Blind Sampling Research Articles

Immunohistochemical analysis of stem cells from human exfoliated deciduous teeth seeded in carbonate apatite scaffold for the alveolar bone defect in Wistar rats (Rattus novergicus)

Background: Stem cells from human exfoliated deciduous teeth (SHED) seeded in carbonate apatite scaffold (CAS) may have multiple functions that could be used to regenerate the alveolar bone defects. The purpose of this study is to examine the ability of SHED and CAS in alveolar bone defects using an immunohistochemical analysis. Methods: ten three-month-old healthy male Wistar rats (R. novergicus) that weighed between 150–250 grams (g) were used as animal models. A simple blind random sampling method was used to select the sample that was assigned to the study group for CAS and SHED seeded in CAS (n=5). The animal study model of the alveolar bone was established by extracting the anterior mandible teeth. Rodent anesthesia was applied to relieve the pain during the procedure for all test animals. Immunohistochemistry was performed after seven days to facilitate the examination of the receptor activator of NF-κβ ligand (RANKL), osteoprotegrin (OPG), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin, and osteopontin expression. The data was analyzed using the unpaired t-test (p<0.01) and Pearson’s correlation test (p<0.05). Results: The OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin expressions were higher in SHED seeded in CAS than CAS only with a significant difference between the groups (p<0.01). Furthermore, the RANKL expression was lower in SHED seeded in CAS compared to CAS only. There was a strong reverse significant correlation between OPG and RANKL expression (p<0.05). Conclusions: The number of osteogenic marker expressing cells, such as OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin, increased. However, RANKL expression in the alveolar bone defects that were implanted with SHED seeded in CAS did not increase after seven days.

Immunohistochemical analysis of stem cells from human exfoliated deciduous teeth seeded in carbonate apatite scaffold for the alveolar bone defect in Wistar rats ( Rattus novergicus)

Background: Stem cells from human exfoliated deciduous teeth (SHED) seeded in carbonate apatite scaffold (CAS) may have multiple functions that could be used to regenerate the alveolar bone defects. The purpose of this study is to examine the ability of SHED and CAS in alveolar bone defects using an immunohistochemical analysis. Methods: ten three-month-old healthy male Wistar rats (R. novergicus) that weighed between 150–250 grams (g) were used as animal models. A simple blind random sampling method was used to select the sample that was assigned to the study group for CAS and SHED seeded in CAS (n=5). The animal study model of the alveolar bone was established by extracting the anterior mandible teeth. Rodent anesthesia was applied to relieve the pain during the procedure for all test animals. Immunohistochemistry was performed after seven days to facilitate the examination of the receptor activator of NF-κβ ligand (RANKL), osteoprotegrin (OPG), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin, and osteopontin expression. The data was analyzed using the unpaired t-test (p<0.01) and Pearson’s correlation test (p<0.05). Results: The OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin expressions were higher in SHED seeded in CAS than CAS only with a significant difference between the groups (p<0.01). Furthermore, the RANKL expression was lower in SHED seeded in CAS compared to CAS only. There was a strong reverse significant correlation between OPG and RANKL expression (p<0.05). Conclusions: The number of osteogenic marker expressing cells, such as OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin, increased. However, RANKL expression in the alveolar bone defects that were implanted with SHED seeded in CAS did not increase after seven days.

Immunohistochemical analysis of stem cells from human exfoliated deciduous teeth seeded in carbonate apatite scaffold for the alveolar bone defect in Wistar rats ( Rattus novergicus).

