Bromosulphophthalein Research Articles

Etude sur modele compartimental de l'adsorption d'un colorant par les proteines. Role eventuel de l'adsorption dans l'excretion hepatique de la bromo-sulfo-phtaleine

A compartmental model was suggested for the study of the hepatic excretion of bromosulphophthalein (BSP). By using a hypothesis concerning the adsorption of the BSP compound by proteins, one derives from the equations of the model several known experimental results, viz. form of concentration curves that vary in accordance with the strength of the injection, existence of a limiting Tm value, etc. An explicit formula is given for calculating Tm.

Changes in renal function in the rat during bromosulpho phthalein (BSP) infusion

Bromosulphophthalein (BSP) is widely used in liver function tests and in the determination of hepatic blood flow. Some side effects of this compound on kidney function are reported in this paper. When BSP was given in a continuous infusion into rats, using a comparable dose to that used experimentally and clinically for function tests, it caused a 45% reduction in urine flow and a 60% reduction in sodium excretion rate. Potassium excretion rate was unaltered. Calculation of the % filtered sodium excreted, from measurements of glomerular filtration rate and plasma sodium concentration, indicated that BSP was affecting tubular reabsorption of sodium. This could be either a direct or indirect effect on the tubule. No substantial changes in effective renal blood flow (determined by p-amino hippuric acid clearance) could be detected.