The results of the evaluation of the antioxidant effect of therapeutic and prophylactic programs based on the use of drinking mineral water, the original phytocomplex, natural koumiss in combination with hydrogen sulphide baths and physical training in 273 people at risk of developing atherosclerosis in a sanatorium are presented. It is established that the developed programs contribute to the inhibition of the processes of lipid peroxidation with a decrease in the level of diene conjugates, malonic dialdehyde, ketodienes and conjugated trienes, lead to an increase in the activity of antioxidant catalase enzymes, superoxide dismutase, an increase in the overall antioxidant activity of blood plasma, with an increase in adaptive and reserve capabilities of cardiovascular system, cardiovascular system in persons at risk of developing atherosclerosis.