Antibacterial Polymer Research Articles

Polymer Blends Based on 1-Hexadecyl-3-methyl Imidazolium 1,3-Dimethyl 5-Sulfoisophthalate Ionic Liquid: Thermo-Mechanical, Surface Morphology and Antibacterial Properties.

In this study, antibacterial polymer blends based on Polyvinyl Chloride (PVC) and Polystyrene-Ethylene-Butylene-Styrene (SEBS), loaded with the ionic liquid (IL) 1-hexadecyl-3-methyl imidazolium 1,3-dimethyl 5-sulfoisophthalate (HdmimDMSIP) at three different concentrations (1%, 5%, and 10%), were produced. The IL/blends were characterized by their thermo-mechanical properties, surface morphology, and wettability. IL release from the blends was also evaluated. The agar diffusion method was used to test the antibacterial activity of the blends against Staphylococcus epidermidis and Escherichia coli. Results from thermal analyses showed compatibility between the IL and the PVC matrix, while phase separation in the SEBS/IL blends was observed. These results were confirmed using PY-GC MS data. SEM analyses highlighted abundant IL deposition on PVC blend film surfaces containing the IL at 5-10% concentrations, whereas the SEBS blend film surfaces showed irregular structures similar to islands of different sizes. Data on water contact angle proved that the loading of the IL into both polymer matrices induced higher wettability of the blends' surfaces, mostly in the SEBS films. The mechanical analyses evidenced a lowering of Young's Modulus, Tensile Stress, and Strain at Break in the SEBS blends, according to IL concentration. The PVC/IL blends showed a similar trend, but with an increase in the Strain at Break as IL concentration in the blends increased. Both PVC/IL and SEBS/IL blends displayed the best performance against Staphylococcus epidermidis, being active at low concentration (1%), whereas the antimicrobial activity against Escherichia coli was lower than that of S. epidermidis. Release data highlighted an IL dose-dependent release. These results are promising for a versatile use of these antimicrobial polymers in a variety of fields.

Enhanced Bacterial-Infected Wound Healing by Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with Self-Optimized Cooperative Multi-Point Anchoring.

Polymeric systems that provide cationic charges or biocide-release therapeutics are used to treat the bacteria-infected wound. However, most antibacterial polymers based on topologies with restricted molecular dynamics still do not satisfy the clinical requirements due to their limited antibacterial efficacy at safe concentrations in vivo. Here a NO-releasing topological supramolecular nanocarrier with rotatable and slidable molecular entities is reported to provide conformational freedom to promote the interactions between the carrier and the pathogenic microbes, hence greatly improving the antibacterial performance. With improved contacting-killing and efficient delivery of NO biocide from the molecularly dynamic cationic ligand design, the NO-loaded topological nanocarrier achieves excellent antibacterial and anti-biofilm effects via destroying the bacterial membrane and DNA. MRSA-infected rat model is also brought out to demonstrate its wound-healing effect with neglectable toxicity in vivo. Introducing flexible molecular motions into therapeutic polymeric systems is a general design to enhance the healing of a range of diseases.

Preparation and Functionalization of Cellulose Nanofibers/Polymer Composite Particles Using Various Kinds of Core Polymers

In the present study, we investigated the development of dry powders comprising polymer particles covered with cellulose nanofibers （CNFs）. CNFs with uniform widths can prepared from wood cellulose by TEMPO （2,2,6,6-tetramethylpiperidine-1-oxyl）-mediated oxidation, which introduces carboxy groups onto the surface of the cellulose. Divinylbenzene （DVB） monomer droplets are stabilized by CNFs in an aqueous emulsion system, and it is possible to obtain poly-DVB （pDVB） microparticles that are densely covered with CNFs by polymerizing the DVB in such a system. Herein, we developed an approach to fabricating CNF-shelled composite microparticles with cores comprising various types of polymers, and investigated the properties of their carriers.We found that it was easier to stabilize the monomer droplets in an emulsion if the CNFs were modified with quaternary ammonium （QA） cations. This strategy enabled us to produce CNF-shelled composite microparticles with various types of core polymers. Moreover, the mechanical properties of these composite particles were superior to those of polymer microparticles without a CNF shell.The electronic interaction with the surface carboxy groups of the CNF shell endowed the composite particles with the pH-sensitive ability to adsorb/desorb various cationic molecules, such as antibacterial agents, metal ions, polymers, and fluorescent or redox dyes. Interestingly, when fluorescent dyes were adsorbed onto the composite particles, the emission wavelength was shorter than in the solid state, which suggests that interaction with the carboxy groups dissociated on the surfaces of the particles prevented the aggregation of the fluorescent dye.The functionalized cellulose nanofibers/polymer composite particles produced by the process have desirable mechanical and carrier properties, and are therefore potentially very useful for industrial applications and in the security field.

