Bistable Loop Research Articles

Manipulation of lasing modes in a deformed octagonal microcavity laser

We have demonstrated a deformed octagonal microcavity semiconductor laser with manipulated lasing modes for bistable operation and direct modulation. There are two sets of degenerated four-bounced modes, S01 and S02, in the octagonal microcavity, and the degeneracy between them is broken by introducing a square hole into the center of the cavity. In the deformed octagonal microcavity laser, mode S01 dominates the lasing process during the current rising process. However, mode S02 also lases when the current decreases and interacts nonlinearly with S01, which is caused by the non-uniform distribution of the refractive index induced by the square-ring-shaped current injection. We observe a counterclockwise bistable hysteresis loop with continuous injection current ranging from 31 to 13 mA at 288 K. We also study the small-signal modulation response of the laser at high and low states with different injection currents. By utilizing the photon-photon resonance effect between modes S01 and S02, we effectively increased the 3-dB bandwidth of the laser from 12 GHz to 16.2 GHz.

Dynamic all-optical memory switching based on atomic optical bistable behavior in a three level Λ-type atomic system

We theoretically investigate the atomic optical bistability (AOB) in a three-level Λ-type atomic system confined in a unidirectional optical ring cavity. The role of the intensity or detuning of the control field on AOB is explored, and results show that absorption, dispersion, and nonlinearity can be modified significantly by the control field due to quantum coherence and interference in multilevel atomic systems. Thus, tuning the intensity or detuning of the control field can manipulate the switch-up and switch-down thresholds, as well as the area of the bistable hysteresis loop. According to the controllability of AOB, we design various schemes to realize dynamical all-optical switching between the high and low outputs of two bistable curves for a fixed cavity input. In addition, dynamical all-optical memory switching can be implemented by adding a pulse sequence for the intensity or detuning of the control field. For appropriate parameters, such as the cooperative coefficient, the extinction ratio of the switching can be improved dramatically.

First-Order Reversal Curves of Sets of Bistable Magnetostrictive Microwires.

Amorphous microwires have attracted substantial attention in the past decade because of their useful technological applications. Their bistable magnetic response is determined by positive or negative magnetostriction, respectively. First-order reversal curves (FORC) are a powerful tool for analyzing the magnetization reversal processes of many-body ferromagnetic systems that are essential for a deeper understanding of those applications. After theoretical considerations about magnetostatic interactions among microwires, this work introduces a systematic experimental study and analysis of the FORC diagrams for magnetostrictive microwires exhibiting an individually bistable hysteresis loop, from a single microwire to sets of an increasing number of coupled microwires, the latter considered as an intermediate case to the standard many-body problem. We performed the study for sets of quasi-identical and different hysteretic microwires where we obtained the coercivity Hc and interaction Hu fields. In the cases with relevant magnetostatic interactions, FORC analysis supplies deeper information than standard hysteresis loops since the intrinsic fluctuations of the switching field generate a complex response. For sets of microwires with very different coercivity, the coercivity distributions of the individual microwires characterize the FORC diagram.

A general hypothesis of multistable systems in pathophysiology

Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity that lays behind. The stability of metabolism, despite the enormous complex of chemical reactions, suggests that reciprocal control is a prerequisite of life. Negative feedback loops have been known for a long time to maintain homeostasis, while more recently, different life processes involved in transitions or changes have been modeled by positive loops giving rise to bistable switches, also including various diseases. The present hypothesis makes a generalization, by assuming that any functional element of a biological system is involved in a positive or a negative feedback loop. Consequently, the hypothesis holds that the starting mechanism of any disease that affects a healthy human can be conceptually reduced to a bistable or multistationary loop system, thus providing a unifying model leading to the discovery of critical therapeutic targets.

A general hypothesis of multistable systems in pathophysiology.

Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity that lays behind. The stability of metabolism, despite the enormous complex of chemical reactions, suggests that reciprocal control is a prerequisite of life. Negative feedback loops have been known for a long time to maintain homeostasis, while more recently, different life processes involved in transitions or changes have been modeled by positive loops giving rise to bistable switches, also including various diseases. The present hypothesis makes a generalization, by assuming that any functional element of a biological system is involved in a positive or a negative feedback loop. Consequently, the hypothesis holds that the starting mechanism of any disease that affects a healthy human can be conceptually reduced to a bistable or multistationary loop system, thus providing a unifying model leading to the discovery of critical therapeutic targets.

