Capacity Ratio Research Articles

Predicting COPD exacerbations based on quantitative CT analysis: an external validation study.

Quantitative computed tomography (CT) analysis is an important method for diagnosis and severity evaluation of lung diseases. However, the association between CT-derived biomarkers and chronic obstructive pulmonary disease (COPD) exacerbations remains unclear. We aimed to investigate its potential in predicting COPD exacerbations. Patients with COPD were consecutively enrolled, and their data were analyzed in this retrospective study. Body composition and thoracic abnormalities were analyzed from chest CT scans. Logistic regression analysis was performed to identify independent risk factors of exacerbation. Based on 2-year follow-up data, the deep learning system (DLS) was developed to predict future exacerbations. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic performance. Finally, the survival analysis was performed to further evaluate the potential of the DLS in risk stratification. A total of 1,150 eligible patients were included and followed up for 2 years. Multivariate analysis revealed that CT-derived high affected lung volume/total lung capacity (ALV/TLC) ratio, high visceral adipose tissue area (VAT), and low pectoralis muscle cross-sectional area (CSA) were independent risk factors causing COPD exacerbations. The DLS outperformed exacerbation history and the BMI, airflow obstruction, dyspnea, and exercise capacity (BODE) index, with an area under the ROC (AUC) value of 0.88 (95%CI, 0.82-0.92) in the internal cohort and 0.86 (95%CI, 0.81-0.89) in the external cohort. The DeLong test revealed significance between this system and conventional scores in the test cohorts (p < 0.05). In the survival analysis, patients with higher risk were susceptible to exacerbation events. The DLS could allow accurate prediction of COPD exacerbations. The newly identified CT biomarkers (ALV/TLC ratio, VAT, and pectoralis muscle CSA) could potentially enable investigation into underlying mechanisms responsible for exacerbations.

Optimal planning and operation for a grid-connected solar–wind–hydro energy system in wastewater treatment plants

This study proposes a multi-objective optimization model for a grid-connected wind–solar–hydro system in wastewater treatment plants, addressing trade-offs among electricity utilization cost, self-sufficiency, complementary effect, and carbon emission. Two modes are explored: one allowing energy export and another leading to curtailment. A case study from a plant with design scale of 50,000 m3/day in China found that a higher complementary rate can slightly increase costs, lower self-sufficiency, and increase carbon emissions. Compared to the initial scheme without the solar–wind–hydro system, the design modes of export and curtail reduce electricity costs by 2.15 and 0.87 million CNY, carbon emissions by 2760 and 1439 tons annually, and increase self-sufficiency to 52% and 42%, respectively. The levelized cost of energy is 25% higher and total installed capacity decreases by 54% when surplus cannot be exported. A 6.7% curtailment minimizes the electricity utilization cost. Complementarity rates show seasonal fluctuations, peaking in August, with the highest yearly rate of 0.1528 at a solar-to-wind capacity ratio of 1.747. Output ratios remain stable across different treatment scales under curtailment mode: imports about 60%, wind and solar about 20% each, and hydropower 2%. Price changes and potential for zero-carbon operation are further discussed.

Clinical Utility of Pulmonary Rehabilitation in Diffuse Parenchymal Lung Diseases

Background: Pulmonary rehabilitation (PR) can help in improving the exercise capacity and quality of life (QoL) in diffuse parenchymal lung diseases (DPLDs), even in end-stage lung diseases listed for lung transplant. With the paucity of literature from the Indian population, the current study assessed PR’s benefits on the respiratory functions and exercise capacity in DPLD. Methods: This prospective interventional study was conducted over 18 months in patients with diagnosed stable DPLD who were previously not involved in any PR program. All the enrolled patients underwent 12-week in-hospital, supervised PR program, which included exercise training with increasing load, endurance training, resistance training, flexibility training, and stretching. The patients were evaluated for the measures at baseline and after 12 weeks of a rehabilitation program. Results: There was a significant improvement in respiratory capacity forced expiratory volume in 1 s (FEV1), 6-min walk distance (6MWD), Modified Medical Research Council (MMRC), and total St. George’s Respiratory Questionnaire scores (P &lt; 0.05) after the completion of the PR program. Among the outcome parameters, there were no significant differences in the PO2 and FEV1/forced vital capacity ratio (P &gt; 0.05) etiologically; the improvement was significant for all outcome parameters except MMRC and symptom score in the idiopathic pulmonary fibrosis (IPF) group (P = 0.165). In the non-IPF group, the improvement was significant for all outcome parameters except PO2 (P = 0.9). On multivariate linear regression, age was the only independent factor for 6MWD (P = 0.0002; 95% confidence interval [CI]: −5.019–−1.665) and MMRC (P = 0.005; 95% CI: 0.007–0.037). Conclusion: This study reveals that PR is effective for people with DPLD in decreasing the symptoms and improving the exercise capacity and QoL. Clinical improvement is greater in those with non-IPF compared to IPF, but both groups as a whole achieved clinically significant improvements. An adaptation of the PR regimen as per age may be necessary for optimizing the clinical benefits.