Background: Stem cells from human exfoliated deciduous teeth (SHED) seeded in carbonate apatite scaffold (CAS) may have multiple functions that could be used to regenerate the alveolar bone defects. The purpose of this study is to examine the ability of SHED and CAS in alveolar bone defects using an immunohistochemical analysis. Methods: ten three-month-old healthy male Wistar rats (R. novergicus) that weighed between 150-250 grams (g) were used as animal models. A simple blind random sampling method was used to select the sample that was assigned to the study group for CAS and SHED seeded in CAS (n=5). The animal study model of the alveolar bone was established by extracting the anterior mandible teeth. Rodent anesthesia was applied to relieve the pain during the procedure for all test animals. Immunohistochemistry was performed after seven days to facilitate the examination of the receptor activator of NF-κβ ligand (RANKL), osteoprotegrin (OPG), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin, and osteopontin expression. The data was analyzed using the unpaired t-test (p<0.01) and Pearson's correlation test (p<0.05). Results: The OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin expressions were higher in SHED seeded in CAS than CAS only with a significant difference between the groups (p<0.01). Furthermore, the RANKL expression was lower in SHED seeded in CAS compared to CAS only. There was a strong reverse significant correlation between OPG and RANKL expression (p<0.05). Conclusions: The number of osteogenic marker expressing cells, such as OPG, RUNX2, TGF-β, VEGF, ALP, osteocalcin, and ostepontin, increased. However, RANKL expression in the alveolar bone defects that were implanted with SHED seeded in CAS did not increase after seven days.

Effect of different white-spot lesion treatment on orthodontic shear strength and enamel morphology: In vitro study

Aim: White-spot lesion treatment is required before fixed appliance insertion as caries prevalence increases during orthodontic treatment. The aim of this study was to analyze the effect of fluoride varnish, casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) varnish, and resin infiltration as white-spot lesion treatments on orthodontic shear strength and enamel morphology. Materials and Methods: This is an observational analysis study with posttest-only control group design and blind total sampling methods. Sixty bovine mandible incisors were cleaned and divided into five groups (n = 12). No treatment was applied on Group 1 (control), whereas the four other groups were immersed in demineralization solution for 96 h before being stored in artificial saliva (Group 2), treated with fluoride varnish (Group 3), CPP-ACPF varnish (Group 4), and resin infiltration (Group 5). After bracket bonding with resin-modified glass ionomer on all samples, shear bond strength was evaluated. Adhesive remnant index (ARI) was observed by using a digital photo. Enamel morphology was evaluated using a scanning electron microscopy (SEM) before bracket bonding and after polishing. The Kruskal–Wallis test (P > 0.05) followed by Mann–Whitney U test was carried out (P < 0.05). Results: The shear strength in Groups 2 and 5 was slightly increased as compared with control group (P > 0.05), whereas it was significantly decreased in Groups 3 and 4 (P < 0.05). The ARI score was found to be highest after treatment with resin infiltration. Conclusion: Pretreatment with resin infiltration is recommended to be performed before bracket bonding on white-spot lesion; however, it may need to be reapplied after debonding and polishing to conceal enamel morphology damage formed after polishing

A 2$\times$ Blind Oversampling FSE Receiver With Combined Adaptive Equalization and Infinite-Range Timing Recovery

A 2 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times $ </tex-math></inline-formula> blind-oversampling, fractionally spaced equalizer (FSE) receiver is presented as an effective way to combine adaptive equalization and timing recovery in a single control loop. To additionally support plesiochronous clocking, the presented work realizes an infinite-range timing recovery using a set of two four-tap FSEs with a 0.5-UI timing offset, only one of which is selected to recover the data. The selection seamlessly alternates between the two, each time a 0.5-UI timing drift occurs. The optimal time to switch the selection is detected by observing the currently adapted FSE tap coefficients and its main cursor position. An equivalent timing recovery loop model is derived. A current-integrating summer and multi-input regenerative latch help the four-tap FSEs and four-tap decision-feedback equalizers (DFEs) achieve low-power dissipation, respectively. A prototype receiver fabricated in a 28-nm CMOS consumes 3.5 pJ/bit and 0.10 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 9 Gb/s while compensating for a 22-dB channel loss and 100-ppm frequency offset between the transmitted data and blind sampling clocks.

