The current research is crucial in order to foster inclusive Islamic education for children with Down syndrome as well as address their psychological well-being. This study aimed to investigate diverse Islamic education methods suitable for children with Down syndrome while emphasizing the importance of educators employing Islamic teaching strategies. This research employed a qualitative approach and the Systematic Literature Review (SLR) method to evaluate the intersection of Islamic learning methods and Down Syndrome. The published papers discussed in this study were obtained using the Publish or Perish 8 software. The papers must be published within the five-year timeframe between 2018 and 2023 with the keywords "Islamic Learning Methods" and "Down Syndrome." The search of papers resulted in the discovery of 222 articles discussing Islamic methods, and only 16 were specific to Down Syndrome, with only four of them addressing the application of Islamic teaching methods for individuals with Down Syndrome. The findings of this study highlighted teaching strategies such as On-Task Conduct, Imitation, Discriminative Usage of Objects, and Word Recognition. The study identifies three main learning strategies for students with Down syndrome: the Talaqqi wa Musyafahah, Quran therapy, and Islamic Full Communication methods. This study concluded the necessity for further research on modified educational approaches that effectively support the learning and well-being of children with Down syndrome within the context of Islamic education.