In the present work, we attempt to explore the size-dependent structural stability of bulk (0.28 µm) and nano-sized (25 nm) anatase TiO2 particles under acoustic shocked conditions. Based on the observed X-ray diffractometric, Raman spectroscopic and transmission electron microscopic results with respect to the number of shock pulses, at the 90-shocked condition, the nano-size particles undergo the anatase to the rutile phase transition, whereas the bulk size TiO2 particles remain to be in the anatase phase. From the comprehensive assessment, it is demonstrated that the bulk TiO2 samples have higher structural stability compared to the nano-size samples. The nano-sized anatase-TiO2particles have values of lower thermal conductivity compared to the bulk-sized particles such that the value of lower thermal conductivity is a prominent crucial factor in initiating the dynamic recrystallization which results in the anatase-to-rutile phase transition. Based on the observed present experimental results and previous reports, it has been authenticated that, while increasing the particle size from nano-scale to micro-scale, the critical shock number for the anatase to rutile phase transition is significantly increased.