Assessment Of Benefits Research Articles

Desmopressin use in major cardiac surgery is associated with renal impairment: a retrospective single-center analysis

BackgroundDesmopressin acetate (1-deamino-8-d-arginine vasopressin—DDAVP) is a analogue of the antidiuretic hormone vasopressin. DDAVP is suggested to reduce bleeding after cardiac surgery using cardiopulmonary bypass. The aim of this study was to determine if DDAVP has any negative impact on renal function leading to acute kidney injury (AKI) and therefore increases the need for renal replacement therapy (RRT).MethodsWe performed a retrospective single institutional cohort analysis of 2,179 patients undergoing elective and urgent cardiac surgery with CPB from 2017 to 2021. Logistic regression analysis was used to investigate any association between DDAVP, the incidence of AKI KDIGO class 3 and the need for RRT, respectively. The model was adjusted for relevant covariates, including preexisting renal impairment, pharmacological hemodynamic support with vasopressors, complexity of the surgery and postoperative lactate. Secondary outcomes included, in hospital mortality and the need for allogenic blood transfusion.ResultsA total of 992 (45.5%) patients received DDAVP intraoperatively during surgery or shortly thereafter. The use of DDAVP was associated with a significant increase in in AKI KDIGO class 3 (OR 2.27; 95% CI 1.46–3.55; p < 0,001) and the need for RRT (OR 2.19; 95%CI 1.48–3.24; p < 0,001). Both findings persisted after covariate adjusting. No increased in-hospital mortality was associated with DDAVP.ConclusionIn cardiac surgery, the use of DDAVP was associated with an increased rate of server AKI and the requirement for RRT. Given the severity of the potential harm associated with DDAVP, an evidence-based reevaluation is needed to enable an accurate risk and benefit assessment.

Flood prevention benefits provided by Canadian natural ecosystems

The escalating impacts of climate change have heightened concerns about the frequency and severity of natural disasters, particularly extreme flooding events. Future projections underscore the necessity for innovative flood prevention strategies, including broad-scale nature-based solutions. Here, we present the first comprehensive assessment of the flood prevention benefits provided by Canadian natural ecosystems and identify key areas crucial for human well-being. Using spatially explicit modeling, we (1) evaluated the potential runoff retention by natural ecosystems and (2) identified downstream urban and agricultural areas critically dependent on these natural benefits, particularly those in floodplains and close proximity to upstream natural ecosystems. The natural ecosystems within the top 5 % of sub-basins, representing regions with a high priority for conservation practices aimed at flood prevention, play a crucial role in safeguarding approximately 54 % (∼6,000 km2) of the total built-up area and 74 % (∼16,900 km2) of the total cropland situated within floodplains. Additionally, they are positioned upstream of floodplain-based urban zones belonging to 358 population centers, directly benefiting 3.7 million people (∼10 % of the Canadian population) and indirectly benefiting almost 20.1 million people (∼56 % of the Canadian population). Moreover, among Canada’s 5.2 million km2 of flood-preventing natural ecosystems, we identified a small fraction (10 %) whose loss or degradation would result in a significant (>50 %) increase in runoff. Several of these crucial ecosystems are situated in less populated northern regions, where local governments might want to incentivize conservation initiatives to support flood prevention. Our research underscores the imperative to integrate nature-based solutions into national strategies that consider the results of spatial planning analyses. Establishing other effective area-based conservation measures in the priority regions highlighted in this study can contribute towards reaching current ambitious environmental goals and provide critical flood prevention benefits. Additionally, our methods are transferable to other regions worldwide, leveraging globally available datasets and ensuring computational feasibility.

Weight management medications for chronic use in 37 veterans affairs medical centers-A medication use evaluation.

