Body Tissues Research Articles

Fetal body composition reference charts and sexual dimorphism using magnetic resonance imaging

BackgroundThe American Academy of Pediatrics advises that the nutrition of preterm infants should target a body composition similar to that of a fetus in utero. Still, reference charts for intrauterine body composition are missing. Moreover, data on sexual differences in intrauterine body composition during pregnancy are limited. ObjectiveThe objective of this study was to create reference charts for intrauterine body composition from 30 to 36+6 weeks post-conception and to evaluate the differences between sexes. MethodsIn this single-center retrospective study, data of 197 normal developing fetuses in late gestation was acquired at 3T magnetic resonance imaging (MRI) scans, including True Fast Imaging with Steady State Free Precession and T1-weighted 2-point Dixon sequences covering the entire fetus, were included. Deep Convolutional Neural Networks were utilized to automatically segment the fetal body and subcutaneous adipose tissue. The fetus's body mass (BM), fat signal fraction (FSF), fat mass (FM), FM percentage (FM%), fat-free mass (FFM), and FFM percentage (FFM%) were calculated. Using the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) method, reference charts were created, and sexual dimorphism was examined using analysis of covariance (ANCOVA). A P-value below 0.05 is deemed significant. ResultsThroughout late gestation, BM, FSF, FM, FM%, and FFM increased, while the FFM% decreased. Reference charts and gestational age and sex-specific percentiles are provided. Males exhibited significantly higher BM (7.2%; 95% confidence interval [95% CI], 1.9-12.4%), FFM (8.5%; 95% CI, 3.7- 13.4%), and FFM% (1.2%; 95% CI, 0.6-1.7%) and lower FSF (-3.6%; 95% CI, -5.6-[-1.8]%) and FM% (-1.2%; 95% CI, -1.7-[-0.6]%), (P<0.001) compared with females, with no significant difference in FM between sexes (P=0.126). ConclusionsMRI-derived intrauterine body composition growth charts are valuable for tracking growth in preterm infants. This study demonstrated that sexual differences in body composition are already present in the intrauterine phase.

The Immunology - Ayurveda Perspective

Introduction: Immunity can be defined as the ability of the human body to resist almost all types of organisms or toxins that tend to damage tissues and organs. Ayurveda, one of the oldest health sciences has its perspectives and practices on immunology delineated under the heads of Vyadhikshmatwa (tolerance against disease), Ojas (the quintessence of all bodily tissues that is responsible for natural bio-strength, vitality and immunity), Bala (strength), and Vikaravighata Bhavas (disease-resisting factors). Materials and Methods: For the present review, the materials were collected from the Ayurvedic literature, including the three major classical texts Brihatrayees Charaka Samhita, Sushruta Samhita, Ashtanga Samgraha and Ashtanga Hridaya, and their important commentaries by Chakrapani, Arunadutta, Hemadri, Indu, and Dalhana. Information from the current scientific literature, articles published in PubMed, and authentic webpages has also been incorporated into this study. Subsequently, an independent analysis of immunology from Ayurvedic classical texts is presented in this review. Discussion: Ayurvedic compendia have vividly described the perspectives and practices of immunity and the promotion of disease-resisting factors. In addition to being the repository of age-old medical practices and the treasure trove of herbal drugs, the immunomodulatory effects of these diseaseresisting factors hold up even when bridging with new models based on modern science and technology. Conclusion: Rather than being a complementary science, Ayurveda is enriched with the concepts and practices of immunology. In order to free humanity from the grip of infections, it is important to explore the standalone and integrative aspects of science now.

Effect of Suanzaoren on Perioperative Analgesia, Hemodynamics and Postoperative Delirium

Hip fracture is not only accompanied by severe pain, but also impair body tissue and organ functions in patients, particularly in elderly individuals who have reduced tolerance and are prone to organ damage after experiencing a hip fracture. Surgery is the primary clinical approach for treating hip fractures. However, both the fracture trauma and surgical procedure can result in significant pain during the perioperative period, leading to abnormal hemodynamic fluctuations and an increased risk of postoperative delirium. Therefore, it is crucial to select an appropriate intervention method to facilitate the postoperative rehabilitation of hip fracture patients. Traditional Chinese Medicine (TCM) acknowledges that surgery will have different degrees of impact on muscles and bones, Qi and blood. Suanzaoren Decoction contains suanzaoren, anemarrhena asphodeloides, ligusticum chuanxiong and other TCM. The effective components of these TCM, such as spinosin, sarsasapogenin, and tetramethylpyrazine, have been proved to have analgesic effects. This study demonstrates, through clinical trials, that Suanzaoren Decoction exerts a positive influence on promoting the postoperative rehabilitation of hip fracture patients by reducing postoperative pain, stabilizing hemodynamic indexes, improving inflammatory state, and shortening the duration of postoperative delirium (all P &lt;0.05). The fact that Suanzaoren Decoction can effectively promote the postoperative rehabilitation of hip fracture patients may be related to the anti-inflammatory, analgesic and neuroprotective effects of the effective ingredients in the prescription, such as spinosin, sarsasapogenin and tetramethylpyrazine. Therefore, this study believes that Suanzaoren Decoction+ERAS intervention program represents an optimal approach for hip fracture surgery patients within the perioperative period.

