Unlike an implantable VAD, the TandemHeart® PTVA® system is intended for short-term use and consists of an extracorporal centrifugal blood pump, long venous and arterial cannulae, and an external controller. The purpose of this study is to analyze the hemodynamics of current adult blood pump design and use this insight to develop a pump that is safe and effective for pediatric application. Due to its proven reduction in expense and time in designing new devices, in-silico prototyping is adopted that is driven by an integrated CAD/CAE design process. Combined computational-experimental analyses including CFD, benchtop testing, and flow visualization of the existing adult pump and an ad-hoc pediatric pump prototype were performed at multiple operating conditions. These analyses yielded valuable insights into the hemodynamic performance and flow-induced blood damage potential of the pumps. Based on CFD analyses, the in-silico prototyping of the pediatric pump consisted of applying an iterative set of design changes to the shapes of its shroud housing and baffle seal. The design changes were found to result in systematic in-silico improvements in the hemodynamic, hemolytic, and thrombogenetic potentials of the pump.