Breaking Events Research Articles

Rencana Bisnis (Business Plan) : Jasa Content Creator

"Business Planning Content Creator Services" is a business plan that offers services in the creative industries. With the rapid development of social media in this digital age, we can see a potential opportunity to plan a content creator service business, which includes several service components, namely photography, videography, design, copywriting, social media handling, and creative ideas for projects. This business plan aims to create a new business plan in the creative industries engaged in services and create opportunities to be able to generate profitable profits. Based on the results of the analysis and discussion, it can be concluded that this business is feasible to be realized on the basis of considerations, among others, because the market potential of the content creator services business increases with the increasing use of social media in Indonesia. This business financial planning also shows that this business will provide profit and deserve to be realized. Financial analysis which consists of Payback Period and Break Event Point (BEP) requires a fairly short estimated time of 2 years 3 months, the Net Present Value (NPV) value of Rp. 291,120,221.5, - this shows that this investment can be profitable and profitable, and the Internal Rate of Return (IRR) of 81% means higher than the interest rate.

Testing and dating structural changes in copula-based dependence measures

This paper is concerned with testing and dating structural breaks in the dependence structure of multivariate time series. We consider a cumulative sum (CUSUM) type test for constant copula-based dependence measures, such as Spearman's rank correlation and quantile dependencies. The asymptotic null distribution is not known in closed form and critical values are estimated by an i.i.d. bootstrap procedure. We analyze size and power properties in a simulation study under different dependence measure settings, such as skewed and fat-tailed distributions. To date breakpoints and to decide whether two estimated break locations belong to the same break event, we propose a pivot confidence interval procedure. Finally, we apply the test to the historical data of 10 large financial firms during the last financial crisis from 2002 to mid-2013.

A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells.

The stabilisation of G-quadruplexes (G4s) by small-molecule compounds is an effective approach for causing cell growth arrest, followed by cell death. Some of these compounds are currently being developed for the treatment of human cancers. We have previously developed a substituted naphthalene diimide G4-binding molecule (CM03) with selective potency for pancreatic cancer cells, including gemcitabine-resistant cells. We report here that CM03 and the histone deacetylase (HDAC) inhibitor SAHA (suberanilohydroxamic acid) have synergistic effects at concentrations close to and below their individual GI50 values, in both gemcitabine-sensitive and resistant pancreatic cancer cell lines. Immunoblot analysis showed elevated levels of γ-H2AX and cleaved PARP proteins upon drug combination treatment, indicating increased levels of DNA damage (double-strand break events: DSBs) and apoptosis induction, respectively. We propose that the mechanism of synergy involves SAHA relaxing condensed chromatin, resulting in higher levels of G4 formation. In turn, CM03 can stabilise a greater number of G4s, leading to the downregulation of more G4-containing genes as well as a higher incidence of DSBs due to torsional strain on DNA and chromatin structure.

Optimasi Desain Pembangkit Listrik Kapasitas 200 kW Menggunakan Tenaga Matahari dengan Sistem Pumped Storage

This research was conducted by analyzing and optimizing the design of solar power plants with pumped storage systems as a source of renewable energy for remote areas in Indonesia. This research is very important to be done to solve the problem of meeting the electricity needs, especially in remote areas. The scheme is implementing 5 options in the pumped storage system. The system design is calculated and analyzed then optimization is done using Ansys fluent software. After that, all options are analyzed and compared in terms of economics related to Life-Cycle Cost (LCC) and Break Event Point (BEP) to get the best scheme. It was found that option A is better than other options in terms of system implementation because it requires the smallest number of pumps. From an economic standpoint, the LCC for option A is 63% lower than option C and higher than option B, D and E which are 2%, 5% and 25%, respectively. The lowest LCC is obtained by option E but has its own challenges in its application because it requires 540 pumps. The fastest BEP is obtained by option A with 9.47 years followed by an option D with 9.6 years. The longest BEP with 12.74 years was obtained by an Option C. Therefore, the use of pumped storage systems in solar power plants as an alternative renewable energy provides opportunities that are technically very possible and have the potential for continuous power supply in remote areas.

