ConspectusProteins exhibit high-binding affinity and selectivity, as well as remarkable catalytic performance. Their binding pockets are hydrophobic but also contain polar and charged groups to contribute to the binding of polar organic molecules in ... Read More
Biochemical Research Articles
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Aryl-Extended and Super Aryl-Extended Calix[4]pyrroles: Design, Synthesis, and Applications
- Accounts of Chemical Research
on Feb 2, 2023
- Aryl-extended Calix
- Charged Guests
- Organic Molecules In Aqueous Solution
- Pyrrole Scaffolds
- Pyrrole Receptors
- Development Of Molecular Sensors
- More +
Localisation of Intracellular Signals and Responses during Phagocytosis
- International Journal of Molecular Sciences
- VOL. 24
on Feb 1, 2023
- Cell Biochemistry
- Recent Advances In Imaging
- Aspects Of Phagocytosis
- Internal Organelle
- Plasma Membrane
- Simple Diffusion
- More +
Phagocytosis is one of the most polarised of all cellular activities. Both the stimulus (the target for phagocytosis) and the response (its internalisation) are focussed at just one part of the cell. At the locus, and this locus alone, pseudopodia fo... Read More
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities
- Current Opinion in Chemical Biology
- VOL. 72
on Feb 1, 2023
- Small Molecule Inhibitors Of Enzymes
- Modulators Of Enzymes
- Genetic Knockdown
- Genetic Perturbations
- Inhibitors Of Enzymes
- Medicinal Chemists
- More +
Small-molecule inhibitors of enzymes are widely used tools in reverse chemical genetics to probe biology and explore therapeutic opportunities. They are often compared with genetic knockdown or knockout and are expected to produce phenotypes similar ... Read More
Use of polymers as wavenumber calibration standards in deep-UVRR
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- VOL. 287
on Feb 1, 2023
- Classification Of Bacterial Species
- Wavenumber Calibration
- Deep-UV Resonance Raman Spectroscopy
- Overtime Changes
- Classification Of Species
- Sharp Bands
- More +
Deep-UV resonance Raman spectroscopy (UVRR) allows the classification of bacterial species with high accuracy and is a promising tool to be developed for clinical application. For this attempt, the optimization of the wavenumber calibration is requir... Read More
Efficient and scalable syntheses of 1,2-thiaselenane-4-amine and 1,2-thiaselenane-5-amine
- Synthesis
on Jan 30, 2023
- Chemical Biology
- Fast Sequences
- Chromatographic Steps
- Scale For Screening
- Value In Biology
- High Value
- More +
We develop the first regioselective syntheses of 1,2-thiaselenane-4-amine (TSA4) and 1,2-thiaselenane-5-amine (TSA5): redox-active motifs with high value in chemical biology, that until now were hindered by tedious synthesis. We leverage an aziridine... Read More
Computational Approaches to Enzyme Inhibition by Marine Natural Products in the Search for New Drugs
- Marine Drugs
- VOL. 21
on Jan 30, 2023
- Marine Natural Products
- Cryptic Biosynthetic Pathways
- Medicinal Chemistry Research
- Cheminformatic Analyses
- Structure-based Drug Design
- Atomic Detail
- More +
The exploration of biologically relevant chemical space for the discovery of small bioactive molecules present in marine organisms has led not only to important advances in certain therapeutic areas, but also to a better understanding of many life pr... Read More
EFMC – Trends that Link Medicinal Chemistry and Chemical Biology to Translational Drug Discovery
- ChemBioChem
on Jan 27, 2023
- Chemical Biology
- Field Of Medicinal Chemistry
- Chemical Starting Points
- Drug Discovery Process
- Field Of Biology
- Chemical Probes
- More +
Ground-breaking research in disease biology and continuous efforts in method development have uncovered a range of potential new drug targets. Increasingly, the drug discovery process is informed by technologies involving chemical probes as tools. Ap... Read More
Proteomics Update and Perspectives from the Proteomics in Cell Biology and Disease Mechanisms Conference
- ChemBioChem
on Jan 26, 2023
- Chemical Biology
- Advances In Chemical Biology
- Proteomics In Biology
- Cell Biology Mechanisms
- Cell Biology
- Biology Mechanisms
- More +
Proteomics, or the large-scale study of proteomes, has benefitted from many recent advances in chemical biology, mass spectrometry, and machine learning. The Proteomics in Cell Biology and Disease Mechanisms conference showcased the synergy between t... Read More
Deciphering the Biological Activities of Antifungal Agents with Chemical Probes
- Angewandte Chemie International Edition
on Jan 26, 2023
- Global Food Security
- Chemical Probes
- Antifungal Agents
- Health Security
- Classes Of Drugs
- Health Food
- More +
The growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these microorganisms pose to animal and human health and global food security. Open questions remain regarding... Read More
Chemical biology tools to interrogate the roles of O-GlcNAc in immunity
- Frontiers in Immunology
- VOL. 13
on Jan 26, 2023
- Post-translational Modification In Mammalian Cells
- Modification In Mammalian Cells
- Chemical Biology Tools
- OGT
- Glycosylation Of Proteins
- Immune Cells
- More +