A general hypothesis of multistable systems in pathophysiology

Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity that lays behind. The stability of metabolism, despite the enormous complex of chemical reactions, suggests that reciprocal control is a prerequisite of life. Negative feedback loops have been known for a long time to maintain homeostasis, while more recently, different life processes involved in transitions or changes have been modeled by positive loops giving rise to bistable switches, also including various diseases. The present hypothesis makes a generalization, by assuming that any functional element of a biological system is involved in a positive or a negative feedback loop. Consequently, the hypothesis holds that the starting mechanism of any disease that affects a healthy human can be conceptually reduced to a bistable or multistationary loop system, thus providing a unifying model leading to the discovery of critical therapeutic targets.

A general theory of multistable systems in pathophysiology.

Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A theory is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity that lays behind. The stability of metabolism, despite the enormous complex of chemical reactions, suggests that reciprocal control is a prerequisite of life. Negative feedback loops have been known for a long time to maintain homeostasis, while more recently, different life processes involved in transitions or changes have been modeled by positive loops giving rise to bistable switches, also including various diseases. The present theory makes a generalization, by assuming that any functional element of a biological system is involved in a positive or a negative feedback loop. Consequently, the theory holds that the starting mechanism of any disease that affects a healthy human can be conceptually reduced to a bistable or multistationary loop system, thus providing a unifying model leading to the discovery of critical therapeutic targets.

A New Bistable Switch Model of Alzheimer's Disease Pathogenesis.

We propose a model to explain the pathogenesis of Alzheimer’s disease (AD) based on the theory that any disease affecting a healthy organism originates from a bistable feedback loop that shifts the system from a physiological to a pathological condition. We focused on the known double inhibitory loop involving the cellular prion protein (PrPC) and the enzyme BACE1 that produces amyloid-beta (Aβ) peptides. BACE1 is inhibited by PrPC, but its inhibitory activity is lost when PrPC binds to Aβ oligomers (Aβo). Excessive Aβo formation would switch the loop to a pathogenic condition involving the Aβo-PrPC-mGluR5 complex, Fyn kinase activation, tau, and NMDAR phosphorylation, ultimately leading to neurodegeneration. Based on the emerging role of cyclic nucleotides in Aβ production, and thereby in synaptic plasticity and cognitive processes, cAMP and cGMP can be considered as modulatory factors capable of inducing the transition from a physiological steady state to a pathogenic one. This would imply that critical pharmacological targets for AD treatment lie within pathways that lead to an imbalance of cyclic nucleotides in neurons. If this hypothesis is confirmed, it will provide precise indications for the development of preventive or therapeutic treatments for the disease.

Tunable optical bistability at microwave frequency based on 1D sandwich photonic structure consisting of a nonlinear dielectric slab and two magnetized cold plasma layers

In this paper, tunable optical bistability that denotes the relationship between input intensity and output intensity is numerically investigated in the microwave frequency region based on the one-dimensional (1D) sandwich photonic structure consisting of a Kerr-type nonlinear material slab and two magnetized cold plasma layers. Results show that, in the case of TM-polarized electromagnetic wave, width and switching thresholds of the bistability loops are dependent on the working frequency, initial incidence angle, layer thickness, plasma density, and external magnetic field, which should be judiciously selected to obtain a required bistability behavior. Compared to the case of switch-down threshold, the switch-up threshold in the bistability loop is more sensitive to the changes of parameters. Through this study, the suggested 1D sandwich photonic structure is beneficial to the all-optical signal processing.

Bistability of zigzag edge magnetism in graphene nanoribbons induced by electric field

In the presence of the Hubbard interaction, graphene zigzag nanoribbons have spontaneous edge magnetism with anti-parallel configuration, whose amplitude can be tuned by a transversal electric field. As the electric field increases or decreases across a critical value, the edges are demagnetized or re-magnetized, respectively. A magnetic field at each edge determines the orientation of the re-magnetization. Thus, a combination of a slowly varying transversal electric field and magnetic field in monolayer graphene zigzag nanoribbons can drive the quantum system into a bistability loop. The same phenomenon can be induced in a bilayer/monolayer zigzag nanoribbon without the magnetic field, because the non-symmetry superexchange interaction controls the orientation of the re-magnetization. In this way, the quantum system is switched between ground state and quasi-stable excited state with different magnetism, band structures and conductance. This feature could be used to develop graphene-based spintronic nano-devices without magnetic field.