Controlled trials have demonstrated successful weight loss associated with certain weight management medications (WMMs). However, there are limited real-world data on prescribing patterns and efficacy and safety profiles of WMMs in Veterans Affairs (VA) patients. To evaluate: utilization patterns of WMMs liraglutide, naltrexone/bupropion, orlistat, phentermine, phentermine/topiramate, and semaglutide; weight loss at three, six, twelve, and more than 12 months; safety; and treatment barriers. A retrospective, cross-sectional medication use evaluation (MUE) was conducted using electronic health records of outpatient Veterans newly initiated on WMMs at 37 VA Medical Centers between 1 March 2020 and 31 March 2022. Chart review was used to identify WMM utilization and capture rates of clinical response, defined as 5% and 10% or greater weight loss at the final weight, adverse drug events (ADEs), non-adherence, and discontinuations. Site-specific surveys evaluated local practices and barriers. Among 1959 eligible Veterans, semaglutide, phentermine/topiramate, and orlistat were most frequently prescribed. The clinical response was highest among phentermine/topiramate, liraglutide, and semaglutide. Naltrexone/bupropion and phentermine demonstrated the highest and lowest ADE rates, respectively. Potential barriers to WMM utilization and successful treatment by site reports were drug shortages, patient perceptions of therapeutic course, personal preferences, and VA WMM use criteria. Smaller weight loss and higher discontinuation rates were observed relative to clinical trials. The MUE data allow for better assessment of benefits and risks for Veterans prescribed WMMs.

Assessment methods and digital tools to support circular building strategies

Abstract The aim of the paper is to highlight how digital technology can be a vector for maintaining information of buildings products, promoting supply chain transparency and traceability of materials and environmental data, contributing to activate a sustainable circular economy. Indeed, the current lack of knowledge of product characteristics often hinders the activation of reverse logistic and the assessment of the environmental benefits of circular material flows. This means, on one hand, the need to trace and collect product characteristics and product environmental information throughout the entire life cycle, and, on the other hand, the to identify ways of communicating and sharing information. This paper outlines current digital tools to support transparency and traceability of materials. Next, the paper verticalises the method and indicators used to declare the circular and sustainable profile of products, emphasising the importance of applying Life Cycle Assessment (LCA). Finally, the prefiguration of a possible integration between traceability tools and the LCA methodology is discussed, identifying possible drivers (e.g. legislative, trainings) and possible key-operators for the widespread of the “LCA-integrated traceability tools”.

Determinants of Success and Complications in Vaginal Birth After Cesarean Section: A Systematic Literature Review

Trial of Labor After Cesarean (TOLAC) is the process of attempting a vaginal delivery after a prior cesarean section. TOLAC offers an alternative to repeat cesarean delivery but requires careful assessment of risks and benefits. This research aims to evaluate the factors affecting VBAC success and associated risks, providing guidance for clinical practice in determining VBAC eligibility. Relevant literature on VBAC was sourced from databases such as PubMed and Cochrane Library using the keywords "VBAC," "VBAC success," and "VBAC risks." Literature searches for these articles are conducted through databases of scientific journals such as PubMed and Google Scholar. Analysis was conducted to assess predictive factors for VBAC success, including previous vaginal delivery history, cervical conditions, and other parameters. VBAC success is significantly influenced by previous vaginal delivery history, cervical conditions at admission, and factors such as BMI and interpregnancy interval. The main risk associated with VBAC is uterine rupture, occurring in approximately 0.2–0.9% of cases. Proper management and careful risk assessment can minimize complications. VBAC can be a safe and effective option for women who meet specific criteria. Adequate monitoring and assessment are crucial to minimize risks and enhance success rates. Individual evaluation and thorough planning are essential for achieving optimal delivery outcomes. The decision to implement VBAC should be made with careful consideration of the benefits and risks to ensure safe and optimal outcomes for both mother and baby.

Assessment of the Nutritional Benefits and Aflatoxin B1 Adsorption Properties of Blackberry Seed Cold-Pressed Oil By-Product.

This study explores the potential valorization of blackberry seed oil cake (BBSOC), a by-product of cold-pressed blackberry seed oil (Rubus fruticosus L.), as a nutritionally valuable material with aflatoxin B1 (AFB1) adsorption properties. The chemical and mineral composition, polyphenols, and antioxidant activity of BBSOC flour were assessed. BBSOC was found to be a significant source of fiber (62.09% dry weight) and essential minerals such as Fe (123.48 mg/kg), Mg (1281.40 mg/kg), K (3087.61 mg/kg), and Ca (1568.41 mg/kg). The high polyphenol content, especially ellagic acid, highlighted its biologically active potential. Moreover, BBSOC demonstrated effective biosorption of AFB1 under in vitro conditions at 37 °C, with adsorption efficiencies of 85.36% and 87.01% at pH 3 and 7, respectively. Characterization techniques including SEM, FTIR analysis, Boehm titration, and pH zero charge determination confirmed its AFB1 adsorbing properties. This valorization process reintroduces a secondary product into the food chain, supporting the circular economy and zero-waste concepts. Thus, BBSOC is nutritionally rich and effective in AFB1 biosorption, presenting potential applications as a food or feed additive.