Mitigation of rockfall geohazards: Full-scale investigation of the performance of a practical baffle design for direct use in the field

To arrest rockfall boulders, baffles are constructed as steel members affixed on top of a concrete footing. Existing designs aim to prevent any footing rotation and steel member bending. As such, existing baffle designs require massive reinforced concrete footings and complex bolt and weld connections. Such designs have limited constructability and result in complex failure mechanisms (i.e., tensile failure of concrete foundation at connections). In this paper, we introduce a new baffle design concept that optimizes the balance between steel member bending and footing rotation to enable a compact design. Full-scale pendulum experiments are conducted to evaluate the proposed easy-to-construct and design baffle under successive boulder impacts of 50 kJ. It is demonstrated that by considering the effects of steel member deflection and concrete foundation rotation, the maximum impact force on baffles is reduced by up to two times when compared with those on a rigid barrier and the failure modes are simplified to either overturning failure of the footing or buckling failure of the steel member. A ratio that defines the flexural capacity of the steel member to the overturning capacity of the shallow concrete foundation is proposed to control the failure mode. The optimized baffle configuration for an impact energy of 50 kJ, with minimum residual deflection, has a target capacity ratio of 2.0.

Food patch selection by the largest European herbivore

AbstractThe scaling relationship between digestive system and body mass shapes foraging strategies in herbivores. The Jarman–Bell principle and the forage maturation hypothesis (FMH), two of the most important predictions formulated in herbivore foraging ecology, have been used to explain this relationship.We aimed to test these predictions for the largest European herbivore—the European bison-which is highly sexually dimorphic and recognised as a refugee species in non-optimal forest habitats. We conducted our study in the Białowieża Primeval Forest, where the European bison has been recognized as a refugee species. We estimated vegetation quality and biomass along the foraging paths of male and female European bison, and the vegetation biomass at random points in different habitats and months. We found no support for the Jarmann-Bell principle at the intraspecific level in European bison, as males and females foraged on patches of similar crude protein and fibre content. However, females selected for higher biomass. The quality of vegetation on the bison foraging patches showed a significant spatio-temporal variation. It increased from May to July and then gradually decreased. It also increased with the fertility and wetness of the habitats being the highest in wet forests. Mean biomass on European bison foraging patches (131.5 g/m2), was significantly lower than on random plots (210.5 g/m2), which supported the FMH. Our study suggests that in rich forest habitats, the abundant food resources available in summer may not constrain the metabolic rate/gut capacity ratio of either sex, potentially leading to dietary segregation. In contrast to open habitats, where vegetation maturation is less temporally variable, European bison in rich forest habitats may optimise patch selection and energy intake by tracking a habitat- and species-specific changes in the plant phenology. Understanding the relationship between European bison forage selection and forage nutritional constraints in forest habitats may be critical for conservation programmes, as European bison are better adapted to more open habitats and are recognised as refugee species in suboptimal forest habitats.

A cation and anion dual-doping strategy in novel Li-rich Mn-based cathode materials for high-performance Li metal batteries