Analysis Of Efficiency Of Windu Shrimp Cultivation Business Policulture System In Tugurejo Sub-District Tugu Districts Semarang City

This study aims to calculate technical efficiency and determine the financial efficiency of the cultivation of windu shrimp with the Polyculture system by farmers in Tugurejo village, Tugu district, Semarang City based on simple investment criteria, namely BC ratio (Benefit Cost Ratio), BEP (Break Event Point), ROI (Revenue On Invensment) to measure how much efficiency the use of capital is against revenue. The method used is descriptive analysis with a questionnaire and field observations. The data used are primary data collected through interviews with respondents and key persons. The sample was 25 people so that all (census) were taken in October 2019-March 2020. The results showed that the BC ratio analysis was 1.64, BEP (Q) tiger prawns were 160.49 kg / Ha per year and for BEP prices IDR 35,680 / kg, BEP (Q) of milkfish as much as 755.25 kg / Ha per year and for BEP prices of IDR 12,175 /kg, ROI is 137.97%> 100%, the tiger prawn cultivation business with an efficient polyculture system in the use of capital to revenue and worthy of cultivation.

Analisis Break Even Point Sebagai Alat Profit Planning Pada Hotel Wijaya Sukabumi

This research is based on the importance of the management of a company and to know the implement of break event point analysis and the margin of safety in which to study and explore the relationship between costs, profits, and volume of activities. This study aims to determine the break event point approach and the margin of safety as a basis in profit planning. The variables used in this study are Break Event Point and Margin of Safety. The population and sample used are social conditions consisting of three components; places, actors, and activities, with a sampling technique using purposive sampling. Resource persons in the study are the owners, managers, and accountants. This research uses a qualitative method with a descriptive approach. Based on the results of research that Hotel Wijaya in 2018 and 2019 has reached the level of break even point. Margin of safety for 2016 was 41%, in 2017 it was 21%, in 2018 it was 39% and in 2019 it was 35%, while in 2020 Hotel Wijaya planned profit with a percentage of 10% with a total of 104,764,000. Thus, to obtain the profit the Wijaya Hotel must be able to rent out rooms with sales of Rp 355,832,589 with as many as 4,211 units sold. So it can be concluded that the growth of assets and leverage only affects 1.4% of the dividend policy and the rest is influenced by other factors not examined in this study.
 Keywords: Break Even Point, Profit Planning

STUDI PENDAPATAN NELAYAN TRADISIONAL DI PESISIR PANTAI KABUPATEN TAKALAR

Traditional fishermen are characterized as poor people with low quality of food and housing, low savings and investment and low standards of living. The income of fishermen's fishing business is very different from that of traders and farmers. If traders can calculate their profit every month, as well as farmers can predict their yields, this is not the case with fishermen whose activities are full of uncertainty and are speculative and volatile. When compared to farmers, fishermen's non-fishing income is less varied because farmers have more time to work outside of agriculture. This study aims to determine the amount of income of traditional fishermen in the Coastal Coast of Takalar Regency. This research was conducted in the Coastal Coast of Takalar Regency. The population in this study were all fishermen who use outboard motor fleets in fishing business on the coast of Takalar Regency. Sampling was done by random sampling method and selected 58 fishermen respondents who are considered to represent all populations. The data obtained were then analyzed using descriptive analysis and Break Event Points. The results showed that the average amount of profit obtained by fishermen in one fishing trip was Rp. 288,900. Meanwhile, the results of the break even point analysis show that the fishermen are at the main point of return when they catch 11.11 kg of fish caught for one time fishing.

Evaluation of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology in Preclinical and Early Alzheimer's Disease.