Assessment of the economic benefit of smoking cessation in cancer patients

Introduction. In 2021, the results of the first large-scale prospective cohort study were published showing the negative impact of post-diagnosis smoking on the prognosis of non-small cell lung cancer (I-IIIа). The purpose of the study is to assess the possible benefits of postdiagnosis smoking cessation of patients with non-small cell lung cancer (NSLC) stage I–IIIa to both the health care system society as a whole. Materials and methods. A mathematical model (calculator) has been developed to calculate the economic benefits of smoking cessation among patients with a confirmed diagnosis of NSCLC (I–IIIa). The calculator uses indicators characterizing the postdiagnosis smoking status of patients with stage I–IIIa NSCLC, the probability of disease progression and survival in the groups of those who continue to smoke and those who quit smoking. These data were obtained from the prospective epidemiologic study performed in the department of clinical epidemiology, N. N. Blokhin NMRC of oncology in cooperation with the IARC. The calculator takes into account the average cost of treating patients with late-stage NSCLC (IIIb-IV stage) in 2020–2022, which is calculated based on an analysis of the medical records of patients who were treated in the Department of Medical Cancer Therapy No. 3 of the of the Federal State Budgetary Institution «N. N. Blokhin National Medical Research Center of Oncology» (Head K. K. Laktionov), statistical data on incidence and mortality from NSCLC in Russia, the Gross Domestic Product (GDP) per capita indicator, and the MINEC Forecast of socio-economic development of the Russian Federation for 2023, 2024 and 2025. Results. Stopping smoking after diagnosis of NSCLC stage I–IIIa results in cost savings due to a reduced likelihood of relapses and an increased number of patients who avoid relapses when quitting smoking. Taking into account the fact that the average cost of treatment for patients with stage IIIb–IV NSCLC is 4,000,000 rubles, savings on treatment due to a decrease in the likelihood of relapses and as a result of an increase in the number of relapse-free patients who quit smoking amounted to 3,321 million rubles. and 9,251 million rubles, respectively, per year. Thus, the total cost savings on treatment will amount to 12,588 million rubles or slightly more than 2.3 million rubles per patient who quit smoking. The second source of saving is maintaining the economically active potential of some patients diagnosed with stage I–IIIa NSCLC, due to increased progression free survival as a result of smoking cessation аmounts to 3 304 million rubles per year in terms of per capita GDP. If 100 % of patients with stage I–IIIa NLCLC hypothetically quit smoking, the potential budget savings could reach a significantly greater value of 29,480 million rubles per year. The economic benefit to society in the total metric of per capita GDP, obtained as a result of increased survival and possible preservation of labor activity, could exceed 14 billion rubles over a 5-year period. Conclusion. Smoking cessation in cancer patients is accompanied not only by clinical benefits, i. e. it reduces mortality and improves survival rates, but also by economic benefits for the healthcare system and the country as a whole.

Applying the driver-pressure-state-impact-response model to ecological restoration: A case study of comprehensive zoning and benefit assessment in Zhejiang Province, China

Ecosystem degradation is a global problem that poses a significant threat to the sustainable development of human societies, particularly in developing countries, such as China. In response, China has implemented a series of ecological restoration (ER) policies over recent years. However, significant regional developmental disparities, pronounced spatial heterogeneity of ecological issues, and substantial historical debt for ER in China present considerable obstacles and financial burdens to the effective implementation of ER strategies. Delineating ER zones and assessing the ER benefits are essential for developing effective ER strategies and implementing ER projects. In this study, we constructed a comprehensive framework for ER utilizing the Driver-Pressure-State-Impact-Response (DPSIR) model, quantified the urbanization levels, ecological state, and restoration costs in Zhejiang Province to delineate ER zones, integrated the patch-generating land use simulation model with the ecosystem service value assessment method to quantify the benefits of ER, and ultimately developed tailored ER strategies. The results showed that: (1) The pattern of urbanization levels was characterized by high levels in the northeast and low levels in the southwest, which constrated with the ecological state. The areas of high restoration costs were located in the northeastern and southeastern regions, and the areas of low restoration costs were situated in the southwestern region. (2) The rate of construction land expansion is significantly curtailed under the ER scenario compared to the natural development scenario in 2035, while forest areas have seen effective protection and an increase from the levels of 2020. (3) The ER policy is projected to generate ecological benefits totaling CNY 8.23 billion by 2035, substantially reducing the rate of ecosystem degradation. (4) Zhejiang Province is divided into five zones at the county scale: ecological autonomous protection zone, ecological core protection zone, ecological priority restoration zone, ecological control zone, and moderate development zone. Strategies have been devised based on the forecasted benefits of ER, offering valuable insights into ecological management. These findings aim to enhance the understanding of ER and support the development and implementation of regional ecological policies.