Lithium (Li)-rich Manganese (Mn)-based cathode materials are considered to be the most hopeful cathode materials for next-generation high-energy-density Li metal batteries. However, the rapid capacity fading and voltage decaying derived from phase transformation still hinder their practical application. Herein, we developed a cation/anion dual-doping strategy by synchronically incorporating Zr4+ cation and F− anion to boost the structural stability of the Li-rich Mn-based cathode. The strengthened transition metal-oxygen bonds raised by doping effect can inhibit the release of oxygen for enhanced electrochemical reversibility and mitigate the anisotropic lattice distortion to stabilize the layered structure. Meanwhile, dual doping strategy expands the lattice distance and increases oxygen vacancy formation energy, thereby improving ion diffusion kinetics and structural stability. As a result, the obtained cathode presents an excellent initial discharge capacity of 268.5 mAh g−1 and a prolonged cycle lifespan beyond 300 cycles. A stable cycling performance can be obtained under a high areal capacity of 5.17 mAh cm−2 with a low negative/positive electrode capacity ratio of 1.93. Our dual-doping strategy provides a valuable new idea for improving the structural stability and electrochemical properties of Li-rich Mn-based cathode materials, further promoting the development of high-energy-density Li metal batteries.

Spirometric Transition of at Risk Individuals and Risks for Progression to Chronic Obstructive Pulmonary Disease in General Population

IntroductionChronic obstructive pulmonary disease (COPD) is a dynamic disease with a high socioeconomic burden. Using data collected prospectively from the general population, we examined factors related to the transition of at-risk individuals to COPD. MethodsWe used the Korean Genome Epidemiology Study (KoGES) database, defining pre-COPD based on respiratory symptoms and radiological abnormalities suggestive of COPD; the preserved ratio impaired spirometry (PRISm) was defined as a forced expiratory volume in 1s (FEV1)/forced vital capacity ratio≥70% and FEV1<80%, as predicted by spirometry. We determined group differences in the rate of lung function decline, risk of future airflow obstruction (AFO). ResultsThe study included 4762 individuals, and longitudinal analysis revealed distinct trends in pulmonary function indicators. Compared to the normal group, the pre-COPD group showed a more rapid decline in lung function, while the PRISm group showed a slower decline. In the pre-COPD and PRISm groups, 4.4% and 3.5%, and 13.6% and 10.8%, respectively, of patients had progressed to COPD at the first and second visits. Pre-COPD and PRISm contributed to an earlier time to first AFO, but consideration of comorbid cardiovascular disease weakened this relationship in the PRISm group. Multivariate logistic regression showed that pre-COPD and PRISm are significant risk factors for future development of COPD (OR 1.80, p<0.001; OR 4.26, p<0.001, respectively). ConclusionPre-COPD and PRISm patients showed different trends in lung function changes over time and both were significant risk factors for future development of COPD.

Pulmonary function in Thai patients with systemic sclerosis;a single center 6-year retrospective study.

Pulmonary involvement is a major cause of internal organ complication and the leading cause of death in patients with systemic sclerosis (SSc). This study aimed to demonstrate the characteristics of pulmonary function (PF) in Thai patients with SSc and the association between PF and body mass index (BMI) and anti-topoisomerase (anti-Scl70). All patients diagnosed with SSc in our tertiary care teaching hospital database between 2016 and 2021 were reviewed and analyzed. Of 211 SSc patients, 128 patients who underwent the PF test were enrolled; 102 (79.7%) were female. The mean age was 54 years. The median BMI for all patients was 21.7 kg/m 2. Regarding anti-Scl70, 10.9% of patients were positive, 7.8% were negative, and the status was unreported for 81.3%. The mean (SD) forced expiratory volume in one second (FEV1) forced vital capacity (FVC) ratio was 0.8 (0.1). The mean (SD) % predicted values of FEV1, FVC, and diffusing capacity of the lungs for carbon monoxide (DLCO) were 76.3 (16.3), 69.1 (15.8), and 75.5 (22.8), respectively. A restrictive spirometry pattern (RSP) was found in 78.8% of the patients. DLCO had a moderate positive linear correlation with FVC (r=0.50, p <0.001) and a moderate negative linear correlation with BMI (r=-0.36, p <0.001). However, there was no correlation between FVC and BMI. There was no statistical difference in demographic data or the presence of anti-Scl70 among patients with or without RSP. RSP is common among Thai patients with SSc. However, the power of using demographic data and the presence of anti-Scl70 to determine the probability of pulmonary involvement remains limited.