Output-Only Vibration-Based Monitoring of Civil Infrastructure via Sub-Nyquist/Compressive Measurements Supporting Reduced Wireless Data Transmission

The consideration of wireless acceleration sensors is highly promising for cost-effective output-only system identification in the context of operational modal analysis (OMA) of large-scale civil structures as they alleviate the need for wiring. However, practical monitoring implementations for OMA using wireless units suffer a number of drawbacks related to wireless transmission of densely sampled acceleration time-series including the energy self-sustainability of the sensing nodes. In this work, two recently proposed approaches for output-only modal identification addressing the above issues through balancing monitoring accuracy with data transmission costs are comparatively studied and numerically assessed using field recorded acceleration datasets from two different structures: (i) an operating on-shore wind turbine, (ii) an open to traffic highway bridge. One approach utilizes non-uniform-in-time deterministic multi-coset sampling at sub-Nyquist rates to capture structural response acceleration time-series under ambient excitation assuming stationary signal conditions. In this approach, a power spectrum blind sampling technique is used to estimate the response acceleration power spectral density matrix from the low-rate sampled measurements and is coupled with the Frequency Domain Decomposition method of OMA. The other is a spectro-temporal compressive sensing approach which recovers response acceleration signals through time-series reconstruction in the time domain from sub-Nyquist non-uniform-in-time randomly sampled measurements. Prior knowledge of signal structure in the spectral domain is exploited through smart on-sensor operations and sensor/server communication. The benefits and limitations of the considered approaches are discussed and demonstrated by processing the field recorded datasets for different levels of signal compression and by estimating battery lifetime gains at a single sensor achieved by reduced data transmission. It is concluded that the two approaches are readily applicable in OMA of large-scale structures and can be used complementarily depending on the requirements of any particular acceleration monitoring campaign: time-series extraction for further interrogation vs. solely modal properties estimation.

Impossibility of blind quantum sampling for classical client

Blind quantum computing enables a client, who can only generate or measure single-qubit states, to delegate quantum computing to a remote quantum server in such a way that the input, output, and program are hidden from the server. It is an open problem whether a completely classical client can delegate quantum computing blindly (in the information theoretic sense). In this paper, we show that if a completely classical client can blindly delegate sampling of subuniversal models, such as the DQC1 model and the IQP model, then the polynomial-time hierarchy collapses to the third level. Our delegation protocol is the one where the client first sends a polynomial-length bit string to the server and then the server returns a single bit to the client. Generalizing the no-go result to more general setups is an open problem.

Calibrated Data Simplification for Energy-Efficient Location Sensing in Internet of Things

The Internet of Things (IoT) has gradually changed the way of people’s lives due to its ability of connecting everything together, and meanwhile the accurate location sensing plays a crucial role in achieving this goal. Up to now, as one of the most representative outdoor localization systems, the global positioning system has been widely used, but its performance may be dramatically declined in indoor environment due to the serious multipath effect and signal attenuation caused by the complicated indoor structure. At the same time, the location fingerprint-based localization approach has become a popular one in indoor environment, and meanwhile the corresponding calibrated signal simplification in location database construction has been primarily considered due to its significant practical meaning in avoiding the blind signal sampling. In this paper, we propose to use an information-theoretic lens to construct the energy-efficient location fingerprint database for the localization in IoT. Interestingly, by analyzing the information loss in signal sampling, we analogize the database construction process into the information propagation process in a lossy channel, and then formulate the relations of sample capacity and localization error from an information-theoretic view. After that, by selecting an appropriate time interval to sample the independent and nonredundant signal, the minimum number of sampled signal under the given expected localization accuracy is determined. Finally, the extensive experimental results show that compared with the state-of-the-art approaches, the proposed one can effectively simplify the calibrated data for the energy-efficient location database construction in different wireless localization networks.

