In this study, the investigation of the Electron-Photon Interaction Cross Sections 2017 (EPICS2017) library on the radiation shielding properties of several clay materials is presented. The EPICS2017 library was interpolated in the recommended interpolation law through the EpiXS program. Calculations were made for the mass attenuation coefficients (MACs), mean free paths (MFPs), half-value layers (HVLs), tenth-value layers (TVLs), and effective atomic numbers (Zeff) of the materials, in photon energies ranging between 1 keV and 100 GeV. The results from EPICS2017 were compared with values from experimental and theoretical methods used in characterizing the photon shielding properties. Experimental MACs agreed well with the EPICS2017 evaluations with percent deviations ranging from 0.1–5.3%. The theoretical MAC values derived using EPDL97 and XCOM-NIST strongly agreed with EPICS2017, with percent deviations ranging from 0.0–0.7% for the discrete gamma-ray energies between 609–1764 keV. Overall, ball clay and kaolin clay demonstrated the most desirable radiation shielding characteristics. From these findings, the EPICS2017 library was demonstrated as an important alternative in future photon shielding research of general construction and building materials. The EpiXS is a versatile tool to compute the radiation shielding parameters mentioned, specifically in using EPICS2017 as a photoatomic library.