Ayurvedic Practitioners Research Articles

Review of research work done on Nishamalaki in type 2 Diabetes at institute of Teaching and Research in Ayurveda, Jamnagar

Background: Nisha and Amalaki Churna are most commonly prescribed drugs used individually as well as in combination with other drugs in various diseases by Ayurvedic practitioners. The use of Nisha and Amalaki in Prameha is found in various classical texts, including Brihatrayees, Chakradatta, Bhaishajya Ratnavali among others. Diabetes is a major cause of health concern affecting around 10.5% of population. The most worrisome part is that its incidence is on the rise even in rural areas. Prameha (Madhumeha) wsr to Type 2 Diabetes) has adverse effects on many physiological processes and anatomical structures in the body (Saptadushya) and is considered as Mahagada. Aim of the present study was to compile such research works carried out on Nishamalaki at ITRA, Jamnagar and provide brief information about the studies. Material & methods: Total nine studies on Nishamalaki were screened from various PG departments of Institute of Teaching and Research in Ayurveda, Jamnagar. Results and Conclusion: All studies revealed that Nishamalaki reduces the clinical symptoms of Diabetes. The clinical efficacy has been evaluated in both type 1 (in modified form) and type 2 Diabetes. Satisfactory response with a decrease in the intensity of signs and symptoms was reported in all the studies. No adverse effects were reported in any of these studies.

A walk through the life of luminary Prof. Madhusudan Shastri

Abstract The tradition of teaching and learning through a teacher-disciple lineage is deeply rooted in our country and in Ayurveda. It is important to mention the name of Vaidya Madhusudan Shastri ji in this context. He not only made significant contributions to the field of Ayurveda but also mentored a generation of Ayurvedic practitioners, leaving behind a lasting legacy. Originally from Rajasthan, Vaidya Madhusudan Shastri ji moved to Jamnagar, Gujarat, in 1956. He taught in the Department of Ayurveda Samhita, holding various positions and eventually serving as the Dean. Known for his gentle nature and eloquence, his students highly respected him. Vaidya Madhusudan Shastri ji was renowned for his clinical practice based on a classical patient dietary regime. This article provides a comprehensive look into the life of Vaidya Madhusudan Shastri ji, highlighting his remarkable qualities and achievements in various areas.

Vaidyakulguru Mahakavi Shri Krishnaram Bhatta (1849–1898): A great versifier of Ayurveda therapeutics

Abstract Much of the traditional knowledge related to Ayurveda remains with ancient physicians. Born into a distinguished lineage of royal physicians in Jaipur, Rajasthan, Vaidyakulguru Mahakavi Shri Krishnaram Bhatt was an eminent figure of nineteenth-century India, who excelled in both Ayurveda and literature. His lineage boasted of a rich tradition of Ayurvedic practice, which he carried forward with his intellectual expertise and poetic talent. The information related to his personality and his biography has been compiled with the help of the books written by him, texts written by other authors, and by conducting direct interviews with his family members for this article. Apart from being a prominent scholar of Ayurveda, its medicinal preparations, and its uses, he was also an expert in Sanskrit literature, poetry, and prosody. His educational journey under the guidance of eminent scholars earned him recognition as a polymath. His seminal work, “Siddha-Bheshajamanimala,” is a comprehensive guide to Ayurvedic formulations, reflecting his clinical acumen and poetic prowess. Apart from this, Kachchvansh Mahakavya, Sara-Shatakam, Jaipur-Vilas, Aryalankar-Shatakam, and other works are also among his important works. Despite his untimely demise, the legacy of Shri Krishnaram Bhatt continues to enrich the tradition of Ayurveda through his descendants. His life embodies a harmonious blend of Ayurvedic knowledge and literary excellence, leaving an indelible mark on India’s cultural and intellectual landscape and inspiring future generations of Ayurvedic practitioners.