Good Intentions, Risky Inventions: A Method for Assessing the Risks and Benefits of AI in Mobile and Wearable Uses

Integrating Artificial Intelligence (AI) into mobile and wearables offers numerous benefits at individual, societal, and environmental levels. Yet, it also spotlights concerns over emerging risks. Traditional assessments of risks and benefits have been sporadic, and often require costly expert analysis. We developed a semi-automatic method that leverages Large Language Models (LLMs) to identify AI uses in mobile and wearables, classify their risks based on the EU AI Act, and determine their benefits that align with globally recognized long-term sustainable development goals; a manual validation of our method by two experts in mobile and wearable technologies, a legal and compliance expert, and a cohort of nine individuals with legal backgrounds who were recruited from Prolific, confirmed its accuracy to be over 85%. We uncovered that specific applications of mobile computing hold significant potential in improving well-being, safety, and social equality. However, these promising uses are linked to risks involving sensitive data, vulnerable groups, and automated decision-making. To avoid rejecting these risky yet impactful mobile and wearable uses, we propose a risk assessment checklist for the Mobile HCI community.

Are Water Use Efficiency and Effectiveness Relatively Lower in Arid Zones? Comparative Analyses of the Water Productivity of Typical Crops

Agriculture is the largest water user of all sectors. In arid regions in particular, achieving efficient water use in agriculture is an important way to solve water scarcity. However, the difference in water use efficiency between arid and humid regions has long been a focus of academic debate. Many studies consider water use efficiency to be higher in humid areas due to the abundance of water resources. This view is based on the fact that less irrigation in humid areas may lead to higher crop yields and better conditions for agricultural production; however, it ignores the efforts of researchers and agricultural workers in arid zones who have attempted to develop efficient water-saving technologies, as well as the effect of natural conditions on agricultural production. Correctly evaluating the efficiency of agricultural water use in arid zones is important for achieving efficient use of water resources, as well as for water management decisions. This study calculates the yield structure and water productivity of typical crops in both arid and humid regions in China based on the footprint theory and other methodologies. This approach allows for an accurate assessment of irrigation water benefits in various regions, providing a scientific basis for improving agricultural water use efficiency under different climatic conditions. The study results indicate that the average reliance on blue water for wheat and cotton gradually increases from 49.9% to 93.6% as regional aridity intensifies, ranging from the Central China Humid Region to the Northwest China Arid Region. Similarly, the average contribution of blue water to crop yield rises from 31.0% to 100%, while irrigation water productivity increases from 0.27 kg·m−3 to 0.53 kg·m−3. Finally, this study concludes that, in arid zones with lower precipitation and more hours of sunshine, a higher dependence on blue water for crop growth and development leads to a higher productivity of irrigation water. In addition, in arid zones, the focus should be on optimizing the use of irrigation water and improving irrigation technology and efficiency, while, in humid zones, there should be more use of natural precipitation to efficiently reduce dependence on irrigation water.

Temporal and spatial variation patterns of chlorophyll a in marine ranching under global interannual events