Bioinspired antifouling and antibacterial polymer coating with intrinsic self-healing property.

Infections caused by biofouling have become a serious concern in the health care sector. Multifunctional coatings with antifouling and antibacterial properties are widely used to combat these biofouling related infections. However, in practice macro or micro scratches or damages can happen to the coating, which can act as an active site for microbial deposition and destroy the antifouling or antibacterial functionality of the coating. Considering this fact, we have developed an excellent biocompatible and multifunctional coating with antifouling, antibacterial and self-healing properties. In this study, prebiotic chemistry inspired self-polymerization of aminomalononitrile (AMN) was used as a primary coating layer, which acted as a primer to graft vitamin B5 analogous methacrylamide polymer poly(B5AMA) and zwitterionic compound 2-methacryloyloxyethyl phosphorylcholine (MPC) containing polymer poly (MPC-st-B5AMA) by forming strong hydrogen bonds. B5AMA having multiple polar groups in the structure acted as an intrinsic self-healing material and showed an excellent antifouling property against protein and bacteria, maintaining a good hydration layer similar to the MPC containing polymer. To impart the antibacterial property to the coating, silver nanoparticles have also been incorporated, which showed more than 90% killing efficiency against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria with significant reduction of their adhesion on the surface. Incorporation of self-healing property into the fouling repelling and antibacterial coating can significantly extend the durability of the multifunctional coating, making it promising for biomedical applications.

Water - Based Polyurethanes for Antibacterial Coatings: an Overview

The spread of bacterial infections and the resulting loss of life and material have led scientists to research ways to develop knowledge in these disease-causing microorganisms. Usage of antibacterial polymer coatings is an important part of this area. Among the polymers, water-based polyurethanes (WPU’s) have received a lot of attention in biomedical fields such as antibacterial coatings, biological products and wound dressings due to their unique properties such as reduced use of volatile organic compounds (VOC), biocompatibility, the possibility of using a variety of raw materials. In this review, the methods of creating antibacterial properties in polymers, the synthesis of WPU’s and WPU-based antibacterial coatings are reviewed. The products produced as a result of these studies have been recommended for various fields such as the dressing and packaging industries, and the coating of medical equipment.

Ultra-transparent, hard and antibacterial coating with pendent quaternary pyridine salt

Pathogenic microbes are ubiquitous, and they can proliferate quickly on wood surface under the suitable conditions to pose a huge hidden threat to public health security and safety. To impart wood surface with outstanding antibacterial activity, we synthesized a pyridine quaternary ammonium (PQAS) monomer by nucleophilic addition reaction between 4-vinylpyridine and 1-bromododecane, and then prepared the cationic antibacterial polymer (CAP) by radical copolymerization. After that, the antibacterial composite emulsion was obtained after uniformly mixing CAP with a commercialized polyacrylate emulsion (PAE). Finally, we obtained an ultra-transparent, hard and antibacterial CAP/PAE coating by brushing CAP/PAE emulsion on the wood surface and then drying at 80 °C for 3 h. And the optimum mixing ratio of coating was explored and explained by using zeta potentialaccording to the theory of polymeric emulsion. Moreover, the chemical structure, antibacterial activity, physicochemical properties, and cytotoxicity of this coating were investigated systematically. The experimental results indicated that the antibacterial activity of CAP/PAE coating against E. coli and S. aureus were greater than 99.9 % without releasing antibacterial components. Even after being irradiated with ultraviolet light at 254 nm for 100 h, its antibacterial rates still reached 97.12 % (E. coli) and 99.35 % (S. aureus), respectively, which are much higher than the required antibacterial rate of Grade 1 (the highest-grade), and superior to most of the reported work. In addition, the CAP/PAE coating exhibited 5H hardness, ultra-transparent, enhanced mechanical properties and low cytotoxicity. Hence, we have developed a facile approach to fabricate multifunctional coating that has potential application in vehicle glass, mobile screens, building wall, furniture and other fields to endow outstanding and rapid bactericidal activity without compromising their appearance physicochemical properties or biocompatibility.

Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films

Antibacterial polymer materials have gained interest due to their capability to inhibit or eradicate biofilms with greater efficiency in comparison with their monomeric counterparts. Among the antimicrobial and anti-biofouling polymers, catecholamine-based polymers — and in particular polydopamine — have been studied due to their favorable adhesion properties, which can be tuned by controlling the pH value. In this study, we used atomic force microscopy (AFM)–based spectroscopy to investigate the relation between the adhesion properties and surface charge density and the pH of electrochemically deposited polydopamine films presenting a dissociation constant of polydopamine of 6.3 ± 0.2 and a point of zero charge of 5.37 ± 0.06. Furthermore, using AFM and attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), the influence of the surface charge density of polydopamine on bacterial adhesion and biofilm formation was investigated. It was shown that the adhesion of Escherichia coli at positively charged polydopamine is three times higher compared to a negatively charged polymer, and that the formation of biofilms is favored at positively charged polymers.Graphical abstract

Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots.

Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry.

Synthesis and Characterization of a Coumarin Antimicrobial Polymer Fluorescent Coating

Polymer materials are widely used in medical materials, food packaging, coatings, and other fields. However, the surface of the materials is easily contaminated by microorganisms, resulting in serious problems. To solve this issue, a new type of antibacterial polymer fluorescent coating was successfully synthesized by copolymerization of divinylbenzene with 7-methacryloxy-4-methyl coumarin, dodecafluoroheptyl methacrylate, and other monomers. The surface structure and thermal stability of the coating were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. Fluorine was polymerized into the polymer, improving the thermal stability compared to polystyrene and polydivinylbenzene. The bactericidal and antibacterial adhesion properties of the coating materials were studied by a contact germicidal test and antibacterial adhesion test. The polymer had a strong inhibitory effect on Staphylococcus aureus. After immersion in room temperature water, the film maintained its strong inhibitory effect on S. aureus fluorescence intensity and had high fluorescence stability.

Recent Advance in Polymer Coatings Combating Bacterial Adhesion and Biofilm Formation†

Comprehensive SummaryImplantable medical device‐associated infections (DAIs) originating from bacterial adhesion and biofilm formation have threatened to the health and life of patients. Antibacterial polymer coatings with antifouling and/or bactericidal properties have showed great potentials to combat DAI issues. In this review, we report recent advances in antibacterial polymer coatings fighting bacterial adhesion and biofilm formation on implantable biomaterial surfaces. We summarize the mechanisms of bacterial adhesion and biofilm formation, which provides guidance for the design of antibacterial coatings. We describe the polymer and coating preparation methods and discuss the structure‐property relationships of antibacterial polymer coatings. Applications of these polymer coatings in medical catheters, orthopaedic implants, and other applications are elaborated. Future challenges and prospects associated with antibacterial polymer coatings for implantable medical devices are discussed.

Antibacterial activity of natural polymer gels and potential applications without synthetic antibiotics