Geo-Hydrobiology and Geoinformatics Mapping of Ethnobotany in the Gandhamardan Hills, Odisha, India

Objective: The Gandhamardan Hills (GMH)range is a group of small mountains in Peninsular India in Balangir district in Odisha state in India. There is uniqueness in geology, geography, geomorphology, climatology, Hydrology, petrology, and lithology. The lithology, soil, water, geomorphology, and traditional use of plants in Ayurveda (India) have holistic medicinal/surgery. origin. Geo-hydro-biological amalgamation through Geological Information Systems (GIS) and chemical analysis is still being explored, and the present research emphasises such studies. Methods: Data about geo-hydro-biology through grapy, geology, geomorphology, hydrology, and traditional medicinal practices are implored from literature sources, using TOPO and Q-GIS maps and ERDAS software; their analytical interpretations were reported. The chemical analysis was conducted using X-ray fluorescence spectrometric studies of the water and soil of GMH, and the exuberance of ethnobotanical species in GMH was correlated. Results Laboratory analysis, literature studies, and interaction with Ayurvedic and Kaviraj practitioners, 154 popular species databases with their pharmacological applications reported for ordinary people. Many species have multidimensional applications that can transform Ayurveda into Materia medica. Conclusion: This ethnobotanical study documented the use of plants by the local community. The natural medicinal plants are cheap for the rural communities. The information gathered can be used for further scientific investigation to develop new commercial plant-based medicines as they will be safer than synthetic drugs. SDGs 1 to 3 and 12, 13, and 15 will be satisfied if we can conserve and adequately manage the hub of medicinal plants in GMH.

A Comprehensive Review of Dietetic Regimen (Pathya- Apathya) in Skin Disorders

For decades, it was thought that there was no relation between the dermatological conditions or the skin disorders and the diet. But recent studies have made an attempt to explore the relationship between the diet and its role in skin disorders. Ayurvedic system of Medicine also known as the Indian traditional medicine has contributed vastly for the diet and the management of skin disorders. In Ayurveda skin disorders are explained under the name Kustha which are twenty in number and two types as Mahakustha and Kshudra kustha. Since 5000yrs, Ayurveda is serving the society with the objective of curing of the disease and prevention of the same. Ahara has been given the prime importance in Ayurveda and is placed one among the Trayopasthambas or the three pillars of life such as Aaahara (diet), Nidra (sleep) and Brahmacharya (celibacy) In depth of diet for the healthy and also the specific diet for the disorders has been described in Ayurveda and is being practiced by Ayurvedic practitioners since centuries which is witnessed in the latest research studies. The present study has made an attempt to assess both the Modern and Ayurvedic concepts of diet that is presently practiced and their importance in the management of skin disorders.

Exploring the Potential Advantages of Traditional Therapies in Autoimmune Blistering Illnesses: A Comprehensive Review and Analysis, Research

Autoimmune blistering diseases, such as Linear IgA Bullous Dermatosis (LABD) and Chronic Bullous Disease of Childhood (CBDC), provide considerable therapeutic treatment issues. Samana Aushadhis are regularly prescribed by Ayurvedic practitioners as part of therapy regimens for dermatological diseases including LABD and CBDC. Although anecdotal data and clinical observations point to the potential usefulness of traditional medicines in promoting long-term remission and alleviating symptoms, the precise mechanisms by which they exert their therapeutic benefits in LABD/CBD remain incompletely known in contemporary science. The potential advantages of traditional therapies in autoimmune blistering illnesses are being investigated through clinical trials, observational research, and mechanistic investigations. The therapeutic potential of these herbal remedies in LABD and CBDC is being investigated through clinical trials, observational research, and mechanistic investigations. Clinical trials, observational studies, and mechanistic investigations are being conducted in an effort to better understand the therapeutic potential of conventional medications in autoimmune blistering disorders. The effectiveness of these herbal treatments in causing remission and easing symptoms in LABD and CBDC is being closely examined. Overall, while traditional therapies hold promise in the management of autoimmune blistering diseases like LABD and CBDC, more research is necessary to fully understand their mechanisms of action and therapeutic potential. Through rigorous scientific inquiry, the integration of traditional and contemporary medicine may offer new avenues for managing these difficult conditions. Clinical trials, observational research, and mechanistic investigations are all contributing to the exploration of the therapeutic potential of these herbal remedies in LABD and CBDC.

