Ayurvedic Formulation Research Articles

Evaluation of the wound healing effect of Nishamalaki, an Ayurvedic formulation comprising Curcuma longa and Phyllanthus emblica in aging rats

BackgroundThere are very few drugs available for healing wounds in the aged population, which is more prone to chronic cutaneous wounds that are particularly hard to heal and require a long healing process. This study which deals with age-related wound healing, investigates the healing effect of Nishamalaki, a classic antidiabetic Ayurvedic formulation comprising turmeric (Curcuma longa) and Indian gooseberry (Phyllanthus emblica), on cutaneous wounds in aging rats.MethodsRats with excision wounds of 7 mm created on their dorsal side received Nishamalaki (500 mg/kg p.o) daily, or a combination of Nishamalaki (500 mg/kg p.o) with 1% Nishamalaki gel applied on the wound or the reference standard metformin (2 μmol) applied on the wound daily till the scabs fell off.ResultsAll treatments enhanced the rate of formation of granulation tissue and wound contraction. All treated rats showed lower blood glucose levels compared with their 1st-day values and significantly lower blood glucose levels when compared with the Aged Control rats. A significant restoration of the aging-depleted L-hydroxyproline, hexosamine, ascorbic acid, PDGF, AMPK, and mTOR levels, and attenuation of the aging-elevated IL-6 and TNF-α levels was elicited by all treatments. The treatments significantly restored the aging-depleted endogenous antioxidants. The Nishamalaki combination treatment of the oral extract and topical gel displayed a better wound-healing effect than the oral treatment alone. The histopathological studies on skin ulceration, hair follicles, granulation tissue, and collagen fiber formation of the wound tissues corroborated the biochemical findings.ConclusionCurcumin and other antioxidant polyphenolic components of Nishamalaki may be responsible for its wound-healing effect. For the first time, the present study has investigated the action of PDGF, AMPK, and mTOR on cutaneous wounds. They seem to be acting together to promote wound healing and repair.Graphical

Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation

Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.

Evaluation and standarisation of Shatavaryadi Churna

Introduction-The Ayurvedic medical system has recently got a lot of medical and healthcare services in India. To evaluate the quality, safety, and effectiveness of the medicine, standards and purity of herbal formulation are crucial. However, pharmacopoeia testing is the protocol that all medicines must follow in order to be accepted globally. A compound herbal formulation called Shatvaryadi Churna is suggested for the treatment of a number of diseases. For the treatment of Timira Vyadhi, patal vyadhi, kancha vyadhi and many other raktaj vikara the formulation was documented in the Ayurvedic classic Yoga Ratnakar. Materials & methods- Shatavaryadi Churna was made by using the standard procedure with all aseptic precautions and as described in the Ayurvedic Pharmacopoeia for Churna Kalpana (Powder Preparation). The manufactured medication has been standardised by adhering to the approved pharmacopeial protocol for quality control procedures. Results- Organoleptic parameters, physiochemical evaluation, and microbiological load test was done these analytical values were within the expected limits.

NYCTANTHES ARBORTRITIS LINN: AN ETHNOPHARMACOLOGICAL MIRACULOUS NATURAL RESOURCE

Nyctanthes arbortritis (Parijat tree) is a medicinal plant that has long been utilized in a variety of Ayurvedic formulations to treat a range of ailments. Many medicinal qualities like analgesic, antipyretic, antifungal, antibacterial, and anti-cancer properties, have been identified through comprehensive research on the pharmacological screening of Nyctanthes arbortritis. It has been demonstrated that the plant both inhibits the growth of certain cancer cells and has cytotoxic effects on them. As a promising therapy option for a range of inflammatory and pain related disorders, the extracts of its different plant parts have also been discovered to possess strong anti-inflammatory and analgesic activity. The plant extracts also have strong antifungal and antibacterial properties, which makes them a possible medicinal source for the creation of novel antibiotics. In this article, we have represented the collective scientific information about the various phytoconstituents and pharmacological activities of the Nyctanthes arbortritis.

