Abstract
Bromosulphophthalein (BSP) is widely used in liver function tests and in the determination of hepatic blood flow. Some side effects of this compound on kidney function are reported in this paper. When BSP was given in a continuous infusion into rats, using a comparable dose to that used experimentally and clinically for function tests, it caused a 45% reduction in urine flow and a 60% reduction in sodium excretion rate. Potassium excretion rate was unaltered. Calculation of the % filtered sodium excreted, from measurements of glomerular filtration rate and plasma sodium concentration, indicated that BSP was affecting tubular reabsorption of sodium. This could be either a direct or indirect effect on the tubule. No substantial changes in effective renal blood flow (determined by p-amino hippuric acid clearance) could be detected.
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