Exploring Rajaswala Paricharya: A Holistic Ayurvedic Perspective on Women's Well-being

Within Ayurveda, menstruation is viewed as a natural physiological process regulated by Doshas, necessitating specific lifestyle adjustments known as Rajaswala Paricharya to maintain women's health and potentially safeguard the well-being of future generations. Despite its intrinsic importance, contemporary awareness and adherence to Rajaswala Paricharya have waned, partly due to the dissemination of misinformation by media and menstrual product manufacturers. While global health initiatives prioritize adolescent reproductive health and sanitation, they often overlook the traditional practices advocated by Ayurveda. Ayurvedic practitioners play a crucial role in advocating for Rajaswala Paricharya to fortify female reproductive health, aiming to prevent Dosha imbalances, Ama formation, and fortify Agni. By encouraging adherence to these guidelines, women may experience reduced menstrual symptoms and better navigate the physiological and psychological changes associated with menstruation. Furthermore, the integration of modern scientific research could provide empirical validation for the efficacy of Rajaswala Paricharya, reinforcing its significance in contemporary women's health practices. Thus, fostering a positive perception and adherence to Rajaswala Paricharya is paramount for empowering women and promoting holistic well-being.

Revolutionizing Education: Crafting a Progressive Teaching Methodology for Ayurveda Undergraduate Courses

In the realm of education, the teaching methodology employed plays a pivotal role in shaping the future practitioners of any field. Ayurveda, being a venerable science with roots deeply embedded in tradition, is ripe for a transformative teaching approach that marries ancient wisdom with contemporary educational practices. The traditional guru-shishya parampara (teacher-student tradition) has been the cornerstone of Ayurvedic education. While the essence of this sacred relationship must be preserved, there is a pressing need to integrate modern teaching methods into Ayurveda undergraduate courses. Embracing innovation, integrating technology, fostering interdisciplinary collaboration, and emphasizing practical experiences will not only elevate the quality of education but also empower the next generation of Ayurvedic practitioners to navigate the complexities of modern healthcare with confidence and competence. It is through such progressive educational approaches that the timeless wisdom of Ayurveda can be seamlessly woven into the fabric of contemporary healthcare practices. This editorial explores the imperative of evolving teaching methodologies to enhance the learning experience for aspiring Ayurvedic practitioners.

Investigating Ayurvedic Strategies: An In-Depth Examination of Managing Diabetes across Different Types.

In light of the escalating global concern surrounding diabetes mellitus, contemporary medical practices predominantly hinge on pharmaceutical interventions, accompanied by inherent side effects and enduring limitations. This investigation accentuates a discernible research void regarding the amalgamation of Ayurvedic principles an age-old traditional medical system with prevalent approaches to diabetes management. Despite Ayurveda's promising potential in furnishing a comprehensive and personalized strategy for diabetes treatment, the imperative for further research and collaboration between Ayurvedic practitioners and contemporary healthcare professionals becomes evident. Existing scholarly works underscore the potential advantages of Ayurveda in delivering holistic diabetes care, encompassing not only glycemic control but also fostering overall well-being. Nevertheless, a closer examination reveals specific limitations, challenges, and gaps in current research, necessitating targeted efforts to enable a more exhaustive exploration of Ayurvedic interventions within diabetes management. This comprehensive review scrutinizes Ayurvedic recommendations pertaining to dietary practices, lifestyle adjustments, and herbal therapeutics, shedding light on their plausible efficacy. It serves as a clarion call for heightened research endeavors, aiming to bridge existing gaps and carve a pathway toward an integrated, patientcentric paradigm in diabetes care. In summary, as diabetes prevalence continues to rise globally, the study underscores the limitations of current pharmaceutical-centric approaches and highlights the need for extensive research and collaboration to unlock the full potential of Ayurvedic principles in providing a more holistic and personalized framework for diabetes management. The review navigates through Ayurvedic recommendations, emphasizing the urgency for intensified research efforts to fill existing gaps and pave the way for a seamlessly integrated, patient-focused approach to diabetes care.

