Nanoscale zero-valent iron (nZVI) is the main nanomaterial used in environmental remediation processes. However, as with any remediation technique, the production and the use of nanomaterials can also cause environmental, economic, and social impacts. Thus, the present study investigated the social life cycle analysis (S-LCA) of nZVI production methods applied in environmental remediation. Three production methods of nZVI were selected for analysis: milling, reduction with sodium borohydride, and reduction with hydrogen gas. The social life cycle analysis was developed based on the ISO 14040 standard steps. Limits of the S-LCA system involve the stages of raw material extraction and manufacturing when not considering the use of nZVI postproduction. The analysis of social impact was conducted considering the involved stakeholders, through the application and improvement of an existing methodology and through the following procedures: characterization of social indicators according to a normalized scale, identification of the normalization factor for the indicators, employment of a social questionnaire, calculation of the total points in each impact subcategory (midpoint), calculation of the total points in the impact categories (endpoint), and calculation of the Social Index. The three production methods of nZVI result in significantly equal Social Indices. All methods were classified as socially sustainable according to the implemented methodology. The sensitivity analysis demonstrates the results dependent with the geographic location of the inventory data, while changes in the weighting can affect the Social Index results. Overall, this study significantly contributed to the state-of-the-art application of S-LCA in studies using nanomaterials; however, several limitations were also observed, and thus, steps for future development were suggested to future researches. In addition, this study improved the S-LCA methodology which can be used to assess the social impact of any product.