AbstractAntibiotics' use has increased, resulting in disadvantages like patients' drug resistance. Consequently, urgent action is required to develop a new generation of antibacterial agents. Most antibacterial platforms still require a modification with further antibacterial agents (e.g., antibiotics) for adequate antibacterial efficiency. Thus, a nonantibiotic methodology is immediately needed. Furthermore, bactericidal agents used for this purpose are usually based on metal nanoparticles, carbon materials, and polymers. Still, chemicals, antibiotics, and biocides lead to environmental damage. Therefore, the help of biocompatible yet durable materials and polymers is highly appreciated. In addition, if a polymer is not biodegradable, it will remain in the environment for more than one hundred years due to its low degradation rate. Moreover, non‐biodegradable polymers are harmful to in vivo applications. Hence, the use of biodegradable and non‐toxic materials has received many considerations. Over the last few years, the design and synthesis of new polymer gels have gained increasing attention. A polymer gel, also known as a hydrogel, is a three‐dimensional and cross‐linked network filled with water or other liquid solvents. Besides, the hydrogels supercritical drying method results in aerogels, and the freeze‐drying method generates cryogels, where their porous and sponge‐like structures are preserved. Additionally, antibacterial polymer gels are a new generation of polymers considered attractive due to their unique properties. The most recent studies and the latest innovations in polymer gels and hybrid polymers with intrinsic antibacterial properties were discussed in the present review. The reviewed studies from 2015 to April 2022 showed a tremendous revival in research about biopolymer hydrogel, aerogel, and cryogel as antibacterial agents.

Antibacterial activity of Tilapia Fish Scales derived Chitosan; Future towards Biomedicines

The research effort aimed to evaluate the antimicrobial activity of Chitosan derived from Tilapia fish scales. The production of Chitosan achieved by chemical hydrolysis involving demineralization, deproteinization and deacetylation. The antibacterial activities performed against Staphylococcus aureus, Bacillus cereus, Streptococcus agalactiea, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi. The bacteriostatic and bactericidal effect is measured via Minimum Inhibitory Concentrations (MIC) and the Minimum Bactericidal Concentrations (MBC). Chitin yielded 32.74% from 100 grams of dried fish scales in this study, whereas Chitosan yielded 62.13%. Also, the ratio of MBC/MIC determination reveals the bacteriostatic effect of a Chitosan at given concentrations. Therefore, the antibacterial cationic polymer isolated from Tilapia fish scales utilized in various industrial field. The use of derivatization shows a positive role in control drug release systems.

Carboxymethyl chitosan capped copper oxide nanomaterials as antibacterial and antibiofilm coating for vulcanized natural rubber film

The constant menace of infections caused by many microorganisms is one of the significant concerns to humankind. Also, implant-associated biofilms are prevalent in the healthcare sector, which opens up the need for various protective armories against diseases, including antibacterial coatings. In the current context, developing an appropriate antibacterial coating for the materials utilized in the health sector has significance. Synthesis of copper oxide (CuO) nanoparticles (NPs) by the chemical precipitation method and capping of CuO with carboxymethyl chitosan (CMC) provides outstanding antibacterial action. Natural rubber is widely used for various biomedical purposes, regardless its dormancy against most pathogens. An economical and practical method has been developed to transform the Natural Rubber Latex (NRL) film surface to be sufficiently antibacterial by CuO/CMC lamination. This paper discusses the antibiofilm activity of the rubber films against Escherichia coli (MTCC No. 729) and Staphylococcus aureus (MTCC No. 902), and the non-cytotoxicity of the NRL films after CuO/CMC lamination. Hence this surface modification over the NRL film provides excellent prospects for antibacterial polymer materials.

Development of antibacterial polymer composite films from cassava starch and silver vein graphite composite

The Ceylon Journal of Science is a peer-reviewed journal published quarterly by the University of Peradeniya, Sri Lanka in March, June, September and December. It is aimed at publishing high quality research articles on topics related to different disciplines in Science. The journal accepts original research articles, book reviews, reviews and mini-reviews, short communications, opinions, research notes, and commentaries and notes. The Journal has its own website https://site.pdn.ac.lk/cjs/. The journal strictly adheres to publication ethics as emphasized by the Committee on Publication Ethics (COPE). It is indexed in Sri Lanka Journals Online (SLJOL), Directory of Open Access Journals (DOAJ), Google Scholar and Zoological Records. According to the Google Scholar;H5-Index: 12H5-Median: 15According to the Exaly (1970 – 2021);Impact Factor: 0.6 (top 19%)Extended IF: 0.6 (top 19%)H-Index: 8 (top 28%)Citations/paper: 1.42

