Abstract
Laceration is a condition in which the structure of body tissue is damaged as a result of the body being slashed by sharp objects such as knives, razors, or cutters. One plant that can be applied to laceration is binahong leaves (Anredera cordifolia (Ten.) steenis and red betel (Piper crocatum). This plant contains a variety of active compounds, including alkaloids, saponins, and flavonoids. This present study aims to determine the effectiveness comparsion of the formulation and the difference in optimal concentrations of binahong and red betel leaf extract ointment formulation for incision healing with concentrations of 7%, 15%, and 30%. Here, Wistar rats incision were compared with ointment extract. To assesses the healing process with length of laceration and bleeding time. Incision demonstrated the elevated length of laceration and bleeding time. In contrast, animals received ointment extract demonstrated better for length of laceration and reduced the bleeding time. Taken the ointment extract, our results suggest ointment extract binahong and red betel leaves exhibit antioxidant and increase the collagen activity which may contribute to the heal of incision.
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