Heat transfer investigation of nano – Encapsulated phase change materials (NEPCMs) in a thermal energy storage device

Phase change natural convection heat transport and flow features of a variety and new types of hybrid nanoliquids, suspension of Nano – encapsulated phase change materials (NEPCMs), within a square cavity is inspected theoretically in this analysis. The capsules are arranged with a shell and a PCM as a core. The shell of this NEPCM prevents the phase change material from the direct interaction of hot fluid and from the leakage. The heat capacity of the suspension contains latent heat generated at the time of phase change. The modeled equations are numerically scrutinized with Finite element method. Variable thermal conductivity parameter 1≤Nc≤5, variable viscosity parameter 1≤Nv≤5, radiation number 0.5≥R≥0.1, Rayleigh parameter 102≤Ra≤103, volume fraction of NEPCMs1%≤ϕ≤5% and fusion temperature (0.2≤θf≤1.0) impact on the patterns of heat capacity ratio, isotherms and velocity lines are examined in detail. The results indicates that, as the volume fraction values of NEPCMs amplifies from 1% to 5% the rates of heat transfer of the nanoliquid magnifies 42% compared to the host fluid. Non – dimensional rates of heat transport magnifies with growing (Ste) values.

Magnetic impacts on double diffusion of a non‐Newtonian NEPCM in a grooved cavity: ANN model with ISPH simulations

AbstractEmploying phase change materials (PCMs) offers the advantage of storing and releasing thermal energy while ensuring temperature stability. This characteristic makes PCMs valuable for reducing energy usage across various industrial applications. To explore the magnetic effects on double diffusion of a non‐Newtonian nano‐encapsulated phase change material (NEPCM) in a grooved cavity, the present study combined the incompressible smoothed particle hydrodynamics (ISPH) approach with an artificial neural network (ANN) model. The grooved shape is made up of three constructed grooves: triangular, curved, and rectangular grooves. In the cavity's walls, three segments of boundaries are considered as , , and . The ANN model correctly predicted the mean Nusselt number and Sherwood number when merged with current ISPH simulations. The study's novelty lies in exploring three distinct thermal and mass scenarios regarding double diffusion of a non‐Newtonian NEPCM within an innovative grooved domain. The relevant parameters include the fractional‐time derivative , power‐law index , Rayleigh number , Hartmann number , Soret–Dufour numbers (Sr and Du), and Lewis number Le. The obtained simulations present the significance of distinct boundary conditions in changing the velocity field, heat capacity ratio, temperature, and concentration in a grooved cavity. The fractional parameter accelerates the shift from unstable to steady condition. The increase in from 1.1 to 1.5 results in a 44.5% drop in the velocity maximum. Because of the Lorentz effect of a magnetic field, increasing from 0 to 50 reduces the maximum velocity by 20.9%.

Carbon-supported hydroxyapatite hybrid catalysts for butan-1-ol conversion: Effect of the nature of carbon support on process selectivity

Hybrid systems of hydroxyapatite supported on carbonaceous materials of different nature (activated charcoals, acetylene black, carbon black, graphite flake, synthesized microporous and mesoporous carbons) are investigated as catalysts for vapor-phase Guerbet condensation of butan-1-ol. The structure, morphology, and acid–base characteristics of hydroxyapatite, carbon supports, and the hybrid systems have been characterized by XRD, SEM-EDX, low-temperature (77 K) nitrogen ad(de)sorption, NMR, XPS, EPR, Raman spectroscopy, and TPD-NH3/CO2 techniques. The butan-1-ol conversion and selectivity towards the reaction products are found to be highly dependent on carbonaceous supports of the hybrid catalysts. The important role of acid–base capacity ratio is highlighted to achieve high selectivity in vapor-phase Guerbet condensation of butan-1-ol to 2-ethylhexan-1-ol. In particular, the surface’s strong basic sites are preferable for elongating the carbon chain. The high selectivity towards 2-ethylhexan-1-ol of about 75% is achieved over HAP/graphite flake and up to 57% over HAP/activated coconut charcoal. Compared to the bulk hydroxyapatite, the enhanced performance of the hybrid catalysts (initial activity and target product yield) is associated with the redistribution of active sites over carbon supports by strength and location.

