Objective To investigate the incidence of abnormalities and adverse reactions of intrauterine device (IUD) by three-dimensional transvaginal ultrasound, and guide the correct selection of IUD. Methods Female volunteers who came to our hospital for health check-up from July 2016 to February 2018 were selected as subjects to obtain information of the belt loop time and number of loops. Three-dimensional transvaginal ultrasound was used to observe and record the IUD types and positions. The incidence of location abnormalities, adverse reactions and cervical lesions of differnet types of IUD were retrospectively analyzed. Results Two thousand one hundred and thirteen eligible subjects were included in the study, including 423 cases of McuIUD, 506 cases of circular ring, 405 cases of uterine ring, 372 cases of T-ring and 407 cases of γ ring. The statistical analysis showed that the incidence of adverse reactions after wearing rings was as high as 34.07%, and the adverse reaction rate of different IUD was different. McuIUD had the highest incidence of adverse reactions, compared with the circular ring, the uterine ring, the T-ring, and the γ ring (47.99% vs 25.88%, 27.41%, 37.10%, 33.66%; all P 0.05). The incarceration rate of the mother ring was higher than that of the circular ring, uterine ring and T-ring (3.07% vs 0, 0.25%, 0.54%; all P 1 and ring times ≥2 were related with the occurrence of adverse reactions of IUD (P<0.05). The incidence of cervical erosion in the T-ring was the highest compared with the McuIUD, circular ring, uterine ring, and γ ring (30.65% vs 16.78%, 16.80%, 18.02%, 17.69%; all P<0.01). Conclusions The incidence of adverse reactions is higher in women with different types of IUD. The incidence of different types of abnormal IUD position is different. The frequency of pregnancy and band ring are related to the occurence of adverse veactions to IUD. Key words: Ultrasonograhpy, transvaginal, three-dimensional; Intrauterine devices; Adverse Reaction; Dislocation of IUD