Prediction of the fatigue performance of lattice structures in additive manufacturing still lacks widely applicable methods. To address this issue, we investigated the effect of a BCC lattice structure combined with thin walls and ribs on the fatigue performance of TC4 alloy samples. The lattice-structured samples were fabricated by selective laser melting. In addition, we proposed a prediction model of fatigue performance that combined ABAQUS finite element analysis with FE-safe fatigue analysis. The simulation and experimental results verified the reliability of the model. Based on this method, the effects of lattice and ribbed plate structures on the bending fatigue performance were investigated. The experimental results showed that the stress concentration generated by lattice structures weakened the fatigue performance. On the contrary, ribbed plates can enhance fatigue performance, which also depends on the orientation of the rib structure. The simulation results showed that increasing the volume fraction of unit cells can mitigate the stress concentration, leading to improved fatigue performance. The lattice structure combined with the rib structure exhibited superior fatigue performance. In addition, the proposed models can also be applied to other metallic materials. The findings in this study can provide a theoretical basis for the design of lattice structures with better fatigue performance.