Cognitive impairment is a significant risk factor for hazardous driving among older drivers with Alzheimer’s dementia, but little is known about how the driving behavior of mildly symptomatic compares with those in the preclinical, asymptomatic phase of Alzheimer’s disease (AD). This study utilized two in-car technologies to characterize driving behavior in symptomatic and preclinical AD. The goals of this pilot study were to (1) describe unsafe driving behaviors in individuals with symptomatic early AD using G-force triggered video capture and (2) compare the driving habits of these symptomatic AD drivers to two groups of cognitively normal drivers, those with and those without evidence of cerebral amyloidosis (CN/A+ and CN/A−) using a global positioning system (GPS) datalogger. Thirty-three drivers (aged 60+ years) were studied over 3 months. G-force triggered video events captured instances of near-misses/collisions, traffic violations, risky driver conduct, and driving fundamentals. GPS data were sampled every 30 s and all instances of speeding, hard braking, and sudden acceleration were recorded. For the early AD participants, video capture identified driving unbelted, late response, driving too fast for conditions, traffic violations, poor judgment, and not scanning intersections as the most frequently occurring safety errors. When evaluating driving using the GPS datalogger, hard breaking events occurred most frequently on a per trip basis across all three groups. The CN/A+ group had the lowest event rate across all three event types with lower instances of speeding. Slower psychomotor speed (Trail Making Part A) was associated with fewer speeding events, more hard acceleration events, and more overall events. GPS tracked instances of speeding were correlated with total number of video-captured near-collisions/collisions and driving fundamentals. Results demonstrate the utility of electronic monitoring to identify potentially unsafe driving events in symptomatic and preclinical AD. Results suggest that drivers with preclinical AD may compensate for early, subtle cognitive changes by driving more slowly and cautiously than healthy older drivers or those with cognitive impairment. Self-regulatory changes in driving behavior appear to occur in the preclinical phase of AD, but safety concerns may not arise until symptoms of cognitive impairment emerge and the ability to self-monitor declines.

ANALISIS TITIK IMPAS PADA INDUSTRI ROTAN HIDAYAH SIDOREJO KECAMATAN CURUP TENGAH

Good profit planning will affect the success of the business in achieving optimal profit. The calculation of future profits is very useful for preparing the profit planning process. In general, almost all management decisions will have more impact on activities or attitudes in the future than on past activities or attitudes. Thus management decision making is a continuous process. This continuous process makes management must be able to anticipate upcoming events and plan what must be done, including planning company profits. Profit Volume Cost Analysis (cost-volume-profit analiysis) is often called a break event point analysis because of the significance of the break event point in this analysis, in the profit volume cost analysis, volume refers to all activity cost triggers, such as sales units are assumed to collaborate with changes in income, costs and profits. Based on the results of the analysis, it can be concluded as follows; The amount of break even points for living room chair products in Hidayah Sidorejo's rattan industry is 4 units, meaning that the company will be in a position where the profit is equal to 0. The amount of contribution margin for living room chair products in Hidayah Sidorejo's rattan industry is Rp. . 2,879,000 The operating profit target is assumed if Hidayah's rattan industry is targeting a profit of Rp. 10,000,000, then the number of units that must be sold is 7 units of living room chairs. The results of the cost volume profit analysis in the decision making for advertising spending show that Hidayah's rattan industry decides to advertise in the newspaper with an advertising cost of Rp. 1000,000, then this will increase the contribution margin by Rp. 2,879,000 and operating profit increased to Rp. 1,879,000 even though the cost continued to increase to Rp. 11,000,000 The results of the cost volume profit analysis in decision making to reduce the selling price from Rp. 6000,000 / chair set becomes Rp. 5,000,000 / set of chairs will reduce the contribution margin by Rp. 10,000,000, although if you lower the selling price the sales will increase to 10 units.

Non-monotonic precursory signals to multi-scale catastrophic failures

Identifying precursory trends in acoustic/seismic observations allows the forewarning/prediction of catastrophic events. However, rupturing across multiple scales leaves it unclear whether features of small events are applicable predictors of the larger ensemble final collapse. To resolve this issue, we present a multiscale heterogeneous model that straightforwardly characterizes the duration and mechanism of multiscale catastrophic failures. Our results identify four distinct classes of failure including random single breaks, small catastrophic failure (SCF) events, large catastrophic failure (LCF) events that consist of subordinate SCF and random break events, and a culminating macroscopic catastrophic failure (MCF) event resulting from the coalescence of subordinate LCF events. Only the local response quantities, recorded at their corresponding position, show an accelerating precursory trend to an SCF event. LCF events can appear in stages both before and after the maximum load in the system. Our findings highlight that although cumulative LCF event and deformation rates for the entire system always exhibit singular accelerating precursors as MCF is approached, this is not true at all individual event points. This may explain why no clearly accelerating precursor is observed before some catastrophic events. Thus, these results suggest a methodology for recognizing and distinguishing effective precursory information from monitoring signals across scales and in eliminating false predictions.

