This study aimed to develop a multidisciplinary approach to assess the ecological status of six moderate-sized French estuaries. For each estuary, we gathered geographical information, hydrobiological data, chemistry of pollutants and fish biology, i... Read More
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Integration of environmental signatures and omics-based approaches on the European flounder to assist with health assessment of estuarine ecosystems in Brittany, France
- Science of The Total Environment
- VOL. 878
on Jun 1, 2023
- Chemistry Of Pollutants
- Deregulation Of Proteins
- Hydrobiological Data
- Transcriptomic Data
- Omics-based Approaches
- Flounder's Responses
- More +
Computational characteristics of the structure-activity relationship of inhibitors targeting Pks13-TE domain
- Computational Biology and Chemistry
- VOL. 104
on Jun 1, 2023
- Target For Anti-tuberculosis Drug Development
- Hydrogen Bond Donors
- Size Of Binding Pocket
- Computational Biology Techniques
- Size Of Pocket
- Shape Of Pocket
- More +
Multiple studies have established the Pks13-TE domain as a promising target for anti-tuberculosis drug development. However, recent findings have revealed that the lead compound currently in the pipeline for Pks13-TE has significant cardiotoxicity is... Read More
Tetrazole Diversification of Amino Acids and Peptides via Silver‐Catalyzed Intermolecular Cycloaddition with Aryldiazonium Salts
- Angewandte Chemie International Edition
on May 22, 2023
- Aryldiazonium Salts
- Intermolecular Cycloaddition
- Amino Acids
- Amino Acid Derivatives
- Organic Chemistry
- Unimolecular Rearrangement
- More +
Selective structural modification of amino acids and peptides is a central strategy in organic chemistry, chemical biology but also in pharmacology and material science. In this context, the formation of tetrazole rings, known to possess significant ... Read More
Assessing the Accuracy of Density Functional Approximations for Predicting Hydrolysis Reaction Kinetics
- Journal of Chemical Theory and Computation
on May 17, 2023
- DFAs
- MRAE
- Reverse Hydrolysis Reactions
- Hydrolysis Reactions
- CBS Level
- Dispersion Correction
- More +
Hydrolysis reactions are ubiquitous in biological, environmental, and industrial chemistry. Density functional theory (DFT) is commonly employed to study the kinetics and reaction mechanisms of hydrolysis processes. Here, we present a new data set, B... Read More
Trends of mitochondrial changes in AD: a bibliometric study
- Frontiers in Aging Neuroscience
- VOL. 15
on May 16, 2023
- Web Of Science Core Collection
- University Of California System
- Bibliometric Analysis
- Mitochondrial Unfolded Protein Response
- Journal Of Biological Chemistry
- Journal Of Alzheimer
- More +
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive progress and memory loss, which eventually develops into dementia. It can cause personality disorders and decreased quality of life of patients. Currently,... Read More
α‐Lactam Electrophiles for Covalent Chemical Biology**
- Angewandte Chemie International Edition
on May 15, 2023
- Chemical Biology
- HepG2 Liver Cancer Cells
- Electrophilic Probes
- Serine Hydrolases
- Probes In Chemical Biology
- Electrophilic Groups
- More +
Electrophilic groups are one of the key pillars of contemporary chemical biology and medicinal chemistry. For instance, 3-membered N-heterocyclic compounds-such as aziridines, azirines, and oxaziridines-possess unique electronic and structural proper... Read More
Enantioselective Strategies for The Synthesis of N−N Atropisomers
- Angewandte Chemie International Edition
on May 15, 2023
- Biological Chemistry
- Laboratory Curiosity
- Asymmetric Synthesis
- Research Field
- Material Chemistry
- Recent Advances
- More +
Axially chiral compounds have been always considered a laboratory curiosity with rare prospects of being applied in asymmetric synthesis. Things have changed very quickly in the last twenty years when it was understood the important role and the enor... Read More
Accelerated Solid Phase Glycan Synthesis: ASGS
- Chemistry – A European Journal
on May 12, 2023
- Inert Atmosphere
- Solid-phase Oligosaccharide
- Solid Phase Synthesis
- Short Reaction Time
- Assembly Steps
- Solid Support
- More +
Solid phase synthesis is the most dominant approach for the preparation of biological oligomers as it enables the introduction of monomers iteratively. Accelerated solid phase synthesis of biological oligomers is crucial for chemical biology, but its... Read More
Recent advances in Raman and surface enhanced Raman spectroelectrochemistry
- Frontiers in Nanotechnology
- VOL. 4
on May 9, 2023
- Chemical Biology
- Surface Enhanced Raman Spectroelectrochemistry
- SEC
- Thermodynamic Processes
- Future Perspectives
- Electrode Materials
- More +
Raman spectroscopy could supply the molecular vibrational process giving the detailed information of molecular structure. At the same time, electrochemistry could provide kinetic and thermodynamic processes. Integration of both technology with the ge... Read More
Highly Diastereoselective One-Pot Synthesis of 4,5-Dihydrofuro[2,3-b]azocin-6-one Derivatives through Cyclization/[4+4] Annulation Reactions
- The Journal of Organic Chemistry
on May 8, 2023
- Biological Chemistry
- Broad Spectrum Of Substrates
- Annulation Reactions
