The energy dissipation in Wireless Body Area Network (WBAN) systems is the biggest concern as it proportionally affects the system longevity. This energy dissipation in the WBAN system mainly takes place due to the signal interference from other networks causing reduction on the dimensionality. The data prediction in WBAN is also a considerable concern corresponding to misinterpretations and faults in the signals. In this paper a novel combination of Principle Component Analysis (PCA) pre-processing along with optimization using the conjugate gradient descent algorithm is proposed. Experimental observations show an improvement in the mean square error and the regression based correlation coefficient when compared to other standard techniques.