Financial feasibility of lime (citrus aurantifolia) farming in Tanah Datar District, West Sumatra

Lime (Citrus aurantifolia) farming is one of the subsystems that form the lime agribusiness system in Tanah Datar District. This business has the potency to be developed. This study aimed to determine the feasibility of lime farming in Tanah Datar District in terms of financial aspects. This study used a survey method with a sample of 30 farmers in Padang Ganting Sub District, Tanjung Emas Sub District, and Lintau Buo Sub District, West Sumatra - Indonesia. Data were analyzed using investment criteria B / C, NPV, IRR, and sensitivity analysis. The analysis shows that the interest rate is 13% and the selling price is IDR 4.300 / Kg during the productive age (15 years), the value of B / C is 1.92, NPV is IDR 51,809,117 and IRR is 37%. Sensitivity analysis shows that the selling price is IDR 500 Kg, then the business is not feasible. While the selling price of IDR 846 / kg, Break Event Point (BEP) is reached. It can be concluded that lime farming is feasible. However, policies in trade and product use are needed so that the selling price does not fluctuate, and farmers do not experience losses.

ANALYSIS OF BUSINESS FEASIBILITY OF BANANA CHIPS

In this study, the method used is the Net Present Value (NPV) method, Internal Rate of Return (IRR), Payback Period (PP) and Break Event Point (BEP). The results of the study show that the net present value (NPV) is Rp. 31,024,617, - and is feasible because the NPV> 0, the Internal Rate of Return (IRR) of 8.25% is feasible because it is greater than the deposit interest value applicable to for the bank at this time, the Payback Period (PP) of 2 months is feasible because it is still smaller than the investment period, and the Break Event Point (BEP) of Rp.44,828,693 is feasible because the business is not profitable and does not lose if it earns income. amounting to Rp. 44,828,693, - The banana chip entrepreneurs still maintain the drying of banana chips by using solar energy, because the considerations of raw material prices and production and marketing costs are very sensitive to affect sales and profits.

Cape storm: A dynamical study of a cut-off low and its impact on South Africa

An intense surface low pressure system and associated cut-off low (COL) that affected the south-western Cape of South Africa on 6–7 June 2017 are analysed. The storm, locally named Cape Storm, was associated with heavy rains, strong winds, runaway fires, storm surge and extremely large waves. These extreme meteorological conditions resulted in a loss of life and damage to infrastructure in various forms around the province. The societal impacts that occurred have been collected and summarized in this study. Cape Storm was tracked back to its initial development as a COL extension to a surface low pressure system to the south-west of South America. ERA-Interim reanalysis is analysed from a potential vorticity (PV) perspective to assess the factors that influenced the development of this impactful storm. The analysis found that the system was associated with a Rossby wave breaking (RWB) event and an intrusion of high-potential vorticity (PV) from the stratosphere, assisting the development of the surface low pressure system. The COL migrated across the South American continent and made its way across the South Atlantic Ocean. As it migrated towards South Africa, two more COLs associated with RWB events and stratospheric intrusions maintained and deepened the surface low pressure system, increasing its eventual impact on South Africa. The surface cyclone deepening events were both associated with high-PV in both the upper to mid-levels and lower levels of the troposphere. One of these events was associated with a deep, tightly wrapped, cyclonic intrusion of high-PV air into the troposphere and higher PV values in the lower tropospheric, resulting in rapid and intense surface cyclogenesis.

