Sleep bruxism (SB) is a common sleep disorder that affects approximately 20% of children and 10% of adults. It may cause orodental problems, such as tooth wear, jaw pain, and temporal headaches. However, the pathophysiological mechanisms underlying S... Read More
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Understanding the pathophysiology of sleep bruxism based on human and animal studies: A narrative review
- Journal of Oral Biosciences
- VOL. 65
on Jun 1, 2023
- Animal Studies
- non-REM Sleep
- RMMA
- SB
- Human Studies
- Light Non-rapid Eye Movement
- More +
Ambient particulate air pollution and the intestinal microbiome; a systematic review of epidemiological, in vivo and, in vitro studies
- Science of The Total Environment
- VOL. 878
on Jun 1, 2023
- Ambient Particulate Air Pollution
- Ambient Air Pollution
- Effect Of Particulate Air Pollution
- Particulate Air Pollution
- Ambient Air Pollution Exposure
- Decrease In Taxa
- More +
A healthy indigenous intestinal microbiome is indispensable for intra- and extra-intestinal human health. Since well-established factors such as diet and antibiotic use only explain 16% of the inter-individual variation in gut microbiome composition,... Read More
Daily intranasal insulin at 40IU does not affect food intake and body composition: A placebo-controlled trial in older adults over a 24-week period with 24-weeks of follow-up
- Clinical Nutrition
- VOL. 42
on Jun 1, 2023
- INI
- Weeks In Older Adults
- Trial In Older Adults
- Primary Outcome
- Food Intake
- Appetite In Response
- More +
Centrally administered insulin stimulates the reward system to reduce appetite in response to food intake in animal studies. In humans, studies have shown conflicting results, with some studies suggesting that intranasal insulin (INI) in relatively h... Read More
A novel caffeic acid derivative prevents angiotensin II-induced cardiac remodeling
- Biomedicine & Pharmacotherapy
- VOL. 162
on Jun 1, 2023
- Differentiation Of Fibroblast
- Ang II-induced Cardiac Fibrosis
- Differentiation Of Cardiac Fibroblasts
- Progression Of Cardiac Fibrosis
- Recovery Of Ejection Fraction
- Cardiac Remodeling
- More +
Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis that causes pathological cardiac remodeling. Cardiac fibrosis is a hallmark of heart disease and is associated with a stiff myocardi... Read More
Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway
- Biochemical and Biophysical Research Communications
- VOL. 663
on Jun 1, 2023
- Animal Studies
- Lactic Acid Metabolism
- SAH
- HIF-1α Pathway
- HIF-1α Levels
- Lactic Acid
- More +
The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. In a clinical trial of inhaled hydrogen in patients with subarachnoid hemorrhage (SAH), we found that hydrogen reduced the accumulation of l... Read More
Exosomes derived from TGF-β1-pretreated mesenchymal stem cells alleviate biliary ischemia–reperfusion injury through Jagged1/Notch1/SOX9 pathway
- International Immunopharmacology
- VOL. 119
on Jun 1, 2023
- Animal Studies
- MSCs
- EXO
- Bone Marrow-derived MSCs
- IRI
- TGF-β1 Pretreatment
- More +
This study aimed to evaluate the efficacy of exosomes (EXO) derived from TGF-β1-pretreated mesenchymal stem cells (MSCs) on biliary ischemia reperfusion injury (IRI) and further reveal the possible mechanisms. Bone marrow-derived MSCs were treated wi... Read More
In vitro and in vivo evaluation of the safety of Levilactobacillus brevis CGMCC1.5954 with probiotic potential based on tri-generation whole genome sequencing and animal studies
- Food Bioscience
- VOL. 53
on Jun 1, 2023
- Animal Studies
- Genome Sequencing Studies
- Genome Sequencing
- Probiotic Potential
Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA)
- Molecular and Cellular Neuroscience
- VOL. 125
on Jun 1, 2023
- COGA
- AW
- Feature Of Alcohol Use Disorder
- Human GWAS
- Population Stratification Effects
- Mixed-ancestry Population
- More +
Alcohol withdrawal (AW) is a feature of alcohol use disorder that may occur in up to half of individuals with chronic, heavy alcohol consumption whenever alcohol use is abruptly stopped or significantly reduced. To date, few genes have been robustly ... Read More
Inhibition of interleukin-6 trans-signaling improves survival and prevents cognitive impairment in a mouse model of sepsis
- International Immunopharmacology
- VOL. 119
on Jun 1, 2023
- SAE
- Mouse Model Of Sepsis
- CLP
- IL-6 Trans-signaling
- IL-6
- Chronic Cognitive Impairments
- More +
Sepsis-associated encephalopathy (SAE) manifests clinically as acute and chronic cognitive impairments, which is associated with increased morbidity and mortality. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is consistently up-regulated in sep... Read More
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells
- Nanomedicine: Nanotechnology, Biology and Medicine
- VOL. 50
on Jun 1, 2023
- Effects Of Polystyrene Micro
- Human Intestinal
- Polystyrene Micro
- Human Intestinal Organoids
- Human Intestinal Models
- Microfold Cells
- More +
Micro- and nano-plastics (MPs and NPs) released from plastics in the environment can enter the food chain and target the human intestine. However, knowledge about the effects of these particles on the human intestine is still limited due to the lack ... Read More
Tranexamic acid use is not associated with the risk of melanoma in Danish women: A nested case-control study using Danish health registries
- Cancer Epidemiology
- VOL. 84
on Jun 1, 2023
- Risk Of Melanoma
