Facility emergence evacuation is often a complicated process under extreme conditions. Most of the buildings today use pre-installed signages to guide the emergence evacuation. However, these guidances are sometimes insufficient or misleading, particularly for evacuating from high-rise buildings or complex buildings, such as schools, hospitals, and stadiums. Following a planned route may lead the crowd to move towards dangers, such as smoke and fire. The future emergency guidance system should be more intelligent and be able to guide people to evacuate with a higher survival possibility. This study proposes a real-time building evacuation model with an improved cellular automata (CA) method. This algorithm combines cellular automata with the potential energy field (PEF) model in fluid dynamic theory (FDT) to choose safe paths for the crowd and reduce the possibility of stampedes. Custom-designed wireless sensors, artificial intelligence (A.I.) enhanced surveillance cameras, intelligent emergency signage systems, and edge computing servers are used to sample fire and crowd data, operate the intelligent evacuation algorithm, and guide the crowd with the signage system in real-time conditions. In addition, we performed the algorithm simulation on a two-dimensional plane generated based on the building structure of the Beijing Capital Airport Hospital. The evacuation drill simulations show that the average escape time is significantly shortened with optimal real-time guidance. In one case, a 72% reduction in evacuation time is achieved compared with evacuation using pre-installed signages. The results also demonstrated that the proposed model and system’s evacuation time reduction performance is particularly good in crowded buildings, such as schools or stadiums.