Applying the fermentability coefficient concept in tropical grass silages

Two experiments were carried out to evaluate whether the fermentability coefficient (FC) concept is applicable to Megathyrsus and Urochloa genera and whether the forage nitrate content alters the fermentation pattern of the respective silages. Guinea grass [Megathyrsus maximus (Jacq.) B.K. Simon & S.W.L. Jacobs (Syn. Panicum maximum Jacq.) cv. MG18 Aries II] and palisade grass [Urochloa brizantha (Hochst. ex A. Rich) R.D. Webster (syn. Brachiaria brizantha (A. Rich) Stapf) cv. Marandu] were used in both experiments. In experiment 1, a broad range of FC was induced by different dry matter (DM) content and soluble carbohydrates (SC):buffering capacity (BC) ratio. The DM content was modified by wilting (i.e., guinea grass: direct cut at ∼200 g/kg, wilted to ∼300 and ∼400 g/kg; palisade grass: direct cut at ∼250 g/kg and wilted to ∼400 g/kg) while the SC:BC ratio was modified by addition of glucose [0, 5 and 10 g/kg of fresh matter (FM)] resulting in a factorial arrangement of 3 × 3 for guinea grass and 2 × 3 for palisade grass, with three replications per treatment. In experiment 2, five doses of sodium nitrate (0, 0.15, 0.30, 1.5 and 3.0 g/kg FM) were added factorially to DM and glucose levels used in experiment 1, leading to a factorial arrangement of 3 × 3 × 5 for guinea grass and 2 × 3 × 5 for palisade grass, with three replications per treatment. Regression analyses were performed using the REG procedure of SAS. An independent dataset of tropical grasses and their silages (n = 226) was used to validate the FC model. The FC equation obtained for tropical grasses in the current study did not diverge from the model derived from temperate forages (i.e., FC = DM + 80 × SC:BC), as the regression slopes were similar (79 vs. 80; P = 0.92). There was a linear negative correlation between FC and minimum content of nitrate required to inhibit butyric fermentation, confirming the clostridia-inhibiting role of nitrate in tropical grass silages too. However, the effect size differed between grass genera. In conclusion, as proposed for temperate forages, FC values ≥350 markedly decreases the risk of butyric fermentation, whereas FC values ≥400 completely suppress butyric fermentation in tropical grasses with moderate levels of nitrate and epiphytic lactic acid bacteria (LAB). The FC required to curtail butyric fermentation decreased linearly with nitrate concentration. Nevertheless, the minimum nitrate content to inhibit Clostridium development during silage fermentation depended on the forage species.

Physical model study on failure mechanism of strip footing on reinforced granular deposit

This study proposes guidelines for predicting the failure mechanism of a shallow strip footing resting on geosynthetic-reinforced granular deposit at different stages of footing settlement. Physical model tests are performed on footings resting on unreinforced and geosynthetic-reinforced soil. The reinforcement parameters varied include the depth between consecutive reinforcements, number of layers and the depth of the reinforced zone. Additionally, contours of deformation and maximum shear strain of soil and mobilised tensile strain in reinforcement with increasing footing settlement are studied. The improvement of bearing capacity ratio and the peak tensile strain in the reinforcement was monitored for three normalised settlement ratios of 5% (low), 10% (medium) and 25% (high). The reinforced soil models were found to depict primarily a punching shear failure limited solely within the reinforced zone at s/B of 5%. This was supplemented with a well-formed triangular wedge in the underlying unreinforced soil at s/B of 10%. In addition to above mechanisms, the radial shear zones were prominent at s/B of 25%. Failure mechanisms have been proposed eventually for each s/B value investigated, including guidelines on the upper and lower bounds of the load dispersion angle in the reinforced soil and wedge angle of the underlying unreinforced soil.

Discrete element analysis of heat transfer characteristics of concrete pavement under electrical heating for snow melting and deicing

The carbon fiber electrothermal method is an efficient approach for snow melting and deicing of pavements in the cold winter. The heat transfer mechanism needs to be explored for the carbon fiber electrothermal system design, especially how the microstructure affects the thermal behavior of pavement. To do so, a discrete element method (DEM) based heat transfer model considering the pavement microstructure has been established in the current study. The shape and content of coarse-grained aggregates have been represented by using the irregular polygonal aggregate method. The accuracy and feasibility of the proposed model were verified by comparing the numerical results with the measured data. On this basis, the heat transfer characteristics of pavements during snow melting and deicing using the carbon fiber electrothermal method have been investigated. The results show that the ambient temperature and the carbon fiber heating wire (CFHW) temperature are the two primary factors affecting the heating efficiency and the maximum temperature on the pavement surface. The spacing and buried depth of the CFHW also play a crucial role in determining the temperature rise rate and the uniformity of temperature distribution of the road surface layer. Furthermore, the effect of the aggregate content on the overall heating rate is not as significant as that of the specific heat capacity ratio of the aggregate to the mortar, suggesting modifying the thermal conductivity of aggregates to enhance deicing efficiency rather than changing the aggregate contents. The effects of the CFHW design parameters on the temperature distribution of the pavement surface are also investigated. The maximum and minimum temperatures of the pavement layer decrease gradually with the increase of the laying spacing and burial depth of the CFHW, but the temperature difference increases with the increase of the laying spacing of the CFHW and decreases with the increase of the burial depth. The research results can provide a reference for the optimization design of snow melting and deicing of pavements by the CFHW heating method.

