The synthesis of iron-based superconductors with thick perovskite-type blocking layers, (Fe2As2)(Ca4(Mg0.25,Ti0.75)3O8) (22438) and (Fe2As2)(Ca5(Sc0.5Ti0.5)4O11) (225411), has been carried out and their transport properties discussed in comparison with those of fluorine-doped SmFeAsO0.8F0.2 (Sm1111) superconductors. Microstructural observation revealed that superconducting grains have a platelet shape and are strongly coupled with each other, particularly in 22438. The onset transition temperature (Tc) of 22438 reached up to 47.5 K and its very high upper critical field at low temperatures was suggested by a steep slope (dHc2/dT) near Tc as large as −19.8 T K−1. The resistance curves under various magnetic fields showed a basically two-step-like character of the superconducting transitions, where the effect of magnetic field is weaker at the onset part near the normal state in comparison to the tail part. The broadening of the tail part suggests a weak-link connection between superconducting grains. Two distinct scales of current flow corresponding to inter- and intragranular currents were confirmed by the remanent magnetization measurement of bulk samples, and their calculated intergranular current densities are relatively low. The analysis of their superconducting properties suggests evidence of the weak-link intergrain nature and high electromagnetic anisotropy of these iron-based superconductors with thick oxide blocking layers.