FAKTOR-FAKTOR YANG MEMPENGARUHI PENDAPATAN USAHATANI KACANG TANAH DI KECAMATAN SEMAU KABUPATEN KUPANG

ABSTRACT
 Peanuts are one of the high economic value commodities in the dry land area. This commodity also contributes to the social life of the dry land area. This research has been conducted in Semau Sub-district, Kupang Regency, with the aim to determine the amount of income, break event point (BEP), R / C ratio, efficiency of capital use and factors that affect the income of peanuts farming, with the number of farmer respondents as many as 92 people , simple randomly selected. Data that has been collected by survey, library and interview methods; analyzed quantitatively-descriptive using regression methods.
 The results showed that the total average income of peanut farming in the study location was IDR 1,739,895 with a total average income of IDR 3,498,261 and a total average cost of IDR 1,758,366. While the break event point average of production is 147 Kg and the break event point price is IDR. 6.509, while for the total average the R / C ratio is
 1.99. With factors that affect income are production (X1), seed costs (X2), and labor costs (X3). From the regression results with the Cobb-Douglass function the coefficient of determination (R2) is 0.822 with the meaning that variations in independent variables such as production, seed costs and labor costs explain the dependent variable namely income (Y) of 82.20% and the rest 17.80 % is explained by variables outside of the variables analyzed. From the results of the F test (diversity test) it was found that the factors X1, X2, and X3 had a significant effect on income at ⍺ 1%, then accept H1 at least one of: βi ≠ 0. Whereas the results of the t test (partial test) obtained that factors significant effect on income, namely production (X1) and labor costs (X2), while the cost of seeds (X3) does not significantly affect income.

Inertia–Gravity Waves Breaking in the Middle Atmosphere at High Latitudes: Energy Transfer and Dissipation Tensor Anisotropy

Abstract We present direct numerical simulations of inertia–gravity waves breaking in the middle–upper mesosphere. We consider two different altitudes, which correspond to the Reynolds number of 28 647 and 114 591 based on wavelength and buoyancy period. While the former was studied by Remmler et al., it is here repeated at a higher resolution and serves as a baseline for comparison with the high-Reynolds-number case. The simulations are designed based on the study of Fruman et al., and are initialized by superimposing primary and secondary perturbations to the convectively unstable base wave. Transient growth leads to an almost instantaneous wave breaking and secondary bursts of turbulence. We show that this process is characterized by the formation of fine flow structures that are predominantly located in the vicinity of the wave’s least stable point. During the wave breakdown, the energy dissipation rate tends to be an isotropic tensor, whereas it is strongly anisotropic in between the breaking events. We find that the vertical kinetic energy spectra exhibit a clear 5/3 scaling law at instants of intense energy dissipation rate and a cubic power law at calmer periods. The term-by-term energy budget reveals that the pressure term is the most important contributor to the global energy budget, as it couples the vertical and the horizontal kinetic energy. During the breaking events, the local energy transfer is predominantly from the mean to the fluctuating field and the kinetic energy production is in balance with the pseudo kinetic energy dissipation rate.

Investigating the Behavior of an Onshore Wall and Trench Combination Ahead of a Tsunami-Like Wave

This study investigates a wall and trench combination to identify its benefits as a defense measure against an overtopping tsunami-like wave. The study focuses on several arrangements and geometries of a wall and trench combined structural system, located on the shoreline. The structural system is assessed via a numerical model, which is initially calibrated by physical experiments of tsunami-like wave transformations. A dam break event is used to model a tsunami-like wave interaction with the structures. Resulted wave properties are investigated to identify the behavior of the structural system from the viewpoint of structure geometry and configuration. The results of the study clearly show that the proposed structure combination can effectively reduce the impact of tsunami-like waves, better than a single sea wall defense system. This is achieved by reducing both wave run-up and wave induced current velocities at the lee side of the structure.

Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing.