Experimental study of the effect of different pulse charging patterns on lithium-ion battery charging

This study aims to experimentally investigate the impact of different pulse charging patterns on the charging time and performance of lithium-ion batteries at room temperature. Experimental results indicate that most pulse charging protocols have a positive impact on shortening the total charging time compared to the CC-CV charging method with the same input charge capacity. This effect is observed not only in LFP batteries but also in NMC batteries. Three pulse charging patterns are studied: constant current charge (C–C), charge rest (C–R), and charge discharge (C-D). The C-D mode results in the shortest charging time and the smallest cell internal resistance. Compared to the 1C CC-CV baseline, the pulse C-D mode reduces the charging time by approximately 6.8 %, decreases the average pulse internal resistance by about 17.5 %, and increases the remaining discharge capacity ratio by 3.76 % after 800 cycles. Additionally, a pseudo-2D physics model is used to study the internal effects on the battery using the pulse C-D mode. The results show that using the pulse charging method (C-D) results in a more even distribution of electrolyte salt concentration and electrode particle lithium concentration across the cell, thereby improving battery performance.

Optimization strategies for the design of pre-cooler based on the synergistic air-breathing rocket engine

A foundation for the engineering of pre-coolers is provided to understand the flow and heat transfer characteristics of air pre-coolers. Using the pre-cooler in the combustor of the Synergistic Air-Breathing Rocket Engine (SABRE) as the research object and selecting the smallest periodic unit of the model, numerical methods were adopted to study the flow field, outlet temperature, total pressure loss, heat transfer coefficient, and heat transfer power under the different number of tube rows, pitch, and helium/air heat capacity ratios. The number of tube rows increased from 7 to 15, the tube pitch increased from 1.5 mm to 3.5 mm, and the helium/air capacity ratio increased from 1.06 to 1.64. The results show that increasing the tube pitch reduces the outlet velocity and decreases the heat exchange efficiency, but the total pressure loss is reduced. Increasing the number of tube rows results in a linear increase in total pressure loss, but the heat exchange efficiency also increases. The increasing trend slows down when the number of tube rows exceeds 11. An increase in the heat capacity ratio can reduce the total pressure loss, increase the heat exchange power, and increase the amount of helium required. It can provide a reliable technical foundation for the practical engineering design of similar pre-coolers.

Efficacy-based comparison between adults and children regarding using advanced counseling for asthma

Background Asthma advanced counseling using smartphone applications has recently become one of the most effective and commonly used methods among adults and children with asthma. Objectives We aimed to compare the advanced counseling effectiveness between adults and children with asthma. Methods A cohort prospective parallel study was performed on a group of adults and children nonsmoking patients with asthma, using a pressurized metered dose inhaler (pMDI). The patients were divided into two groups namely adults with asthma with ages ranging from 19 to 60 years and Children with asthma with ages ranging from 11 to 18 years, the two groups received a 2-month course of advanced counseling using “Asthma software” and “Asthma Dodge” smartphone applications, during which the two groups were monitored using the forced expiratory volume in the first second to the forced vital capacity (FEV1/FVC) ratio and asthma control test (ACT). The study has obtained ethical approval with the serial number REC-H-PhBSU-23002, adhering to the principles outlined in The Declaration of Helsinki, from the Ethical Approval Committee of Beni-Suef University Faculty of Pharmacy. Results With a total of 60 patients with asthma (N = 60), 31 adults (N = 31), and 29 children (N = 29), We found that starting from the first-month visit of counseling the children group showed superiority over the adult group in terms of the pulmonary function improvement p = .006. Also, regarding ACT scores the children group showed a superiority over the adult group this significance started from the first-month visit and continued to the second-month visit with p values = .032 and .011, respectively. Conclusion The advanced counseling achieved better asthma control and pulmonary function improvement in children and adults; however, the improvement was much better in children with asthma than adults with asthma.

