In 2018, the megafire episodes on record occurred in California, causing a large number of civilian deaths and damages. As an important part of the “fire environment triangle,” the fuel moisture content (FMC) of both live (LFMC) and dead (DFMC) vegetation were broadly accepted as the important drivers of wildfire ignition and spread, but their effects on the 2018 megafires in California were less explored. Here, we explored and compared the effects of LFMC and DFMC on the 2018 megafire in California, allowing for highlighting the role of different types of FMC in megafire risk assessment. The LFMC was collected from the global LFMC product. We used three indices obtained from the Canadian Forest Service Fire Weather Index Rating System as a proxy of DFMC products, including the fine fuel moisture code, duff moisture code (DMC), and drought code. We analyzed the long-term series (2001–2018) of these four indices in California to test whether these indices were indicative of the occurrence of the megafire, and which of the index was the most powerful driving the 2018 megafires. The results showed that all these indices were correlated with the fires in California. The LFMC showed the highest correlation with the fire occurrence between 2001 and 2018, whereas the DMC performed a major role in driving the 2018 megafire in California. This study presented the insights that the LFMC and DMC should be carefully considered in future operational fire risk assessments for megafire prescription, suppression, and response.