- Tranexamic Acid
- Danish Women
- Tranexamic Acid Use
- Higher Risk Of Melanoma
- Danish Health Registries
- More +
Repurposing already approved drugs in a cancer setting has gained increasing interest in recent years. Tranexamic acid is an anti-fibrinolytic drug that has recently been suggested as an anti-cancer drug due to its anti-inflammatory and anti-carcinog... Read More
Making Urban Environments: Infrastructures of Power, Resistance and Negotiation
- Global Environment
- VOL. 16
on Jun 1, 2023
- Animal Studies
- Black Soldier Fly
- Community Gardens
- Political Entanglements
- Landscape Planning
- Urban Environments
- More +
As scholars from the fields of history, anthropology and animal studies, as well as landscape planning and management, we discuss various forms of urban and urbanising infrastructures and their political entanglements. Questioning and illuminating ho... Read More
On the noxious black Amazonian scorpion, Tityus obscurus (Scorpiones, Buthidae): Taxonomic notes, biology, medical importance and envenoming treatment
- Toxicon
- VOL. 228
on Jun 1, 2023
- Tityus Obscurus
- Cases Of Scorpion Stings
- Eastern Brazilian Amazon
- Electric Shock
- Children Stung
- Commercial Antivenom
- More +
Tityus obscurus has caused mild, moderate and severe accidents of medical relevance in the eastern Brazilian Amazon and French Guiana. Tityus obscurus has sexual dimorphism although males and females have uniform black coloration. In the Amazon, one ... Read More
Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus
- American Journal of Physiology-Endocrinology and Metabolism
- VOL. 324
on Jun 1, 2023
- EDCs
- Risk Factors For Diabetes Mellitus
- Chronic Nutrient Excess
- Epidemiological Studies
- BPs
- Expression Of Key Genes
- More +
Plastic pollution breaks a planetary boundary threatening wildlife and humans through its physical and chemical effects. Of the latter, the release of endocrine disrupting chemicals (EDCs) has consequences on the prevalence of human diseases related... Read More
Current microfluidic platforms for reverse engineering of cornea
- Materials Today Bio
- VOL. 20
on Jun 1, 2023
- Treatment Of Corneal Blindness
- Tissue Engineering Technology
- Corneal Blindness
- Corneal Disease
- Corneal Transplantation
- Microfluidic Platforms
- More +
According to the World Health Organization, corneal blindness constitutes 5.1% of global blindness population. Surgical outcomes have been improved significantly in the treatment of corneal blindness. However, corneal transplantation is limited by gl... Read More
Fine particulate matter (PM2.5)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony
- Science of The Total Environment
- VOL. 877
on Jun 1, 2023
- Insulin Sensitivity In Mice
- Changes In Glucose Homeostasis
- Overexpression Of Extracellular Superoxide Dismutase
- Pulmonary Oxidative Stress
- Insulin Signaling In Skeletal Muscle
- Sensitivity In Male Mice
- More +
Results of human and animal studies independently suggest that either ambient fine particulate matter (PM2.5) air pollution exposure or a disturbed circadian rhythm (circadian dyssynchrony) are important contributing factors to the rapidly evolving t... Read More
Preclinical animal study of electrospun poly (l-lactide-co-caprolactone) and formulated porcine fibrinogen for full-thickness diabetic wound regeneration
- Biomedicine & Pharmacotherapy
- VOL. 162
on Jun 1, 2023
- Chronic Complications Of Diabetes Mellitus
- Rat Diabetic Model
- Animal Wound Model
- Fibroblast Accumulation
- Wound Healing
- Macroscopic Observation
- More +
Diabetic foot ulcer is one of the most serious chronic complications of diabetes mellitus. It may lead to amputation of the lower extremities for diabetics. Our study was to evaluate the effect of electrospun poly (L-lactide-co-caprolactone) and form... Read More
A corneo-retinal hypercitrullination axis underlies ocular injury to nitrogen mustard
- Experimental Eye Research
- VOL. 231
on Jun 1, 2023
- NM
- Analog Of SM
- Retinal Degenerative Conditions
- PTM
- SM
- Reactive Gliosis
- More +
The vesicant sulfur mustard (SM) is a chemical warfare agent that causes acute and chronic injury to the cornea and proximal anterior segment structures. Despite clinical evidence of SM-exposure causing unexplained retinal deficits, there have been n... Read More
Corticosterone injection into the infralimbic prefrontal cortex enhances fear memory extinction: Involvement of GABA receptors and the extracellular signal-regulated kinase
- Physiology & Behavior
- VOL. 265
on Jun 1, 2023
- IL
- GRs
- GABA Receptors
- Fear Extinction In Rats
- Fear Extinction
- Extinction In Rats
- More +
This study investigated the interactive effect of glucocorticoid and Gamma-aminobutyric acid (GABA) receptors in the Infralimbic (IL) cortex on fear extinction in rats' auditory fear conditioning task (AFC). Animals received 3 conditioning trial tone... Read More
Apremilast loaded lyotropic liquid crystalline nanoparticles embedded hydrogel for improved permeation and skin retention: An effective approach for psoriasis treatment
- Biomedicine & Pharmacotherapy
- VOL. 162
on Jun 1, 2023
- LCNPs
- Skin Retention
- Entrapment Efficiency
- Skin Irritation Study
- HaCaT Cells
- Stratum Corneum
- More +
The present work aimed to prepare and evaluate Apremilast loaded lyotropic liquid crystalline nanoparticles (LCNPs) formulation for skin delivery to enhance the efficacy with reduced adverse effects of the oral therapy in psoriasis treatment. The LCN... Read More