The determination of rheological model about the debris flow is the basis of the simulation of mud flow impact distance and sedimentary fan. By using a mcr301 rheometer, rheological experiments of Chengdu clay slurry with different solid volume concentrations were carried out and the effect of solid volume concentration on shear stress were analyzed. Then the rheological process of Chengdu clay slurry with different solid volume concentration was fitted on the basis of the power law model, the Bingham model and the H–B model. The conclusions are drawn as follows: Chengdu clay mud is a typical shear-thinning non-Newtonian body. The influence of solid concentration on the flow curve is different. When the solid volume concentration is not less than 34% and the shear rate is less than 1.0 s−1, the shear stress increases rapidly as the shear rate increases. Meanwhile, when the shear rate is greater than 1.0 s−1 the shear stress decreases with the increase in the shear rate. When the solid volume concentration is less than 31.6% and the shear rate is less than 1.0 s−1, the shear stress increases with the increase in the shear rate, while when the shear rate is more than 1.0 s−1, the shear stress is less affected by shear rate. In the range of low shear rate (less than 1.0 s−1), the increase amplitude of shear stress (slope of semi logarithmic coordinate flow curve) increases as the solid volume content increases. The flow curve of Chengdu clay mud can be reflected in the whole process by using the Herschel and Bulkley model. It is the best mathematical model to fit the rheological process of Chengdu clay mud. According to the above results, the effect of solid volume concentration on the yield stress of the H–B model is analyzed.