Ayurveda Education Reforms: Nurturing the foundations of Holistic Healthcare

One crucial aspect of Ayurvedic education reform is aligning the curriculum with modern scientific standards. While Ayurveda's ancient wisdom is invaluable, integrating it with contemporary medical knowledge is essential for bridging the gap between tradition and modern healthcare expectations. A curriculum that incorporates evidence-based practices, clinical research, and interdisciplinary studies will empower Ayurvedic practitioners to collaborate seamlessly within the broader healthcare landscape. In conclusion, the need for Ayurveda education reform is not merely a call for change; it is a commitment to preserving and enriching a timeless legacy. By embracing innovation, aligning with scientific standards, and fostering a global perspective, Ayurveda can transcend geographical boundaries to emerge as a formidable force in the realm of holistic healthcare. The reform is not just a necessity; it is an opportunity to unlock the full potential of Ayurveda, ensuring that its wisdom continues to benefit humanity for generations to come.

A Review on Probable Mode of Action of Gandhaka Rasayana - An Ayurvedic Herbo-Mineral Formulation with Multifaceted Action

As per ancient Ayurvedic scholars for getting a desirable outcome of any medication, it should be precisely analysed before prescribing to the patient. There are numbers of classical formulations successfully practiced by Ayurvedic physicians for treating various ailments but in maximum cases there is lack of data regarding their details mechanism of action. Such one multidrug classical formulation is Gandhaka rasayana which is widely practiced Ayurvedic formulation. Gandhaka rasayana have been used in Ayurvedic Rasashastra to treat various types of diseases related to Tvak, Mandhagni, various Srotas. It is a time tested formulation used by Ayurvedic practitioners for correcting Kushta, Indralupta, Vatarakta, Palitya, Dushta vrana, Arumsika etc. Modern scientific world needs explanation and logic behind the mode of action of Gandhaka rasayana with respective to each particular disease. This review is an attempt to explain multiple mode of action of Gandhaka rasayana in various diseases on analysing properties of ingredients. Analysis of mode of action gives deep insight about use of formulation with a better understanding.

Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC

BackgroundJatamansi/Nardostachys jatamansi (NJ) is an important aromatic shrub widely used by Ayurvedic practitioners for centuries due to its usefulness in intellect-enhancing (Medhya), strengthening (Balya), and skin disorders. Several classical dosage forms like hot or cold infusion, decoction, distillate, powders, etc. have been mentioned for NJ. Clinical trials of Jatamansi Oil (JO) as a head massage conducted by clinicians and therapists have shown encouraging results in de-stressing/stress management of cancer patients through head anointing treatment. ObjectiveSuch effective proprietary formulation needs assessment of its characteristics using modern analytical technologies to comprehend the Ayurvedic concept of dermal pharmacology. Materials and methodsTriplicate batches of JO were prepared by evaporating its decoction in sesame oil (SO). Basic physicochemical analysis of the raw material, in-process samples, and finished products was carried out to develop a monograph. Further, raw SO and finished product JO were subjected to TLC, and extracted in hexane and dichloromethane separately for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to profile several bioactive molecules from NJ in the final product, JO. ResultsStandard Operating Procedure was developed and a basic monograph was prepared for JO. GC-MS analysis revealed several phytocompounds dissolved/dispersed in SO after processing, while 18 additional distinct peaks were observed in JO as compared to SO. ConclusionThis preliminary analysis supports the Ayurvedic concept of lipid-based formulations. The plausible phytocompounds anticipated based on retention times can be further quantified and studied for their probable action as anointing treatment. A detailed experimental strategy for understanding the phytochemical changes during the entire process needs to be planned and performed.

IN VITRO INVESTIGATION OF ANTIOXIDANT AND ANTI-UROLITHIATIC ACTIVITY OF HOMONOIA RETUSA ROOTS

Ayurvedic practitioners utilise Pashanabheda as an anti-urolithiatic. The root of Homonoia retusa (Euphorbiaceae), which grows in the Indian town of Tirupathi, was chosen for this study's screening for its antioxidant and anti-urolithiatic properties. The hydrogen peroxide assay (H2O2), ferric reducing antioxidant power (FRAP), and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) techniques were utilised to assess antioxidant activity. The anti-urolithiatic activity was evaluated by nucleation and aggregation assay by adding 0.01 M sodium oxalate solutions that caused the crystallisation of Calcium oxalate. By measuring turbidity in the presence or absence of extract at 620 nm using a spectrophotometer, the effect of extract (200, 400, 600, 800, and 1000 µg/ml) was investigated. According to the result, aqueous root extract can prevent crystal growth and aggregation more than methanol-based root extract.

