Climate change potential impacts are evaluated through the changes in the local and regional climate. However, Global and Regional Climate simulated outputs do not often capture these changes well, hampering their direct applicability. Impact studies using coarse resolution data require bias-correction of climate variables, a process that minimizes the discrepancy between observed and simulated climate variables. This study assessed climate projections in the Volta Basin using an ensemble of 4 Regional Climate Models under the Representative Concentration Pathways-RCPs 4.5 and 8.5 scenarios in the CORDEX-Africa datasets. These datasets were bias-corrected using the Climate Model data for hydrologic modeling tool (CMhyd) and 27-years of Climate Forecast System Reanalysis data. The performances of the ensemble bias-corrected precipitation ranged from 97-99%, 93-99%, 70-485mm, and -9-5% for R2, NSE, RMSE, and PBIAS respectively. TMAX bias-correction performances ranged from 65-99%, 27-99%, 0-4°C and -2-7% for R2, NSE, RMSE and PBIAS respectively. For TMIN, the performances ranged from 91–99%, 91–99%, 0-1°C and 0-1% for R2, NSE, RMSE and PBIAS respectively. The annual projected change in precipitation under RCP4.5 and 8.5 indicated a decrease in precipitation for the near (the 2020s), the mid-century (2050s), and the end far (2080s) with a relative increase from late November to January, a period currently part of dry season period in the Volta Basin. This suggests that the basin could expect a potential shift in the rainy season. The 12-month standard precipitation index suggests more frequent and longer drought periods in the future. Changes in annual mean monthly maximum temperature revealed an increase under all scenarios and throughout the century with an intensified increase by the end of the century under the higher CO2 concentration scenario (RCP 8.5). The study showed that under RCP 4.5 and 8.5 scenarios, the Volta Basin will experience frequent drought and extreme precipitation events, warmer days, and nights temperatures although RCP 4.5 showed a relatively lower magnitude of these extremes. It is therefore important to emphasize the need for strong adaptation to preserve water resources, limit negative impacts on energy and agricultural production, and other ecosystems services in the Volta Basin.