Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor that usually occurs in the proximal extremities and trunk. The purpose of this systematic review was to assess patient demographics, treatment approach, and outcomes for patients with ... Read More
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Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review.
- Hand (New York, N.Y.)
on Jan 24, 2023
- LGFMS
- Distal Extremity
- non-English Publications
- MEDLINE
- Upper Extremity
- Negative Margins
- More +
Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model.
- Pflugers Archiv : European journal of physiology
on Jan 24, 2023
- MIIT
- LRG1
- Lipid Metabolism Regulators
- 8weeks Of Intervention
- Adipose Triglyceride Lipase
- Ginger Juice
- More +
Aging is a natural process coupled with oxidative stress and chronic inflammation, gradually associated with losing organ function over time. Therefore, the objective of the current work was to peruse the protective effects of 8-week moderate-intensi... Read More
A systematic review of optimal pharmacokinetic/pharmacodynamic parameters for beta-lactam therapy in infective endocarditis.
- The Journal of antimicrobial chemotherapy
on Jan 24, 2023
- Animal Studies
- OHAT
- IE
- Causes Of Infective Endocarditis
- Optimal Drug Exposure
- PRISMA
- More +
Beta-lactam antibiotics are the mainstay of therapy for most bacterial causes of infective endocarditis (IE). Traditionally considered as agents with a broad therapeutic index, there is increasing recognition that standard doses may be subtherapeutic... Read More
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III
- International Journal of Molecular Sciences
- VOL. 24
on Jan 23, 2023
- PK Level
- MEK Inhibitors In Melanoma
- PK/PD
- Virtual Clinical Trial
- Inhibitors In Melanoma
- Vivo Translation
- More +
The development of in vitro/in vivo translational methods and a clinical trial framework for synergistically acting drug combinations are needed to identify optimal therapeutic conditions with the most effective therapeutic strategies. We performed p... Read More
High preoperative serum strontium levels increase the risk of acute kidney injury after cardiopulmonary bypass
- Clinical and Experimental Nephrology
on Jan 23, 2023
- BUN Levels
- AKI Patients
- Trace Metal Levels
- AKI
- Incidence Of AKI
- Risk Of Acute Kidney Injury
- More +
Acute kidney injury (AKI) is a common complication of cardiac surgeries. The incidence of AKI after cardiac surgeries using cardiopulmonary bypass (CPB-AKI) is high, emphasizing the need to determine strategies to prevent CPB-AKI. This study investig... Read More
Comparative Study of Different Acupoints for Treating Acute Myocardial Ischemia in Mice
- Journal of Cardiovascular Translational Research
on Jan 23, 2023
- Myocardial Ischemia In Mice
- MI Injury
- TCM
- Related Pathways
- Myocardial Injury
- Systolic Function
- More +
Acupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection from myocard... Read More
Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip
- Investigative Opthalmology & Visual Science
- VOL. 64
on Jan 23, 2023
- EV
- Nonarteritic Anterior Ischemic Optic Neuropathy
- EV miRNAs
- Function Of Retinal Ganglion Cells
- Quantitative RT-PCR Analyses
- FVEPs
- More +
Photolabile paper-based chips were developed to isolate extracellular vesicles (EVs) from small-volume samples (less than 30 µL), such as vitreous humor. Putative neuroprotective effects of EVs' microRNAs were investigated by using the paper chip and... Read More
Statins In Preeclampsia Or Fetal Growth Restriction: A Systematic Review and Meta‐Analysis on Maternal Blood Pressure and Fetal Growth Across Species
- BJOG: An International Journal of Obstetrics & Gynaecology
on Jan 22, 2023
- MBP
- FGR
- SMD
- BW In Grams
- Effects Of Statins
- Route Of Administration
- More +
Several human RCTs are investigating the effects of statins on preeclampsia (PE) and fetal growth restriction (FGR). This cross-species meta-analysis summarizes the preclinical evidence of statin use for PE and FGR. Evaluate the effects of statins on... Read More
Long-Term Cola Intake Does Not Cause Evident Pathological Alterations in the Femoral Bone Microstructure: An Animal Study in Adult Mice
- Nutrients
- VOL. 15
on Jan 22, 2023
- Femoral Bone Microstructure
- Cola Intake
- Cola Consumption
- Vascular Canals
- BMD
- Association Studies In Humans
- More +
Short-term animal experiments and association studies in humans have shown that cola intake may have a detrimental impact on bone mineral density (BMD); however, other bone parameters have not been investigated. This study examined the effects of lon... Read More
Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation
- Cancers
- VOL. 15
on Jan 21, 2023
- MBRT
- Treatment Of Ocular Tumours
- Orthovoltage X-ray
- Ocular Tumours
- Rat Glioma Models
- Small Animal Experiments
- More +
(1) Background: Radiotherapeutic treatments of ocular tumors are often challenging because of nearby radiosensitive structures and the high doses required to treat radioresistant cancers such as uveal melanomas. Although increased local control rates... Read More