Vanilla: A Review of Powerful Herb with Ayurvedic Medicinal Properties

Vanilla, derived from the beans of the Vanilla planifolia orchid, is a globally cherished spice known for its sweet aroma and flavor. Beyond its culinary applications, this review delves into the Ayurvedic medicinal properties of vanilla, unraveling its potential as a powerful herb in traditional medicine. Ayurveda, the ancient Indian system of medicine, recognizes vanilla for its diverse therapeutic attributes. The active compounds in vanilla, such as vanillin, contribute to its antioxidant and anti-inflammatory properties. These qualities align with Ayurvedic principles, emphasizing the balance of bodily functions and prevention of diseases. Vanilla has been historically employed to alleviate digestive disorders, respiratory ailments and stress-related conditions. Ayurvedic practitioners harness its calming effects on the nervous system, promoting mental well-being. Moreover, vanilla is explored for its potential antimicrobial properties, adding a layer of significance in the context of Ayurveda where natural remedies play a pivotal role. The herb's use in Ayurvedic formulations underscores its adaptability across diverse health concerns. This review consolidates current scientific research alongside traditional Ayurvedic wisdom to provide a comprehensive understanding of vanilla's medicinal potential. As consumer interest in holistic well-being grows, the integration of vanilla into Ayurvedic practices not only expands its applications but also exemplifies the synergy between traditional and contemporary approaches to health. Unveiling the multifaceted nature of vanilla as a potent herb, this exploration encourages further investigations and applications of its Ayurvedic medicinal properties in modern healthcare.

Nadi Vikriti in Pranavaha Srotas diseases

Ayurveda involves the practice of aligning one's life with the principles of nature. Its aims and objectives include maintaining the perfect health of a healthy person and preventing and curing diseases in an unhealthy person. Dosha, Dhatu, and Mala are the basis of diagnosing and treating any disease. Srotas are the channels of the body that carry Dosha, Dhatu, and Mala in them, which makes its examination vital. Various acharyas have given different types of diagnostic methods like Trividha Pareeksha, Dashvidha Pareeksha, Ashthvidha Pareeksha etc. The concept of Nadi Pareeksha is found under the Ashtavidha Pareeksha mentioned by Yogaratnakar. Nadi Pareeksha is an ancient technique of diagnosis through pulse. Through Nadi, we can determine Prakriti-Vikriti, disorders of Dhatus, Dosha predominance, and vitiation in various Srotas. One such Srotas is the Pranvaha Srotas, which is the channel in our body that maintains our respiration, making it essential for maintaining life and longevity. Hence it becomes crucial to successfully diagnose any vitiation or pathology of this Srotas. If used correctly by ayurvedic practitioners, Nadi Pareeksha can be a cost-effective, valuable diagnostic tool that can help access ailments at a primitive stage.

Artificial intelligence in Ayurveda: Current concepts and prospects

Abstract Background: Artificial intelligence (AI) has become a powerful tool in health care, and its integration with Ayurveda, presents promising opportunities. Aims: This review aims to Explore AI’s role in enhancing Ayurvedic diagnosis, personalized treatments, and drug discovery, challenges related to AI integration in Ayurveda. Methods and Materials: A comprehensive literature search was conducted to identify relevant studies and articles on the integration of AI and Ayurveda. The search included databases such as PubMed, Google Scholar, and relevant journals. The collected data were analyzed to present a comprehensive overview of the topic. Results: AI algorithms analyze patient data to enhance accuracy in diagnosis. They can integrate genomic, lifestyle, and environmental data for precise Prakriti determination. AI can digitize traditional diagnostic tools for standardization, such as pulse and tongue examination. AI tailors personalized treatments based on an individual’s constitution and imbalances. AI accelerates the discovery of medicinal herbs and predicts herb-drug interactions. It formulates personalized herbal combinations, preserving traditional knowledge. AI-driven health monitoring provides personalized lifestyle recommendations based on Ayurvedic principles. Conclusions: The integration of AI into Ayurveda holds promise in transforming traditional medicine and health care. Collaboration between Ayurvedic practitioners, technology experts, and policymakers is essential to address challenges. The future prospects of AI in Ayurveda are bright, offering personalized treatments, preventive health care, and research advancements while preserving Ayurveda’s holistic essence.