Marine ecosystems are facing numerous environmental challenges due to global climate change. In response to these challenges, the establishment and growth of marine ranching has emerged as a pivotal solution. Chlorophyll a concentration (Chla) is recognized as a valuable indicator for the ecological assessment of marine ranching. This study focused on the spatiotemporal distribution of Chla and its response to environmental factors according to the dataset in the marine ranching area of Haizhou Bay (Lianyungang, Jiangsu, China) from 2003 to 2022. The results showed that Chla had a significant cycle of summer > spring > autumn and was distributed evenly in the central area of the marine ranching. During interannual changes, Chla patches were centered in the central region during 2014, 2015, and 2016. The Chla patches predominantly focused on the eastern area in 2018–2019, shifting to the western area in 2020–2021. The generalized additive model (GAM) indicated that salinity, depth, temperature, biological oxygen demand (BOD5) and SiO3−–Si were the main environmental factors affecting Chla during spring, summer and autumn. However, during El Niño events, salinity, depth, temperature, BOD5 and transparency became the main environmental factors. We concluded that salinity, depth and temperature consistently played a crucial role in determining Chla under various climate conditions, and SiO3−–Si and transparency will no longer be an environmental factor limiting Chla. In addition, The effect of interannual variability on upwelling and vertical mixing of water layers may potentially alter the spatial distribution pattern of Chla. These findings can offer ideas into predicting the variation of Chla in marine ranching under global interannual events in the future. Furthermore, this can contribute to the comprehensive assessment of ecological benefits and the in-depth construction of marine ranching. Ultimately, it can provide essential data and scientific references for offshore ecological environment assessment and ecosystem restoration.

Myelodysplastic syndrome/ Myeloproliferative disorder, Nos.

Background: Population-based research is limited for myelodysplastic syndrome/ myeloproliferative neoplasm, not otherwise specified (MDS/MPN-NOS) which comprises a heterogenous group of patients that do not fit into the other established MDS/MPN subgroups. Methods: We identified patients from the Surveillance, Epidemiology, and End Results (SEER) database with a diagnosis of MDS/MPN-U logged from 2010-2020. Age-standardized incidence rates (ASIR) and incidence rate ratios (IRR) were calculated using eight age subgroups. Subgroup analyses were performed for race and gender. Join point regression analyses were performed to model trends in ASIRs, and annual percent change (APC) was calculated. Results: A total of 2447 patients over age 50 were included in analysis. Incidence of MDS/MPN-U increased gradually between 2010-2016 (APC 12.90) then decreased between 2016-2020 (APC -19.56). ASIR was significantly higher in males compared to females in several age groups (age 65-69, 80-84, 85+). Conclusion: The underlying molecular complexity of these diseases remains a significant challenge. It is critical to identify MDS/MPN- specific therapeutic response criteria and suitable end points correlated with survival and AML risk for transformation to acute myeloid leukemia (AML) uniform assessment of treatment benefit.

Modeling and significance assessment of road construction participant and user benefits using expert evaluation methods

Human activities are related to obtain economic, technical, social and environmental benefits. The road construction process participants and road users have direct or indirect benefits from elaboration of new infrastructure. The number of the benefits received by individual entities is publicly discussed by politicians, lobbyists, experts and other decision-makers without having quantitative estimates of benefits, i.e., often relying on intuition or considering theoretical reasoning. The paper suggests a system of 19 benefit entities (criteria) assigned the ranks given by experts. The study involved three categories of experts, including 35 road engineers, 36 transport engineers and 61 road users. The values of the concordance coefficients obtained as a result of the conducted research were found significantly higher than critical values and showed that the opinions of the experts in each category were consistent (not contradictory). This made it possible to consider the average of the opinions of the expert group as a reliable result of solving the problem. Rank averages were replaced by the normalized weights of criteria using Average Rank Transformation into Weight-Linear (ARTIW-L) and – Nonlinear (ARTIW-N) methods. The global averages of criterion weights were used employing the Inverse Hierarchy for Assessment Main Criteria Importance (IHAMCI) method thus calculating the normalized weights of the road-related classified entities (three main criteria). The findings prove that road users benefit the most (weight 0.3485), the road construction contractor (weight 0.3325) is in the next position and the road owner (investor) takes the weight equal to 0.3190. The generated research data can be used for justifying the rationality of road investment.