Ayurvedic Management of Pancreatitis

Pancreatitis is the life threatening metabolic pathology of the gastrointestinal system. It progressively damages the pancreas and result in the loss of its functions. The prevalence rate of pancreatitis in India is 7.9 per 10, 0000. For male and female respectively 8.6 and 8 in India. With overall 10 year and 20 year survival rates are estimated to be about 70% to 45% respectively. In the contemporary science the treatment protocol is limited to painkillers, intravenous fluids and pancreatic enzymes. Despite of advance techniques in the allopathic science the prognosis of the disease is unclear. Ayurvedic formulations of mineral complex including a diet and moderate rest have shown excellent result. In this case report a 40 year old male patient a known case of chronic pancreatitis with recurrent abdominal pain which radiates to back, nausea, vomiting, tenderness, anorexia, along with elevated serum amylase level was managed effectively with Ayurvedic medications by the Department of PG Study in Shalyatantra OPD Dr. BRKR Government Ayurvedic Medical College and Hospital, Hyderabad. In Ayurveda this condition can be correlated Agnashayashoth which comes under Pittodara. And it was successfully treated with the medications like Shankha vati, Kravyadi ras, Arogyavardgani vati. Within 4 months of treatment patient become normal. There was no pain abdomen, nausea, vomiting, bloating of abdomen. And serum amylase came to its normal level. This shows that Ayurvedic herbo mineral formulations showing promising result in the management of pancreatitis.

Development of Analytical Profile of Ocimum sanctum L. leaves Powder prepared by Classical and Lyophilization method through Accelerated Stability Studies

Shelf life means the time period during which the potency of a drug remains unaffected from environmental factors or microbial contamination. Nowadays diverse procedures of making powder are available which affect on shelf life of them. Ocimum sanctum L. is most common household herb in Indian subcontinent. Hence, the present study is aimed to develop analytical profile of Ocimum sanctum L. leaves powder by classical and lyophilized method and compare the stability of both the samples. Materials and Methods: Ocimum sanctum L. leaves powder was prepared by two different drying methods and accelerated stability study was conducted as per ICH guideline Q1A (R2). Physicochemical analysis was repeated at interval of 0, 1, 3 and 6 months. Organoleptic parameters, microbial limits and heavy-metal analysis were observed at specific intervals. Result and Discussion: No significant changes were observed in organoleptic characters of both the samples up to storage of 6 months at accelerated condition. The values of physicochemical parameters of both the samples were within the prescribed limit specified in Ayurvedic Pharmacopeia of India. Results of Microbiological limit test were also below the limit and considerably decreased at specific intervals. Heavy metals namely arsenic, cadmium and mercury were not detected and lead was present below detectable limits. Conclusion: Analysis revealed that the classically prepared powder has better shelf life (3.08 years) than lyophilized powder (2.70 years) and also provides the modest and effective ways for optimal Eugenol extraction in accelerated conditions.

Determination of Polyphenolic Compounds Present in Guduchyadi Kashaya Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

The utilization of various contemporary analytical methods has become indispensable when it comes to assessing polyherbal Ayurvedic formulations, aiming to ensure their quality, safety, and effectiveness. Quality control of herbal medicines involve analytical evaluation using instrumental techniques such as TLC, HPTLC, HPLC, GC-MS, LC-MS and spectrophotometer etc. Among them Liquid Chromatography with tandem Mass Spectrometry (LC-MS/MS) is a powerful hyphenated analytical technique that combines the separating power of liquid chromatography with the mass analysis capabilities of mass spectrometry. Generally, its application is oriented towards the specific detection and potential identification of chemicals in a complex mixture. Polyphenolic compounds are usually referred to as a diverse group of naturally occurring compounds containing multiple phenolic functionalities. The anti-inflammatory, anti-aging, antiproliferative, and antioxidant like biological properties of phenolic compounds have been described in several studies. This research study was taken to analyse polyphenolic compounds in Guduchyadi kashaya by LC-MS/MS. Phenolic compounds are abundant in the ingredients of Guduchyadi kashaya, as evidenced by previous studies. So, to determine the polyphenolic contents of Guduchyadi kashaya, this study was conducted. The quantification of the polyphenols was carried out on Shimadzu Shim Pack GISS C18 column with .1%formic acid as mobile phase. A total of 28 polyphenolic compounds were analysed, and 24 of these compounds were found to be present in Guduchyadi kashaya. The results showed that the phenolic compounds present in the ingredients were also present in the formulation in high abundance.