Review of Structural and Functional Anatomy of Kidney in Ayurvedic Literature with Special Reference to Diseases of the Kidney

Description of organs and their treatment in Ayurvedic texts is very brief. In today’s world when the diseases of organs like kidneys, heart, liver, and brain etc., are becoming very common, Ayurvedic practitioners find these descriptions inadequate to treat patients with such diseases. An effort was made to assess whether critical analysis of references related to kidneys in classical Ayurvedic texts provide inputs to an Ayurvedic Practitioner to understand the pathogenesis of Chronic Kidney Disease (CKD). Tantrayukti based interpretation of references of kidneys in classical Ayurvedic texts establishes that kidneys were known to, and are elaborately described in Ayurveda, with their anatomical details such as embryological origin, name, number, relation with other abdominal organs, location etc. They are known by the name of Vrukka, which are the abdominal organs that are two in number and are described as Basti Marma (which includes the kidneys, ureter, and Bladder) for the purpose of diagnosis, prognosis, and treatment of all urine related diseases. Basti Marma is one of the three Maha Marmas i.e., most important vital organs of the body viz., Shiro (~brain), Hridaya (~heart) and Basti (~bladders). Vrukka (kidney) is formed from the nutritious part of Kapha, Meda and Rakta, gives the inputs to the practitioner to consider the metabolism of these factors in diagnosis and treatment of CKD. Physiology of formation of urine is also elaborately described in Ayurveda. The reference of Sushruta which discusses about Sahastrshaha Sukshma mukhani (~ thousands of minute openings invisible to naked eye) where urine is formed resembles the description of glomerular filtration. Formation and processing by Samaana, role of Jathar Agni, Dhatvagni and Bhutagni in formation of Mutra (~urine), storage and excretion at the level of Bladder, by Apaana is defined clearly, and this description is of immense value for practitioners. Relation of Basti Marma to Kleda (~body fluids) and its pathological connection with specific diseases is also evident. Understanding of various factors viz., Kleda (~body fluids), Marma (~vital organs), Prana (~life force), Oja (~vitality), Kalaa (~Internal membranes) Jathar Agni, Dhatvagni, Bhutagni etc., and their role in pathogenesis of CKD provides Vaidyas with inputs to devise the line of treatment of patients suffering from CKD, taking into consideration the individual condition of each patient.

Amlapitta in Ayurveda: A Critical Analysis through the Lens of Guna Siddhanta

Abstract: This scientific paper presentation offers a meticulous examination of Amlapitta, a prevalent digestive disorder in Ayurveda, employing the lens of Guna Siddhanta (the theory of qualities) to gain deeper insights into its pathophysiology and therapeutic approaches. Amlapitta, is a very common annavaha srotas vyadhi characterized by symptoms such as katu-amla udgara (hyperacidity), urodaha (heartburn), and avipaka (indigestion). It is a primarily Pitta Dosha Pradhan vyadhi but later on it is associated with other doshas also. The paper delves into the core principles of Guna Siddhanta, elucidating how the interplay of Gunas (qualities) - such as Guru (heavy), Snigdha (unctuous), Tikshna (sharp), and Ushna (hot) - contributes to the manifestation and exacerbation of Amlapitta. It explores the relationship between Amlapitta and dietary factors, emphasizing the role of Guna in aggravating or pacifying the condition. Furthermore, the presentation critically assesses the Samprapti formation, Samprapti vighatana (Ayurvedic pathophysiology) and chikitsa siddhanta (therapeutic approaches) for Amlapitta in the context of Guna Siddhanta. It discusses the selection of appropriate Ahara (diet), Vihaara (lifestyle), and Aushadha (medicinal interventions) based on the concept of Gunas, ensuring a holistic and individualized treatment strategy. In conclusion, this paper offers a unique perspective on Amlapitta by analyzing it through the framework of Guna Siddhanta, providing valuable insights for Ayurvedic practitioners and researchers. It underscores the significance of understanding the subtle qualities of substances and their impact on health, paving the way for more refined and effective Ayurvedic interventions for Amlapitta management.

