Since curcumin and curcuminoids include potential functional groups (such as α, β-unsaturated β-diketone, α, β-unsaturated ketone, and β 0-hydroxy-α, β-unsaturated ketone linked with aromatic rings on both sides), they have been the subject of much discussion. These groups have anti-inflammatory, anti-cancer, and antioxidant qualities, among other bioactivities. Using spectroscopic techniques, novel compounds of curcumin were created and described. This study assessed the antibacterial and anti-inflammatory properties of PDB ID:1IU 4 and PDB ID: 4LHF molecular docking, utilizing in silico models. In terms of binding affinity, compounds C-04 and C-05 they had a greater affinity for the 1IU4 and 4LHF, respectively. Using the Agar disc diffusion plate method (500μg/mL), the derivatized compounds were evaluated for their in-vitro antibacterial properties against two strains: S. Aureus and E. coli. When compared to conventional ciprofloxacin, compound C-04 demonstrated good to exceptional antibacterial efficacy against two distinct strains. they were further tested utilizing the carrageenan-induced paw edema method for anti-inflammatory efficacy. By using the HRBC membrane stabilizing test method, Compound C-05 showed strong anti-inflammatory action, while Compounds C-05 &and C-06 demonstrated noteworthy anti-inflammatory activity.