Safety of Allogeneic Mesenchymal Stem Cell Seeding of NeuraGen® Nerve Guides in a Rabbit Model
- Tissue Engineering Part C: Methods
on Jan 21, 2023
- Allogeneic MSCs
- MSCs
- Application Of Autologous MSCs
- Nerve Guides
- Local Immune Response
- WBC
- More +
Mesenchymal stem cells (MSC) stimulate nerve and tissue regeneration and are primed for clinical translation. Application of autologous MSCs is limited by requirements for expedient harvesting procedures, proliferative expansion to increase cell numb... Read More
The effect of Pimpinella Anisum herbal tea on human milk volume and weight gain in the preterm infant: a randomized controlled clinical trial
- BMC Complementary Medicine and Therapies
- VOL. 23
on Jan 21, 2023
- Human Milk Volume
- Human Milk Production
- Infant Weight Gain
- Preterm Infant Weight
- Pimpinella Anisum
- Significant Difference In Terms
- More +
Background and aimsHuman milk supports pre-term infants to thrive. Yet human milk production can be inhibited when infants are born prematurely. Pimpinella Anisum has been evidenced to increase milk production and infant weight gain in previous anima... Read More
A review of cognitive and behavioral outcomes of Brivaracetam
- The Kaohsiung Journal of Medical Sciences
on Jan 20, 2023
- Animal Studies
- BRV
- Synaptic Vesicle Protein 2A Ligand
- Pooled Analysis Of Clinical Trials
- ASMs
- Low-quality Of Evidence
- More +
Anti-seizure medications (ASMs) can cause cognitive or behavioral adverse drug reactions, which is an important consideration when selecting an appropriate ASM. Brivaracetam (BRV) is a newer synaptic vesicle protein 2A ligand, which is expected to re... Read More
Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review
- Intensive Care Medicine Experimental
- VOL. 11
on Jan 20, 2023
- CPR
- WLST
- Advances In Cardiopulmonary Resuscitation
- HIBI
- Poor Neurological Outcome
- Normal Cardiac Function
- More +
BackgroundTo date cardiac arrest (CA) remains a frequent cause of morbidity and mortality: despite advances in cardiopulmonary resuscitation (CPR), survival is still burdened by hypoxic–ischemic brain injury (HIBI), and poor neurological outcome, eve... Read More
Circadian Disruption and Colorectal Cancer Incidence in Black Women
- Cancer Epidemiology, Biomarkers & Prevention
on Jan 20, 2023
- Night Shift Work
- Black Women
- History Of Night Shift Work
- Circadian Disruption
- Long-term Night Shift Work
- Time Zone
- More +
Abstract Background: Animal and experimental studies suggest circadian disruption increases colorectal cancer risk, but evidence in humans is limited. We examined night shift work, chronotype, and r... Read More
Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference
- Pediatric Critical Care Medicine
- VOL. 24
on Jan 20, 2023
- PARDS
- Pediatric Acute Lung Injury Consensus
- Acute Lung Injury Consensus Conference
- Acute Respiratory Distress Syndrome Pathobiology
- Clinical Recommendation
- Severity Stratification
- More +
To review the literature for studies published in children on the pathobiology, severity, and risk stratification of pediatric acute respiratory distress syndrome (PARDS) with the intent of guiding current medical practice and identifying important a... Read More
Platelet-Rich Plasma in Large Paraesophageal Hernia Repair: A Feasibility Study
- Foregut: The Journal of the American Foregut Society
on Jan 20, 2023
- PRP
- PEH Repair
- Underwent PEH Repair
- Hiatal Hernia Recurrence
- Hiatal Hernia Repair
- Promotes Wound Healing
- More +
Background: The Achilles heel of antireflux surgery is hiatal hernia recurrence, and no treatment modalities to date have improved this outcome. Platelet-rich plasma (PRP) is an autologous therapy that promotes wound healing by upregulating extracell... Read More
Effectiveness of acupuncture in migraine rats: A systematic review
- PLOS ONE
- VOL. 18
on Jan 20, 2023
- Migraine In Rats
- Paw Withdrawal Threshold
- CNKI
- CGRP
- Effectiveness Of Acupuncture
- SP
- More +
Objective To systematically evaluate the effectiveness and potential underlying mechanisms of acupuncture in the treatment of experimental model of migraine in rats. Methods Nine electronic databases, including CNKI (China National Knowledge Infra... Read More
Consideration for the validation of clinical laboratory methods in nonclinical fields
- Bioanalysis
on Jan 19, 2023
- Animal Studies
- Nonclinical Fields
- Clinical Laboratory Test
- Nonclinical Studies
- Clinical Test Method
- Method Validation
- More +
In new drug development, cells or animals are treated with the selected candidate compound to confirm its efficacy and safety in nonclinical studies. Clinical laboratory tests are carried out using samples from experimental animals in these studies.... Read More
[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
- European Journal of Nuclear Medicine and Molecular Imaging
on Jan 19, 2023
- SRTM
- AIF
- 5-HT1A Receptors
- Test Retest Protocol
- Tissue Compartment Model
- Two-tissue Compartment Model
- More +
Abstract Purpose F13640 (a.k.a. befiradol, NLX-112) is a highly selective 5-HT1A receptor ligand that was selected as a PET radiopharmaceutical-candidate based on animal studies. Due to its high efficacy agonist propertie... Read More