Research Progress and Hotspot Analysis of Low-Carbon Landscapes Based on CiteSpace Analysis

Global climate change caused by carbon dioxide emissions has become a hot topic globally. It is of great significance to study how low-carbon landscapes can reduce carbon emissions and improve the ecological environment. In this study, CiteSpace software was used to conduct a bibliometric analysis of the research field. The analysis data were based on 2910 studies published in the research field from 2002 to 2023. By analyzing the number of publications in the research field, cooperation networks, keywords, etc., the research status, processes, and hotspots of low-carbon landscapes were systematically reviewed. The results show the following: (1) Between 2002 and 2023, low-carbon landscape research developed rapidly, gradually becoming a multidisciplinary field. A large number of studies were conducted by relevant institutions and scholars from 106 countries. (2) The research focuses on carbon emission reduction, renewable energy, life cycle assessment, etc. The research mainly goes through the following stages: theoretical research on low-carbon technology, the application of low-carbon technology, and the development of the low-carbon economy. (3) Research frontiers focus on low-carbon landscape emission-reduction technologies, low-carbon landscape research methods, and the development and application of low-carbon materials. This study deeply analyzes the research process of low-carbon landscapes and puts forward a research direction for low-carbon landscapes in future urban development, such as economic benefit assessments, ecosystem restoration and protection, social participation, and policy support, in order to provide a reference for low-carbon landscape research.

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial.

In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. A multicentre, randomized, open label, phase-II study was conducted and included 42 patients from July 2009 to January 2017. The primary endpoint was the objective response rate of the docetaxel-curcumin combination in comparison with docetaxel alone. The secondary endpoints were the assessment of clinical benefit, overall survival, time-to-progression, progression-free survival, compliance, and safety. An interim analysis was planned to evaluate safety and efficacy. In this interim analysis conducted on 37 patients (19 in the control group vs. 18 in the experimental group), no difference was observed for the objective response rate (p = 0.25, control 73.7% vs. experimental 55.6%). Concerning clinical benefit, overall survival and time-to-progression, we also failed to show any difference between the two arms. A slight tendency towards longer progression-free survival at 12 months after randomization was observed in the curcumin group (65.5% vs. 41.4%) but this difference did not reach significance (p = 0.14). In this study, we showed for the first time that adding oral curcumin for advanced and metastatic breast cancer patients treated with first or second-line docetaxel was not efficacious, although safe. Consequently, this study was stopped for reasons of futility. Further studies with a larger number of patients, a different curcumin preparation, a longer treatment period and a pharmacokinetic evaluation of curcumin are needed to explore the real efficacy of this compound.

52306 Clinical Assessment of Anti-Aging Benefits of a Facial Skincare Formulation: a biomarker-centered approach to antioxidative defense

52306 Clinical Assessment of Anti-Aging Benefits of a Facial Skincare Formulation: a biomarker-centered approach to antioxidative defense

Sound Localization in Active Transcutaneous Bone Conduction Implant Users with Single-Sided Deafness.

Evaluate sound localization accuracy of subjects with single-sided deafness (SSD) with active transcutaneous bone conduction implants (atBCIs). Prospective case-control study. Tertiary referral center. Ten SSD patients (with ATBCIS) and 10 controls. Localization was assessed in a semianechoic chamber using a 24-speaker array. Stimuli included broadband noise (BBN) and narrowband noise (NBN). Perceived stimulus angle was recorded and compared with presented location. Statistical analyses were performed using ANOVA and Wilcoxon rank sum tests. The primary outcome measures were as follows: 1) mean angular error (MAE) error (°) and regression slope and 2) subjective benefit assessment (Speech Spatial Qualities questionnaire). Subjects with SSD demonstrated worse localization by MAE and regression slope compared with controls for both broadband noise (p < 0.0001) and narrowband noise at 500 Hz and 1000 kHz (p < 0.0001). There was no statistically significant difference (p = 0.1090) in slope between all groups at 4000 Hz. There was no significant difference in slope or MAE aided compared with unaided. Localization ability varied widely within the SSD cohort, with some individuals showing some ability in the unaided condition, best at 4000 Hz. Although SSQ confirmed particular difficulty in the spatial hearing domain, all domains improved with device use. Localization ability for individuals with SSD falls into a somewhat bimodal distribution. Some have fair localization, particularly at high frequencies, that is preserved but not improved with the atBCI. Others have minimal to no localization ability at any frequency, with no apparent device benefit.

Application of Business Intelligence Technology Model to Sustainable Supply Chain

Under the backdrop of globalization, sustainable supply chains are becoming one of the most important directions for commercial development in the future. The efficiency of supply chain management (SCM) will be significantly improved when business intelligence is used in the supply chain. Sustainable supply chain refers to the integration of sustainable development elements on the basis of traditional supply chain management, introducing the assessment and management of social, environmental, economic benefits and other risks. The aim of this paper is to look at how different BI techniques affect different business models. Most of this paper is a summary of previous scholars work. The most successful and widespread application of BI is the final outcome of the technology acceptance model. These three BI models have different effects on sustainable supply chains, but in general, BI is very helpful for sustainable supply chain development in all aspects. Future results would be much more accurate and effective if three techniques were actually able to monitor and compare the sustainability of supply chains.