Management of Primary Hyperhidrosis With <i>Patolakaturohinyadi Kashayam</i> and <i>Shireeshadi Choornam</i> (<i>Avachoornana</i>) – A Case Report

ABSTRACT Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.

Ayush Kwath: A Major Contribution of Ayurveda in Preventing COVID- 19 Infection

Background: Ayush Kwath is an Ayurvedic polyherbal formulation (PHF) of dry Tulsi leaves, Cinnamon bark, Sunthi rhizome, and black pepper fruit. Methods: This PHF contain phytochemicals that help in boosting immunity; hence, it is suggested as a preventive measure against the coronavirus. Ayurveda is an ancient Indian medicine system that offers treatment for various diseases with the help of herbal, animal, or mineral-based formulations. Currently, the entire globe is facing the challenge of combating the COVID-19 pandemic. COVID-19 (Coronavirus disease 19) is a highly infectious disease caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus-2) that belongs to a large family of coronaviruses. Results: Most people who are affected by this virus experience mild to moderate symptoms of pneumonia, but older people or those with weakened immune systems, for example, those suffering from cancer, diabetes, cardiovascular disease, or chronic respiratory diseases, are more likely to develop serious respiratory illnesses. As there is no registered medicine against COVID-19, strengthening the immune system is an effective way to tackle this disease. Conclusion: Ayush Kwath, a natural immunity booster, has been approved by the Ministry of AYUSH as a prophylactic measure to fight against novel coronavirus infection.

Isolation, Formulation and Assessment of Anti-inflammatory Properties of Ursolic Acid from<i> Nerium oleander</i>

Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model. Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA. Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.

Analytical and antimicrobial study of herbo-mineral formulation Shwasakasari Rasa in selected respiratory micro-organism

Shwasakasari Rasa (SKR) is mentioned in Rasa Yoga Sagar,[1] (part 2) as a remedy of Shwasa & Kaasa Roga. This type of Rasa Aushadhi are more effective against bacteria. These drugs have a multi dimension effect like Broad-spectrum antibiotics. The Rasaushadies mentioned in Ayurvedic Pharmacopoeia should be analysed for physical & chemical properties to confirm purity & safety before administration in human beings. Hence it become obligatory to adopt modern analytical methodology for better understanding and interpretation of physio-chemical changes occurred during the process. SKR was analysed on the following parameter Organoleptic parameter, Physiochemical analysis, Advanced physiochemical analysis. SKR sample was tested for antimicrobial activity against standard strains of Staphylococcus aureus, Klebsiella pneumonia and Streptococcus pneumonia. The prepared Shwasakasari Rasa was studied for their MIC (Minimum Inhibitory Concentration & the zone of inhibition. The prepared drug was compared with Azithromycin (standard drug) of macrolide group to evaluate its antimicrobial efficacy. These tests was conducted in, S.R Labs & Research Centre, Jaipur.