Investigating the effect of water on collagen triple helix stability

Collagen provides essential structural support to diverse body tissues through its unique triple helix structure. Collagen stability is crucial for proper tissue function and any disruptions in its stability can lead to various health issues. Prior research has identified multiple factors affecting collagen stability. However, despite its fundamental presence in biological systems, the influence of water remains inadequately explored. Here, we performed molecular dynamics simulations on collagen model peptides (CMPs) with varying experimental stability profiles to investigate the influence of water on collagen stability. Our simulations revealed variations in both the hydrogen bonding (H-bonding) patterns between the CMPs and surrounding water molecules, as well as the water networks formed around CMPs. We noted that water molecules form H-bonds with collagen residues which enhance its structural stability. Additionally, water molecules assemble around the collagen and form topological water networks (TWNs) through intermolecular H-bonding. These TWNs further stabilizes the collagen structure. Overall, this research provides insight into the role of water molecules in preserving the stability of the collagen triple helix.

Cistanche deserticola polysaccharide-functionalized dendritic fibrous nano-silica as oral delivery system for H9N2 vaccine to promote systemic and mucosal immune response.

Most infectious diseases are caused by pathogens that invade the body tissues through mucosal tract. Therefore, it is essential to develop effective vaccines administered through the mucosa as a first-line of defense against major infectious diseases. Oral delivery of vaccines is currently of great interest due to its potential to elicit both mucosal and systemic immune responses, high compliance rate and non-invasive nature. However, their development is limited by the challenging gastrointestinal (GI) environment, the low permeability of the mucus barrier, and the lack of effective and safe mucosal adjuvants. Currently, nanoparticle-based strategies show significant potential for improving oral vaccine delivery systems. Herein, the dendritic fibrous nano-silica (DFNS) grafted with Cistanche deserticola polysaccharide (CDP) nanoparticles (CDP-DFNS) were developed for oral delivery of H9N2 antigen. CDP-DFNS induced the activation of macrophages, thereby enhancing antigen uptake in vitro. Additionally, CDP-DFNS/H9N2 significantly activated the dendritic cells (DCs) in Peyer's patches (PPs), and T/B cells in mesenteric lymph nodes (MLNs). Moreover, CDP-DFNS/H9N2 enhanced the HI titers and levels of H9N2-specific antibody IgG, secretory IgA (SIgA) and H9N2-specific IgA in intestinal and respiratory mucosa, as well as Th-associated cytokines. Our results indicate that CDP-DFNS could be a promising oral vaccine adjuvant delivery system.

Essential Oils of Some Potential Medicinal Plants and their Wound Healing Activities.

The wound has been recognised as a deep cut or tearing of the epidermis, which is also referred to as trauma and harm to the body tissues. Healing of wounds requires a coordinated series of cellular processes, including cell attraction, proliferation, differentiation, and angiogenesis. These processes involve interactions between various cells, such as macrophages, endothelial cells, keratinocytes, fibroblasts, growth hormones, and proteases. The outcome of wounds can be fatal if not treated properly, resulting in chronic wounds, chronic pain, and even death. Wound healing is replacing missing tissue with tissue repairs and regeneration. Some local variables are the presence of tissue maceration, foreign objects, biofilm, hypoxia, ischemia, and wound infection. Sustained growth factor delivery, siRNA delivery, micro-RNA targeting, and stem cell therapy are all emerging possible therapeutic approaches for wound healing. Traditional approaches, such as Ayurveda, Siddha, and Unani medicines, are also being used for treatment. The therapeutic application of nanoformulations in wound infections has shown various beneficial effects. Several herbal medicines, especially essential oils have shown potential wound healing activities, such as lavender, tea tree, sesame, olive, etc. Various nanoparticles and their nanoformulations have been explored in wound healing therapy. The present review article highlights several aspects of essential oils for wound healing activity through a novel drug delivery system. Further, some patents on wound healing through herbal medicine have been listed.

