Less conventional non-covalent interactions such as chalcogen bonds attract the attention of researchers in various fields (organocatalysis, material sciences, biological chemistry, …). We present here useful descriptors to easily discriminate the st... Read More
Biochemical Research Articles
Overview
26391 Articles
Published in last 50 years
Articles published on Biochemical
Journals
Select journals
Duration
Select duration
27753 Search results
Recency
Crystal structures of organoselenium compounds: structural descriptors for chalcogen-bonds
- Synthesis
on Aug 9, 2022
Radical Hydro‐Fluorosulfonylation of Unactivated Alkenes and Alkynes
- Angewandte Chemie International Edition
on Aug 9, 2022
Recently, radical fluorosulfonylation is emerging as an appealing approach for the synthesis of sulfonyl fluorides, which are highly in demand in various disciplines, particularly in chemical biology and drug discovery. Here, we report the first esta... Read More
Multipolar Atom Types from Theory and Statistical Clustering (MATTS) Data Bank: Restructurization and Extension of UBDB
- Journal of Chemical Information and Modeling
on Aug 9, 2022
A fast and accurate operational model of electron density is crucial in many scientific disciplines including crystallography, molecular biology, pharmaceutical, and structural chemistry. In quantum crystallography, the aspherical refinement of cryst... Read More
A DNA Aptamer for Theophylline with Ultrahigh Selectivity Reminiscent of the Classic RNA Aptamer
- ACS Chemical Biology
on Aug 9, 2022
Since the report of the RNA aptamer for theophylline, theophylline has become a key molecule in chemical biology for designing RNA switches and riboswitches. In addition, theophylline is an important drug for treating airway diseases including asthma... Read More
Partition of the electronic energy of the PM7 method via the interacting quantum atoms approach.
- Physical chemistry chemical physics : PCCP
on Aug 8, 2022
Partitions of the electronic energy such as that provided by the Interacting Quantum Atoms (IQA) approach have given valuable insights for numerous chemical systems and processes. Unfortunately, this kind of analysis may involve the integration of sc... Read More
MACAW: An Accessible Tool for Molecular Embedding and Inverse Molecular Design.
- Journal of chemical information and modeling
- VOL. 62
on Aug 8, 2022
The growing capabilities of synthetic biology and organic chemistry demand tools to guide syntheses toward useful molecules. Here, we present Molecular AutoenCoding Auto-Workaround (MACAW), a tool that uses a novel approach to generate molecules pred... Read More
Native metabolomics identifies the rivulariapeptolide family of protease inhibitors
- Nature Communications
- VOL. 13
on Aug 8, 2022
The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is the compound purification needed for bioactivity assignments and downstream struc... Read More
Construction of an Artificial Light-Harvesting System with Efficient Photocatalytic Activity in an Aqueous Solution Based on a FRET-Featuring Metallacage.
- Inorganic chemistry
on Aug 8, 2022
Over the past few decades, the design and construction of high-efficiency artificial light-harvesting systems (LHSs) involving multistep fluorescence-resonance energy transfer (FRET) processes have gradually received considerable attention within wid... Read More
Native metabolomics identifies the rivulariapeptolide family of protease inhibitors.
- Nature communications
- VOL. 13
on Aug 8, 2022
The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is the compound purification needed for bioactivity assignments and downstream struc... Read More
Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase
- Molecules
- VOL. 27
on Aug 2, 2022
A specific mosquito enzyme, 3-hydroxykynurenine transaminase (HKT), is involved in the processing of toxic metabolic intermediates of the tryptophan metabolic pathway. The HKT enzymatic product, xanthurenic acid, is required for Plasmodium spp. devel... Read More
Highlighting the roles of transition metals and speciation in chemical biology
- Current Opinion in Chemical Biology
- VOL. 69
on Aug 1, 2022
Transition metal ions play key structural and functional roles, affecting structures of biomolecules and enzyme function. The importance of transition metal ions in chemical biology is, thus, undisputed. However, the aqueous chemistry of metal ions i... Read More
Chemical biology and pharmacology of histone lysine methylation inhibitors
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- VOL. 1865
on Aug 1, 2022
Approaches to advance drug discovery for neglected tropical diseases
- Drug Discovery Today
- VOL. 27
on Aug 1, 2022
Neglected tropical diseases (NTDs), which include leishmaniasis, Chagas disease, human African trypanosomiasis (HAT), and schistosomiasis, remain public health problems in developing countries, as highlighted in the 2021-2030 WHO Roadmap on NTDs. Thi... Read More
Responses of two marine fish to organically complexed Zn: Insights from microbial community and liver transcriptomics
- Science of The Total Environment
- VOL. 835
on Aug 1, 2022
The diversity and adjustability of metal-organic complex enhance the function of metals and promote the burgeoning fields of chemical biology. In the present study, we chose two marine fish to explore the effects of a dihydromyricetin (DMY)-Zn(II) co... Read More
Excavating proteoglycan structure-function relationships: modern approaches to capture the interactions of ancient biomolecules
- American Journal of Physiology-Cell Physiology
- VOL. 323
on Aug 1, 2022
Proteoglycans are now well regarded as key facilitators of cell biology. Although a majority of their interactions and functions are attributed to the decorating glycosaminoglycan chains, there is a growing appreciation for the roles of the proteogl... Read More
The chemical biology of NAD+ regulation in axon degeneration
- Current Opinion in Chemical Biology
- VOL. 69
on Aug 1, 2022
During axon degeneration, NAD+ levels are largely controlled by two enzymes: nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and sterile alpha and toll interleukin motif containing protein 1 (SARM1). NMNAT2, which catalyzes the formation o... Read More
Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis
- Pharmacological Research
- VOL. 182
on Aug 1, 2022
The pathological features of inflammatory bowel disease necessitate therapeutic strategies aimed at restoring intestinal mucosal barrier function in addition to controlling inflammation. Paeoniflorin, a bioactive herbal constituent isolated from the ... Read More
Endogenous Proteins Modulation in Live Cells with Small Molecules and Light
- ChemBioChem
on Jul 29, 2022
Protein modulation by light illumination enables the investigation of biological function in high spatiotemporal precision. Compared to genetic methods, the small molecule approach is uniquely suited for modulating endogenous proteins. Endogenous pro... Read More
The 1,3‐Dipolar Cycloaddition: From Conception to Quantum Chemical Design
- Chemistry – An Asian Journal
on Jul 28, 2022
The 1,3-dipolar cycloaddition (1,3-DCA) reaction, conceptualized by Rolf Huisgen in 1960, has proven immensely useful in organic, material, and biological chemistry. The uncatalyzed, thermal transformation is generally sluggish and unselective, but t... Read More
Fluorogenic Protein Labeling by Generation of Fluorescent Quinoliziniums Using [Cp*RhCl<sub>2</sub>]<sub>2</sub>
- Organic Letters
on Jul 28, 2022
Fluorogenic labeling has received considerable attention as a result of the high demand in chemical biology and synthetic biology applications. Herein, we develop a new strategy for fluorescent turn-on ligation targeting alkyne- and quinoline-linked ... Read More