Abstract
In this issue of Cell Chemical Biology, Kim etal.1 present a novel optogenetic tool, opto-PLCβ, to control PLCβ signaling optically. In addition to eliciting PIP2 hydrolysis and downstream signaling in cells, opto-PLCβ also enabled probing the impact of PLCβ signaling on amygdala synaptic plasticity and fear learning in mice.
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