New models for prediction of postoperative pulmonary complications in lung resection candidates.

In recent years, ventilatory efficiency (minute ventilation (V'E)/carbon dioxide production (V'CO2 ) slope) and partial pressure of end-tidal carbon dioxide (P ETCO2 ) have emerged as independent predictors of postoperative pulmonary complications (PPC). Single parameters may give only partial information regarding periprocedural hazards. Accordingly, our aim was to create prediction models with improved ability to stratify PPC risk in patients scheduled for elective lung resection surgery. This post hoc analysis was comprised of consecutive lung resection candidates from two prior prospective trials. All individuals completed pulmonary function tests and cardiopulmonary exercise testing (CPET). Logistic regression analyses were used for identification of risk factors for PPC that were entered into the final risk prediction models. Two risk models were developed; the first used rest P ETCO2 (for patients with no available CPET data), the second used V'E/ V'CO2 slope (for patients with available CPET data). Receiver operating characteristic analysis with the De-Long test and area under the curve (AUC) were used for comparison of models. The dataset from 423 patients was randomly split into the derivation (n=310) and validation (n=113) cohorts. Two final models were developed, both including sex, thoracotomy, "atypical" resection and forced expiratory volume in 1 s/forced vital capacity ratio as risk factors. In addition, the first model also included rest P ETCO2 , while the second model used V'E/V'CO2 slope from CPET. AUCs of risk scores were 0.795 (95% CI: 0.739-0.851) and 0.793 (95% CI: 0.737-0.849); both p<0.001. No differences in AUCs were found between the derivation and validation cohorts. We created two multicomponental models for PPC risk prediction, both having excellent predictive properties.

Na3P interphase reduces Na nucleation energy enabling stable anode-less sodium metal batteries

Sodium metal batteries (SMBs) are rising as viable alternatives to lithium-ion systems due to their superior energy density and sodium's relative abundance. However, SMBs face significant impediments, particularly the exceedingly high negative-to-positive capacity ratios (N/P ratios) which severely encumber energy density and hinder their practical application. Herein, a novel nucleophilic Na3P interphase on aluminum foil has been designed to significantly lower the nucleation energy barrier for sodium atom deposition, resulting in a remarkable reduction of nucleation overpotential and efficient mitigation of dendritic growth at high sodium deposition of 5 mA h cm−2. The interphase promotes stable cycling in anode-less SMB configurations with a low N/P ratio of 1.4 and high cathode mass loading of 11.5 mg cm−2, and demonstrates a substantial increase in high capacity retention of 92.4% after 500 cycles even under 1 C rate condition. This innovation signifies a promising leap forward in the development of high-energy-density, anode-less SMBs, offering a potential solution to the longstanding issues of cycle stability and energy efficiency.

Long COVID symptoms after 8-month recovery: persistent static lung hyperinflation associated with small airway dysfunction

BackgroundLimited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients with post-acute sequelae of COVID-19 (PASC) especially dyspnea and fatigue.Methods64 patients with PASC were enrolled between July 2020 and December 2022 in a prospective observational cohort. Pulmonary function tests, impulse oscillometry (IOS), and symptom questionnaires were performed two, five and eight months after acute infection. Multivariable logistic regression models were used to test the association between SLH and patient-reported outcomes.ResultsSLH prevalence was 53.1% (34/64), irrespective of COVID-19 severity. IOS parameters and circulating CD4/CD8 T-cell ratio were significantly correlated with residual volume to total lung capacity ratio (RV/TLC). Serum CD8 + T cell count was negatively correlated with forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) with statistical significance. Of the patients who had SLH at baseline, 57% continued to have persistent SLH after eight months of recovery, with these patients tending to be older and having dyspnea and fatigue. Post-COVID dyspnea was significantly associated with SLH and IOS parameters R5-R20, and AX with adjusted odds ratios 12.4, 12.8 and 7.6 respectively. SLH was also significantly associated with fatigue.ConclusionSAD and a decreased serum CD4/CD8 ratio were associated with SLH in patients with PASC. SLH may persist after recovery from infection in a substantial proportion of patients. SAD and dysregulated T-cell immune response correlated with SLH may contribute to the development of dyspnea and fatigue in patients with PASC.