Effects Of Exercise Therapy On Igf-1 Level And Body Tissue Health In Patients With Osteosarcopenia

Effects Of Exercise Therapy On Igf-1 Level And Body Tissue Health In Patients With Osteosarcopenia

The Impact of Viruddhahara on Lifestyle Disorders: An Ayurvedic Perspective

Abstract: Ayurveda, an ancient medical system, highlights the significance of Ahara (diet) in maintaining health and preventing disease. A core aspect of Ayurvedic theory is the concept of Viruddhahara, which refers to incompatible food combinations that are believed to disrupt the equilibrium of the body's Doshas, potentially leading to various health complications. This review examines the concept of Viruddhahara and its implications for contemporary lifestyle-related disorders such as hypertension, diabetes, obesity, and cardiovascular diseases. In the current fast-paced environment, improper eating habits and the proliferation of fast food have led to widespread consumption of Viruddhahara, contributing to metabolic disturbances and chronic conditions. Ayurveda categorizes Viruddhahara into several types, including incompatibilities based on properties, timing, and combinations. For instance, the pairing of fish with milk or the consumption of heated honey serves as examples of how such food combinations can negatively impact health. The review emphasizes the importance of adhering to dietary guidelines to prevent disturbances in Dosha and the degradation of body tissues, which are essential for preserving health. With the rising incidence of lifestyle-related disorders, it is crucial to understand the scientific underpinnings of Viruddhahara and its role in disease etiology. This research aims to enhance awareness about the adverse effects of incompatible diets and to advocate for the incorporation of Ayurvedic principles into contemporary dietary practices. By conducting a thorough review of classical Ayurvedic texts alongside modern research, this study seeks to establish a framework for integrating Ayurvedic dietary principles into modern lifestyles, offering a comprehensive approach to the prevention and management of lifestyle-related diseases.

Токсичные и биогенные элементы в органах и тканях белой куропатки (Lagopus lagopus L., 1758) на севере Красноярского края (обзор)

Studying the concentration of biogenic and toxic microelements in the body tissues of wild animals is relevant for organizing regional environmental monitoring, assessing the state of populations and ensuring the safety of meat and wild products. The studies were carried out to determine the content of biogenic and toxic elements in the organs and tissues of the willow ptarmigan in the north of the Krasnoyarsk Region, Russia, where different levels of technogenic pollution are expected. The iron, copper, nickel, lead, and cadmium content in the pectoral muscles and liver of willow ptarmigan (Lagopus lagopus L.) (n=162), bagged during five hunting seasons in 2005–2019, were determined using atomic absorption spectrometry. The levels of lead, cadmium and iron in the tissues were significantly higher in contaminated areas, while the copper levels did not differ. Element concentrations in liver and skeletal muscle in impact areas were highly correlated with each other. This may be related to common sources of pollutant emissions. Sex differences in micronutrient content can be determined by spatial differentiation of the sexes during migration, seasonal feeding patterns, and the specific birds’ metabolism in reproductive period. Cadmium and lead content in liver and muscle tissue samples from impact areas exceeded current food hygiene standards, which may pose a threat to consumers. Probably, high levels of lead and cadmium reflect the increased content of metals in food items primarily willow sprouts and buds, which are the most important winter food for ptarmigan.

PANORAMA DA FISIOTERAPIA OFERTADA A PACIENTES COM SEQUELAS DE QUEIMADURA

Introduction: Burns are thermal, electrical, chemical or radioactive traumas that damage body tissues and can lead to death. Objective: To analyze the data and information collected in the system, referring to the quantity of physiotherapeutic care offered, by the SUS, to patients with burn sequelae, in Brazil, in the last 10 years. Materials and methods: Data were obtained from the DATASUS database. The collected data was organized in an Excel spreadsheet, displayed in graphs and analyzed based on scientific literature. Result: In Brazil, in the last 10 years, 97,685 physiotherapeutic services were offered to medium and large burn patients, through the SUS. The largest number of care for medium and large burn patients was concentrated in the northeast region of Brazil and the smallest number in the Central-West region. Conclusion: The study provided a broad overview of the physiotherapeutic care provided to patients with burns in Brazil over the last ten years.