Nonlinearity-Induced Reciprocity Breaking in a Single Nonmagnetic Taiji Resonator

We report on the demonstration of an effective, nonlinearity-induced non-reciprocal behavior in a single non-magnetic multi-mode Taiji resonator. Non-reciprocity is achieved by a combination of an intensity-dependent refractive index and of a broken spatial reflection symmetry. Continuous wave power dependent transmission experiments show non-reciprocity and a direction-dependent optical bistability loop. These can be explained in terms of the unidirectional mode coupling that causes an asymmetric power enhancement in the resonator. The observations are quantitatively reproduced by a numerical finite-element theory and physically explained by an analytical coupled-mode theory. This nonlinear Taiji resonator has the potential of being the building block of large arrays where to study topological and/or non-Hermitian physics. This represents an important step towards the miniaturization of nonreciprocal elements for photonic integrated networks.

Coherent perfect absorption in a weakly coupled atom-cavity system

We study coherent perfect absorption (CPA) theoretically based on a weakly coupled atom-cavity system with an optically pumped second-order nonlinear crystal (SOC) embedded in the cavity. Our system does not require a strong coupling, which is often needed for CPA in previous studies but is challenging to implement experimentally in some systems. The role of the SOC is to introduce a tunable effective decay rate of the cavity, which can lead to CPA in the weak coupling regime. The proposed system exhibits bistable behaviors, with bistable patterns switchable between conventional and unconventional shapes. By varying the properties of the SOC, the operation point of CPA can be tuned to be inside or outside the bistable regime. It can also be located at the upper or the lower stable branch or even the unstable branch of the bistable hysteresis loop. It is however robust against the parameters of the SOC for any fixed effective decay rate. Our system can potentially be applied to realize optical devices such as optical switches in the weakly coupled regime.

External Switching Dynamics of Optical Bistability System Simulation

In this work, the external switching dynamics of a Fabry-Perot etalon are studied via optical bistability system simulation. The simulated set-up of this investigation consists of two laser beams; the first beam is continuous (CW) which is considered as a biasing beam and capable of holding the bistable system for a certain range, which we are interested in, from a point that is very close self-switching to a point where the switching is unachievable. The second beam is modulated by passing the first beam through an acousto-optic modulator (AOM) to produce pulses with a minimum rise time and is used as an external source (coherent switching). In this work, we obtained the optical bistable loops by applying absorption coefficient (α) = 20cm-1, e sample etalon thickness (D) = 110μm, forward mirror reflectivity (Rf) = 0.6, and backward mirror reflectivity (Rb) = 0.95. The steady state characteristic of an initial detuning of the cavity (φ0) = 0.8 was studied at the conditions of no external input pulse intensity (M(t) = 0) and switching that takes place at Is(ON)= 0.57mW and Is(OFF) = 0.4mW.

808 nm-excited multiband NIR emission with looping mechanism and intrinsic bistability in Er3+ singly-doped BiOCl layered semiconductor

In this work, under excitation at 808 nm, not only an unusual dominant emission of 2I11/2 → 4I15/2 transition (1.0 μm) but also the relatively weaker 1.55 μm luminesce (2I13/2 → 4I15/2) of Er3+ ions are observed with multi-phonon process and optical bistability behavior simultaneously for the first time. The bistability loops exhibit uniformly clockwise cycle characterized by a relatively lower trace of emission intensity at decreasing pump power. The result show that the looping behavior of NIR emissions has been found to be related to the 808 nm excited multi-photon band transition of BiOCl. Temperature sensing behavior of Er3+ indicate that such bistability effect is associated with thermally enhanced nonradiative decay and reduced luminescence quantum yield due to the strong pump-induced local thermal loading. This work may offer a novel insight into the transition behavior of lanthanides in layered semiconductors and promote the potential applications in optical switchers and temperature sensing.

Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions

The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby blocking Yki-dependent transcriptional control. In post-mitotic Drosophila photoreceptors, a bistable negative feedback loop forms between the Hippo-dependent kinase Warts/Lats and Yki to lock in green vs blue-sensitive neuronal subtype choices, respectively. Previous experiments indicate that sd and yki mutants phenocopy each other's functions, both being required for promoting the expression of the blue photoreceptor fate determinant melted (melt) and the blue-sensitive opsin Rh5. Here, we demonstrate that Sd ensures the robustness of this neuronal fate decision via multiple antagonistic gene regulatory roles. In Hippo-positive (green) photoreceptors, Sd directly represses both melt and Rh5 gene expression through defined TEAD binding sites, a mechanism that is antagonized by Yki in Hippo-negative (blue) cells. Additionally, in blue photoreceptors, Sd is required to promote the translation of the Rh5 protein through a 3′UTR-dependent and microRNA-mediated process. Together, these studies reveal that Sd can drive context-dependent cell fate decisions through opposing transcriptional and post-transcriptional mechanisms.

