We report the application of CuxPd1-xO nanoparticle-reduced graphene oxide nanocomposites as efficient catalysts for direct CH bond activation using alcohols as carbonyl sources. The composition of the CuxPd1-xO nanoparticles plays a vital role in determining their catalytic activity because of a composition-dependent synergistic effect. We show that the catalysts can be reused for successive 5 cycles without obviously losing their catalytic activity. Our catalysts offer considerable advantages over previous metallic alloy nanoparticles not only due to their catalytic performance but also for the ease of their synthesis and catalytic robustness.