Sistem Pakar Diagnosis Penyakit Gigi pada Anak Usia 5-12 Tahun Menggunakan Metode Forward Chaining

Children's dental health is a crucial aspect that must be carefully attended to, as despite being the hardest tissue in the human body, teeth are highly susceptible to bacterial attacks. Many parents neglect their children's dental health, mainly due to limited economic resources and insufficient knowledge about the importance of early dental care. Dental diseases in children can lead to more severe health problems if not properly treated. Therefore, a system is needed to help detect dental problems in children at an early stage. This expert system for diagnosing dental diseases in children is designed to replicate the thought process of a dentist in diagnosing dental issues based on symptoms inputted by the user. This study uses the forward chaining method, which is reliable in accurately identifying dental problems and providing early treatment recommendations, as well as oral health information. The system is expected to assist parents in detecting their children's dental issues and offering appropriate recommendations before consulting a dentist. Furthermore, this system has the potential to be used in clinics or health centers to support the dental diagnosis process more quickly and efficiently.

Comparison of binahong &lt;em&gt;(Anredera cordifolia) (Ten. Steenis)&lt;/em&gt; and red betel &lt;em&gt;(Piper crocatum)&lt;/em&gt; leaves ointment formulations toward length of laceration and bleeding time in rats

Laceration is a condition in which the structure of body tissue is damaged as a result of the body being slashed by sharp objects such as knives, razors, or cutters. One plant that can be applied to laceration is binahong leaves (Anredera cordifolia (Ten.) steenis and red betel (Piper crocatum). This plant contains a variety of active compounds, including alkaloids, saponins, and flavonoids. This present study aims to determine the effectiveness comparsion of the formulation and the difference in optimal concentrations of binahong and red betel leaf extract ointment formulation for incision healing with concentrations of 7%, 15%, and 30%. Here, Wistar rats incision were compared with ointment extract. To assesses the healing process with length of laceration and bleeding time. Incision demonstrated the elevated length of laceration and bleeding time. In contrast, animals received ointment extract demonstrated better for length of laceration and reduced the bleeding time. Taken the ointment extract, our results suggest ointment extract binahong and red betel leaves exhibit antioxidant and increase the collagen activity which may contribute to the heal of incision.

Importance of ferritin research in clinical practice

Serum ferritin (SF) is typically present in serum at concentrations directly related to iron (Fe) storage and is therefore traditionally used as an indicator of Fe levels in body tissues. Reducing its level is the “gold standard” for diagnosing widespread iron deficiency conditions. No less significant is hyperferritinemia — a nonspecific syndrome that occurs when Fe reserves are overloaded, a number of immunoinflammatory, infectious, oncological diseases, liver diseases, etc. In many pathological conditions, the level of SF determines the severity and prognosis of the disease. Ferritin concentrations greater than 1000 ng/mL, regardless of cause, have been shown to be associated with higher mortality. The reason for the increase in the level of SF in liver pathologies (cancer, hepatitis, cirrhosis) is associated with the process of its release from hepatocytes during their destruction. On the other hand, excessive synthesis and/or cellular secretion of ferritin occurs under the influence of various stimuli (cytokines, oxidative stress, hypoxia, oncogenes and growth factors). The interpretation of elevated ferritin values goes far beyond the role of an indicator of replenishment of Fe stores in tissues. Only 10% of cases of hyperferritinemia are associated with iron overload; in most patients, it is defined as the result of the acute phase and a reactive increase in ferritin levels against the background of any disease. The variety of symptoms of iron deficiency syndromes and hyperferritinemia is due to the involvement of many organs and systems, which requires a thorough examination (study of complaints, anamnesis, family and concomitant diseases, as well as the necessary laboratory and instrumental studies) to search for possible causes. Systemic Fe homeostasis must be closely monitored on a regular basis. It is required to comply with the conditions for blood sampling for SF. Reference values for SF concentrations vary depending on the analytical methods used and the population studied. Age and gender play an important role. Given the range of reference values, it is important for a particular patient to focus on the initial level of his ferritin, determined against the background of health and well-being during clinical observation.