The O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation of proteins is an essential and dynamic post-translational modification in mammalian cells that is regulated by the action of two enzymes. O-GlcNAc transferase (OGT) incorporates this monosa... Read More
Real-time observation of functional specialization among phosphorylation sites in CFTR
- Journal of General Physiology
- VOL. 155
on Jan 25, 2023
- Changes In Channel Activity
- Consensus Sites
- Nearby Site
- Eukaryotic Proteins
- Channel Activity
- Phosphorylation Sites
- More +
Phosphoregulation is ubiquitous in biology. Defining the functional roles of individual phosphorylation sites within a multivalent system remains particularly challenging. We have therefore applied a chemical biology approach to light-control the sta... Read More
Electrotaxis behavior of droplets composed of aqueous Belousov-Zhabotinsky solutions suspended in oil phase
- Scientific Reports
- VOL. 13
on Jan 24, 2023
- BZ
- Oil Phase
- DC Electric Field
- Chemical Wave
- Target Pattern
- Electric Field
- More +
Taxis is ubiquitous in biological and physical chemistry systems as a response to various external stimulations. We prepared aqueous droplets containing Belousov-Zhabotinsky (BZ) solutions suspended on an oleic acid oil phase subject to DC electric f... Read More
Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins
- Frontiers in Molecular Biosciences
- VOL. 10
on Jan 24, 2023
- GCE
- Post-translational Modifications In Bacteria
- Acids In Eukaryotes
- Skeletal Muscle Regeneration
- Selenocysteine Insertion
- PTMs
- More +
Post-translational modifications (PTMs) can occur on almost all amino acids in eukaryotes as a key mechanism for regulating protein function. The ability to study the role of these modifications in various biological processes requires techniques to ... Read More
Studying Reversible Protein Post‐translational Modification through Co‐translational Modification
- ChemBioChem
on Jan 24, 2023
- Genetic Code Expansion Technology
- Chemical Biology Tools
- Post-translational Modification
- Genetic Technology
- Perspectives Of Technology
- Concept Of Biology
- More +
Understanding post-translational modifications of targeted protein is of great significance to manipulate physiological processes of eukaryotes. Chemical biology tools have been utilized to investigate the biological roles of those post-translational... Read More
Synthesis of Pentacycloundecane (PCUD) Based Spiro-Pyrano-Cage Framework via Ring-Closing Metathesis
- Molbank
- VOL. 2023
on Jan 23, 2023
- Biological Chemistry
- Key Building Block
- Grignard Addition
- Cage Systems
- Olefin Metathesis
- RCM
- More +
Here, we demonstrate a short synthetic route to pyrano cage systems containing pentacycloundecane units by employing ring-closing metathesis (RCM) as a key step. These cage systems were constructed starting with readily available starting materials b... Read More
Development and Recent Advances in Lysine and N-Terminal Bioconjugation for Peptides and Proteins
- Molecules
- VOL. 28
on Jan 21, 2023
- Applications In Chemical Biology
- Native Protein Modification
- Regulation Of Protein Function
- Lysine Residue
- Good Nucleophilicity
- Bioconjugation Methods
- More +
The demand for creation of protein diversity and regulation of protein function through native protein modification and post-translational modification has ignited the development of selective chemical modification methods for peptides and proteins. ... Read More
Template-Assembled Synthetic G-Quartets (TASQs): multiTASQing Molecular Tools for Investigating DNA and RNA G-Quadruplex Biology
- Accounts of Chemical Research
on Jan 20, 2023
- G4 Ligands
- Cambridge Dictionary
- Molecular Tools
- Four-stranded DNA
- Rich Sequences
- Biomimetic Approach
- More +
ConspectusBiomimetics is defined as a "practice of making technological design that copies natural processes", with the idea that "nature has already solved the challenges we are trying to solve" (Cambridge Dictionary). The challenge we decided to ad... Read More
Stability of enzyme immobilized on the nanofluidic channel surface
- Analytical Sciences
on Jan 20, 2023
- Biological Chemistry
- Catalytic Cycles
- Immobilization Process
- Enzyme Activities
- Lifetime Metrics
- Nonuniform Space
- More +
The lifetime of an enzyme is critical to prevent system failure and optimize maintenance schedules in biological and analytical chemistry. The lifetime metrics of an enzyme can be evaluated from enzyme activity in terms of catalytic cycles per enzyme... Read More
Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis
- Frontiers in Physiology
- VOL. 14
on Jan 20, 2023
- MCU
- Cocited Author
- Role Of Mitochondrial Calcium Uniporter
- Journal Of Biological Chemistry
- Mitochondrial Calcium Homeostasis
- Permeability Transition
- More +
Background: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive an... Read More
Arylazopyrazole-Based Photoswitchable Inhibitors Selective for Escherichia coli Dihydrofolate Reductase
- ACS Chemical Biology
on Jan 20, 2023
- Human DHFR
- Bulky Moieties
- MTX
- Substitution Of Group
- Chemical Tools
- Control Of Activity
- More +
Selective inhibitors of Escherichia coli dihydrofolate reductase (eDHFR) are crucial chemical biology tools that have widespread clinical applications. We developed a set of eDHFR-selective photoswitchable inhibitors by derivatizing the structure of ... Read More