The pointing accuracy of a radio telescope is usually less than one-tenth of its antenna beam width. For large-aperture antennas at the short-centimeter band or millimeter-wave band, the pointing accuracy must be as high as several arc seconds. Therefore, for large-diameter and high-frequency reflector antennas, the pointing problem has become an important focal point to realize the antenna performance. Among many structural subsystem factors that affect the antenna pointing accuracy, there has been only less study on the factor of main reflector deformation. Based on the structural characteristics of the antenna, a reflector space coordinate system is established in this paper. And based on the space coordinates of the main reflector surface points after deformation, a non-linear least squares fitting method with 3 degrees of freedom is proposed to accurately predict the antenna pointing. Finally, the space geometric relationship is used to strictly derive the precise adjustments on the elevation and azimuth in order for correcting the antenna pointing error, and the indirect relationship between the main reflector deformation and the pointing error is constructed. This has certain guiding significance for improving the pointing accuracy of large radio antennas.