Preparation of ε-polylysine and hyaluronic acid self-assembled microspheres loaded bacterial cellulose aerogels with excellent antibacterial activity

ε-Polylysine (ε-PL) is a broad antibacterial polymer. In this work, ε-PL and hyaluronic acid (HA) were self-assembled into microspheres and loaded into regenerated bacterial cellulose (RBC) to prepare RBC/HA/ε-PL aerogels. The RBC/HA/ε-PL aerogel showed a three- dimensional network structure with high porosity. The antibacterial activity of the prepared RBC/HA/ε-PL aerogel against E. coli, C. albicans and S. aureus was carried out by bacterial growth evaluation, bacteria fluorescent stain, bacterial morphology observation and the leaked protein determination. The results showed that RBC/HA/ε-PL aerogel exhibited excellent antibacterial performance by destroying the cell membranes. This work provides a novel and green material prepared by natural polymers, with potential applications in antibacterial materials area.

Electrospun Polylactic Acid-Based Fibers Loaded with Multifunctional Antibacterial Biobased Polymers.

Here, we report the development of antibacterial and compostable electrospun polylactic acid (PLA) fibers by incorporation of a multifunctional biobased polymer in the process. The multifunctional polymer was synthesized from the bio-sourced itaconic acid building block by radical polymerization followed by click chemistry reaction with hydantoin groups. The resulting polymer possesses triazole and hydantoin groups available for further N-alkylation and chlorination reaction, which provide antibacterial activity. This polymer was added to the electrospinning PLA solution at 10 wt %, and fiber mats were successfully prepared. The obtained fibers were surface-modified through the accessible functional groups, leading to the corresponding cationic triazolium and N-halamine groups. The fibers with both antibacterial functionalities demonstrated high antibacterial activity against Gram-positive and Gram-negative bacteria. While the fibers with cationic surface groups are only effective against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus aureus), upon chlorination, the activity against Gram-negative Escherichia coli and Pseudomonas aeruginosa is significantly improved. In addition, the compostability of the electrospun fibers was tested under industrial composting conditions, showing that the incorporation of the antibacterial polymer does not impede the disintegrability of the material. Overall, this study demonstrates the feasibility of this biobased multifunctional polymer as an antibacterial agent for biodegradable polymeric materials with potential application in medical uses.

Potent Antibacterial Composite Nonwovens Functionalized with Bioactive Peptides and Polymers

AbstractThis study presents a set of strategies for producing potent antibacterial fabrics by functionalizing nonwoven fabrics (NWFs) with antimicrobial peptides and polymers (AMPs). The incorporation of AMPs is initially optimized on 2D substrates by evaluating conjugation on a poly(maleic anhydride) copolymer coating versus adsorption on polycationic/anionic films and microgels. The evaluation of the resulting surfaces against S. aureus and E. coli highlights the superior antibacterial activity of poly‐ionic films loaded with daptomycin and polymyxin B as well as microgels featuring controlled release of bacitracin and polymyxin B. These formulations are translated onto spun‐bond polypropylene and poly(ethylene terephthalate) NWFs. The poly‐ionic coatings are either covalently anchored or physically adsorbed onto the surface of the fibers, while the microgels and antibacterial polymers are adsorbed and photo‐crosslinked thereon using a ultraviolet (UV)‐crosslinkable benzophenone‐based polymer. Selected formulations loaded with bacitracin and polymyxin B afford a 105‐fold reduction of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in artificial sweat, respectively, on par with commercial antibacterial NWFs. The proposed antibacterial fabric, however, outperforms its commercial counterparts in terms of biocompatibility, showing virtually no adverse effect on human epidermal keratinocytes. Collectively, these results demonstrate affordable and scalable routes for developing antimicrobial NWFs that efficiently eliminate resilient pathogenic bacteria.