Potent pollen gene regulation by DNA glycosylases in maize

Although DNA methylation primarily represses TEs, it also represses select genes that are methylated in plant body tissues but demethylated by DNA glycosylases (DNGs) in endosperm or pollen. Either one of two DNGs, MATERNAL DEREPRESSION OF R1 (MDR1) or DNG102, is essential for pollen viability in maize. Using single-pollen mRNA sequencing on pollen-segregating mutations in both genes, we identify 58 candidate DNG target genes that account for 11.1% of the wild-type transcriptome but are silent or barely detectable in other tissues. They are unusual in their tendency to lack introns but even more so in their TE-like methylation (teM) in coding DNA. The majority have predicted functions in cell wall modification, and they likely support the rapid tip growth characteristic of pollen tubes. These results suggest a critical role for DNA methylation and demethylation in regulating maize genes with the potential for extremely high expression in pollen but constitutive silencing elsewhere.

Economic burden and quality of life of caregivers of patients with sickle cell disease in the United Kingdom and France: a cross-sectional study

BackgroundSickle cell disease (SCD), a genetic blood disorder that affects red blood cells and oxygen delivery to body tissues, is characterized by haemolytic anaemia, pain episodes, fatigue, and end-organ damage with acute and chronic dimensions. Caring for patients with SCD imposes a high burden on informal caregivers. This study aims to capture the impact on health-related quality of life (HRQoL) and economic burden of caregiving for patients with SCD.MethodsValidated instruments of HRQoL (EQ-5D-5L, Carer Quality of Life-7 dimensions [CarerQol-7D]) and productivity (Work Productivity and Activity Impairment Questionnaire: Specific Health Problem [WPAI: SHP]) were administered via a cross-sectional online survey to caregivers in the United Kingdom (UK) and France. Demographics, HRQoL, and economic burden data were analyzed using descriptive statistics. Economic burden was determined using country-specific minimum and average wage values. Subgroup analysis examined caregivers with and without SCD.ResultsSixty-nine caregivers were recruited (UK, 43; France, 26), 83% were female, and 22% had SCD themselves. The mean (SD) caregiver EQ-5D-5L score was 0.66 (0.28) (UK, 0.62; France, 0.73), and the mean CarerQol-7D score was 80.69 (24.40) (UK, 78.72 [25.79]; France, 83.97 [22.01]). Mental health problems were reported in 72% and 70% of caregivers measured using the EQ-5D-5L and CarerQol-7D, respectively. Financial problems were reported by 68% of caregivers, with mean annual minimum wage productivity losses of £4209 and €3485, increasing to £5391 and €9319 for average wages. Sensitivity analysis determined additional HRQoL decrements for caregivers with and without, SCD.ConclusionCaring for patients with SCD impacts the HRQoL and economic burden of caregivers. Further research to support the complex needs of SCD caregivers is required.

Fundamental Body Composition Principles Provide Context for Fat-Free and Skeletal Muscle Loss With GLP-1 RA Treatments.

During weight loss, reductions in body mass are commonly described using molecular body components (eg, fat mass and fat-free mass [FFM]) or tissues and organs (eg, adipose tissue and skeletal muscle). While often conflated, distinctions between body components established by different levels of the 5-level model of body composition-which partitions body mass according to the atomic, molecular, cellular, tissue/organ, or whole-body level-are essential to recall when interpreting the composition of weight loss. A contemporary area of clinical and research interest that demonstrates the importance of these concepts is the discussion surrounding body composition changes with glucagon-like peptide-1 receptor agonists (GLP-1RA), particularly in regard to changes in FFM and skeletal muscle mass. The present article emphasizes the importance of fundamental principles when interpreting body composition changes experienced during weight loss, with a particular focus on GLP-1RA drug trials. The potential for obligatory loss of FFM due to reductions in adipose tissue mass and distribution of FFM loss from distinct body tissues are also discussed. Finally, selected countermeasures to combat loss of FFM and skeletal muscle, namely resistance exercise training and increased protein intake, are presented. Collectively, these considerations may allow for enhanced clarity when conceptualizing, discussing, and seeking to influence body composition changes experienced during weight loss.

Protein Extraction Methods Suitable for Muscle Tissue Proteomic Analysis.

Muscle tissue is one of the most dynamic and plastic tissues of the mammalian body and covers different roles, such as force generation and metabolic control. Muscular proteomics provides an important opportunity to reveal the molecular mechanisms behind muscle pathophysiology. To ensure successful proteomic analysis, it is necessary to have an efficient and reproducible protein extraction method. This study aimed to evaluate the efficacy of two different extraction protocols of muscle samples for two-dimensional gel electrophoresis. In particular, mouse muscle proteins were extracted by an SDS-based buffer (Method A) and by a UREA/CHAPS/DTE/TRIS solution (Method B). The efficacies of the methods were assessed by performing an image analysis of the 2DE gels and by statistical and multivariate analyses. The 2DE gels in both preparations showed good resolution and good spot overlapping. Methods A and B produced 2DE gels with different means of total spots, higher for B. Image analysis showed different patterns of protein abundance between the protocols. The results showed that the two methods extract and solubilize proteins with different chemical-physical characteristics and different cellular localizations. These results attest the efficacy and reproducibility of both protein extraction methods, which can be parallelly applied for comprehensive proteomic profiling of muscle tissue.