A Study on Paradiguna (Samskara) W.S.R to “Samaskarohi Gunantaradhanam Uchyate” and ITS Applied Aspect in the Management of Mukhadushika with an Indiginous Drug

Introduction: Acharya Charaka has clearly said that if one does not understand these Paradi Guna in proper way then he cannot perform Chikitsa in desire manner. Paradi Gunas are the one in which a physician needs to be expertise. Paradigunas are necessary in the field of pharmaceutical science, as well as by the physicians to treat the patients and researchers conducting research and creating new formulation. Samskara Guna is one of the important factors in the hands of Ayurvedic physician for improving other third padas of Bhesaja (i.e., Bahuta, Yogyatwa, and Sampat). Thus in this study, an attempt was made to know the comparative effect of Manjistha Lepa and Samskrita Manjistha with Madhu Lepa in the management of Mukhadushika. Aims and Objectives: The aim of the study was to study about the comparative clinical efficacy of Manjistha Lepa and triturated with Madhu Lepa in the management of Mukhadushika. Materials and Methods: This is a single-blind comparative clinical study with a pre-test and post-test design. The patients were randomly categorized into two groups. Forty patients of Group A (20) and Group B (20) patients were registered from outpatient department of Government Ayurvedic College and Hospital, Balangir, and Saradeswari Government Hospital, Balangir, presented with subjective parameters and objective parameters. After diagnosis, they were under trial with Ayurvedic formulations of Manjistha Lepa for local application and Manjistha triturated Madhu Lepa given 05 g in morning time daily, after drying face wash with normal water for 15 days, respectively. The subjective and objective parameters were assessed in 7-day interval to interpret the result by statistical evaluation. Observation and Results: It had been observed that the result of trial drug Group B patients was significant (<0.05) to reduce both subjective and objective parameters after 15 days of treatment as compared to Group A patients. In Group A, NO patients had marked improvement, while 15% of patients had moderate improvement, 65% mildly improved and 20% had shown unsatisfactory result. In Group B, no patients had marked improvement, 50% moderate, 40% mildly improved, and 10% of patients showed unsatisfactory results. In both groups, the result was statistically significant, but more improvement was noticed in Group B. Conclusion: On comparison between two groups, Manjistha triturated with Madhu Lepa in Group B had shown more effect than Manjistha Lepa in Group A. No adverse effects were noticed during clinical trial in both groups.

Randomised controlled clinical study to evaluate the efficacy of Rajinidvandvadi Kwatha and Nisha Amalaki Kwatha in Prameha Upadrava vis-a-vis Diabetic Peripheral Neuropathy

In Ayurveda, although there is no direct correlation for Diabetic Peripheral Neuropathy but the most basic symptoms mentioned under Purvaroopa and Upadrava of Prameha such as Karapada Daha, Karapadasuptata, Toda (Shoola), Harsha / Chuchumaya (tingling sensation), Shosha (wasting), Dourbalya (weakness), and Angasaad (malaise) all these resemble the condition of DPN. Pathology behind it is can be studied under Madhumeha Upadrava caused by Avarana Janya Vata Prakopa. And Upadravas are those which develop after the onset of main disease and are dependent on Pradhaana Vyadhi. It will have the same Nidaana, Dosha, and Dushyas as that of the main Disease, though they have Samprapti of its own. When main Disease is managed well, complications will disappear. With this intention, Rajanidvandvadi Kwatha one of the classical Ayurvedic formulations mentioned under Prameha whose all the ingredients are herbal in origin and are known to have Pitta and Vatahara effects but its efficacy has not been documented. Also, Rajani (Nisha) is considered to be Agraoushadha (Drug of choice) in Prameha hence an effort has been made to evaluate the efficacy of Rajanidvandvadi Kwatha in Prameha Upadrava.

Review on purification and incineration of Maharasa varga: Unveiling the alchemical processes in Rasashastra

Rasashastra is a distinctive branch of Ayurveda that focuses on the pharmaceutics of medicines derived from minerals, metals, animal products, and more, classifying drugs into various groups. Following Rasa, the next crucial category of minerals is named Maharasa. The most valuable medications are characterized within the Maharasa group. Purification and incineration are essential processes in the field of Rasashastra; Maharasa Varga undergoes these processes to enhance its therapeutic potential. Purification involves multiple stages of soaking, rinsing, and drying the raw material to eliminate impurities and toxins. Each purification step aims to refine the mineral, resulting in a purified product. Incineration, or calcination, follows purification and subjects the material to controlled high temperatures, transforming it into ash. This process further eliminates impurities and enhances the chemical and energetic properties of the substance. The resulting ash is then utilized in Ayurvedic formulations for medicinal purposes. This article provides an overview of the purification and incineration techniques employed in the preparation of Maharasa Varga, offering insights into the unique practices of Rasashastra and their significance in Ayurvedic medicine.

