The ejectors are crucial in enhancing the efficiency of the CO2-based refrigeration cycle. Although the ejector can be optimized by experimental and computational fluid dynamic simulation to improve its performance, these methods are time-consuming and complicated. This research aims to present a fast and systematic approach for optimizing CO2 ejector by combining variance analysis, surrogate model, and non-dominated sorting genetic algorithm. Firstly, the key geometric structures affecting the performance of ejector were determined by variance analysis. Secondly, the influence of key geometric structures and boundary conditions on ejector efficiency and entrainment ratio was analyzed by using computational fluid dynamic simulation, and the database was generated. Next, the artificial neural network surrogate model was established to forecast the ejector performance. Finally, the non-dominated sorting genetic algorithm was involved to optimize the ejector for maximizing ejector efficiency and entrainment ratio. The results show that the efficiencies of the optimized ejectors are above 42%, and the entrainment ratios exceed 0.7. Compared with the basic model, the average efficiencies have increased about 13.20%. When the pressure lift is 0.7 MPa, the entrainment ratios of the optimized ejectors are 0.696 (−20 °C ≤ Te < −15 °C), 0.82(-15 °C ≤ Te < −5 °C), 0.60 (−5 °C ≤ Te < 5 °C) and 0.90 (5 °C ≤ Te < 15 °C), respectively. The above research demonstrates that the success of this approach in addressing time-consuming multi-optimization problems. It offers a fast and systematic approach for the multi-objective optimization of CO2 ejector as a valuable reference for engineering applications.
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