Human immunodeficiency virus type-1 (HIV-1) infection has resulted in the death of upward of 39 million people since being discovered in the early 1980s. A cure strategy for HIV-1 has eluded scientists, but gene editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) offer a new approach to developing a cure for HIV infection. While the CRISPR/Cas9 system has been used successfully in a number of different types of studies, there remains a concern for off-target effects. This review details the different aspects of the Cas9 system and how they play a role in off-target events. In addition, this review describes the current technologies available for detecting off-target cleavage events and their advantages and disadvantages. While some studies have utilized whole genome sequencing (WGS), this method sacrifices depth of coverage for interrogating the whole genome. A number of different approaches have now been developed to take advantage of next generation sequencing (NGS) without sacrificing depth of coverage. This review highlights four widely used methods for detecting off-target events: (1) genome-wide unbiased identification of double-stranded break events enabled by sequencing (GUIDE-Seq), (2) discovery of in situ Cas off-targets and verification by sequencing (DISCOVER-Seq), (3) circularization for in vitro reporting of cleavage effects by sequencing (CIRCLE-Seq), and (4) breaks labeling in situ and sequencing (BLISS). Each of these technologies has advantages and disadvantages, but all center around capturing double-stranded break (DSB) events catalyzed by the Cas9 endonuclease. Being able to define off-target events is crucial for a gene therapy cure strategy for HIV-1.

ANALYSIS OF BREAK-EVEN POINT IN CV.BATA CIKARANG INDONESIA

This study was obtained from the balance sheet and income statement of CV Bata Cikarang Indonesia in 2018, then the title is: Break Event Point Analysis on CV Bata Cikarang Indonesia. The goal is to find out the performance of CV Bata Cikarang seen from the company's Break Event Point. The research method is Field Research by visiting research objects and conducting interviews, and Library Research by exposing existing data in the form of Balance Sheet and Profit and Loss reports, and sales of data in the form of quantitative data and in the form of descriptive. Break Event Point analysis is performed to determine the company's financial performance, can also be used as a reference in making decisions that affect the company's future. As for the results in 2017 the BEP unit is 1,055,194 and the rupiah BEP is IDR 422,077,922 and 2018 the BEP unit = 1,027,397.26 and the IDR BEP is IDR 462,392,108.

Molecular Cytogenomic Characterization of the Murine Breast Cancer Cell Lines C-127I, EMT6/P and TA3 Hauschka.

Background: To test and introduce effective and less toxic breast cancer (BC) treatment strategies, animal models, including murine BC cell lines, are considered as perfect platforms. Strikingly, the knowledge on the genetic background of applied BC cell lines is often sparse though urgently necessary for their targeted and really justified application. Methods: In this study, we performed the first molecular cytogenetic characterization for three murine BC cell lines C-127I, EMT6/P and TA3 Hauschka. Besides fluorescence in situ hybridization-banding, array comparative genomic hybridization was also applied. Thus, overall, an in silico translation for the detected imbalances and chromosomal break events in the murine cell lines to the corresponding homologous imbalances in humans could be provided. The latter enabled a comparison of the murine cell line with human BC cytogenomics. Results: All three BC cell lines showed a rearranged karyotype at different stages of complexity, which can be interpreted carefully as reflectance of more or less advanced tumor stages. Conclusions: Accordingly, the C-127I cell line would represent the late stage BC while the cell lines EMT6/P and TA3 Hauschka would be models for the premalignant or early BC stage and an early or benign BC, respectively. With this cytogenomic information provided, these cell lines now can be applied really adequately in future research studies.

A Unified Breaking Onset Criterion for Surface Gravity Water Waves in Arbitrary Depth

AbstractWe investigate the validity and robustness of the Barthelemy et al. (2018, https://doi.org/10.1017/jfm.2018.93) wave‐breaking onset prediction framework for surface gravity water waves in arbitrary water depth, including shallow water breaking over varying bathymetry. We show that the Barthelemy et al. (2018) breaking onset criterion, which they validated for deep and intermediate water depths, also segregates breaking crests from nonbreaking crests in shallow water, with subsequent breaking always following the exceedance of their proposed generic breaking threshold. We consider a number of representative wave types, including regular, irregular, solitary, and focused waves, shoaling over idealized bed topographies including an idealized bar geometry and a mildly to steeply sloping planar beach. Our results show that the new breaking onset criterion is capable of detecting single and multiple breaking events in time and space in arbitrary water depth. Further, we show that the new generic criterion provides improved skill for signaling imminent breaking onset, relative to the available kinematic or geometric breaking onset criteria in the literature. In particular, the new criterion is suitable for use in wave‐resolving models that cannot intrinsically detect the onset of wave breaking.