Modern evaluation of abnormal uterine bleeding

Abnormal uterine bleeding in women older than age 40 years, and certainly in menopausal patients, mandates evaluation, mainly to exclude cancer and hyperplasia, but also to better diagnose the source of the bleeding to appropriately manage the patient. In the past, dilation and curettage was the mainstay of diagnosis. This gave way to in-office suction pump-generated biopsies. Most recently, disposable biopsy instruments with their own internal piston to generate suction have become the standard of care. Rarely has such a technique received such widespread acceptance with such limited validation. Transvaginal ultrasonography, when technically feasible, is a noninvasive way to image the endometrial cavity. Saline-infusion sonohysterography is a subset of transvaginal ultrasonography reserved for patients in whom an adequate endometrial echo is not seen or when an endometrial echo is seen but not sufficiently thin. Appropriate understanding and use of transvaginal ultrasonography and addition of sonohysterography when necessary can allow a clinical algorithm that can triage patients with abnormal uterine bleeding to (1) no anatomic pathology best treated expectantly; (2) a global endometrial process, in which case random blind endometrial sampling is appropriate; or (3) a focal endometrial abnormality in which case endometrial sampling should be done with the visualization offered by hysteroscopy. Newer disposable office hysteroscopes finally allow office hysteroscopy to be done as a truly “point-of-care option.” Finally, the incidence of thick endometrial echo found incidentally in postmenopausal women with no bleeding is extremely high (10–17%) and should not trigger automatic invasive endometrial evaluation.

Role of Chromohysteroscopy in Evaluation of Endometrial Pathology Using Methylene Blue Dye.

Chromohysteroscopy is expected to help in diagnosing subtle endometrial pathologies which could be missed on conventional hysteroscopy and also help in targeting biopsy from endometrium. To study staining pattern of endometrium in patients undergoing chromohysteroscopy andto evaluate and compare the histopathology of chromohysteroscopy-guided endometrial biopsy with conventional endometrial sampling. This was a cross-sectional study conducted during the period of 18 months in Department of Obstetrics and Gynaecology, ESI PGIMSR, New Delhi, India, from September 2016 to February 2018. Totally, 60 women with complaints of infertility, failed intrauterine insemination (IUI), recurrent spontaneous abortions (RSA), heavy menstrual bleeding (HMB), intermenstrual bleeding (IMB) and postmenopausal bleeding (PMB) meeting inclusion criteria were evaluated and enrolled in the study. In patients with normal looking endometrium on hysteroscopy, methylene blue dye was administered through the hysteroscopic inlet. Tissue samples were obtained from stained areas followed by blind endometrial sampling immediately. The results of chromohysteroscopy-guided biopsy from light- and dark-blue-stained areas and blind biopsy were compared. Mean age of the study group was 37 years, with mean BMI of 24 kg/m2. There were 24 cases of HMB, 9 of IMB, 7 of PMB, 15 of infertility, 2 of failed IUI and 3 with RSA. On chromohysteroscopy, 39(65%) cases showed light-stained endometrium (group I) and 21(35%) showed dark-stained endometrium (group II). Comparison was done between histopathology obtained through chromohysteroscopy and blind endometrial sampling. The diagnostic accuracy of chromohysteroscopy-guided endometrial biopsy in evaluation of endometrial pathology was 86.67% with sensitivity of 91.67%, specificity of 85.41%, PPV of 61.12% and NPV of 97.61% (P <0.001). Chromohysteroscopy was able to detect endometrial pathology which was missed on conventional hysteroscopy and detected more cases of endometrial pathology than blind endometrial sampling.

