Introduction: Hypersensitivity to latex is common. Balloon-tipped right heart catheters are typically made from latex. Latex-free catheters while available have limitations including the need for large sized vascular sheaths. It is unknown if latex balloon catheters can be safely used in patients who have cutaneous reactions to latex. Goals: The goal of this study was to assess the safety of using latex-containing catheters for right heart catheterization (RHC) in patients with a prior history of cutaneous allergy to latex. Methods: Electronic medical records and cardiac catheterization procedure database identified 127 consecutive patients with a history of cutaneous hypersensitivity (rash, urticaria) to latex who underwent RHC with balloon-tipped catheters. Patients with known anaphylaxis to latex were excluded. The primary outcome was the occurrence of periprocedural hypersensitivity reactions. Outcomes of patients with latex-containing catheters (LC Group, n=99) were compared to patients with latex-free catheters (LF Group, n=28). Results: The study population consisted of 28 men and 99 women, aged 65 + 14 years. Indications for RHC were heart failure in 48 (38%), pulmonary hypertension in 25 (20%), cardiomyopathy in 19 (15%), valvular heart disease in 19 (15%), unexplained dyspnea in 13 (10%), and heart transplant in 2 (2%). LC and LF patients had comparable demographics, cardiac risk factors, and indications for RHC. In-body catheter exposure times in the LC and LF groups were 8.6 + 5.0 and 9.7 + 6.1 minutes, respectively (p=ns). Venous sheath sizes were smaller in the LC group; sheaths < 5 Fr were used in 52/99 (53%) of the LC group vs. 0/28 in the LF group (p<0.001). Antecubital vein access was used in 42/99 (42%) of the LC group but in none of the LF group (p<0.001). There were no procedural hypersensitivity reactions in either the LC or LF groups. Repeat procedures were common; in total, 149 RHC were performed using latex catheters with no reactions. Conclusions: In patients with a history of non-anaphylactic cutaneous hypersensitivity to latex, the use of latex balloon-tipped catheters was not associated with allergic reactions. Latex catheters offer technical advantages including smaller sized vascular sheaths and more options for venous access.