Preclinical Hemotoxicological Profile Investigations of an Ayurvedic Medication Following Long-Term Adminidration to Male Sprague-Dawley Rats

Kutajarista (KTJ) is an Ayurvedic preparation used as a traditional medicine in ulcerative colitis in the rural population. A self-made alcoholic preparation derived from the Indian Medical System known as Kutajarishta. The main ingredient in this polyherbal combination is Holarrhena antidysenterica Wall. Ex DC (Family: Apocynaceae). It is used to treat gastrointestinal disorders, diarrhea, and amebic dysentery. Ayurvedic practitioners have been using Kutaja formulations for centuries, as they have been found to be quite helpful clinically in certain diseases. This study was conducted using mainly old literature as a basis method. At a dose of 40 milliliters per kilogram, KTJ was given chronically to male Sprague-Dawley rats in order to determine its toxicological characteristics. Following a continuous 28-day KTJ preparation administration, the following toxicological alterations were observed. Several erythrocytic parameters were found in this experiment. The anemia panel studies' findings are as follows: The total amount of red blood cells in the male rat has decreased by [7.98%]. This drop was noticeable (p=0.083) even if it was not statistically significant. There is a [8.08 %] decrease in the Hemoglobin content of the blood of the male rat, the decrease though not significant yet it was prominent (p=0.097). There is a [8.03 %] decrease in the Hematocrit level of the blood of the male rat, the decrease though not significant yet it was prominent (p=0.072). There is a statistically insignificant (p=0.882) [0.19 %] increase in the Mean corpuscular volume, a red cell index of the male rat. There is a statistically insignificant (p=0.420) [3.02 %] decrease in the Mean corpuscular hemoglobin, a red cell index of the male rat. A statistically insignificant (p=0.203) [8.50 %] increase in the red cell volume distribution width, a red cell index of the male rat, is observed, along with a negligible [3.01 %] decrease in the Mean corpuscular hemoglobin concentration, a red cell index of the male rat, which was statistically not at all significant (p=0.561).

A Review of Punarnava’s Pharmacological Profile Focusing on its Beneficial and Adverse Effects

Background: Punarnava is recognized as an essential remedy because it treats a wide range of health problems. It is commonly known as a rejuvenator. Its chemical constituents are all responsible for pharmacological activity in the body in some ways. There is a lot of evidence that the leaves, stems, and roots can be used as medicine. Objective: The morphological, chemical, and pharmacological characteristics of Boerhaavia diffusa are discussed in this article. The purpose of this review is to discuss the pharmacological profile of Punarnava and its chemical elements, as well as the benefits and drawbacks of its steroidal component β-Ecdysone. Method: This article compiled information by reviewing a variety of published articles and research papers from several sources, including Research Gate, WJPRT, IJPSM, Elsevier, Taylor & Francis, Springer Nature, and The Journal of Ayurveda and Integrated Medicine. Result: It is a widely used remedy for numerous ailments among diverse cultural groups, Ayurvedic, and traditional practitioners. To some extent, it is used in a variety of formulations to treat sciatica, cancer, immunomodulation, obesity, diabetes, jaundice, inflammation, asthma, rheumatism, nephrological difficulties, ascites, anemia, and gynaecological disorders. Conclusion: Herbal medications are becoming increasingly popular nowadays. Punarnava is one of the most beneficial herbs available. More analysis is needed to investigate the impacts of each chemical ingredient in Punarnava. β-Ecdysone is a key component of Punarnava, which is both beneficial and detrimental to humans in different ways. Hence, further research is also needed to emphasize the impacts of each Punarnava chemical ingredient.