Estimation of Quality, Safety and Efficacy of Ashwagandhadi Leha Using Chromatographic Technique

Ashwagandhadi leha falls under the category of avaleha-paka group of Ayurvedic formulations. If the raw material to be used in a formulation and routine checking stage by stage processes of manufacture are standardized, the resulted product can be expected to confirmed uniform standard, therefore present study envisaged to develop quality control parameters in order to evaluate the quality, safety and efficacy of the formulation (Ashwagandhadi leha).

Therapeutic uses of Cannabis in Indian Traditional medicine with attention on Gastrointestinal disorders

Ayurveda is the world's oldest and most complete spiritual teachings, as well as the "oldest medicinal system" known to man. Ayurvedic treatments along with natural substances do not have any usual side effects as contemporary drugs. The cannabis plant has been used as a medicine for thousands of years to treat various illnesses including gastrointestinal disorders. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well-known and researched phyto cannabinoids, with impressive therapeutic properties for a variety of neurological, gastrointestinal, ophthalmic, and skin problems. Cannabis and cannabinoids are beneficial in healing the sign and symptoms of several gastrointestinal diseases, according to research, in part because they interact with the digestive tracts endogenous cannabinoid receptors. This could help in relaxing pain and cramps, reducing discomfort, and improving motility. Many Indian classical formulations were found cannabis is used processing agent in pharmaceuticals. For the treatment of GI issues, there are some popular cannabis-based ayurveda or herbal formulations on the market. CBD levels are frequently higher in medical marijuana, while THC levels are lower. For certain people, the therapeutic CBD is desirable for medicinal purposes, but the psychoactive THC may be needless and undesired. There are numbers of traditional cannabis formulations on the market that lack standardised quality control parameters and methods of evaluation.So, there is a need to develop a standardization technique with special reference to CBD and THC content to include this system of medicine in the main stream of health science. Standardization of popular Ayurvedic or herbal formulations is essential in order to assess the quality, safety, efficacy of that.

MANAGEMENT OF ASRIGDRA W.S.R. TO DUB- CASE STUDY

In Ayurveda, the most common bleeding disorders in women are referred to as Asrigdara and are characterised by Pradirana (excess excretion) of Raja (menstrual blood). In modern medicine, it is called "Dysfunctional Uter-ine Bleeding." Despite their high costs, hormonal therapy, anti-prostaglandins, and anti-fibrinolytic agents have not proven their definitive efficacy in modern medicine; their side effects have resulted in hormonal imbalances. In Ayurvedic classics, all gynaecological disorders are classified as Yonivyapad. Charaka Acharya Raktapra-dara is described as Pradara Roga by Charaka Aacharya. Excessive vaginal white discharge is referred to as Shweta Pradara and excessive or heavy menstrual bleeding is referred to as Raktapradara. It is known as Pra-dara due to pradirana (excessive excretion) of raja (menstrual blood) and Asrigdara due to dirana (excessive excretion) of Asrk (menstrual blood). Menorrhagia is treated with Haemostatic, analgesic, and hormonal thera-pies in modern medicine, which has limitations. As a result, an integrated and comprehensive therapeutic inter-vention in Ayurveda is required to prevent recurrence. Sodhana and Shamana therapies are recommended, but if Rugnabala is low, only Shamana is recommended. Many herbals and herbo-mineral preparations are mentioned in Ayurveda to treat Asrgdara and related symptoms, and these can be used according to Anubandha Dosha and Lakshana. Because Asrgdara is primarily caused by Vata Pitta Dosha, Kashaya Rasa and Pittashamaka Chikitsa may be used. Ayurvedic formulations aid in the breakdown of Asrgdara pathogeneses and their recur-rence.