Identifying the optimal type and locations of natural water retention measures using spatial modeling and cost-benefit analysis

Water management has shifted from solely technical and engineering approaches towards nature-based solutions (NBS), like natural water retention measures (NWRM), offering benefits beyond hydrology, such as improved well-being and biodiversity conservation. Determining the best type and location of these measures is challenging due to diverse options with varying benefits and effects depending on measure type and location characteristics. While most studies regarding the optimal allocation and implementation of NBS focus on the urban environment, this study presents a methodology for decision-makers focusing on inter-urban regions with limited data on NWRM implementation. Through hydrological modeling and cost-benefit analysis (CBA), we identify Pareto optimal NWRM sites and types, considering water quantity and quality alongside economic, environmental, and social objectives. We defined optimal locations that seek the most significant reduction of runoff, sediment, and pollutants, whilst optimal NWRM types are defined to seek the most cost-effective measures based on hydrological, ecological, and social criteria. Using the Open Non-point Source Pollution and Erosion Comparison Tool (OpenNSPECT), we simulated increased infiltration in different inter-urban areas and identified the optimal placement. The criteria for selecting suitable NWRM types for the identified areas are derived from the EU Directorate General for the Environment (DG-ENV) NWRM database. The results show different effective areas for reducing runoff, sediment, and pollutants. While one NWRM (natural bank stabilization) was identified as most beneficial for reducing sediment, several measures were selected for runoff reduction. Interestingly, measures with high potential for pollutant reduction seem to offer limited social and biodiversity benefits, suggesting conflicting objectives and highlighting the importance of accounting for multiple criteria. By employing simplified models and qualitative benefit assessments, this paper presents a practical decision-making approach to facilitate NWRM implementation in data-scarce areas.

Updated analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany.

A recent analysis from our group ( https://pubmed.ncbi.nlm.nih.gov/37014400/ ) has shown that the immense costs of the 20 protein kinase inhibitors for oncology approved from 2015 to 2019 are largely caused by drugs whose additional benefit has not been proven. We updated our analysis by adding the newly approved protein kinase inhibitors of the years 2020 and 2021. Based on the 2021 and 2022 Arzneiverordnungsreport (AVR), we expanded our analysis to include a total of nine protein kinase inhibitors newly approved by the European Medicines Agency (EMA) in 2020 and 2021. As a result, 29 protein kinase inhibitors were identified for an update of our analysis. For these 29 drugs, all additional benefit assessments published by the Gemeinsamer Bundesausschuss (GBA) were analyzed. The additional benefit assessments of the GBA were compared with the corresponding assessments of the European Society for Medical Oncology (ESMO), the Deutsche Gesellschaft für Hämatologie und Onkologie (DGHO, German Society for Hematology and Oncology) and the Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ, Drug Commission of the German Medical Association). In addition, a total number of 91 drug advertisements published in the journal Oncology Research and Treatment in 2022 were analyzed. The number of protein kinase inhibitors for which no additional benefit can be found by the GBA is increasing, whereas the number of drugs for which a considerable additional benefit can be found is decreasing. Thus, in the current 2022 (re)assessment of additional benefit by the GBA, no additional benefit was identified for 50% of the drugs (2020, 46%). Nineteen percent were assessed with a minor additional benefit (2020, 18%) and also 19% with a considerable additional benefit (2020, 27%). For 12% of the drugs, the additional benefit could not be quantified by the GBA (2020, 9%). The benefit assessments by other medical societies often differ significantly from those of the GBA, mainly due to different evaluations of various endpoint parameters. In addition, more and more protein kinase inhibitors are being approved as orphan drugs. However, their additional benefit cannot be quantified by the GBA in most cases (78%). In 38% of the advertisements of an oncology journal, protein kinase inhibitors are promoted, which shows the pharmacoeconomic importance of these drugs. In summary, the current additional benefit assessment procedure in Germany is very questionable, and reforms are urgently needed to maintain the stability of the German healthcare system, which is being undermined by the high cost of medicines, particularly for drugs whose additional benefits have not been proven.