Synthesis and characterisation of modified antibacterial styrene-acrylate emulsions for polymer cement waterproof coatings

PurposeThe purpose of this paper is to develop the efficiency of styrene-acrylate (SA) emulsions for polymer cement waterproof coatings with improved bacteria resistance and mechanical properties.Design/methodology/approachFor effective bacteria resistance and excellent mechanical properties, various concentrations of methacryloxyethylhexadecyl dimethylammonium bromide (MHDB) were synthesised and incorporated into SA emulsions. The properties of SA emulsions modified with MHDB were characterised and compared with those of unmodified ones according to the formulations of polymer cement waterproof coatings.FindingsThe SA emulsions modified with MHDB exhibited significant enhancement of bacteria resistance and mechanical properties over the unmodified ones. The positive quaternary nitrogen and long-chain alkyl groups of MHDB in SA emulsions could attract phospholipid head groups of bacterial and insert them into the cell wall, which results in biomass leak and bactericidal effect. Moreover, MHDB as a softened monomer was beneficial to the synthesis of SA copolymer with low glass-transition temperature (Tg), then the copolymer and cement would form a more compact film which was the main reason for the enhancement of mechanical properties.Research limitations/implicationsThe modifier MHDB was synthesised from diethylaminoethyl methacrylate (DEAM) and 1-bromohexadecane. Besides, the congeners of MHDB could be synthesised from DEAM and 1-bromododecane, 1-tetradecyl dromide, 1-octadecyl bromide, etc. In addition, the efficiency of other modifications into SA emulsions for antibacterial polymer cement waterproof coatings could be studied as well.Practical implicationsThe method provided a practical solution for the improvement of water-based antibacterial acrylate polymer cement waterproof coatings.Originality/valueThe method for enhancing bacteria resistance and mechanical properties of the waterproof coating was novel and valuable.

Engineering Antimicrobial Polymer Nanocomposites: In Situ Synthesis, Disruption of Polymicrobial Biofilms, and In Vivo Activity.

The increasing incidence of microbial infections and a limited arsenal of effective antibacterial and antifungal agents have entailed the need for new broad-spectrum therapeutics. Polymer-inorganic nanocomposites have emerged as an integral choice of antimicrobials but are limited by complicated synthesis, narrow-spectrum activity, and poor in vivo efficacy. Herein, chloride counterions of a nontoxic, moderately antibacterial polymer have been explored for in situ nanoprecipitation-based synthesis of water-soluble polymer-silver chloride nanocomposites. With the controlled release of silver ions, the nanocomposites were highly active against multidrug-resistant bacteria as well as fluconazole-resistant fungi. Alongside the elimination of metabolically inactive bacterial cells, the nanocomposites disrupted polymicrobial biofilms, unlike antibiotics and only silver-based ointments. This underlined the role of the engineered composite design, where the polymer interacted with the biofilm matrix, facilitating the penetration of nanoparticles to kill microbes. Further, the nanocomposite diminished Pseudomonas aeruginosa burden in mice skin infection (>99.9%) with no dermal toxicity proving its potential for clinical translation.

NIR‐Responsive Polyurethane Nanocomposites Based on PDA@FA Nanoparticles with Synergistic Antibacterial Effect

AbstractAt present, high‐performance antibacterial polymer materials have attracted widespread attention, possessing huge application prospects in the fields of medical and biological science, and packaging. In this work, polydopamine nanoparticles (PDA NPs) with photothermal ability and active sites are designed to adsorb fusidic acid (FA) molecules with targeted antibacterial capability; then, polydopamine@fusidic acid (PDA@FA) is introduced into the polyurethane (PU) to obtain multifunctional and antibacterial PU materials (PUDA@FA). The structures and morphologies of PDA NPs and PDA@FA are successfully characterized by Fourier transform‐infrared spectroscopy and scanning electron microscopy. With the introduction of PDA@FA, the nano‐sized reinforcement not only greatly improves the mechanical properties (tensile strength 19.31 MPa and toughness 10.6 MJ m−3) of PU film but also due to the photothermal effect of PDA NPs and the antibacterial of FA, the scavenging activities of DPPH and ABTS reach 70–85% and 55–70%, respectively. The antibacterial rate of Staphylococcus aureus reaches more than 99.9% and presents long‐term antibacterial ability. In this way, this work provides new guidance for the preparation of high‐performance PU materials with both antibacterial and anti‐oxidation properties, broadening the application scope of antibacterial materials.