Quality assessment, HPTLC-DPPH, analytical quality by design based HPTLC method development for estimation of piperine in piper species and marketed formulations

BackgroundQuality assessment of herbs is an essential aspect. In this study HPTLC method is developed by employing the quality based optimization approach with the aid of analytical quality by design tools and the quality assessment of the Piper species. ResultThe Quality assessment was carried out for the piper species which was under the acceptance criteria of Ayurvedic Pharmacopeia of India. Eco-friendly and Quality based HPTLC method was developed and validated for Piperine in Extracts as well as marketed formulation. Further the antioxidant potential was checked by the HPTLC-DPPH (2,2-diphenyl-1-picrylhydrazyl) method. ConclusionQuality assessed extracts and Analytical quality based HPTLC method which was eco-friendly, simple and reliable was developed and validated.

Accelerated Stability Study of Kailas Jeevan – A Proprietary Ayurvedic formulation

Background: Stability studies are the test to assess the shelf life of the Ayurvedic proprietary medicines. Govt. of India made mandatary test for licencing and renewal of licencing of the proprietary medicine. Accelerated stability studies, testing interval of 0,3 and 6 months. Kailas Jeevan is a proprietary semisolid dosage form prepared in GMP approved Ayurveda Sumshodanalaya (P) Pvt. Ltd. Dhayri, Pune. It is indicated in Constipation, Cracked heels, Wounds, Pimples, Burns etc.
 Aims and Objectives: To evaluate the shelf life of Kailas Jeevan through accelerated stability study. Materials and Methods: The formulation was prepared in the GMP approved pharmacy. Shelf life of product was evaluated by assessing in changes in physicochemical, Microbial and quantification profiles, after keeping it in stability chamber at specific temperature (40±2°C) and relative humidity (75±5%). Analysis was carried out at the intervals of 0, 1, 3, 6, 9,12, 18 and 24 months. Average 25% degradation time was calculated to find the shelf life as per the Ayurvedic Pharmacopoea of India, Part I Vol ix guidelines. Results and Conclusion: The parameters assessed in accelerated study of Kailas Jeevan, was shown under limits till 24 months. Based on multiplication factor shelf life of Kailas Jeevan is 7.02 year.
 Key Words: Stability, Shelf life, Kailas Jeevan, Accelerated stability study

Ayurvedic Management of Adenomyosis

Adenomyosis is a gynaecologic condition characterized by ectopic endometrial tissue within the uterine myometrium. Adenomyosis, if not treated can lead to endometriosis, and hence can lead to more complications and hysterectomy might be the option. But by using Ayurvedic formulation with properties like Anulomaka, Vatashamaka, Lekhagana, Rakta prasadaka etc properties patient got significant relief from pain and irregular menses along with improvement in quality of life. Uterine adenomyosis is a benign condition in which endometrium like epithelial and stromal tissues appear in myometrium, surrounded by hypertrophic smooth muscle. Endometrial cells from the lining of endometrial cavity, migrate; most commonly into the posterior side or back wall of uterus, as these cells respond to monthly hormonal change. Severity and symptoms associated with adenomyosis, directly proportional to degree of involvement and penetration of uterine muscle. Adenomyosis can cause heavy menstrual bleeding (cyclic or acyclic) or scanty menstruation (oligomennorhoea or hypomenorrhoea) along with dysmenorrhoea. So in this case study patient having adenomyosis presented symptom of dysmenorrhoea with scanty menses and irregular menses. In this study there is Sanga of Doshas predominantly of Vata- kapha, so Lekhana is accepted and Vatavaigunya is present were Mamsa-rakta dusti is present, so Vatanulomana and Rakta prasadan chikitsa is adapted. So adenomyosis can be compared in Ayurveda with Udavartini yonivyapada among 20 Yonivyapada.