The Relationship of Smoking Status and Ventilation Extent with The Incident of Tuberculosis

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium Tuberculosis and attacks the organs or tissues of the human body, especially the lungs, which is caused by an imbalance between the environment, agent and host. Factors that can cause the spread of tuberculosis, if treatment is not carried out quickly, will cause an increase in the number of cases of tuberculosis. The aim of this research is to analyze the relationship between family smoking status and ventilation area with the incidence of tuberculosis in the working area of ​​the Banjarejo Community Health Center, Madiun City. In this research, researchers used quantitative research as an approach. The research method used is an analytical survey while the type of research is Case Control. The total population was 35 tuberculosis cases with a sample size of 52 respondents who were divided between the case group and the control group using the Chi-Square test. The results of the study showed that there was a significant relationship between the independent variables of family smoking status (p-value = 0.018), ventilation area (p-value = 0.007) with the incidence of tuberculosis in the working area of ​​the Banjarejo Community Health Center, Madiun City.

Monte Carlo Simulation of Radioactive Elements Production in Tissues by Spallation in Cancer Therapy

Purpose: High-energy heavy ions generated by accelerators utilized in industrial and medical uses. Ar, C, and He heavy ions have been used in the treatment of cancer. In this research, it was tried to calculate the radioactive elements production in healthy tissues around tumors by heavy ions spallation process in the direct usage of high-energy ions for the treatment of cancerous tumors. Materials and Methods: The radioactive elements production in body tissues irradiated with heavy ions was calculated by Monte Carlo N Particle X-version (MCNPX) code based on the Monte Carlo method. The F8 tally card with FT8 command was utilized to derive the activation and spallation data in the range of Z1 to Z2 atomic numbers. Results: A wide range of radioactive elements was created in healthful tissues in Ne, C, Ar, and He heavy ions therapy. Results show that 10Be,14C, 26Al, 36Cl, 39Ar, 40K, 39Ar, 32Si, 22Na, and 36Cl radioactive materials were produced for high-energy heavy ions spallation in healthy soft tissue. Conclusion: The results of this research show that due to using directly high-energy ions to treat internal tumors, healthy soft tissue is activated. Also, by irradiated Ne, C, Ar, and He ions, the radioactive elements are produced with high gains and long half-lives. Therefore, in the therapy of cancerous tumors with high-energy ions, due to the production of radioactive agents, healthy tissues are at high risk.

Physiological research of young Russian sturgeons in modern ecological conditions of the Caspian sea

In the Volga-Caspian fisheries basin, artificial reproduction of sturgeon species is the primary source of replenishing their natural populations. The aim of this study is to conduct physiological research on juvenile Russian sturgeon (Acipenser gueldenstaedtii) in the western part of the Northern Caspian Sea, to establish the features of fish homeostasis. The physiological condition of the specimens was studied using a set of physiological and biochemical parameters. Hematological, biochemical, and morpho-histological parameters were evaluated. In the blood of the fish, the contents of hemoglobin, total protein, glucose, inorganic phosphorus, calcium, creatinine, bilirubin, total lipids, cholesterol, and triglycerides were determined. In the muscle tissue of juvenile Russian sturgeon, the physiological and biochemical indicators studied included the content of the main reserve substances of the body — total lipids and water-soluble protein. Histological methods were used to assess the morpho-functional state of the gills. The variability of physiological and biochemical parameters in juvenile Russian sturgeon was calculated using descriptive statistics based on parametric and non-parametric criteria in the blood and muscles. According to the results of correlation statistical analysis, significant changes were observed in the tissues of the sturgeon juveniles, aimed at providing the body with sources of energy and nutrients used for the functioning of body tissues and serving as reserve stocks, as well as maintaining regulatory mechanisms of metabolism and its changes depending on fluctuating environmental conditions. The morphological examination of the gills revealed vascular disorders, hyperplasia, swelling, and hypertrophy of the respiratory epithelium cells, corresponding to borderline disturbances from mild to moderate damage, which was the organ’s response to external environmental influences.