Congenital heart disease (CHD) represents a global health problem. In Mexico, in children<1year of age it is the second cause of mortality. The aim was to determine mortality trends from CHD and the great vessels in children and adults nationwide, by state and socioeconomic region. Records of mortality associated to CHD and the great vessels for 2000-2015 were obtained from the National Institute of Statistics and Geography. This information is collected from death certificates issued nationwide. International Classification of Diseases, 10th revision, codes corresponding to the basic cause of death from CHD and the great vessels. To calculate mortality rates for individuals≥1year of age, population counts from the national population, estimated by the National Population Council for 2000-2015, were used in the denominator; for infant mortality, live birth counts were used. Rates of mortality nationwide, by state, and by socioeconomic region were calculated. The seven socioeconomic regions were elaborated by the National Institute of Statistics and Geography and include the 31 states and Mexico City according to indicators that are related to well-being such as education, occupation, health, housing, and employment. In the period 2000-2015, 70741 individuals among children and adults died from CHD. Age-adjusted mortality rate per 100000 individuals increased from 3.3 to 4. In the age group<1year of age, mortality rate per 100000 live births increased from 143.9 to 217.3. In the period 2000-2015, age-adjusted mortality rate per 100000 individuals increased from 3.3 to 4. Mexico City as region 7 had the highest mortality from CHD and the great vessels.
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