Variation of non-syndromic Cleft Lip/Palate in Yayasan Surabaya cleft Lip/Palate Center Surabaya, Indonesia

Objectives: Congenital anomalies are the biggest cause of prenatal, perinatal, or infant mortality and morbidity. A total of 15% of congenital abnormalities involve the craniofacial and oral segment. Orofacial cleft (OC) is one of the most common examples of congenital abnormalities. One example of OC is cleft lip and/or palate (CL/P). The occurrence of the incident varies depending on geographical location, ethnicity, race, environmental exposure, and socioeconomic status of the patients. The aim of the study was to investigate the variation of non-syndromic CL/P (nsCL/P) in Yayasan Surabaya CLP Center, East Java, Indonesia, as well as the number of occurrences of clefts in each gender. Materials and Methods: An analytical observational study with cross-sectional and blind total sampling method was presented. Data obtained from Yayasan Surabaya CLP Center were grouped by type and classified by the LAHSHAL classification system. The numbers were calculated and then divided into occurrence per gender and per family history. A descriptive analysis was applied and then presented in table form. Results: The number of patients with cleft lip and palate (CLP), cleft lip (CL), and cleft palate (CP) were 163, 57, and 16, respectively. The more detailed type: ...SHAL, .....AL, and ..HSH.., had the highest number of cases, which were 79, 28, and 10, respectively. Conclusion: Most types of CL/P at Yayasan Surabaya CLP Center were CLP, followed by CL and finally CP. The incidence of CLP and CL was more common in men, whereas CP was more common in women.

Socioeconomic status and health-related quality of life among adults and older with overactive bladder.

To study the effect of socioeconomic status (SES) on health-related quality of life (HRQoL) among persons with overactive bladder (OAB). A randomized HRQoL study was conducted from the year 2014 until the year 2016 based on the OAB pathology department of the regional clinical diagnostics center. The medical institutions where the study was conducted had outpatient care. The simple response frequency was 81%. A total of 1893 men and women with OAB aged 35-85 (average 58.3 years) were selected by blind random sampling. Included into the group of examined individuals were persons who diagnosis provided after the examination was OAB. Evaluation of HRQoL was conducted using the SF-6D questionnaire. The OAB diagnosis was confirmed using the OAB-questionnaire and uroflowmetry. We hypothesized that the impact of SES on the HRQoL of patients with OAB has significant features. Described for the first time were HRQoL measures in various SES levels within different ages of people suffering from OAB. The strongest relationship was identified between education level, professional activity and HRQoL measures; meanwhile the weakest relationship was between income and HRQoL measures. We also confirmed the efficiency of evaluating HRQoL while using SF-6D and SRH as an external standard. The improvement of HRQoL in persons with OAB is contingent upon increment in their level of awareness about the methods of OAB treatment and the effectiveness of treatment for severe symptoms of LUT pathology, increased social support and, possibly, physical activity.

A multi-sensor sub-Nyquist power spectrum blind sampling approach for low-power wireless sensors in operational modal analysis applications

A novel multi-sensor power spectrum blind sampling (PSBS) approach is proposed supporting low-power wireless sensor networks (WSN) for Operational Modal Analysis (OMA) applications. The developed approach relies on arrays of wireless sensors, employing deterministic non-uniform in time multi-coset sampling to acquire structural response acceleration signals at sub-Nyquist sampling rates, treated as realizations of stationary random processes without making any assumption about the average signal frequency content and spectral support. The acquired compressed measurements are transmitted to a central server and collectively processed via a PSBS technique, herein extended to the multi-sensor case, to estimate the power spectral density matrix of an underlying spatially correlated stationary response acceleration random process directly from the compressed measurements. Structural modal properties are then extracted through standard frequency domain decomposition (FDD). The efficacy of the proposed approach to resolve closely-spaced modes is numerically tested for various data compression levels using noisy response acceleration signals of a white-noise excited finite element model of a space truss as well as field-recorded acceleration time-histories of an instrumented bridge under operational loading. It is shown that accurate mode shapes based on the modal assurance criterion can be obtained from as low as 89% less measurements compared to conventional non-compressive FDD at Nyquist sampling rate. Further, significant gains in energy consumption and battery lifetime prolongation of the order of years are estimated, assuming wireless sensors operating on multi-coset sampling at different data compression levels. It is, therefore, concluded that the proposed PSBS approach could provide long-term structural health monitoring systems with low-maintenance cost once wireless sensors with multi-coset sampling capabilities become commercially available.