- Eight-membered Ring
- Medicinal Science
- Diastereoselective Synthesis
- More +
A variety of 4,5-dihydrofuro[2,3-b]azocin-6-one derivatives were expediently assembled through Au(I)-catalyzed cyclization and 2-(tert-butyl)-1,1,3,3-tetramethylguanidine (BTMG)-mediated [4+4] annulation reactions of enyne-amides and ynones. The reac... Read More
Benthic foraminifera as bioindicators for the heavy metals in the severely polluted Hurghada Bay, Red Sea coast, Egypt
- Environmental Science and Pollution Research
on May 6, 2023
- Red Sea Of Egypt
- LCR
- Benthic Foraminifera
- FoRAM Index
- Red Sea
- Red Sea Coast
- More +
AbstractTwenty-nine sediment samples were collected from the Hurghada Bay, a heavily polluted bay on the Red Sea of Egypt, to inspect the environmental quality status and anthropogenic consequences on benthic foraminifera. Some foraminiferal species ... Read More
Rational Design of Esterase-Insensitive Fluorogenic Probes for In Vivo Imaging
- ACS Sensors
on May 5, 2023
- Chemical Biology
- Fluorogenic Probes
- Research In Chemical Biology
- Biomedical Fields
- Probes For Targets
- Design Of Probes
- More +
Small-molecule fluorogenic probes are indispensable tools for performing research in biomedical fields and chemical biology. Although numerous cleavable fluorogenic probes have been developed to investigate various bioanalytes, few of them meet the b... Read More
Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology
- ChemBioChem
on May 4, 2023
- Chemical Biology
- Innovation In Life Sciences
- Field Of Biology
- Life Sciences
- Activities In Industry
- Innovation In Sciences
- More +
Breakthroughs in life sciences require multidisciplinary research. Activities in academia and industry are often complementary, so collaborations between both parties hold great potential for achieving superior overall results and accelerating innova... Read More
Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next Generation Therapeutics
- ChemMedChem
on May 2, 2023
- Success Rate In Clinical Trials
- Drug Discovery Campaign
- Stereochemical Diversity
- DD
- Product Strategies
- Chemical Space
- More +
Stereochemical and skeletal complexity are particularly important vis-à-vis the cross-talks between a small molecule and a complementary active site of a biological target. This intricate harmony is known to increase selectivity, reduce toxicity, and... Read More
Development of Bifunctional, Raman Active Diyne‐Girder Stapled α‐Helical Peptides
- Chemistry – A European Journal
on May 2, 2023
- Peptide Drug Discovery
- Amino Acid Side-chains
- Field Of Drug Discovery
- Cell Permeability
- Distinct Amino Acids
- Potential Use
- More +
Stapled peptides are a unique class of cyclic α-helical peptides that are conformationally constrained via their amino acid side-chains. They have been transformative to the field of chemical biology and peptide drug discovery through addressing many... Read More
Oxidation-labile linkers for controlled drug delivery
- Bioorganic & Medicinal Chemistry Letters
- VOL. 87
on May 1, 2023
- Chemical Biology
- Peptide-drug Conjugates
- Controlled Drug Delivery
- Relevant Publications
- Neurodegenerative Diseases
- Cancer Types
- More +
The continuous symbiosis throughout chemical biology and drug discovery has led to the design of innovative bifunctional molecules for targeted and controlled drug delivery. Among the different tools, protein-drug and peptide-drug conjugates are tren... Read More
Exploiting Molecular Symmetry to Quantitatively Map the Excited-State Landscape of Iron–Sulfur Clusters
- Journal of the American Chemical Society
on May 1, 2023
- Valence Isomers
- X-type Ligands
- Six-level System
- L-type Ligands
- Fitting Protocol
- Protein's Active Site
- More +
Cuboidal [Fe4S4] clusters are ubiquitous cofactors in biological redox chemistry. In the [Fe4S4]1+ state, pairwise spin coupling gives rise to six arrangements of the Fe valences ("valence isomers") among the four Fe centers. Because of the magnetic ... Read More
Identification of a druggable pocket of the calcium-activated chloride channel TMEM16A in its open state
- Journal of Biological Chemistry
on May 1, 2023
- Open State
- Calcium-activated Chloride Channel TMEM16A
- Enhanced Sampling Algorithm
- Design Of Novel Inhibitors
- Druggable Pocket
- Secretory Diarrhea
- More +
The calcium-activated chloride channel TMEM16A is a potential drug target to treat hypertension, secretory diarrhea, and several cancers. However, all reported TMEM16A structures are either closed or desensitized, and direct inhibition of the open st... Read More
Elucidating the biological chemistry of peroxynitrite, a stealthy oxidant
- Free Radical Biology and Medicine
- VOL. 201
on May 1, 2023
- Biological Chemistry
- Chemistry Of Peroxynitrite
The inorganic chemistry of the cobalt corrinoids – an update
- Journal of Inorganic Biochemistry
- VOL. 242
on May 1, 2023
- Axial Ligand Substitution Reactions
- Derivatives Of Vitamin B12
- Chemical Redox Reactions
- Non-biological Reactions
- DFT Calculations
- Computational Methods
- More +
The inorganic chemistry of the cobalt corrinoids, derivatives of vitamin B12, is reviewed, with particular emphasis on equilibrium constants for, and kinetics of, their axial ligand substitution reactions. The role the corrin ligand plays in controll... Read More