseling with a p-value of 0.006 with role cadre in give prevention of dengue fever. Related factors with activity prevention fever dengue bleeding is level knowledge cadres and activities counseling. second factor This has enough influence big on activities prevention fever dengue bleeding. Factors that don’t relate is inspection flick mosquito because society has capable of doing it yourself in the environment or each other’s house.

Dengue Fever and Global Warming: An Epidemiological Analysis

The article analyzes the connection between the rising number of cases of dengue fever and the warming of the planet’s atmosphere. We underline the significant role that Aedes mosquitoes play in the development of dengue fever by undertaking an in-depth examination of the factors that lead to the disease, how it is transmitted, and how it may be treated. Following that, the study explores the epidemiology of dengue fever and investigates the patterns and trends that the sickness demonstrates in different parts of the globe. We also evaluate the impact that a changing climate has had on the prevalence of dengue fever by relying on data from a wide variety of sources. Preventive measures to battle dengue fever, future patterns in dengue sickness, and the ramifications of those patterns are also discussed.

Faktor-Faktor Yang Berhubungan Dengan Pencegahan Penyakit Demam Berdarah Dangue (DBD) Di Desa Pulau Panggung Wilayah Kerja UPTD Puskesmas Tanjung Agung Kabupaten Muara Enim Tahun 2023

Background: World Health Organization (WHO) stated that the number of reported cases of dengue fever has increased more than 8-fold over the last 4 years, from 505,000 cases increasing to 4.2 million in 2022. The number of reported deaths has also increased from 403 to 960. Not only is the number of cases increasing as the disease spread to new regions including Asia, but explosive outbreaks also occurred. The threat of a possible dengue fever outbreak now exists in Asia.Objective: Know the factors related to preventive measures for dengue fever dengue (DBD) in Pulau Panggang Village, Tanjung Agung Community Health Center, Muara Enim Regency in 2023 Method: This research has an analytical approach cross sectional use chi square. This research sample uses probability sampling totaling 91 respondents. This research uses univariate and bivariate analysis. Results: The results of bivariate analysis showed a significant relationship between knowledge and prevention of dengue fever range p-value 0.003, there is a significant relationship between attitude and prevention of dengue fever range p-value 0.002, there is a significant relationship between education and the prevention of dengue fever range p-value 0.003, there is a significant relationship between knowledge and prevention of dengue fever range p-value 0,004. Conclusion: There is a significant relationship between knowledge, attitudes, education and family support and the prevention of dengue fever.

CLINICAL PROFILE OF DENGUE INFECTION IN PEDIATRIC AGE GROUP AT SOCIAL SECURITY TEACHING HOSPITAL,LAHORE

Dengue viral infection is a significant tropical disease and have become a major global public health concern. The present study sketches the evolving clinical spectrum of dengue especially highlighting the unusual manifestations. Methodology: Data of 120 suspected dengue fever cases was collected, compiled, and analysed during the monsoon and post-monsoon seasons in the year 2022 at the Department of Pediatric Medicine, Social Security Teaching Hospital, and Lahore. Patients with serological confirmation of dengue infection were classified according to Dengue GCP Guidelines 2020. Clinical parameters were studied. Results: Out of 120 suspected patients with dengue fever enrolled in the study, 48 (40%) had serologically confirmed dengue infection. Out of 120 cases, 68 (56.66%) patients were males and 52(43.33%) were females. 66.66 % patients had classical dengue fever while 33.33% had dengue hemorrhagic fever. DHF grade I/II was seen in 25 % cases and grade III DHF in 8.33% The most common symptoms after fever were vomiting (85.4% ), abdominal pain ( 68.75%), headache (37.5%), rash (20.83%) and itch (16.66%). Hemorrhagic manifestations were observed in 43.75% patients. Atypical manifestations were documented in 4 patients (8.33%) patients. Overall outcome in this study was good with no mortality.&#x0D; Conclusion: Dengue infection has posed a huge burden to the health-care system. Its spectrum ranges from mild self-limiting disease to severe fatal disease. It can have varied and multi-systemic manifestations which can go unnoticed. Pediatricians should have a high index of suspicion for atypical manifestations so revelation of the exact clinical profile is important for patient effective management.