ACOG Committee Opinion No. 734: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.

Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. The clinical approach to postmenopausal bleeding requires prompt and efficient evaluation to exclude or diagnose endometrial carcinoma and endometrial intraepithelial neoplasia. Transvaginal ultrasonography usually is sufficient for an initial evaluation of postmenopausal bleeding if the ultrasound images reveal a thin endometrial echo (less than or equal to 4 mm), given that an endometrial thickness of 4 mm or less has a greater than 99% negative predictive value for endometrial cancer. Transvaginal ultrasonography is a reasonable alternative to endometrial sampling as a first approach in evaluating a postmenopausal woman with an initial episode of bleeding. If blind sampling does not reveal endometrial hyperplasia or malignancy, further testing, such as hysteroscopy with dilation and curettage, is warranted in the evaluation of women with persistent or recurrent bleeding. An endometrial measurement greater than 4 mm that is incidentally discovered in a postmenopausal patient without bleeding need not routinely trigger evaluation, although an individualized assessment based on patient characteristics and risk factors is appropriate. Transvaginal ultrasonography is not an appropriate screening tool for endometrial cancer in postmenopausal women without bleeding.

ACOG Committee Opinion No. 734 Summary: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.

Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. The clinical approach to postmenopausal bleeding requires prompt and efficient evaluation to exclude or diagnose endometrial carcinoma and endometrial intraepithelial neoplasia. Transvaginal ultrasonography usually is sufficient for an initial evaluation of postmenopausal bleeding if the ultrasound images reveal a thin endometrial echo (less than or equal to 4 mm), given that an endometrial thickness of 4 mm or less has a greater than 99% negative predictive value for endometrial cancer. Transvaginal ultrasonography is a reasonable alternative to endometrial sampling as a first approach in evaluating a postmenopausal woman with an initial episode of bleeding. If blind sampling does not reveal endometrial hyperplasia or malignancy, further testing, such as hysteroscopy with dilation and curettage, is warranted in the evaluation of women with persistent or recurrent bleeding. An endometrial measurement greater than 4 mm that is incidentally discovered in a postmenopausal patient without bleeding need not routinely trigger evaluation, although an individualized assessment based on patient characteristics and risk factors is appropriate. Transvaginal ultrasonography is not an appropriate screening tool for endometrial cancer in postmenopausal women without bleeding.

Fish scale identification: From individual to species-specific shape variability

Background. Species identification from recovered fish scales, e.g., from the sediment or stomach contents, has proven to be problematic for clupeid species. To ensure reliable species discrimination within Clupeidae, we attempted to reveal inter- and intra-specific, as well as, the intra-individual variability of scale shape in two sympatric clupeid species the European pilchard, Sardina pilchardus (Walbaum, 1792) and the round sardinella, Sardinella aurita Valenciennes, 1847. Our aim was to test, whether the landmark-based geometric morphometric method is reliable for species identification from mixed samples. Materials and methods. The specimens of European pilchard and round sardinella were collected between May and October 2014 from the Gulf of Ambracia, Greece. The scale samples were taken from ten body areas (marked by letters A&ndash;J) of 487 specimens in total. A multiple-step analysis was conducted on randomly selected blind samples. The differences between body areas were assessed with canonical variate analysis (CVA) and discriminant function analysis (DFA) to compute generalized Mahalanobis distances (D) and discriminant functions (T2), respectively. Results. The CVA based on the total scale samples showed that in sardinella, all body areas differed significantly from each other (D = 2.54 &plusmn; 0.79, P &lt; 0.001) except for one (area I vs. J: D = 22.36, P = 0.085). In pilchard, two body area pairs represented non-significant group pairs (area D vs. G: D = 1.03, P = 0.12; and area F vs. G: D = 1.21, P = 0.06), whereas all other areas were significantly different (D = 2.43 &plusmn; 0.88, P = 0.003). At the last step of the blind sampling procedure, all scales were correctly classified by species with an average discrimination rate as high as 96.3%. Conclusion. In contrast to scale identification based merely on morphology, the geometric morphometric method is capable of detecting differences in scale shape from mixed samples that are unattainable with the former approach. Therefore, a more reliable and effective species identification can be accomplished from recovered scales, especially when discriminating species within the same family or genus.

