This study aims to extract and purify flavonoids from licorice by an efficient and environmentally friendly approach. The ultrasonic microwave-assisted micellar extraction (UMAME) method was used to extract licorice flavonoids (LFs). The optimal extraction parameters including lauryl sodium sulfate concentration, microwave power, solvent-material ratio and extraction time were investigated by a single factor method and response surface methodology. The extraction rate of LFs was up to 3.65% under the optimal conditions. The extraction solution was pretreated with ethyl acetate and the purity of raw LFs reached 36.47%. The purity of raw LFs was increased from 36.47% to 90.32% by metal complex method and antisolvent recrystallization method. The antioxidant test results showed that the finally purified LFs with an IC50 value of 3.519 μg/mL had a strong scavenging ability on DPPH free radical.