O-31B6-4 Background/Aims: Our goal is to produce indicators for the surveillance of Canadians' exposures to environmental carcinogens that reflect spatial variability. Methods: We developed a spreadsheet-based tool to estimate life-stage weighted average daily intake. Factors considered include frequency of detection, bodyweight, intake rates, and time spent indoor and outdoor for 5 life-stages (infant, small child, child, teen, and adult). Using benzene as an example, we populated the tool with data from the National Air Pollution Surveillance network, Canadian Food Inspection Agency reports, US Food and Drug Administration Total Diet Study reports, the 2006 Statistics Canada Food Statistics report, California Office of Environmental Health Hazard Assessment cancer potency values, and peer-reviewed literature. For outdoor air, we linked the results with a spatial model of benzene concentrations and block point population data from Statistics Canada. Results: Estimated lifetime average daily intake levels (and associated cancer risk) are: outdoor air, 3.4 μg/d (1:161,000); indoor air, 32 μg/d of benzene (1:20,250); drinking water, 1.5 μg/day (1:388,500); and food, less than 2.25 × 10–6 μg/day (>1:114 billion). After including the spatial variation in population locations and outdoor benzene concentrations, we assigned estimated excess lifetime risk for each of 487,000 block point locations (50th percentile = 1:263,000, 5th percentile = 1:399,000; 95th percentile = 1:75,250). Overall, we estimate that in 2006, the lifetime excess risk of cancer was 1:100,000 or more for 11.1 million Canadians, 35 percent of the total population. Conclusion: The tool provides a flexible but comprehensive method for producing comparable screening level indicators of exposure and excess cancer risk for numerous known and suspected carcinogens. Incorporating spatial variation, when appropriate, provides a new level of detail that aids in targeting prevention efforts.