Dynamical switching and memory via incoherent pump assisted optical bistability

We analyze the dynamical behavior of all-optical switching and memory based on tunable optical bistability in a three-level Λ-type atomic system driven by a probe field circulating in an optical ring cavity, a coherent coupling field and an incoherent pump field outside cavity. Owing to the incoherent pump process, the absorption and Kerr nonlinearity near the atomic resonance change dramatically as a result of varied population distribution and atomic coherence, and then the switch-up and switch-down thresholds, as well as the width (or area) of bistable curve, can be manipulated effectively. By tuning the intensity of either coherent coupling field or incoherent pump field, we can make the system output flip between the lower and upper branches of different bistable hysteresis loops while the cavity input keeps to a constant value. Accordingly, all-optical switching and memory can be implemented via dynamical control of the bistable behavior under the assistance of incoherent pump. The proposed scheme can find potential applications in all-optical communication and computation.

Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.

In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative potential remain unclear. In Drosophila, wing imaginal discs become unable to regenerate upon damage during the third larval stage (L3). Here, we show that production of ecdysone after larvae reach their critical weight (CW) terminates the window of regenerative potential by acting on a bistable loop composed of two antagonistic Broad-complex/Tramtrack/Bric-à-brac Zinc-finger (ZBTB) genes: chinmo and broad (br). Around mid L3, ecdysone signaling silences chinmo and activates br to switch wing epithelial progenitors from a default self-renewing to a differentiation-prone state. Before mid L3, Chinmo promotes a strong regenerative response upon tissue damage. After mid L3, Br installs a nonpermissive state that represses regeneration. Transient down-regulation of ecdysone signaling or Br in late L3 larvae enhances chinmo expression in damaged cells that regain the capacity to regenerate. This work unveils a mechanism that ties the self-renewing and regenerative potential of epithelial progenitors to developmental progression.

Study of optical bistability in a fully optimized laser Fabry-Perot system

The analytical study of optical bistability is concerned in a fullyoptimized laser Fabry-Perot system. The related phenomena ofswitching dynamics and optimization procedure are also included.From the steady state of optical bistability equation can plot theincident intensity versus the round trip phase shift (φ) for differentvalues of dark mistuning 12,6,3,1.50 , o    or finesse (F= 1, 5, 20,100). In order to obtain different optical bistable loops. The inputoutputcharacteristic for a nonlinear Fabry-Perot etalon of a differentvalues of finesse (F) and using different initial detuning (φ0) are usedin this research. When the cavity finesse values increase, the switch-ON intensity increases for the same value of (φ0), because thebistable loop width increases with increasing the cavity finessevalues.

Bistability in a multiferroic composite resonator

Bistable characteristics of a nonlinear multiferroic composite resonator containing ferromagnetic and piezoelectric layers are investigated. The resonator was a borosilicate glass substrate of 25 mm × 2 mm dimensions and 150 μm thickness with a 2 μm thick amorphous ferromagnetic FeCoSiB layer and a 2 μm thick piezoelectric AlN layer deposited on its sides by magnetron sputtering. The resonator was excited by ac voltage at a frequency of 156 kHz, matching its longitudinal acoustic resonance frequency. The bistability loops were observed with increasing and decreasing frequency at constant excitation voltage and with increasing and decreasing voltage at constant frequency. With increasing excitation voltage, the resonator frequency first decreases by ∼0.7 kHz and then increases again to the initial value. A bistability model is suggested that uses Lorentzian shape resonance line and measured dependences of the resonance frequency and transmission coefficient on the output signal, which quantitatively describes experimental data. It is shown that bistability in a multiferroic resonator arises due to the nonlinearity of the ferromagnetic layer.

A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer.

Discovering regulatory interactions between genes that specify the behavioral properties of cells remains an important challenge. We used the dynamics of transcriptional changes resolved by PRO-seq to identify a regulatory network responsible for endocrine resistance in breast cancer. We show that GDNF leads to endocrine resistance by switching the active state in a bi-stable feedback loop between GDNF, EGR1, and the master transcription factor ERα. GDNF stimulates MAP kinase, activating the transcription factors SRF and AP-1. SRF initiates an immediate transcriptional response, activating EGR1 and suppressing ERα. Newly translated EGR1 protein activates endogenous GDNF, leading to constitutive GDNF and EGR1 up-regulation, and the sustained down-regulation of ERα. Endocrine resistant MCF-7 cells are constitutively in the GDNF-high/ ERα-low state, suggesting that the state in the bi-stable feedback loop may provide a ‘memory’ of endocrine resistance. Thus, we identified a regulatory network switch that contributes to drug resistance in breast cancer.