385 - The Role of the MyoSure Hysteroscopic Tissue Removal System in the Office Setting at Detecting Abnormal Pathology in Women with Post-Menopausal Bleeding, who have had Blind Endometrial Sampling Reported as Inadequate, Inactive or Benign Endometrium

Study Objective: Identify any histological discrepancy between blind endometrial sampling (ES) reported as inadequate, inactive or benign endometrium and office based hysteroscopy with the MyoSure tissue removal system in women with post-menopausal bleeding (PMB).

Assessment of sub-Nyquist deterministic and random data sampling techniques for operational modal analysis

This article assesses numerically the potential of two different spectral estimation approaches supporting non-uniform-in-time data sampling at sub-Nyquist average rates (i.e. below the Nyquist frequency) to reduce data transmission payloads in wireless sensor networks for operational modal analysis of civil engineering structures. This consideration relaxes transmission bandwidth constraints in wireless sensor networks and prolongs sensor battery life since wireless transmission is the most energy-hungry on-sensor operation. Both the approaches assume acquisition of sub-Nyquist structural response acceleration measurements and transmission to a base station without on-sensor processing. The response acceleration power spectral density matrix is estimated directly from the sub-Nyquist measurements, and structural mode shapes are extracted using the frequency-domain decomposition algorithm. The first approach relies on the compressive sensing theory to treat sub-Nyquist randomly sampled data assuming that the acceleration signals are sparse/compressible in the frequency domain (i.e. have a small number of Fourier coefficients with significant magnitude). The second approach is based on a power spectrum blind sampling technique considering periodic deterministic sub-Nyquist “multi-coset” sampling and treating the acceleration signals as wide-sense stationary stochastic processes without posing any sparsity conditions. The modal assurance criterion is adopted to quantify the quality of mode shapes derived by the two approaches at different sub-Nyquist compression rates using computer-generated signals of different sparsity and field-recorded stationary data pertaining to an overpass in Zurich, Switzerland. It is shown that for a given compression rate, the performance of the compressive sensing–based approach is detrimentally affected by signal sparsity, while the power spectrum blind sampling–based approach achieves modal assurance criterion >0.96 independently of signal sparsity for compression ratios as low as 22% the Nyquist rate. It is concluded that the power spectrum blind sampling–based approach reduces effectively data transmission requirements in wireless sensor networks for operational modal analysis, without being limited by signal sparsity and without requiring a priori assumptions or knowledge of signal sparsity.

Endometrial Biopsy: American College of Nurse-Midwives.

Endometrial biopsy can be used to diagnose endometrial hyperplasia, endometrial cancer, and uterine infections. This cost-effective procedure has minimal side effects, and complications are rare. The purpose of this clinical bulletin is to provide clinicians with guidance about endometrial biopsy including the procedure's advantages and disadvantages, indications and contraindications, and side effects. In addition, step-by-step instructions for performing endometrial biopsy, the equipment required, selection of sampling devices, and care before and after the procedure are discussed.

Temporal Update Dynamics Under Blind Sampling

Network applications commonly maintain local copies of remote data sources in order to provide caching, indexing, and data-mining services to their clients. Modeling performance of these systems and predicting future updates usually requires knowledge of the inter-update distribution at the source, which can only be estimated through blind sampling—periodic downloads and comparison against previous copies. In this paper, we first introduce a stochastic modeling framework for this problem, where updates and sampling follow independent point processes. We then show that all previous approaches are biased unless the observation rate tends to infinity or the update process is Poisson. To overcome these issues, we propose four new algorithms that achieve various levels of consistency, which depend on the amount of temporal information revealed by the source and capabilities of the download process.